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BMC Microbiology 03/05/17 Simultaneous detection of chikungunya virus, dengue virus and human pathogenic Leptospira genomes using a multiplex TaqMan® assay. The aim of our study was to implement a syndromic approach based upon the use of a multiplex real time RT-PCR assay to facilitate rapid diagnosis of dengue-like syndromes in Reunion Island.

BMC Microbiology 03/05/17 Simultaneous detection of chikungunya virus, dengue virus and human pathogenic Leptospira genomes using a multiplex TaqMan® assay

This syndromic approach was in phase with regional health agency preoccupations because of the recurrent occurrences of leptospirosis but also taking into account the unprecedented major CHIKV outbreak in 2005–2006 and the regular number of clustered cases of DENV [22]. On the one hand, the use of a syndromic panel is appealing for economic reasons. It is cost saving due to the use of lower amount of enzyme than in simplex reactions.

The multiplex assay requires less handle-time and it is subjected to lower risk of undesirable cross-reaction contaminations. On the other hand, multiplex assays have been criticized for a loss of sensitivity compared to their simplex counterparts. Dealing with multiplex set up assays, we paid a critical attention to sensitivity. CDC EID - AVRIL 2017 – Au sommaire notamment : Biologic Evidence Required for Zika Disease Enhancement by Dengue Antibodies. Author affiliation: Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA Highlight and copy the desired format.

CDC EID - AVRIL 2017 – Au sommaire notamment : Biologic Evidence Required for Zika Disease Enhancement by Dengue Antibodies

Abstract The sudden appearance of overt human Zika virus infections that cross the placenta to damage fetal tissues, target sexual organs, and are followed in some instances by Guillain-Barré syndrome raises questions regarding whether these outcomes are caused by genetic mutations or if prior infection by other flaviviruses affects disease outcome. Parasites & Vectors 11/03/17 How does the dengue vector mosquito Aedes albopictus respond to global warming? How global warming potentially influences vector-borne diseases has prompted great concerns from both the general public and ecological scientists [1, 2].

Parasites & Vectors 11/03/17 How does the dengue vector mosquito Aedes albopictus respond to global warming?

Dengue fever, known as the most prevalent mosquito-borne epidemic, generates 50–100 million cases per year and is constantly growing with the expansion of urban residence, increased air travel and the growth of global population [2, 3, 4, 5]. In addition to human-induced factors, the observed global warming trend plays a potential role in the generation and transmission of the disease [6].

The complex interplay between global warming and dengue viruses has been a subject of debate yet to be fully understood; one critical component in the long chain of transmission events is the altered population dynamics of the vector, Aedes albopictus, commonly known as the Asian Tiger mosquito [7, 8, 9, 10]. Ae. albopictus is native to the humid tropics of Southeast Asia [11].

PLOS 21/12/16 The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries. Abstract Background.

PLOS 21/12/16 The Impact of the Newly Licensed Dengue Vaccine in Endemic Countries.

BMC 04/01/17 Evaluation of the importance of fever with respect to dengue prognosis according to the 2009 WHO classification: a retrospective study. Dengue is an infectious disease that exhibits acute evolution [1].

BMC 04/01/17 Evaluation of the importance of fever with respect to dengue prognosis according to the 2009 WHO classification: a retrospective study

The incidence of dengue has increased across all age groups [2] to become a clear public health problem [3]. The causative dengue virus (DENV) belongs to the Flaviviridae family within the Flavivirus genus [4], and harbors RNA genetic material that encodes three structural (capsid [C], membrane protein [M] and glycoprotein for the viral envelope [E]) and seven non-structural (NS1, NS2a, NS2b, NS3, NS4a, NS4b and NS5) proteins [5] essential for viral replication in host cells [4, 6]. DENV is transmitted by a bite from a female Aedes aegypti mosquito [7] that caries one of the four virus serotypes [4]. The viremic period of the disease is defined as the period during which dengue virus can be detected in the blood of an infected human [6].

