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PLOS 15/09/15 Community-Effectiveness of Temephos for Dengue Vector Control: A Systematic Literature Review. Abstract The application of the organophosphate larvicide temephos to water storage containers is one of the most commonly employed dengue vector control methods.

PLOS 15/09/15 Community-Effectiveness of Temephos for Dengue Vector Control: A Systematic Literature Review

This systematic literature review is to the knowledge of the authors the first that aims to assess the community-effectiveness of temephos in controlling both vectors and dengue transmission when delivered either as a single intervention or in combination with other interventions. A comprehensive literature search of 6 databases was performed (PubMed, WHOLIS, GIFT, CDSR, EMBASE, Wiley), grey literature and cross references were also screened for relevant studies. Data were extracted and methodological quality of the studies was assessed independently by two reviewers. 27 studies were included in this systematic review (11 single intervention studies and 16 combined intervention studies).

All 11 single intervention studies showed consistently that using temephos led to a reduction in entomological indices. Author Summary Methods. PLOS 04/05/18 Early warning and response system (EWARS) for dengue outbreaks: Recent advancements towards widespread applications in critical settings. Abstract Background Dengue outbreaks are increasing in frequency over space and time, affecting people’s health and burdening resource-constrained health systems.

PLOS 04/05/18 Early warning and response system (EWARS) for dengue outbreaks: Recent advancements towards widespread applications in critical settings

The ability to detect early emerging outbreaks is key to mounting an effective response. The early warning and response system (EWARS) is a toolkit that provides countries with early-warning systems for efficient and cost-effective local responses. EWARS uses outbreak and alarm indicators to derive prediction models that can be used prospectively to predict a forthcoming dengue outbreak at district level. Methods We report on the development of the EWARS tool, based on users’ recommendations into a convenient, user-friendly and reliable software aided by a user’s workbook and its field testing in 30 health districts in Brazil, Malaysia and Mexico. Findings 34 Health officers from the 30 study districts who had used the original EWARS for 7 to 10 months responded to a questionnaire with mainly open-ended questions.

Conclusion. PLOS 23/03/17 The relationship between entomological indicators of Aedes aegypti abundance and dengue virus infection. PLOS 06/03/14 Vectorial Capacity of Aedes aegypti: Effects of Temperature and Implications for Global Dengue Epidemic Potential. Abstract Dengue is a mosquito-borne viral disease that occurs mainly in the tropics and subtropics but has a high potential to spread to new areas.

PLOS 06/03/14 Vectorial Capacity of Aedes aegypti: Effects of Temperature and Implications for Global Dengue Epidemic Potential

Dengue infections are climate sensitive, so it is important to better understand how changing climate factors affect the potential for geographic spread and future dengue epidemics. Vectorial capacity (VC) describes a vector's propensity to transmit dengue taking into account human, virus, and vector interactions. VC is highly temperature dependent, but most dengue models only take mean temperature values into account. Recent evidence shows that diurnal temperature range (DTR) plays an important role in influencing the behavior of the primary dengue vector Aedes aegypti.

PLOS 27/03/14 Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak. Abstract Background During a dengue outbreak with co-circulation of DENV-1 and -2 in the city of Boa Vista, one patient was diagnosed with DENV-4, a serotype supposed absent from Brazil for almost 30 years.

PLOS 27/03/14 Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak

The re-emergence of DENV-4 triggered the intensification of mechanical and chemical Aedes aegypti control activities in order to reduce vector density and avoid DENV-4 dissemination throughout the country. Methods/Principal Findings Vector control activities consisted of (a) source reduction, (b) application of diflubenzuron against larvae and (c) vehicle-mounted space spraying of 2% deltamethrin to eliminate adults. Conclusions Despite the intense effort, mosquito infestation levels were only slightly reduced. Citation: Maciel-de-Freitas R, Avendanho FC, Santos R, Sylvestre G, Araújo SC, Lima JBP, et al. (2014) Undesirable Consequences of Insecticide Resistance following Aedes aegypti Control Activities Due to a Dengue Outbreak. Editor: Rick Edward Paul, Institut Pasteur, France Methods. PLOS 15/04/14 The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication. Abstract Dengue is a public health problem, with several gaps in understanding its pathogenesis.

PLOS 15/04/14 The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication

Studies based on human fatal cases are extremely important and may clarify some of these gaps. In this work, we analyzed lesions in different organs of four dengue fatal cases, occurred in Brazil. Tissues were prepared for visualization in optical and electron microscopy, with damages quantification. As expected, we observed in all studied organ lesions characteristic of severe dengue, such as hemorrhage and edema, although other injuries were also detected. Citation: Póvoa TF, Alves AMB, Oliveira CAB, Nuovo GJ, Chagas VLA, Paes MV (2014) The Pathology of Severe Dengue in Multiple Organs of Human Fatal Cases: Histopathology, Ultrastructure and Virus Replication. PLOS 08/05/14 Assessing the Relationship between Vector Indices and Dengue Transmission: A Systematic Review of the Evidence. Abstract Background.

