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TRANSBOUNDARY AND EMERGING DISEASES 24/01/17 Wildlife Plague Surveillance Near the China–Kazakhstan Border: 2012–2015. IDAHO DEPARTMENT OF HEALTH & WELFARE - 2015 - FREQUENTLY ASKED QUESTIONS ABOUT PLAGUE. CELL - OCT 2015 - Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago. INDEPENDENT 15/07/16 Russian boy catches the bubonic plague while hunting in Siberian mountains. A 10-year-old boy caught bubonic plague while hunting with his grandfather in Siberian mountains.

INDEPENDENT 15/07/16 Russian boy catches the bubonic plague while hunting in Siberian mountains

The Russian is believed to have caught the potentially deadly disease when he cut himself with a knife while skinning a marmot. Marmots are large rodents which are known to be susceptible to carrying the disease. Marmot hunting is banned in the area due to the risk of catching bubonic plague but the ban is widely ignored. Bubonic plague caused the Black Death epidemic in the 13th century, killing an estimated 30 per cent of the European population. The unnamed child is in a "serious but stable condition" according to doctors, Mirror reports. Vaccines, enough for at least 15,000, are being rushed to the remote area of Kosh-Agach in the Altai Mountains to combat any potential outbreak. Marmots are known to be susceptible to Bubonic plague and hunting them in Siberia is banned as a result (Reuters) At least 4,000 local residents will be vaccinated as a precaution.

Reuse content. CDC EID - Volume 21, Number 2—February 2015 Au sommaire : Murine Typhus, Reunion, France, 2011–2013. Elsa Balleydier1.

CDC EID - Volume 21, Number 2—February 2015 Au sommaire : Murine Typhus, Reunion, France, 2011–2013

Journal of microbiological methods. 06/2015; Monitoring biothreat agents (Francisella tularensis, Bacillus anthracis and Yersinia pestis) with a portable real-time PCR instrument. The PikoReal technology presents a strong candidate for further development to support more common public health diagnostic.

Journal of microbiological methods. 06/2015; Monitoring biothreat agents (Francisella tularensis, Bacillus anthracis and Yersinia pestis) with a portable real-time PCR instrument

BELOIT DAILY NEWS 16/09/16 Forget about the Bubonic plague: Professor presents on emerging diseases. BELOIT — Don’t kiss a pig.

BELOIT DAILY NEWS 16/09/16 Forget about the Bubonic plague: Professor presents on emerging diseases

That message and many other fun knowledge nuggets were part of Beloit College professor Rachel Bergstrom’s presentation on emerging public health threats such as Ebola and Zika. She spoke at a Society for Learning Unlimited (SLU) presentation at First Congregational Church on Thursday morning. Bergstrom explained how microbial adaptation, human susceptibility to infection and changing ecosystems are some of many growing factors in the outbreak of disease in a time when antibiotic production is not keeping up with demand.

"We are running out of antibiotics," Bergstrom said. "All of the last-resort antibiotics are being held onto tightly. Human susceptibility to infection is impacted by microbial adaptation and change. Although the human body is filled with bacteria, having it in the wrong place can also equal infection. “Every time they replicate, they may mutate,” she said. CDC EID - JUNE 2008 - Persistence of Yersinia pestis in Soil Under Natural Conditions. CDC EID - JUILLET 2011 - Yersinia pestis in Small Rodents, Mongolia. Suggested citation for this article To the Editor: Plague is known to be endemic in several areas of Mongolia, but transmission to humans seems to play only a minor role because the number of recognized cases is relatively low (Figure) (1).

CDC EID - JUILLET 2011 - Yersinia pestis in Small Rodents, Mongolia

The first human cases in Mongolia were reported to the World Health Organization in 1980, and <20 human cases have occurred each year since then (2). However, human plague was first reported in 1897 (3), such infections have been documented since the 1940s, and Yersinia pestis can be found in many provinces of Mongolia (Figure; T. Damindorj, pers. comm.) (3,4). CDC EID - FEV 2013 - Au sommaire: Yersinia pestis Plasminogen Activator Gene Homolog in Rat Tissues. PLOS 11/02/16 Two Distinct Yersinia pestis Populations Causing Plague among Humans in the West Nile Region of Uganda. Abstract Background Plague is a life-threatening disease caused by the bacterium, Yersinia pestis.