Following inoculation of the virus into the host, the incubation period may vary from 4 to 10 days [8, 9], after which various clinical signs and symptoms will emerge [9]. MALARIA JOURNAL 03/01/17 The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection.

The first case of dengue-malaria dual infection was reported in France in 2005 [6] in which P. falciparum-DENV co-infection was detected, followed by a few more case reports.

MALARIA JOURNAL 03/01/17 The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection

One year later in 2006, cases on P. vivax-DENV dual infection were reported [18, 19]. Although concurrent infection is uncommon, it has subsequently been mentioned with increasing frequency in literature. Acta Tropica Volume 164, December 2016, Non-human primate antibody response to mosquito salivary proteins: Implications for dengue virus transmission in Puerto Rico. Open Access Highlights Twenty-two dengue virus infected non-human primates were evaluated for exposure to mosquito bites.

Acta Tropica Volume 164, December 2016, Non-human primate antibody response to mosquito salivary proteins: Implications for dengue virus transmission in Puerto Rico

Annals of Clinical Microbiology and Antimicrobials 22/07/16 ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics. Arthropod-borne viruses are becoming and increasing threat worldwide, especially in the New World, which has recently witnessed an unprecedented outburst of Arboviral outbreaks [1, 2, 3, 4], such as the recent and ongoing chikungunya (CHIKV) [1] and Zika (ZIKV) [2] epidemics throughout the Pacific and the Americas.

Annals of Clinical Microbiology and Antimicrobials 22/07/16 ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics

These emerging viral infections are largely due to a number of factors such as climate change [5, 6, 7], ever-increasing trends towards urbanization and growing travel and commercial exchange activities [8, 9, 10, 11, 12]; which have led to a spillover of these pathogens from their naturally occurring sylvatic niches and reservoirs into susceptible urban settings and newly unexposed geographic areas [13, 14, 15, 16]. Although 80 % of cases are asymptomatic, symptoms of ZIKV classically include mild or no fever, pruriginous maculopapular rash, conjunctivitis, arthralgia and myalgia, headache, malaise and fatigue (Table 1) [3, 25]. Competing interests. Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses - Volume 22, Number 7—July 2016.

Jesse J.

Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses - Volume 22, Number 7—July 2016

Waggoner, Lionel Gresh, Alisha Mohamed-Hadley, Gabriela Ballesteros, Maria Jose Vargas Davila, Yolanda Tellez, Malaya K. Sahoo, Angel Balmaseda, Eva Harris, and Benjamin A. Pinsky. Cell report - JUIN 2016 - Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. BIORXIV 24/03/16 Comparative analysis of dengue and Zika outbreaks reveals differences by setting and virus.

BMC 03/03/16 Co-distribution and co-infection of chikungunya and dengue viruses. We are witnessing a rapid expansion in the geographical extent of chikungunya which mirrors that of dengue as described by Gubler in the 1990s [67].

BMC 03/03/16 Co-distribution and co-infection of chikungunya and dengue viruses

This has come about partly through the increased opportunity for pathogen and vector spread that has resulted from globalisation [68], and the multifaceted effects on infectious diseases of a growing human population with resultant environmental changes [69]. Perhaps equally important, however, is the reporting bias that has obscured the public health impact of this pathogen, from its discovery until quite recently; CHIKV was first isolated in 1953 from the serum of a suspected dengue patient [70] and its conflation with dengue has persisted.

