Overall Vision: This is a very exciting time to do biomedical research. With past and ongoing breakthroughs in screening technologies, we are witnessing an unprecedented explosion in data generation. This development is an obvious boon for computational and theoretical researchers. For perhaps the first time in history, some disciplines within biology may become "analysis-limited" rather than being "data-limited", which has been the historical situation. In other words,interpretation of available data, using computational and theoretical tools may become the limiting and the most important step.