rhubarb
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Far from being immortal , most cancer cells seem unable to multiply limitlessly and spread throughout the body. Dot Bennett of St George's University of London and colleagues found that only four of 37 skin cancer samples they examined displayed the supposed hallmark of cancer. "We thought they'd all be immortal, but they weren't," she says.
Cultivation notes Any fertile garden soil can be used for rhubarb as long as it is well drained and in full sun. Crowns (‘sets’) can be cropped for ten or more years, though division may be necessary after about five years.
This large tumor presented as a protuberant mass on the buttock of a 45-year-old woman. Microscopically it showed sheets of undifferentiated cells with high nuclear/cytoplasmic ratio, a high mitotic rate, a occasional inconspicuous nucleoli. Immunostains showed strong dot-like and diffuse cytoplasmic positivity for cytokeratins 20, CAM5.2, and AE1-AE3, as well as granular staining for synaptophysin and chromogranin. There were negative reactions for cytokeratin 7, gross cystic disease fluid protein 15, melan-A, S-100 protein, and thyroid transcription factor 1-alpha. Even though the histologic features and immunostain profile was characteristic of a primary skin tumor, the presentation is atypical. Usually, Merkel cell carcinoma presents on the sun-exposed areas of elderly individuals.
Merkel cell carcinoma. Gross pathology specimen. Merkel cell carcinoma - also known as "cutaneous APUDoma," "primary neuroendocrine carcinoma of the skin,", "primary small cell carcinoma of the skin," and "trabecular carcinoma of the skin" [ 1 ] ) - is a rare and highly aggressive cancer in which malignant cancer cells develop in hair follicles , or on or beneath the skin . The majority of Merkel cell carcinomas appear to be caused in part by a virus , which has been named Merkel cell polyomavirus (MCV). Direct evidence for this oncogenetic mechanism comes from research showing that inhibition of production of MCV proteins causes MCV- infected Merkel carcinoma cells to die but has no effect on malignant Merkel cells that are not infected with this virus. [ 2 ] MCV-uninfected tumors, which account for approximately 20% of Merkel cell carcinomas, appear to have a separate (and as-yet unknown) cause. [ 3 ]
We are physicians and researchers who work on Merkel cell carcinoma (MCC), a rare and aggressive skin cancer. If you, your patient, or a loved one has recently been diagnosed with MCC, we hope you will find this website a great resource for information on the many pressing decisions that will need to be made. The information on this website includes frequently asked questions (FAQ) about MCC, the symptoms, causes, treatment and multidisciplinary management by established teams of doctors with expertise in MCC, a glossary of terms relating to Merkel cell carcinoma that patients need to be familiar with, clinical photos of MCC tumors, as well as staging and prognosis information. To improve the treatment and diagnosis of Merkel cell carcinoma we have formed an MCC Multicenter Interest Group (MMIG) composed of 120 physicians and researchers from more than 20 institutions in 4 countries. To participate in our MCC studies, click here .
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Rhubarb is a wonderful plant, with many uses and application. This web site is all about rhubarb. Since June 1994 these web pages have been available to anyone interested in gaining an understanding and appreciation of this fine vegetable. This compendium is a collection of rhubarb information from many sources. Much of the information is from world wide web pages or postings to various news groups (rec.gardens, rec.food.cooking, rec.food.recipes), some is from my own personal rhubarb growing experience, and some has been directly contributed by friends, associates, and visitors to The Rhubarb Compendium.
Rhubarb is a group of plants that belong to the genus Rheum in the family Polygonaceae . They are herbaceous perennial plants growing from short, thick rhizomes . They have large leaves that are somewhat triangular-shaped with long fleshy petioles . They have small flowers grouped in large compound leafy greenish-white to rose-red inflorescences . Although the leaves are toxic, various parts of the plants have medicinal and culinary uses.