PLOS 11/02/16 Two Distinct Yersinia pestis Populations Causing Plague among Humans in the West Nile Region of Uganda

Since the 1990s, Africa has accounted for the majority of reported human cases. PLOS 27/03/14 New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague. Abstract Bubonic plague (a fatal, flea-transmitted disease) remains an international public health concern.

PLOS 27/03/14 New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

Although our understanding of the pathogenesis of bubonic plague has improved significantly over the last few decades, researchers have still not been able to define the complete set of Y. pestis genes needed for disease or to characterize the mechanisms that enable infection. Here, we generated a library of Y. pestis mutants, each lacking one or more of the genes previously identified as being up-regulated in vivo. We then screened the library for attenuated virulence in rodent models of bubonic plague. Importantly, we tested mutants both individually and using a novel, “per-pool” screening method that we have developed. Author Summary In order to understand and combat infectious diseases, it is essential to characterize the full set of genes required by pathogenic bacteria to overcome the many immunological and physiological challenges encountered during infection.

Figures. RT 29/01/14 Scientists find DNA of first-ever bubonic plague, warn of new outbreaks. Trakia Journal of Sciences - 2014 - YERSINIA PESTIS - OLD AND NEW CHALLENGES IN HUMANS AND IN ANIMALS. ESCIENCECENTRAL 20/06/13 Could the ‘Black Death’ Become a Re-Emerging Infectious Disease? Rev. Soc. Bras. Med. Trop. vol.46 no.4 Uberaba July/Aug. 2013 Seroprevalence of hantavirus and Yersinia pestis antibodies in professionals from the Plague Control Program. Short Communications.

Rev. Soc. Bras. Med. Trop. vol.46 no.4 Uberaba July/Aug. 2013 Seroprevalence of hantavirus and Yersinia pestis antibodies in professionals from the Plague Control Program

MMN 22/08/14 Bubonic plague found in Colorado fleas. Colorado health officials have issued a warning to Boulder County residents after bubonic plague was found in fleas taken from a prairie dog.

MMN 22/08/14 Bubonic plague found in Colorado fleas

Flea samples were taken from a Boulder property when a homeowner notified officials of several dead prairie dogs on the property. The neighborhood has been posted with signs warning residents to protect themselves and their pets. The plague has been active in the area every year since 2005, according to Heather Swanson, a wildlife ecologist for Boulder Open Space and Mountain Parks, but this is the first confirmed case in the county since 2011, when a pet cat and a dead squirrel tested positive for it. Journal of Wildlife Diseases, 44(3), 2008, pp. 731-736 Prevalence of Yersinia pestis in Rodents and Fleas Associated with Black-tailed Prairie Dogs (Cynomys ludovicianus) at Thunder Basin National Grassland, Wyoming.

PNAS 26/12/12 Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis. PLOS - OCT 2012 - Dynamics of Yersinia pestis and Its Antibody Response in Great Gerbils (Rhombomys opimus) by Subcutaneous Infe. Journal of Pathogens Volume 2012 (2012) Rapid Detection and Identification of Yersinia pestis from Food Using Immunomagnetic Sep. IOWA STATE UNIVERSITY - 2012 - Thèse en ligne : New tools for studying mal gene regulation in Yersinia pestis. Abstract Y. pestis, the etiologic agent of plague, is a significant human pathogen because of its historic role as the cause of three major pandemics and its current role as a potential bioterrorism agent.

