The International Society for Neglected Tropical Diseases via YOUTUBE 23/11/21 Biological control of schistosomiasis: potential, evidence and the way forward. PATHOGENS 25/11/21 From the One Health Perspective: Schistosomiasis Japonica and Flooding. Schistosomiasis is a water-borne parasitic disease distributed worldwide, while schistosomiasis japonica localizes in the People’s Republic of China, the Philippines, and a few regions of Indonesia.
Although significant achievements have been obtained in these endemic countries, great challenges still exist to reach the elimination of schistosomiasis japonica, as the occurrence of flooding can lead to several adverse consequences on the prevalence of schistosomiasis. This review summarizes the influence of flooding on the transmission of schistosomiasis japonica and interventions responding to the adverse impacts from the One Health perspective in human beings, animals, and the environment. J. CLIN. MED. 01/02/21 Loop-Mediated Isothermal Amplification in Schistosomiasis. The evaluation of schistosomiasis treatment success with diagnostic tools has been traditionally very limited, due to the low sensitivity of parasitological methods, particularly in light infections, and the limited value of antibody-based immunological methods.
On the other hand, serum-PCR methods have shown their usefulness to evaluate treatment success on a long-term basis (1-year after initial treatment), not in early treatment monitoring . In this sense, LAMP assays have been used to evaluate the efficacy of chemotherapy in schistosomiasis. However, studies are still limited to S. japonicum infections, performed both in experimentally infected animals [45,46,47] and in patients . In a first study, Xu et al.  studied praziquantel treatment in rabbits experimentally infected with a high dose of S. japonicum (500 cercariae). PARASITES & VECTORS 06/08/21 A loop-mediated isothermal amplification assay for Schistosoma mansoni detection in Biomphalaria spp. from schistosomiasis-endemic areas in Minas Gerais, Brazil. 1.World Health Organization.
MEDRXIV 04/11/21 THE EFFECTIVENESS OF PRAZIQUANTEL PREVENTIVE CHEMOTHERAPY ON MORBIDITY IN SCHISTOSOMIASIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. BMC INFECTIOUS DISEASES 30/09/21 Novel tools and strategies for breaking schistosomiasis transmission: study protocol for an intervention study. Study aim The overall objective of the study is to investigate new tools and strategies for breaking schistosomiasis transmission.
Primary and secondary objectives The primary objective of this study is to quantify the sensitivity of an adaptive surveillance-response approach for its ability to detect S. haematobium infected individuals in low-prevalence areas to trigger an appropriate intervention response. The primary outcome variable will be the number of S. haematobium infected individuals detected and reported through the surveillance approach divided by the number of positive individuals in the population as extrapolated from the cross-sectional surveys, i.e. the mean sensitivity of the surveillance-response approach determined over 3 years. Secondary outcome analyses will cover additional performance parameters of the surveillance approach, as defined by WHO .
FRONT. TROP. DIS. 05/08/21 Context-Specific Procedures for the Diagnosis of Human Schistosomiasis – A Mini Review. Introduction Schistosomiasis is a neglected tropical disease (NTD) caused by parasitic blood flukes of the Schistosoma genus, affecting over 250 million people of which the majority reside in sub-Saharan Africa (1, 2).
The main species infecting humans are S.mansoni, S.japonicum (both causing intestinal schistosomiasis) and S.haematobium (causing urogenital schistosomiasis) (1, 2). Furthermore, hybrid infections, resulting from interactions between human and animal schistosome species and potentially enhanced by zoonotic transmission, are increasingly being reported and may present a considerable risk of human pathology (3). Schistosomiasis can lead to significant morbidity and even mortality if not treated. The most effective and widely used drug is praziquantel (PZQ), which is safe and efficacious against the adult worm stages of all Schistosoma spp (4). 1. Obviously, assay verification and validation are critical steps when implementing diagnostic tests. 2. Endemic Settings Travelers. PARASITES & VECTORS 03/02/21 Modeling schistosomiasis transmission: the importance of snail population structure.
