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PARASITOLOGY - 2006 - Vaccines against the zoonotic trematodes Schistosoma japonicum, Fasciola hepatica and Fasciola gigantica. THE LANCET - OCT 2019 - Improving public health control of schistosomiasis with a modified WHO strategy: a model-based comparison study. Summary Background Schistosomiasis is endemic in many low-income and middle-income countries. To reduce infection-associated morbidity, WHO has published guidelines for control of schistosomiasis based on targeted mass drug administration (MDA) and, in 2017, on supplemental snail control.

We compared the current WHO guideline-based strategies from 2012 to an alternative, adaptive decision making framework for control in heterogeneous environments, to estimate their predicted relative effectiveness and time to achievement of defined public health goals. Methods In this model-based comparison study, we adapted an established transmission model for Schistosoma infection that couples local human and snail populations and includes aspects of snail ecology and parasite biology. Findings Interpretation The modified adaptive decision making framework is predicted to be more effective than the current WHO guidelines in reaching 2025 public health goals, especially for high-prevalence regions. Funding. SCIENTIFIC REPORTS 14/10/19 Progress in loop-mediated isothermal amplification assay for detection of Schistosoma mansoni DNA: towards a ready-to-use test. 1.WHO/Department of control of neglected tropical diseases.

Integrating neglected tropical diseases in global health and development: fourth WHO report on neglected tropical diseases (2017).2.McManus, D. P. et al. Schistosomiasis. Nat. Rev. PLOS 13/05/20 Impacts of host gender on Schistosoma mansoni risk in rural Uganda—A mixed-methods approach. Abstract Background The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas.

However, as hotspots with high (re)infection rates remain, additional research on risk factors and implementing interventions to complement MDA are required to further reduce disease burden in these settings. Through a mixed-methods study we aimed to gain deeper understanding of how gender may impact risk and reinfection in order to inform disease control programmes and ascertain if gender-specific interventions may be beneficial. Methodology/Principal findings In Bugoto, Mayuge District, Eastern Uganda we conducted ethnographic observations (n = 16) and examined epidemiology (n = 55) and parasite population genetics (n = 16) in school-aged children (SAC), alongside a community-wide household survey (n = 130). Methods A. PLOS 11/09/19 Real-time PCR for diagnosis of imported schistosomiasis. Citation: Guegan H, Fillaux J, Charpentier E, Robert-Gangneux F, Chauvin P, Guemas E, et al. (2019) Real-time PCR for diagnosis of imported schistosomiasis. PLoS Negl Trop Dis 13(9): e0007711.

Editor: Mike J. Doenhoff, University of Nottingham, UNITED KINGDOM Received: April 8, 2019; Accepted: August 15, 2019; Published: September 11, 2019 Copyright: © 2019 Guegan et al. Data Availability: All relevant data are within the manuscript and its Supporting Information files. Funding: This study was supported in part by the French "Agence Nationale de la Recherche" (ANR 18 CE35 0001 03) (AB, JF, JB).

Competing interests: The authors have declared that no competing interests exist. Introduction Schistosomiasis is a snail-borne parasitic disease of great concern worldwide, occurring mainly in Africa, Asia, and to a lesser degree in South America and the Middle East [1,2]. Materials and methods Ethics statement Study design Microscopy (ME) DNA extraction. PATHOGENS 06/01/20 Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review.

An increasing global focus on neglected tropical diseases (NTDs) has resulted in the set up of numerous control and elimination activities worldwide. This is partly true for Taenia solium taeniasis/cysticercosis, the most important foodborne parasitic infection. Despite substantial progress, adequate monitoring and surveillance (M&S) are required to sustain a status of control/elimination. This is often lacking, especially for T. solium.

Therefore, the objective was to conduct a systematic literature review of the currently available M&S systems at the control/elimination stage of the four top-ranked helminth NTDs. Specifically, Taenia spp., Echinococcus spp., Schistosoma spp., and soil-transmitted helminths (STHs) were considered to determine if there are any similarities between their M&S systems and whether certain approaches can be adopted from each other. ►▼ Show Figures Figure 1. Parasitology International Volume 75, April 2020, Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines. Parasite Epidemiology and Control Volume 9, May 2020, Global prevalence status of avian schistosomes: A systematic review with meta-analysis. Aldhoun et al., 2009 J. Aldhoun, L. Kolářová, P.

