SCIENTIFIC AMERICAN 13/10/16 Long-Forgotten Research Unearths New Mystery about Lyme Disease. DOVEPRESS 13/09/16 Lyme disease: the promise of Big Data, companion diagnostics and precision medicine. Video abstract presented by Raphael B Stricker.
Views: 20. PHYSORG 25/08/16 How Lyme disease bacteria spread through the body. Researchers have developed a live-cell-imaging-based system that provides molecular and biomechanical insights into how Lyme disease bacteria latch onto and move along the inside surface of blood vessels to reach key destinations in the body where they may be able to persist longer and avoid treatment.
Ironically, the same strategies that these bacteria use to spread through the body are also used by immune cells to protect against infectious disease. The study appears August 25 in Cell Reports. "There is very little known about the biomechanics of bacterial-vascular interactions, even though understanding this is really important for understanding how bacteria spread through the body via the cardiovascular system, and for developing methods to block bacterial dissemination," says senior study author Tara Moriarty of the University of Toronto.
NATURE 16/06/16 Contrasting emergence of Lyme disease across ecosystems. Study areas—regional descriptions The LD incidence data come from across the whole of Norway.
We grouped into four regions based on biogeography; East (Østfold, Akershus, Oslo, Hedmark, Oppland and Buskerud Counties); South (Vestfold, Telemark, Aust-Agder and Vest-Agder Counties); West (Rogland, Hordaland, Sogn and Fjordane, and Møre and Romsdal Counties); and North (Sør-Trøndelag, Nord-Trøndelag, Nordland, Troms and Finnmark Counties). These four regions span contrasting ecosystems. The West region is separated from East by a mountain range, which is a major climatic division with resulting differences in vegetation.
Further, topography differs markedly between West and East. Int. J. Mol. Sci. 2014, 15(3), 4284-4298; Detection of Borreliae in Archived Sera from Patients with Clinically Suspect Lyme Disease. 1.
Introduction In North America, Lyme disease is most often caused by Borrelia burgdorferi sensu stricto . According to the guidelines of the Centers for Disease Control and Prevention (CDC), its diagnosis is primarily based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks; laboratory testing is helpful if used correctly and performed with validated methods . However, the clinical manifestations of Lyme disease are highly variable and often not easily distinguished from those caused by other illnesses in clinical practice . The characteristic erythema migrans (EM) rash may not display a classic bull’s-eye (ring-within-a-ring) appearance, a fact that may be underappreciated. The Turkish Journal of Pediatrics 2015; 57: 522-524 A presentation of Lyme disease: pseudotumor cerebri. SCARSDALETVETS_COM - JANV 2014 - Lyme diseace. ENTOMOLOGY TODAY 29/02/16 Scientists Have Sequenced the Genome of the Tick that Transmits Lyme Disease.
The blacklegged tick, Ixodes scapularis, can transmit Lyme disease and a number of other illnesses.
Photo by Andrew Nuss. An international team of scientists led by Purdue University has sequenced the genome of the tick that transmits Lyme disease, the most common vector-borne illness in North America. Ixodes scapularis, known as the blacklegged tick or the deer tick, is the first tick species to have its genome sequenced. The decade-long project, involving 93 authors from 46 institutions, decodes the biology of an arachnid with sophisticated spit, barbed mouthparts, and millions of years of successful parasitism. The genome of Ixodes scapularis also sheds light on how ticks acquire and transmit pathogens and offers tick-specific targets for control. “The genome provides a foundation for a whole new era in tick research,” said Catherine Hill, lead author of a paper that was published in Nature Communications. “Genomic resources for the tick were desperately needed,” Hill said. Like this: NATURE 09/02/16 Genomic insights into the Ixodes scapularis tick vector of Lyme disease.
The first genome assembly for a tick vector of disease The assembly, IscaW1, comprises 570,640 contigs in 369,495 scaffolds (N50=51,551 bp) representing 1.8 Gbp, including gaps (Table 1, Supplementary Table 2).
The ab initio annotation of 18,385 scaffolds >10 Kbp in length and representing 1.2 Gbp (57% of the genome) predicted 20,486 protein-coding genes, and 4,439 non-coding RNA genes (Supplementary Figs 1–6 and Supplementary Table 3). Ixodid ticks typically have haploid genomes that exceed 1 Gbp (ref. 8). In contrast, the 90 Mbp genome of the two-spotted spider mite, Tetranychus urticae, a horticultural pest, is the smallest of any known arthropod, and contains <10% transposable elements9. Repetitive DNA is estimated to comprise ~70% of the I. scapularis genome10, reflecting an extreme case of tandem repeat and transposable element accumulation. The I. scapularis genome possesses 26 acrocentric autosomes and two sex chromosomes (XX:XY)11, 12. Full size image (177 KB) CDC 02/11/15 Borrelia mayonii. In 2013, scientists at the Mayo Clinic noticed an unusual result while testing blood from patients suspected of having Lyme disease.