1.World Health Orgnization.
Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2016. Wkly Epidemiol Rec. 2017;92:749–60. Google Scholar 2.Gryseels B, Polman K, Clerinx J, Kestens L. Human schistosomiasis. MICROORGANISMS 31/05/21 Special Issue "Schistosoma and Schistosomiasis" Causal agents of schistosomiasis are dioecious, digenean schistosomes affecting mankind in 76 countries.
Preventive measures are manifold but need to be complemented by vaccination for long-term protection; vaccine candidates in advanced pre-clinical/clinical stages include Sm14, Sm-TSP-2/Sm-TSP-2Al®, Smp80/SchistoShield®, and Sh28GST/Bilhvax [...] Read more. MATHEMATICS 05/08/21 Schistosomiasis Model Incorporating Snail Predator as Biological Control Agent.
All articles published by MDPI are made immediately available worldwide under an open access license.
The epidemiology of schistosomiasis in Egypt: summary findings in nine governorates. Am J Trop Med Hyg. 2000;62(2 Suppl):88–99.CAS PubMed Article Google Scholar 2.Jordan P. From katayama to the Dakhla Oasis: the beginning of epidemiology and control of bilharzia. Acta Trop. 2000;77(1):9–40.CAS PubMed Article Google Scholar 3.Hotez PJ, Alvarado M, Basanez MG, Bolliger I, Bourne R, Boussinesq M, et al. J. CLIN. MED. 24/01/21 T Cell Peptides Derived from Invasive Stages of Schistosoma mansoni as Potential Schistosomiasis Vaccine. All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.
Feature Papers represent the most advanced research with significant potential for high impact in the field. Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication. The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature.
EMORY_EDU 11/03/21 Water temperature key to schistosomiasis risk and prevention strategies. About one billion people worldwide are at risk for schistosomiasis — a debilitating disease caused by parasitic worms that live in fresh water and in intermediate snail hosts. A new study finds that the transmission risk for schistosomiasis peaks when water warms to 21.7 degrees centigrade, and that the most effective interventions should include snail removal measures implemented when the temperature is below that risk threshold.
The Proceedings of the National Academy of Sciences published the results, led by Emory University, the University of South Florida and the University of Florida. BLOG BUGBITTEN 08/06/21 Spatial sampling and machine learning approaches to improve schistosomiasis control. Specimens of eggs of S. japonicum. Source: CDC. The use of the material, including any links to the materials on the CDC, ATSDR or HHS websites, does not imply endorsement by CDC, ATSDR, HHS or the United States Government of any person, company, product, facility, service or enterprise mentioned here. Schistosomiasis, a serious parasitic disease caused by trematode worms belonging to the genus Schistosoma, is not only harmful to health but also holds up the development of the economy and society in the endemic areas.
According to the World Health Organization (WHO), the disease is prevalent in 78 tropical and subtropical countries around the world, where it affects the lives of more than 700 million people in endemic areas, with at least 240 million actually infected. Proc Natl Acad Sci U S A. 2006 May 2; An integrated approach for risk profiling and spatial prediction of Schistosoma mansoni–hookworm coinfection. OPEN FORUM INFECTIOUS DISEASES 15/04/21 Control and elimination of schistosomiasis as a public health problem thresholds fail to differentiate schistosomiasis morbidity prevalence in children. PLOS 24/03/21 Detecting and identifying Schistosoma infections in snails and aquatic habitats: A systematic review.
Abstract Background We were tasked by the World Health Organization (WHO) to address the following question: What techniques should be used to diagnose Schistosoma infections in snails and in the water in potential transmission sites? PARASITOLOGY - 2006 - Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. THE LANCET - OCT 2019 - Improving public health control of schistosomiasis with a modified WHO strategy: a model-based comparison study. Summary Background Schistosomiasis is endemic in many low-income and middle-income countries. To reduce infection-associated morbidity, WHO has published guidelines for control of schistosomiasis based on targeted mass drug administration (MDA) and, in 2017, on supplemental snail control. We compared the current WHO guideline-based strategies from 2012 to an alternative, adaptive decision making framework for control in heterogeneous environments, to estimate their predicted relative effectiveness and time to achievement of defined public health goals.
