PLOS 23/03/17 The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection. PLOS 06/03/14 Vectorial Capacity of Aedes aegypti: Effects of Temperature and Implications for Global Dengue Epidemic Potential. Abstract Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has a high potential to spread to new areas.
Dengue infections are climate sensitive, so it is important to better understand how changing climate factors affect the potential for geographic spread and future dengue epidemics. Vectorial capacity (VC) describes a vector's propensity to transmit dengue taking into account human, virus, and vector interactions. VC is highly temperature dependent, but most dengue models only take mean temperature values into account. Recent evidence shows that diurnal temperature range (DTR) plays an important role in influencing the behavior of the primary dengue vector Aedes aegypti. PLOS 27/03/14 Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak. Abstract Background During a dengue outbreak with co-circulation of DENV-1 and -2 in the city of Boa Vista, one patient was diagnosed with DENV-4, a serotype supposed absent from Brazil for almost 30 years.
The re-emergence of DENV-4 triggered the intensification of mechanical and chemical Aedes aegypti control activities in order to reduce vector density and avoid DENV-4 dissemination throughout the country. Methods/Principal Findings Vector control activities consisted of (a) source reduction, (b) application of diflubenzuron against larvae and (c) vehicle-mounted space spraying of 2% deltamethrin to eliminate adults. Conclusions Despite the intense effort, mosquito infestation levels were only slightly reduced. Citation: Maciel-de-Freitas R, Avendanho FC, Santos R, Sylvestre G, Araújo SC, Lima JBP, et al. (2014) Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak.
Editor: Rick Edward Paul, Institut Pasteur, France. PLOS 15/04/14 The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication. Abstract Dengue is a public health problem, with several gaps in understanding its pathogenesis.
Studies based on human fatal cases are extremely important and may clarify some of these gaps. In this work, we analyzed lesions in different organs of four dengue fatal cases, occurred in Brazil. Tissues were prepared for visualization in optical and electron microscopy, with damages quantification. As expected, we observed in all studied organ lesions characteristic of severe dengue, such as hemorrhage and edema, although other injuries were also detected. Citation: Póvoa TF, Alves AMB, Oliveira CAB, Nuovo GJ, Chagas VLA, Paes MV (2014) The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication.
PLOS 08/05/14 Assessing the Relationship between Vector Indices and Dengue Transmission: A Systematic Review of the Evidence. Abstract Background Despite doubts about methods used and the association between vector density and dengue transmission, routine sampling of mosquito vector populations is common in dengue-endemic countries worldwide.
This study examined the evidence from published studies for the existence of any quantitative relationship between vector indices and dengue cases. Methodology/Principal Findings From a total of 1205 papers identified in database searches following Cochrane and PRISMA Group guidelines, 18 were included for review. PLOS 20/11/14 Development, Characterization and Application of Monoclonal Antibodies against Brazilian Dengue Virus Isolates. Abstract Dengue is the most prevalent human arboviral disease.
The morbidity related to dengue infection supports the need for an early, quick and effective diagnostic test. Brazil is a hotspot for dengue, but no serological diagnostic test has been produced using Brazilian dengue virus isolates. This study aims to improve the development of immunodiagnostic methods for dengue virus (DENV) detection through the production and characterization of 22 monoclonal antibodies (mAbs) against Brazilian isolates of DENV-1, -2 and -3.
The mAbs include IgG2bκ, IgG2aκ and IgG1κ isotypes, and most were raised against the envelope or the pre-membrane proteins of DENV. PLOS 20/11/14 Approaches to Refining Estimates of Global Burden and Economics of Dengue. Results Dengue burden data and sources of variability Estimates of the disease and economic burden of dengue were derived by combining surveillance, clinical, and cost data.