Cooperation between Mayo Clinic, state public health agencies, and CDC confirmed the discovery as a new bacterial species, also found in blacklegged ticks. Joint efforts between these groups are currently underway to find more patients infected with this bacteria, to look for additional areas where infected ticks live, and to identify other bacteria that cause tickborne disease. What is Borrelia mayonii? Borrelia mayonii is the proposed name for a new bacteria species recently found to cause Lyme disease in six people who live in the upper Midwestern United States. The Nature Of Things VIA YOUTUBE 01/10/15 Ticked Off The Mystery Of Lyme Disease Cldd. OREGON STATE UNIVERSITY 17/02/15 Climate change may affect tick life cycles, Lyme disease.
CORVALLIS, Ore. – A new study suggests that changing climate patterns may be altering the life cycles of blacklegged ticks in the northeastern United States, which could increase transmission among animals – and ultimately humans – of certain pathogens, including the bacterium that causes Lyme disease.
Other colder regions of the country that have sufficient populations of blacklegged ticks – particularly Wisconsin and Minnesota – may also experience a higher risk of Lyme disease. However, the changing life cycles of the ticks may result in a less-likely probability of transmitting a more deadly pathogen that results in Powassan encephalitis, the researchers say.
Results of the research are being published this week in a special issue of Philosophical Transactions of the Royal Society B dedicated to climate change and vector-borne diseases. Blacklegged ticks can be found in hardwood forests all along the eastern seaboard as well as in the northern states. THE HORSE 25/07/14 Equine Lyme Disease: What You Need to Know. Female adult Ixodes spp. ticks are believed to be primarily responsible for transmitting B. burgdorferi to horses.
Photo: James Gathany/Centers for Disease Control Lyme disease in North America is caused by the bacteria Borrelia burgdorferi sensu stricto. B. burgdorferi survives in a small rodent and Ixodes spp. tick cycle. Horses and many other mammals can become infected during tick feeding. Generally, 24 to 48 hours of attachment are required to transfer B. burgdorferi from the tick to the mammalian host. Female adult Ixodes spp. ticks are believed to be primarily responsible for transmitting B. burgdorferi to horses, while in humans the smaller and harder to see nymphs are responsible for more infections.
B. burgdorferi infection in horses is common in several areas of North America. A wide variety of clinical signs have been attributed to B. burgdorferi infection in horses, but cause and effect have been difficult to document in most cases. CONTACTS: Thomas Divers, DVM, Dipl. ENTOMOLOGY TODAY 30/03/15 Mice Aren’t Nice, They Help Transmit Lyme Disease. By Hannah Foster Upon hearing the words “Lyme disease,” most people think of two things: ticks and deer.
Although these are certainly important aspects of the disease, ticks and deer are only two pieces of the puzzle. Lyme disease is actually extremely complicated, and its spread is affected by a wide range of organisms. Knowing the full story is important for individuals to protect themselves, and it’s necessary for scientists and epidemiologists to determine how to control the disease. Hannah Foster Lyme disease is the most common tick-borne disease in the United States, with around 300,000 cases per year, mainly in the Northeast. A primary strategy for controlling the spread of Lyme disease has been to decrease the deer population. PLOS 17/02/15 The Lyme Disease Pathogen Has No Effect on the Survival of Its Rodent Reservoir Host. Abstract Zoonotic pathogens that cause devastating morbidity and mortality in humans may be relatively harmless in their natural reservoir hosts.
The tick-borne bacterium Borrelia burgdorferi causes Lyme disease in humans but few studies have investigated whether this pathogen reduces the fitness of its reservoir hosts under natural conditions. PLOS 04/02/15 Health Care Costs, Utilization and Patterns of Care following Lyme Disease. Abstract Background Lyme disease is the most frequently reported vector borne infection in the United States. The Centers for Disease Control have estimated that approximately 10% to 20% of individuals may experience Post-Treatment Lyme Disease Syndrome – a set of symptoms including fatigue, musculoskeletal pain, and neurocognitive complaints that persist after initial antibiotic treatment of Lyme disease. INFECTION ECOLOGY & EPIDEMIOLOGY - 2011 - Global ecology and epidemiology of Borrelia garinii spirochetes.
UNIVERSIDAD ZARAGOZA via EFSA - 2012 - Inventory of available data and data sources and proposal for data collection on vector-b. Centre for tick-borne diseases. Klinikai és laboratóriumi vizsgálatokat végzünk kullancs által terjesztett betegségek (elsősorban Lyme és TIBOLA) igazolására és kizárására. A diagnózis megállapítása után irányítjuk a kezelést is. Csak telefonons bejelentkezés alapján fogadunk betegeket. Mielőtt telefonálna, olvassa el a "Mit tegyünk, mit ne tegyünk? " című írást a laikusoknak szóló fejezetben!!! Telefon: (06 1) 329-38-98, 06 30-934-9956Rendelő: 1132 Budapest, Visegrádi u. 14. A rendelőt az Országos Egészségbiztosítási Pénztár nem támogatja. Évente kb. 6000 Borrelia immunoblot (Western blot) vizsgálatot végzünk, minden bizonnyal az országban a legnagyobb számban. Lyme disease. VIRGINIA DEPARTMENT OF HEALTH - 2011 - Lyme disease tracking & prevention.