SCIENTIFIC REPORTS 14/10/19 Progress in loop-mediated isothermal amplification assay for detection of Schistosoma mansoni DNA: towards a ready-to-use test. 1.WHO/Department of control of neglected tropical diseases. Integrating neglected tropical diseases in global health and development: fourth WHO report on neglected tropical diseases (2017).2.McManus, D. P. et al. Schistosomiasis. Nat. Rev. PLOS 13/05/20 Impacts of host gender on Schistosoma mansoni risk in rural Uganda—A mixed-methods approach. PLOS 11/09/19 Real-time PCR for diagnosis of imported schistosomiasis. Citation: Guegan H, Fillaux J, Charpentier E, Robert-Gangneux F, Chauvin P, Guemas E, et al. (2019) Real-time PCR for diagnosis of imported schistosomiasis.
PATHOGENS 06/01/20 Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review. Parasitology International Volume 75, April 2020, Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines. Parasite Epidemiology and Control Volume 9, May 2020, Global prevalence status of avian schistosomes: A systematic review with meta-analysis. Aldhoun et al., 2009 J. Aldhoun, L. Kolářová, P. Horák, K. SkírnissonBird schistosome diversity in Iceland: molecular evidence J. NATURE 17/02/20 A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics. INFECTIOUS DISEASES OF POVERTY 10/05/19 Assessing the nonhuman primate reservoir of Schistosoma mansoni in Africa: a systematic review.
AJTMH - 2019 - Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): Its Foundations, Development, and Evolution. Acta Tropica Volume 202, February 2020, Recent advances in Schistosoma mekongi ecology, transcriptomics and proteomics of relevance to snail control. Illinois_edu 07/02/20 Researchers discover compound to stop a pervasive parasitic flatworm - A microscopic aquatic animal is key to halting schistosomiasis. A microscopic animal produces a compound that can paralyze parasitic worms that have infected over 200 million people worldwide, an interdisciplinary team of scientists from the University of Illinois and the University of Wisconsin reported in a recent PLOS Biology article. The discovery of the compound, known as Schistosome Paralysis Factor, could be critical for producing a treatment against schistosomiasis, a parasitic disease whose impact the CDC has called “second only to malaria.” People are often infected while swimming, fishing or washing clothes in waters infested with the parasitic flatworms known as schistosomes.
Those who are infected, mostly from poor and rural areas in developing countries, can suffer from the disease for years if left untreated, with symptoms including abdominal pain, enlarged liver and an increased risk of some types of cancer. Before the parasites enter the water where they infect people, the worms live in snails. Parasite Epidemiology and Control Volume 9, May 2020, Global prevalence status of avian schistosomes: A systematic review with meta-analysis. SCIENTIFIC REPORTS 14/10/19 Progress in loop-mediated isothermal amplification assay for detection of Schistosoma mansoni DNA: towards a ready-to-use test. NEJM 26/12/19 Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals. PATHOGENS 06/01/20 Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review.
Int. J. Environ. Res. Public Health 2020, 17(1), 181; The Effect of Climate Change and the Snail-Schistosome Cycle in Transmission and Bio-Control of Schistosomiasis in Sub-Saharan Africa. PLOS 11/09/19 Real-time PCR for diagnosis of imported schistosomiasis. PLOS 21/03/19 A major hurdle in the elimination of urogenital schistosomiasis revealed: Identifying key gaps in knowledge and understanding of female genital schistosomiasis within communities and local health workers.
MEDICAL XPRESS 07/12/18 Tea infusions of wormwood plant cured schistosomiasis faster than commonly used drug in clinical trial. JOURNAL OF HEALTH RESEARCH & REVIEWS 30/04/18 Schistosomiasis: A neglected tropical disease of poverty: A call for intersectoral mitigation strategies for better health. Clinical Microbiology and Infection Available online 20 February 2019 Intestinal schistosomiasis: a very long-lived tropical parasite.