Since dengue is a reportable disease in many endemic countries, the incidence of dengue in a population can be estimated initially from cases reported to the surveillance system. But because surveillance systems are not designed to capture all episodes of symptomatic dengue, relatively low reporting rates lead to conservative incidence estimates –. PLOS 30/04/15 Reviewing Dengue: Still a Neglected Tropical Disease? 1) Review of common definitions of NTDs The definitions of NTDs have been developed over time and are being used by different agencies differently.
One of the earliest “official” definitions of NTDs emerged from a series of WHO cohosted meetings in 2003 and 2005, the “Berlin meetings” [5,6]. NTDs are “chronic endemic tropical diseases,” “neglected in the public health arena,” and affect almost exclusively “poor and marginalised populations.” Since the establishment of the Department for the Control of Neglected Tropical Diseases in 2005, WHO has been using a similar definition, focusing on the link between poverty and NTDs and the lack of public health awareness of NTDs.
“Today, neglected tropical diseases are a symptom of poverty and disadvantage. Similarly, the Centers for Disease Control (CDC) in the United States of America focuses its definition of NTDs not only on poverty but also the diversity of the diseases. Table 1. Doi:10.1371/journal.pntd.0003632.t001 Table 2. Table 3. PLOS 06/02/15 Developing a Social Autopsy Tool for Dengue Mortality: A Pilot Study. Abstract Background Dengue fever is a public health problem in the tropical and sub-tropical world.
Dengue cases have grown dramatically in recent years as well as dengue mortality. Colombia has experienced periodic dengue outbreaks with numerous dengue related-deaths, where the Santander department has been particularly affected. Although social determinants of health (SDH) shape health outcomes, including mortality, it is not yet understood how these affect dengue mortality. Methods and Findings The tool was developed and pre-tested in three steps. Conclusions The SA tool is based on the scientific literature, a validated conceptual framework, researchers’ and health professionals’ expertise, and a pilot study.
PLOS 11/12/14 The Effect of Virus-Blocking Wolbachia on Male Competitiveness of the Dengue Vector Mosquito, Aedes aegypti. PLOS 22/05/12 Surveillance of Dengue Fever Virus: A Review of Epidemiological Models and Early Warning Systems. Abstract Dengue fever affects over a 100 million people annually hence is one of the world's most important vector-borne diseases.
The transmission area of this disease continues to expand due to many direct and indirect factors linked to urban sprawl, increased travel and global warming. Current preventative measures include mosquito control programs, yet due to the complex nature of the disease and the increased importation risk along with the lack of efficient prophylactic measures, successful disease control and elimination is not realistic in the foreseeable future. Epidemiological models attempt to predict future outbreaks using information on the risk factors of the disease. Through a systematic literature review, this paper aims at analyzing the different modeling methods and their outputs in terms of acting as an early warning system.
Author Summary Figures Editor: Assaf Anyamba, NASA Goddard Space Flight Center, United States of America Copyright: © 2012 Racloz et al. Methods. PLOS 31/05/11 The Early Clinical Features of Dengue in Adults: Challenges for Early Clinical Diagnosis. PLOS 31/05/11 Using Web Search Query Data to Monitor Dengue Epidemics: A New Model for Neglected Tropical Disease Surveillance. Abstract Background A variety of obstacles including bureaucracy and lack of resources have interfered with timely detection and reporting of dengue cases in many endemic countries.
Surveillance efforts have turned to modern data sources, such as Internet search queries, which have been shown to be effective for monitoring influenza-like illnesses. However, few have evaluated the utility of web search query data for other diseases, especially those of high morbidity and mortality or where a vaccine may not exist. In this study, we aimed to assess whether web search queries are a viable data source for the early detection and monitoring of dengue epidemics. PLOS 31/05/11 A New Approach to Monitoring Dengue Activity. Citation: Madoff LC, Fisman DN, Kass-Hout T (2011) A New Approach to Monitoring Dengue Activity. PLoS Negl Trop Dis 5(5): e1215. doi:10.1371/journal.pntd.0001215.