PLOS 08/05/14 Assessing the Relationship between Vector Indices and Dengue Transmission: A Systematic Review of the Evidence

PLOS 20/11/14 Development, Characterization and Application of Monoclonal Antibodies against Brazilian Dengue Virus Isolates. Abstract Dengue is the most prevalent human arboviral disease.

PLOS 20/11/14 Development, Characterization and Application of Monoclonal Antibodies against Brazilian Dengue Virus Isolates

The morbidity related to dengue infection supports the need for an early, quick and effective diagnostic test. Brazil is a hotspot for dengue, but no serological diagnostic test has been produced using Brazilian dengue virus isolates. This study aims to improve the development of immunodiagnostic methods for dengue virus (DENV) detection through the production and characterization of 22 monoclonal antibodies (mAbs) against Brazilian isolates of DENV-1, -2 and -3. The mAbs include IgG2bκ, IgG2aκ and IgG1κ isotypes, and most were raised against the envelope or the pre-membrane proteins of DENV.

Citation: Zanluca C, Mazzarotto GACA, Bordignon J, Duarte dos Santos CN (2014) Development, Characterization and Application of Monoclonal Antibodies against Brazilian Dengue Virus Isolates. Editor: Nicholas J. Received: June 11, 2014; Accepted: September 15, 2014; Published: November 20, 2014 Copyright: © 2014 Zanluca et al. Results. PLOS 20/11/14 Approaches to Refining Estimates of Global Burden and Economics of Dengue. Results Dengue burden data and sources of variability Estimates of the disease and economic burden of dengue were derived by combining surveillance, clinical, and cost data.

PLOS 20/11/14 Approaches to Refining Estimates of Global Burden and Economics of Dengue

Since dengue is a reportable disease in many endemic countries, the incidence of dengue in a population can be estimated initially from cases reported to the surveillance system. But because surveillance systems are not designed to capture all episodes of symptomatic dengue, relatively low reporting rates lead to conservative incidence estimates [23]–[26]. PLOS 30/04/15 Reviewing Dengue: Still a Neglected Tropical Disease? 1) Review of common definitions of NTDs The definitions of NTDs have been developed over time and are being used by different agencies differently.

PLOS 30/04/15 Reviewing Dengue: Still a Neglected Tropical Disease?

PLOS 06/02/15 Developing a Social Autopsy Tool for Dengue Mortality: A Pilot Study. Abstract Background Dengue fever is a public health problem in the tropical and sub-tropical world.

PLOS 06/02/15 Developing a Social Autopsy Tool for Dengue Mortality: A Pilot Study

Dengue cases have grown dramatically in recent years as well as dengue mortality. Colombia has experienced periodic dengue outbreaks with numerous dengue related-deaths, where the Santander department has been particularly affected. Although social determinants of health (SDH) shape health outcomes, including mortality, it is not yet understood how these affect dengue mortality. PLOS 11/12/14 The Effect of Virus-Blocking Wolbachia on Male Competitiveness of the Dengue Vector Mosquito, Aedes aegypti. PLOS 22/05/12 Surveillance of Dengue Fever Virus: A Review of Epidemiological Models and Early Warning Systems.

Abstract Dengue fever affects over a 100 million people annually hence is one of the world's most important vector-borne diseases. The transmission area of this disease continues to expand due to many direct and indirect factors linked to urban sprawl, increased travel and global warming. Current preventative measures include mosquito control programs, yet due to the complex nature of the disease and the increased importation risk along with the lack of efficient prophylactic measures, successful disease control and elimination is not realistic in the foreseeable future. Epidemiological models attempt to predict future outbreaks using information on the risk factors of the disease. Through a systematic literature review, this paper aims at analyzing the different modeling methods and their outputs in terms of acting as an early warning system.

Author Summary Figures Editor: Assaf Anyamba, NASA Goddard Space Flight Center, United States of America. PLOS 31/05/11 The Early Clinical Features of Dengue in Adults: Challenges for Early Clinical Diagnosis. PLOS 31/05/11 Using Web Search Query Data to Monitor Dengue Epidemics: A New Model for Neglected Tropical Disease Surveillance. Abstract Background A variety of obstacles including bureaucracy and lack of resources have interfered with timely detection and reporting of dengue cases in many endemic countries. Surveillance efforts have turned to modern data sources, such as Internet search queries, which have been shown to be effective for monitoring influenza-like illnesses.

However, few have evaluated the utility of web search query data for other diseases, especially those of high morbidity and mortality or where a vaccine may not exist. In this study, we aimed to assess whether web search queries are a viable data source for the early detection and monitoring of dengue epidemics. PLOS 31/05/11 A New Approach to Monitoring Dengue Activity. Citation: Madoff LC, Fisman DN, Kass-Hout T (2011) A New Approach to Monitoring Dengue Activity. PLoS Negl Trop Dis 5(5): e1215. doi:10.1371/journal.pntd.0001215.