Horák, K. J. Aldhoun and Horne, 2015 J.A. Parasitol. Appleton, 1983 C. Int. Appleton, 1986 C. Afr. Athari et al., 1990 A. Barber and Caira, 1995 K.E. J. Bayssade-Dufour et al., 2006 C. Parasite., 13 (2006), pp. 205-214 Birmani et al., 2013 N. J Anim Plant Sci., 23 (2013), pp. 1215-1218 Blair and Ottesen, 1979 D. J. Blankespoor and Meier, 1981 B.C.S.H.D. Proc. Brackett, 1942 S. J. Brant, 2007 S.V. Folia Parasitol., 54 (2007), pp. 99-104 Brant and Loker, 2009a S.V. J. Brant and Loker, 2009b S.V. J. Brant et al., 2006 S.V. J. Brant et al., 2017 S.V. J. Caumes et al., 2003 E. Ann. Cheatum, 1941 E. J. Cotton, 2003 P.A. Proc Natl Acad Sci India Sect., 100 (2003), pp. 12219-12222 Davis, 2006 N. New Zealand, J Helminthol., 80 (2006), pp. 33-40 Fain, 1955 A. Rev. Fain, 1956 A. Rev. Fakhar et al., 2016 M. Northern Iran, Parasitol. Farahnak and Essalat, 2003 A. South western Iran, BMC Public Health., 3 (2003), p. 35 Gay et al., 1999 P.

Med. De Gentile et al., 1996 S. B.D. Proc. NATURE 17/02/20 A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics. Study design This phase I trial (ClinicalTrials.gov identifier: NCT02755324) was an open-label dose-escalation study at the Leiden University Medical Center (LUMC). Male cercariae were produced as previously reported34. The initial dose was 10 cercariae (n = 3), which was escalated to 30 (n = 3) and subsequently de-escalated to 20 cercariae (n = 3) on the basis of AEs. The 20 cercariae infection was then validated in another group (n = 8). The viability of cercariae was confirmed by imaging of cercariae penetrating skin explants35. The cercariae were applied to the volunteer’s forearm in 0.5–1 ml of water for 30 min, the number of remaining cercariae were counted by microscopy. Volunteers were observed for 30 min after exposure.

Volunteers were followed bi-weekly between week 0–24 and on week 52. The pre-patent period was defined as the time until serum CAA levels were above 1.0 pg ml−1 (ref. 24). Informed consent procedure Inclusion and exclusion criteria Inclusion criteria Adverse events. INFECTIOUS DISEASES OF POVERTY 10/05/19 Assessing the nonhuman primate reservoir of Schistosoma mansoni in Africa: a systematic review. 1.Engels D, Chitsulo L, Montresor A, Savioli L. The global epidemiological situation of schistosomiasis and new approaches to control and research. Acta Trop. 2002;82(2):139–46.CAS Article Google Scholar 2.Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk. Lancet Infect Dis. 2006;6(7):411–25.Article Google Scholar 3.World Health Organization. Elimination of schistosomiasis. In: SIXTY-FIFTH WORLD HEALTH ASSEMBLY. AJTMH - 2019 - Schistosomiasis Consortium for Operational Research and Evaluation (SCORE): Its Foundations, Development, and Evolution.

Acta Tropica Volume 202, February 2020, Recent advances in Schistosoma mekongi ecology, transcriptomics and proteomics of relevance to snail control. Illinois_edu 07/02/20 Researchers discover compound to stop a pervasive parasitic flatworm - A microscopic aquatic animal is key to halting schistosomiasis. A microscopic animal produces a compound that can paralyze parasitic worms that have infected over 200 million people worldwide, an interdisciplinary team of scientists from the University of Illinois and the University of Wisconsin reported in a recent PLOS Biology article. The discovery of the compound, known as Schistosome Paralysis Factor, could be critical for producing a treatment against schistosomiasis, a parasitic disease whose impact the CDC has called “second only to malaria.” People are often infected while swimming, fishing or washing clothes in waters infested with the parasitic flatworms known as schistosomes.

Those who are infected, mostly from poor and rural areas in developing countries, can suffer from the disease for years if left untreated, with symptoms including abdominal pain, enlarged liver and an increased risk of some types of cancer. Before the parasites enter the water where they infect people, the worms live in snails. Parasite Epidemiology and Control Volume 9, May 2020, Global prevalence status of avian schistosomes: A systematic review with meta-analysis. SCIENTIFIC REPORTS 14/10/19 Progress in loop-mediated isothermal amplification assay for detection of Schistosoma mansoni DNA: towards a ready-to-use test.

NEJM 26/12/19 Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals. The WHO provides guidance on the expected number of years of treatment to reach schistosomiasis control and the elimination of schistosomiasis as a public health problem (5 to 10 years for control, plus an additional 3 to 6 years for elimination). These data show that these thresholds are often reached sooner, whether treatment occurs annually or every 2 years. With the exception of S. haematobium infection in Niger, all the programs reached the disease-control target in two or fewer treatment rounds (i.e., between 1 and 2 years, depending on treatment frequency). However, six country programs started with a prevalence of heavy-intensity infection of less than 5% for S. mansoni infection, which indicated that they were already within the disease-control target at baseline.

