BMC Biotechnology 30/05/17 Development of plant-produced protein body vaccine candidates for bluetongue virus. Bluetongue (BT) is a non-contagious, arthropod-borne viral disease that affects ruminants .
BT was first recognised and described in South Africa after the introduction of fine-wool sheep from Europe over 200 years ago [2, 3]. The classical form of BT is seen in sheep; however, cattle are also a natural reservoir for the virus . The causative agent of BT is bluetongue virus (BTV), the type species of the genus Orbivirus in the family Reoviridae . BTV is mostly transmitted by adult females of the haematophagous midges that belong to the genus Culicoides . Since 1998 BTV has become one of the most widespread animal pathogens, as it has spread to areas that were previously free of the virus . A number of vaccines have been developed against BT. The BTV structural protein VP2 is the major serotype-specific antigen of BTV [14, 23]. Epitopes are localised regions on the surfaces of antigens that are involved in recognition by antibodies. Bluetongue and Epizootic Hemorrhagic Diseases Part1 Jim MacLachlian.
NATURE SCIENTIFIC REPORTS 08/02/16 Using shared needles for subcutaneous inoculation can transmit bluetongue virus mechanically between ruminant hosts. Global Veterinaria 17 (1): 63-77, 2016 Diagnosis, Prevention and Control of Blue Tongue in Sheep: Review. VIROLOGY JOURNAL 02/07/16 Requirements and comparative analysis of reverse genetics for bluetongue virus (BTV) and African horse sickness virus (AHSV) Bluetongue (BT), African horse sickness (AHS), and epizootic haemorrhagic disease (EHD) are OIE listed arthropod borne animal diseases caused by the viruses in the genus Orbivirus, family Reoviridae.
These viruses are spread by specific species of Culicoides biting midges. Outbreaks and geographic expansion of affected areas are associated to various factors, including climate change [1, 2], and the presence of competent biting Culicoides midges . Culicoides species in countries with a moderate climate are competent insect vectors for BTV [4, 5, 6]. This implies that countries historically free of disease are probably at risk for BT and other midge borne diseases . The prototype bluetongue virus (BTV) and African horse sickness virus (AHSV) are the best studied orbiviruses, reviewed in . For a long time, research on orbiviruses has been hampered by the lack of reverse genetics systems. RG has also been used to develop very promising novel vaccines for orbiviruses. Parasites & Vectors 17/09/15 Bluetongue virus infection creates light averse Culicoides vectors and serious errors in transmission risk estimates.
Because BTV is not transovarially transmitted  only previously blood-fed (parous) females were tested for BTV.
Of 674 total pools (representing about 13,000 parous female midges), 212 were from CO2 traps, 145 were from UV traps, and 317 were from CO2 + UV traps. Of the tested pools, 126 (18.7 %) were positive for BTV (Ct < 31). Pool sizes (parous insects per pool) did not differ significantly for the three trap types (p = 0.421). When the data from all three dairies were combined, there was an overall highly significant difference between the traps (×2 = 76.52, df = 2, p < 0.001) (Table 2). VETERINARIA ITALIANA ISSUES ONLINE 2015 - Volume 51 (4), October-December The changing global face of Bluetongue: from the beginning. VETERINARIA ITALIANA ISSUES ONLINE 2015 - Volume 51 (4), October-December Bluetongue: a disease that does not speak 'one tongue' only. It is now 1 year since the IV International Conference on Bluetongue and Related Orbiviruses closed its doors.
This is the first of 2 issues of Veterinaria Italiana dedicated to this international event, collecting selected papers presented at the conference. A second issue will be published at the beginning of next year. Thinking of the Rome conference, I am sure I am not wrong when I say that it was really a great meeting, whose success is well represented in Ford's words: "coming together is a beginning; keeping together is progress; working together is success" (Henry Ford).
The conference was an unmissable occasion to start new collaborations and new research activities, it provided the opportunity for the over 300 delegates among researchers and regulators at the highest international level to speak the same 'blue' tongue. These peculiarities were clearly emphasised in the meeting and a constant monitoring of the genetic evolution of the BT virus was recommended.