GENOME BIOLOGY 02/03/16 Genomic approaches for understanding dengue: insights from the virus, vector, and host. Immune responses to DENV Once ingested in a bloodmeal taken from an infected human, DENV first infects the midgut epithelium of the mosquito. It subsequently disseminates to other organs via the hemolymph, finally infecting the salivary glands. The virus is secreted into mosquito saliva, and injected into a human host during a subsequent blood-feeding event [5]. Mosquitoes remain infected and able to transmit the virus for life (~2–3 weeks in the wild), but DENV does not appear to exert a fitness cost on the vector during natural infection [63]. NATURE 01/03/16 Highly divergent dengue virus type 1 genotype sets a new distance record. Viruses 2014, 6, 683-7 Targeting Host Factors to Treat West Nile and Dengue Viral Infections. Molecules 2014, 19(6), 8151-8176 Natural Products as Source of Potential Dengue Antivirals.

1 Departamento de Química, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil 2 Instituto Federal de Educação, Ciência e Tecnologia do Norte de Minas, 39900-000 Almenara, MG, Brazil 3 Departamento de Microbiologia, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil 4 Departamento de Biologia Geral, Universidade Federal de Viçosa, 36570-900 Viçosa, MG, Brazil * Authors to whom correspondence should be addressed. Received: 14 March 2014 / Revised: 4 June 2014 / Accepted: 5 June 2014 / Published: 17 June 2014 Dengue is a neglected disease responsible for 22,000 deaths each year in areas where it is endemic.

To date, there is no clinically approved dengue vaccine or antiviral for human beings, even though there have been great efforts to accomplish these goals. Several approaches have been used in the search for dengue antivirals such as screening of compounds against dengue virus enzymes and structure-based computational discovery. MDPI and ACS Style AMA Style. Int. J. Environ. Res. Public Health 2015, 12(1), 1-15 A Systematic Review and Meta-Analysis of Dengue Risk with Temperature Change. * Authors to whom correspondence should be addressed. Received: 16 September 2014 / Accepted: 8 December 2014 / Published: 23 December 2014 Dengue fever (DF) is the most serious mosquito-borne viral disease in the world and is significantly affected by temperature. Although associations between DF and temperatures have been reported repeatedly, conclusions have been inconsistent.

Six databases were searched up to 23 March 2014, without language and geographical restrictions. The articles that studied the correlations between temperatures and dengue were selected, and a random-effects model was used to calculate the pooled odds ratio and 95% confidence intervals. Int. J. Environ. Res. Public Health 2015, 12(8), 9454-9474 Dengue Vaccines: A Perspective from the Point of View of Intellectual Property. For all author emails please log in. Pontifical Catholic University of Paraná, PUCPR, Rua Imaculada Conceição, 1155 Prado Velho, 80215-901 Curitiba, PR, Brazil † These authors contributed equally to this work. * Author to whom correspondence should be addressed. Received: 19 June 2015 / Revised: 2 August 2015 / Accepted: 5 August 2015 / Published: 12 August 2015 Dengue is a serious infectious disease and a growing public health problem in many tropical and sub-tropical countries.

To control this neglected tropical disease (NTD), vaccines are likely to be the most cost-effective solution. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. MDPI and ACS Style. PARASITES & VECTORS - 2014 - Global temperature constraints on Aedes aegypti and Ae. Albopictus persistence and competence for dengue virus transmission. Int. J. Environ. Res. Public Health 2015, 12(1), 1-15 A Systematic Review and Meta-Analysis of Dengue Risk with Temperature Change.

Références OMS

Références PLOS. INFECTION ECOLOGY & EPIDEMIOLOGY - 2013 - Dengue viruses – an overview. Anne Tuiskunen Bäck, PhD1,2,3* and Åke Lundkvist, Professor1,2,4 1Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; 2Swedish Institute for Communicable Disease Control, Solna, Sweden; 3Swedish International Development Cooperation Agency, Unit for Research Cooperation, Stockholm, Sweden; 4IMBIM, BMC, Uppsala University, Uppsala, Sweden Abstract Dengue viruses (DENVs) cause the most common arthropod-borne viral disease in man with 50–100 million infections per year.

