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A Report From the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association Abstract Abstract This report is the continuation of two earlier reports that defined human arterial intima and precursors of advanced atherosclerotic lesions in humans.
A Definition of Advanced Types of Atherosclerotic Lesions and a Histological Classification of Atherosclerosis
Atherosclerosis Pathology
The early lesions consist of 2 nonatherosclerotic intimal lesions referred to as adaptive intimal thickening and intimal xanthoma ("fatty streak" in the AHA classification) (see the image below). Intimal xanthoma denotes a lesion rich in foamy macrophages without extracelullar lipid pools. Adaptive intimal thickening is present from birth and grow in areas of low shear stress, and are consist mainly of smooth muscle cells in a proteoglycan rich matrix. Observations from experimental models and autopsy studies in young human subjects suggest that monocyte adherence to the endothelial surface and transmigration into the intima occur as the earliest events in the development of atherosclerotic lesions.
The early lesions consist of 2 nonatherosclerotic intimal lesions referred to as adaptive intimal thickening and intimal xanthoma ("fatty streak" in the AHA classification) (see the image below). Intimal xanthoma denotes a lesion rich in foamy macrophages without extracelullar lipid pools. Adaptive intimal thickening is present from birth and grow in areas of low shear stress, and are consist mainly of smooth muscle cells in a proteoglycan rich matrix. Observations from experimental models and autopsy studies in young human subjects suggest that monocyte adherence to the endothelial surface and transmigration into the intima occur as the earliest events in the development of atherosclerotic lesions.
Atherosclerosis Pathology
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