Exp Appl Acarol. 2010 Oct; 52(2): 183–192. Potential role of ticks as vectors of bluetongue virus. VET ITAL - 2004 - Environmental effects on vector competence and virogenesis of bluetongue virus in Culicoides: interpreting laboratory data in a field context. VET. ITAL - 2004 - The history of bluetongue and a current global overview. Braz. arch. biol. technol. vol.56 no.6 Curitiba Nov./Dec. 2013 Epub Oct 25, 2013 Evaluation of different adjuvants formulations for bluetongue vaccine. Evaluation of different adjuvants formulations for bluetongue vaccine Ludmila Branco MacedoI; Zélia Inês Portela LobatoII; Sílvia Ligório FialhoIII; Aline de Marco ViottII; Roberto Maurício Carvalho GuedesII; Armando Silva-CunhaI,* IFaculdade de Farmacia; Universidade Federal de Minas Gerais; Belo Horizonte - MG - Brasil IIEscola de Veterinaria; Universidade Federal de Minas Gerais, Belo Horizonte - MG - Brasil IIIDivisão de Desenvolvimento Farmacotécnico e Biotecnológico; Fundação Ezequiel Dias; Belo Horizonte - MG - Brasil This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV).
Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of application. Advances in Animal and Veterinary Sciences - 2013 - Diversity among Topotypes of Bluetongue Virus Serotype 9 as Revealed by Whole Genome Sequence Analysis. Surveillance network for bluetongue in the Eastern and Balkanic Regions EAST BTNET - Bibliographie 1998 à 2006.
40 (4), October-December Bluetongue proceedings, Part II. VETERINARIA ITALIANA40 (3), July-September Bluetongue proceedings, Part I. VETERINARY WORLD - OCT 2011 - Au sommaire notamment: Studies of the Antigenic relationships between Bluetongue virus serotypes 2. Open Access, Research 2.
Studies of the antigenic relationships between bluetongue virus serotypes 2, 9 & 15 isolated in Andhra Pradesh, India - Deepthi Balam, Sreenivasulu Daggupati, Himaja Maddireddy Vet World. 2011; 4(10): 444-448 Abstract l PDF 3. Pharmacokinetic study of flunixin and its interaction with enrofloxacin after intramuscular administration in calves - K. 4. 5. 6. 7. 8. Sci Rep. 2012; 2: 319. Modelling bluetongue virus transmission between farms using animal and vector movements. Journal of Life Sciences - JANV 2013 - Bluetongue: A Hypothesis of Control Strategy through Decrease of Culicoides and Their Ass. Genome Announc. 2013 Jul-Aug; 1(4): e00403-13. Full-Genome Sequence of Bluetongue Virus Serotype 1 (BTV-1) Strain Y863, the Firs.
INSTITUTE FOR ANIMAL HEALTH PIRBRIGHT 05/05/10 Présentation : Bluetongue on the wind: Long distance dispersal of Culicoides vect. VIROLOGY JOURNAL 11/06/15 Identification of four novel group-specific bluetongue virus NS3 protein B-cell epitopes. With the trends of global warming and the expansion of activities of Culicoides midges, BT disease has raised global attention with its extensively spreading.
Up to date, 27 distinct BTV serotypes make diagnose and prevention of BTV more difficult and complicated. How to make group-specific diagnose of BTV quickly and efficiently is crucial. We focused on NS3 protein of BTV to develop better group-specific diagnose and research reagents. NS3 protein may represent a target for BTV group-specific diagnose because NS3 protein is highly conserved among different BTV serotypes. NS3 has been shown to possess protein-protein interaction domain that facilitate interactions with various proteins in infected cells, including cellular proteins p11, ESCRT-I protein Tsg101 and the BTV VP2 protein, involving in trafficking and release of BTV [17, 19, 25].
Tamilnadu J. Veterinary & Animal Sciences 8 (2) 101-103, March - April, 2012 - DEVELOPMENT OF MULTIPLEX RT-PCR FOR THE DETERMINATION OF BLUETONGUE VIRUS SEROTYPES.
Références VETERINARY RESEARCH. Advances in Animal and Veterinary Sciences - SEPT 2015 - Seroprevalence of Bluetongue in Free-range Mithuns (Bos frontalis) Global Veterinaria 14 (6): 800-804, 2015 Observations on the Epidemiology of Bluetongue Disease.