IOWA STATE UNIVERSITY - 2012 - Thèse en ligne : New tools for studying mal gene regulation in Yersinia pestis

Gene regulation in this organism is complex and multiple microarray studies have shown that the expression of several genes is affected by quorum sensing as well as temperature. INDIAN ACADEMY OF SCIENCES 25/05/12 Thèse en ligne: The 1994 plague epidemic of India: molecular diagnosis and characterization. Panda, S. K. ; Nanda, S. K. ; Ghosh, A. ; Sharma, C. ; Shivaji, S. ; Seshu Kumar, G. ; Kannan, K. ; Batra, H. V. ; Tuteja, U. ; Ganguly, N. K. ; Chakrabarty, A. ; Sharat Chandra, H. (1996) The 1994 plague epidemic of India: molecular diagnosis and characterization of Yersinia pestis isolates from Surat and Beed Current Science, 71 (10). pp. 794-799. PLOS 28/11/12 Yersinia pestis: New Evidence for an Old Infection. The successful reconstruction of an ancient bacterial genome from archaeological material presents an important methodological advancement for infectious disease research.

The reliability of evolutionary histories inferred by the incorporation of ancient data, however, are highly contingent upon the level of genetic diversity represented in modern genomic sequences that are publicly accessible, and the paucity of available complete genomes restricts the level of phylogenetic resolution that can be obtained. Here we add to our original analysis of the Yersinia pestis strain implicated in the Black Death by consolidating our dataset for 18 modern genomes with single nucleotide polymorphism (SNP) data for an additional 289 strains at over 600 positions. Figures Citation: Bos KI, Stevens P, Nieselt K, Poinar HN, DeWitte SN, et al. (2012) Yersinia pestis: New Evidence for an Old Infection. CURRENT SCIENCE, VOL. 88, NO. 5, 10 MARCH 2005 Is Yersinia pestis a distinct species? PLOS 15/09/11 Plague and Climate: Scales Matter.

Corrections 7 May 2012: Ben-Ari T, Neerinckx S, Gage KL, Kreppel K, Laudisoit A, et al. (2012)Correction: Plague and Climate: Scales Matter.PLoS Pathog 8(5):10.1371/annotation/84f83f75-2e53-48cf-9f43-7e5eaed74437. doi: 10.1371/annotation/84f83f75-2e53-48cf-9f43-7e5eaed74437 | View correction Plague is enzootic in wildlife populations of small mammals in central and eastern Asia, Africa, South and North America, and has been recognized recently as a reemerging threat to humans. Its causative agent Yersinia pestis relies on wild rodent hosts and flea vectors for its maintenance in nature. Climate influences all three components (i.e., bacteria, vectors, and hosts) of the plague system and is a likely factor to explain some of plague's variability from small and regional to large scales.

Here, we review effects of climate variables on plague hosts and vectors from individual or population scales to studies on the whole plague system at a large scale. Figures. Parasites & Vectors 2011, 4:191 Effects of temperature on the transmission of Yersinia Pestis by the flea, Xenopsylla Cheopis, i. BBC 12/10/11 Black Death genetic code 'built' 12 October 2011Last updated at 18:02 By Matt McGrath Science reporter, BBC World Service The ancient burial site is under what is now the Royal Mint The genetic code of the germ that caused the Black Death has been reconstructed by scientists for the first time. The researchers extracted DNA fragments of the ancient bacterium from the teeth of medieval corpses found in London.

They say the pathogen is the ancestor of all modern plagues. The research, published in the journal Nature, suggests the 14th Century outbreak was also the first plague pandemic in history. Humans have rarely encountered an enemy as devastating as the bacterium, Yersinia pestis. Now scientists have uncovered some of the genetic secrets of the plague, thanks to DNA fragments drilled from the teeth of victims buried in a graveyard in London's East Smithfield.

Professor Johannes Krause from the University of Tubingen, Germany, was a member of the research team. Continue reading the main story The plague Tooth power. Nature. 2011 Oct 12;478(7370):506-10. A draft genome of Yersinia pestis from victims of the Black Death. PNAS 31/01/12 Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation. Yersinia pestis. OREGON - Yersinia pestis as a Bioterrorist Agent. CLINICAL MICROBIOLOGY REVIEWS, Apr. 2004, p. 434–464 Intraspecific Diversity of Yersinia pestis.