J Vector Borne Dis 47, December 2010, pp. 228–234 Epidemiology and control of Schistosomiasis and other intestinal parasitic infections among school children in three rural villages of south Saint Lucia. PLOS 02/08/18 Precision mapping: An innovative tool and way forward to shrink the map, better target interventions, and accelerate toward the elimination of schistosomiasis. Trop. Med. Infect. Dis. 2017, 2(3), 42; The Interdependence between Schistosome Transmission and Protective Immunity. THE LANCET 27/01/18 Underestimation of the global burden of schistosomiasis. PLOS 26/10/17 Why reinvent the wheel? Lessons in schistosomiasis control from the past.
PLOS 18/07/17 Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites. INTECH 16/01/13 Epidemiological Survey of Human and Veterinary Schistosomiasis. BLOG BMC 16/03/18 The timing and the tools for tallying up trematodes: diagnosing and quantifying the burden of intestinal schistosomiasis. NATURE 26/02/18 Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts.
PLOS 26/10/17 Why reinvent the wheel? Lessons in schistosomiasis control from the past. BIOMED BUGBITTEN 14/07/17 Schistosome infections in snails alter snail physiology. International Journal of Infectious Diseases Volume 54, January 2017, A new global strategy for the elimination of schistosomiasis. Ethiop. J. Health Dev. 192 2011 Current status of intestinal Schistosomiasis and soiltransmitted helminthiasis among primary school children in Adwa Town, Northern Ethiopia. ONE HEALTH 28/02/17 Integrated preventive chemotherapy and WASH for intensified schistosomiasis and soil transmitted helminthiasis control.
Am J Trop Med Hyg. 2014 Apr;90(4):667-9. Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. BLOG PLOST 15/08/16 Highlighting notable helminth research and a PLOS Science Weds AMA preview for #WormWeek. PARASITES & VECTORS - 2015 - Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. CDC EID – OCT 2015 – Au sommaire notamment: Spatiotemporal Patterns of Schistosomiasis-Related Deaths, Brazil, 2000–2011 ;
Int. J. Environ. Res. Public Health 2015, 12(9), 11756-11769 Identifying Spatial Clusters of Schistosomiasis in Anhui Province of China: A Study from the Perspective of Application. Rev. Soc. Bras. Med. Trop. vol.46 no.4 Uberaba July/Aug. 2013 Epidemiological aspects of schistosomiasis in workers of the Movement of Landless Rural Workers. THE LANCET 20/06/14 Prehistoric schistosomiasis parasite found in the Middle East. Infectious Diseases of Poverty 2015, 4:4 Urban schistosomiasis and associated determinant factors among school children in Bamako, Mali, West Africa. ECDC 22/05/14 Local transmission of Schistosoma in Corsica, France: Risk limited to residents and people visiting the area, infection only through contact with freshwater.
DURHAM UNIVERSITY - 2015 - Thèse en ligne : Modelling the effects of temperature changes on Schistosoma mansoni transmission. Clinical Microbiology and Infection Volume 21, Issue 6, June 2015, New diagnostic tools in schistosomiasis. CDC EID - AOUT 2013 - Au sommaire: Autochthonous Human Schistosomiasis, Malaysia. Case Reports in Infectious Diseases Volume 2012 (2012), Acute Schistosomiasis in Brazilian Traveler: The Importance of Tourism i.
MEM INST OSWALDO CRUZ RIO DE JANEIRO - 1995 - Molluscicide control of snail vectors of Schistosomiasis. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 101(Suppl. I): 91-96, 2006 Analysis and estimative of schistosomiasis prevalence for. Ethiop J Health Dev 2011;25(1) Schistosomiasis mansoni and soil-transmitted helminthiasis in Bushulo village, southern Ethiopia. Schistosomiasis. PLOS 20/12/11 Tools to Support Policy Decisions Related to Treatment Strategies and Surveillance of Schistosomiasis Japonica tow.