With regard to S. mansoni infection, the goal of elimination of schistosomiasis as a public health problem was reached by five programs with the use of three or fewer treatment rounds. PATHOGENS 06/01/20 Currently Available Monitoring and Surveillance Systems for Taenia spp., Echinococcus spp., Schistosoma spp., and Soil-Transmitted Helminths at the Control/Elimination Stage: A Systematic Review. Int. J. Environ. Res. Public Health 2020, 17(1), 181; The Effect of Climate Change and the Snail-Schistosome Cycle in Transmission and Bio-Control of Schistosomiasis in Sub-Saharan Africa. 1. Introduction Neglected tropical diseases (NTDs) are a group of chronic infectious diseases that have been ignored for several decades but which typically affect poor people who live on wages below US $2 per day, particularly those living in poor rural areas as well as destitute urban regions with limited access to public health facilities, which are prominent in sub-Saharan Africa (SSA) [1,2,3].

Over 500 million people in this region bear the full impact of these group of diseases which have a significant influence on the health, social, financial and economic status of both governments and households. According to the 10th meeting of the World Health Organization (WHO) Strategic and Technical Advisory Group for NTDs in 2017, the number of NTDs has been increased to 20 following the addition of three diseases namely, scabies and other ectoparasites, snakebite envenoming, and chromoblastomycosis and other deep mycoses. 2. 3. 3.1. 3.2. 4. Figure 1. 4.1. 4.2. 4.3. 4.4. 4.5. 4.6. 5. 6. PLOS 11/09/19 Real-time PCR for diagnosis of imported schistosomiasis.

PLOS 21/03/19 A major hurdle in the elimination of urogenital schistosomiasis revealed: Identifying key gaps in knowledge and understanding of female genital schistosomiasis within communities and local health workers. Abstract Background Urogenital schistosomiasis is endemic throughout Ghana with elevated infection levels in certain areas e.g. Lake Volta Region. While the primary focus of the national control program is on mass drug administration of praziquantel to school-aged children, Female Genital Schistosomiasis (FGS), a disease-specific affliction of girls and women, has been largely overlooked.

To better focus future actions, our study investigated the perceptions, knowledge and understanding of FGS amongst community members and health providers. Method/Principal findings We used qualitative methods including 12 focus group discussions and 34 in-depth interviews. Conclusion/Significance There is a clear imperative for the national control program to better engage on FGS and implement interventions to meet girls and women’s needs. Author summary Female Genital Schistosomiasis (FGS) is a serious, chronic gynecological condition that affects up to 56 million African women and girls. Introduction. MEDICAL XPRESS 07/12/18 Tea infusions of wormwood plant cured schistosomiasis faster than commonly used drug in clinical trial.

Tea infusions made from two species of the wormwood plant cured the tropical disease schistosomiasis significantly faster than the drug most commonly used against the ailment—and with no adverse side effects—in a large clinical trial conducted in the Democratic Republic of Congo. The study's authors, including a professor and two research associates at Worcester Polytechnic Institute (WPI), say the treatment should be considered for implementation on a global scale.

Schistosomiasis, which is caused by parasitic flatworms, affects nearly 210 million people worldwide, primarily in Africa, Asia, and South America, and is responsible for about 200,000 deaths each year, according to the World Health Organization. Infecting the intestines and urinary tract, it causes a range of symptoms, including abdominal pain and diarrhea, and in more severe case can lead to liver damage, kidney failure, and even bladder cancer. More information: Jérôme Munyangi et al. JOURNAL OF HEALTH RESEARCH & REVIEWS 30/04/18 Schistosomiasis: A neglected tropical disease of poverty: A call for intersectoral mitigation strategies for better health. Schistosomiasis: A neglected tropical disease of poverty: A call for intersectoral mitigation strategies for better health Kaliyaperumal Karunamoorthi, Mohammed Jubran Almalki, Khalid Yaser Ghailan Department of Environmental Health, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan, Kingdom of Saudi Arabia Correspondence Address:Prof.

Kaliyaperumal KarunamoorthiFaculty of Public Health and Tropical Medicine, Jazan University, Jazan Kingdom of Saudi Arabia Source of Support: None, Conflict of Interest: None DOI: 10.4103/jhrr.jhrr_92_17 Schistosomiasis (SCH) is one of the neglected tropical diseases, and it is endemic over 78 resource-constrained countries. Keywords: Mitigation strategies, neglected tropical disease, poverty, schistosomiasis Female genital schistosomiasis (FGS), infection increases the risk of HIV-1 infection in women.