Because of the lack of a vaccine and antiviral drugs, the sole measure of control is limiting the Aedes mosquito vectors. International journal of Science Commerce and Humanities - OCT 2013 - Social Representations of Zoonosis Control Agents about de. FEMS Immunol Med Microbiol 53 (2008) 287–299 Vascular endothelium: the battle¢eld of dengueviruses. MEM INST OSWALDO CRUZ, RIO DE JANEIRO, 107(8) December 2012 Vector biology prospects in dengue research. Dengue disease is a growing public health burden in tropical and subtropical regions throughout the world.

With at least two-fifths of the world's population living in areas that are vulnerable to dengue epidemics and 50-100 million infections each year, dengue is the most prevalent arboviral disease of humans worldwide (Guzman et al. 2010). Recent results from a vaccine trial showing only partial protection (Sabchareon et al. 2012) suggest that dengue will continue to impact global public health for the years to come. International Journal of Epidemiology & Infection - 2013 - Temporal and Spatial Relationship by Environmental Factors as an Effe. CDC EID – JUILLET 2013 – au sommaire:Possible Cause of Liver Failure in Patient with Dengue Shock Syndrome. Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home CDC 24/7: Saving Lives. Protecting People. AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH 16/08/13 Challenges and future prospects for Dengue vector control.

FEMS Immunol Med Microbiol 47 (2006) Dengue and dengue haemorrhagic fever: implications of host genetics. Environ. Res. Lett. 7 (2012) 034003 (6pp) Potential impacts of climate change on the ecology of dengue and its mosquito vector t. INTECH - MARS 2012 - Implicating the Need for Serological Testing of Borna Disease Virus and Dengue Virus During Blood Transfusi. Tropical Medicine and International Health 14, 9 (2009) 1134-42 Spatial distribution and risk factors of dengue and Japanese enc. 17%20Aziz%20Shafie. Mathematical Biosciences - Modeling dengue outbreaks. Abstract We introduce a dengue model (SEIR) where the human individuals are treated on an individual basis (IBM) while the mosquito population, produced by an independent model, is treated by compartments (SEI). We study the spread of epidemics by the sole action of the mosquito.

Exponential, deterministic and experimental distributions for the (human) exposed period are considered in two weather scenarios, one corresponding to temperate climate and the other to tropical climate. Virus circulation, final epidemic size and duration of outbreaks are considered showing that the results present little sensitivity to the statistics followed by the exposed period provided the median of the distributions are in coincidence. Only the time between an introduced (imported) case and the appearance of the first symptomatic secondary case is sensitive to this distribution.

Highlights Keywords Epidemiology; Dengue; Individual based model; Compartmental model; Stochastic Copyright © 2011 Elsevier Inc. Dengue fever. Dengue Virus Database. Site portail concernant la dengue. The Value of Educational Messages Embedded in a Community-Based Approach to Combat Dengue Fever: A Systematic Review and Meta Regression Analysis. PNAS - 2011 - Impact of daily temperature fluctuations on dengue virus transmission by Aedes aegypti. GRIDA - Potential dengue transmission in case of temperature rise. Experts Rev Vaccins 3(5) 2004 Dengue, one of the great emerging health challengs of the 21st Century.

Mol. Biol. Evol. 20(10):1650-1658. 2003 Selection-Driven Evolution of Emergent Dengue Virus. The 20 Most-Frequently Cited Articles in Clin. Microbiol. Rev. as of January 1, 2009. Veterinary World - 2008 - Threat and strategic control of dengue infection in man. TROPIKA - OCT 2006 - Dengue Transmission Dynamics: Assessment. EUROSURVEILLANCE Volume 6 - numéro 39, septembre 2002 - DengueNet - WHO's internet based system for the global surveillance of d. Globally, 2.5 billion people live in areas where dengue viruses are transmitted. The disease is now endemic in more than 100 countries in Africa, the Americas, the eastern Mediterranean, South East Asia, and the Western Pacific. South East Asia and the western Pacific are most seriously affected (1).