The most infected people are school-aged children under 14, those living in rural and urban slums settings. History of schistosomiasis. Clinical Microbiology and Infection Available online 20 February 2019 Intestinal schistosomiasis: a very long-lived tropical parasite. J Vector Borne Dis 47, December 2010, pp. 228–234 Epidemiology and control of Schistosomiasis and other intestinal parasitic infections among school children in three rural villages of south Saint Lucia. PLOS 02/08/18 Precision mapping: An innovative tool and way forward to shrink the map, better target interventions, and accelerate toward the elimination of schistosomiasis.

Citation: Tchuem Tchuenté L-A, Stothard JR, Rollinson D, Reinhard-Rupp J (2018) Precision mapping: An innovative tool and way forward to shrink the map, better target interventions, and accelerate toward the elimination of schistosomiasis. PLoS Negl Trop Dis 12(8): e0006563. Editor: Jennifer Keiser, Swiss Tropical and Public Health Institute, SWITZERLAND Published: August 2, 2018 Copyright: © 2018 Tchuem Tchuenté et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: LATT and JRS participate in the research programme consortium COUNTDOWN funded by the Research and Evidence Division of the Department for International Development, UK. LATT also received financial support from the Bill & Melinda Gates Foundation, Grand Challenges Explorations. Fig 1. Trop. Med. Infect. Dis. 2017, 2(3), 42; The Interdependence between Schistosome Transmission and Protective Immunity.

THE LANCET 27/01/18 Underestimation of the global burden of schistosomiasis. PLOS 26/10/17 Why reinvent the wheel? Lessons in schistosomiasis control from the past. PLOS 18/07/17 Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites.

INTECH 16/01/13 Epidemiological Survey of Human and Veterinary Schistosomiasis. BLOG BMC 16/03/18 The timing and the tools for tallying up trematodes: diagnosing and quantifying the burden of intestinal schistosomiasis. NATURE 26/02/18 Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts. PLOS 26/10/17 Why reinvent the wheel? Lessons in schistosomiasis control from the past. BIOMED BUGBITTEN 14/07/17 Schistosome infections in snails alter snail physiology. International Journal of Infectious Diseases Volume 54, January 2017, A new global strategy for the elimination of schistosomiasis.

Ethiop. J. Health Dev. 192 2011 Current status of intestinal Schistosomiasis and soiltransmitted helminthiasis among primary school children in Adwa Town, Northern Ethiopia. ONE HEALTH 28/02/17 Integrated preventive chemotherapy and WASH for intensified schistosomiasis and soil transmitted helminthiasis control. Am J Trop Med Hyg. 2014 Apr;90(4):667-9. Current status of human hookworm infections, ascariasis, trichuriasis, schistosomiasis mekongi and other trematodiases in Lao People's Democratic Republic. BLOG PLOST 15/08/16 Highlighting notable helminth research and a PLOS Science Weds AMA preview for #WormWeek. PARASITES & VECTORS - 2015 - Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. CDC EID – OCT 2015 – Au sommaire notamment: Spatiotemporal Patterns of Schistosomiasis-Related Deaths, Brazil, 2000–2011 ;

Références PLOS

Int. J. Environ. Res. Public Health 2015, 12(9), 11756-11769 Identifying Spatial Clusters of Schistosomiasis in Anhui Province of China: A Study from the Perspective of Application. Rev. Soc. Bras. Med. Trop. vol.46 no.4 Uberaba July/Aug. 2013 Epidemiological aspects of schistosomiasis in workers of the Movement of Landless Rural Workers.

THE LANCET 20/06/14 Prehistoric schistosomiasis parasite found in the Middle East. Infectious Diseases of Poverty 2015, 4:4 Urban schistosomiasis and associated determinant factors among school children in Bamako, Mali, West Africa. ECDC 22/05/14 Local transmission of Schistosoma in Corsica, France: Risk limited to residents and people visiting the area, infection only through contact with freshwater. DURHAM UNIVERSITY - 2015 - Thèse en ligne : Modelling the effects of temperature changes on Schistosoma mansoni transmission. Clinical Microbiology and Infection Volume 21, Issue 6, June 2015, New diagnostic tools in schistosomiasis. CDC EID - AOUT 2013 - Au sommaire: Autochthonous Human Schistosomiasis, Malaysia.

Case Reports in Infectious Diseases Volume 2012 (2012), Acute Schistosomiasis in Brazilian Traveler: The Importance of Tourism i. MEM INST OSWALDO CRUZ RIO DE JANEIRO - 1995 - Molluscicide control of snail vectors of Schistosomiasis. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 101(Suppl. I): 91-96, 2006 Analysis and estimative of schistosomiasis prevalence for. Ethiop J Health Dev 2011;25(1) Schistosomiasis mansoni and soil-transmitted helminthiasis in Bushulo village, southern Ethiopia. Schistosomiasis. PLOS 20/12/11 Tools to Support Policy Decisions Related to Treatment Strategies and Surveillance of Schistosomiasis Japonica tow.

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