JOURNAL OF VIROLOGY 24/05/17 Ebola Virus Delta Peptide is a Viroporin. PLOS 18/05/17 The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory. Citation: Shorten RJ, Wilson-Davies E (2017) The risk of transmission of a viral haemorrhagic fever infection in a United Kingdom laboratory.
PLoS Negl Trop Dis 11(5): e0005358. Editor: Sunit Kumar Singh, Banaras Hindu University (BHU), INDIA Published: May 18, 2017 Copyright: © 2017 Shorten, Wilson-Davies. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: The authors received no specific funding for this work. Competing interests: The authors have declared that no competing interests exist. The 2013–2016 Ebola virus outbreak centred in West Africa is the largest ever recorded and has resulted in a substantial global response across Guinea, Sierra Leone, and Liberia. There have been 18 confirmed cases of VHF imported to the UK since 1971 (Public Health England data).
JOURNAL VETERINARY QUARTERLY 13/04/17 Ebola virus – epidemiology, diagnosis, and control: threat to humans, lessons learnt, and preparedness plans – an update on its 40 year's journey. WebImagesPlus… Connexion Recherche avancée Scholar Recherche avancée Articles contenant ex. : "P Flajolet" ou J Fauvet ex. : Journal de la Société de biologie ou Revue Romane.
TRANSBOUNDARY AND EMERGING DISEASES 27/08/15 Assessing the Potential Role of Pigs in the Epidemiology of Ebola Virus in Uganda. Summary Uganda has experienced 4 Ebola outbreaks since the discovery of the virus.
Recent epidemiological work has shown pigs are hosts for Ebola viruses. Due to their high reproduction rates, rapid weight gain, potential to provide quick financial returns and rising demand for pork, pig production in Uganda has undergone massive expansion. Antiviral Research Volume 140, April 2017, Implementation of a non-human primate model of Ebola disease: Infection of Mauritian cynomolgus macaques and analysis of virus populations.
JOURNAL OF INFECTIOUS DISEASE 24/05/16 The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for Three Different Species of Ebolavirus. American Journal of Infection Control Volume 44, Issue 12, 1 December 2016, Ebola virus disease and social media: A systematic review. GAO 02/11/16 Emergency Funding for Ebola Response: Some USAID Reimbursements Did Not Comply with Legislative Requirements and Need to Be Reversed. What GAO Found As of July 1, 2016, the U.S.
Agency for International Development (USAID) and the Department of State (State) had obligated 58 percent and disbursed more than one-third of the $2.5 billion appropriated for Ebola activities. In the early stages of the U.S. response in West Africa, USAID obligated $883 million to control the outbreak, and State obligated $34 million for medical evacuations, among other activities. Subsequently, the United States shifted focus to mitigating second-order impacts, such as the deterioration of health services and food insecurity, and strengthening global health security. Accordingly, USAID obligated $251 million to restore health services, among other activities, and $183 million for activities such as strengthening disease surveillance, while State obligated $5 million for biosecurity activities. Why GAO Did This Study What GAO Recommends.
CENTER FOR GLOBAL DEVELOPMENT 03/11/16 GAO Report Misses the Point on USG Ebola Response. In late 2014, Congress appropriated $5.4 billion in emergency funding for Ebola preparedness and response.
As part of the appropriations act, the General Accounting Office (GAO) was tasked with conducting “oversight of USAID and Department of State activities to prevent, prepare for, and respond to the Ebola outbreak and reimbursements made pursuant to specific provisions.” This week, the GAO report was released. The headline? Virus Research Volume 210, 2 December 2015 Viral bioterrorism: Learning the lesson of Ebola virus in West Africa 2013–2015.
ELIFESCIENCES 14/07/16 Updates to the zoonotic niche map of Ebola virus disease in Africa. Summary: The reviewers and Reviewing Editor felt that this update to your previous model onthe zoonotic niche for Ebola virus disease in Africa (Pigott et al. 2014)addressed an important, original and timely research question.
The study was welldesigned, analysed and presented. The manuscript is clearly written in goodEnglish, and was an interesting read. While the reviewers supported the general idea of updating previous maps toincorporate new data, there were reservations in particular about the inclusion ofbat groups 2 and 3 and the clinical inclusion of animal cases. We would like to see a revised manuscript with much more explanation and support for these inclusions (as detailed in major comment 1 below). We thank the editors and reviewers for the overall positive comments. Essential revisions: 1) The explanatory power from the two bats species in group 3 was interesting. We have considerably bolstered this section and added the following text: We have clarified this section. YENISAFAK 22/03/16 Two new deaths, 816 suspected Ebola cases in Guinea. Guinean authorities have announced the death of two people from Ebola virus and 816 suspected cases in the southern part of the country where the virus reappeared last week.
So far the deadly virus has killed four people since it reappeared last week in the West African state, Fode Tass Sylla, communications officer of Guinea's National Coordination of the Fight Against Ebola, said late Monday. "A little girl died in the city of N'zerekore while her mother, also contaminated, is currently in the Ebola treatment center," Sylla said. The second victim died in Macente, 150 kilometers from N'zerekore, Sylla added. Tass also said that the National Coordination of the Fight Against Ebola will start vaccinating the 816 suspected cases on Tuesday. The vaccination “is to stop people from transmitting the virus," Sylla said. “We hope to stop the virus very quickly with the cooperation of the people," he added. NATURE 26/05/15 A review of epidemiological parameters from Ebola outbreaks to inform early public health decision-making.
MICROSOFT RESEARCH - 2015 - Ebola data from the Internet: An opportunity for syndromic surveillance or a news event? International Journal of Infectious Diseases Volume 38, September 2015, Epidemiological features and trends of Ebola virus disease in West Africa. Figure 1 Numbers of cases of Ebola virus disease and simulated predictions in three West African countries (Guinea, Liberia, and Sierra Leone).
(A) Distribution of accumulated cases in Guinea, Liberia, and Sierra Leone over time. (B) Number of new cases on average per day from April 2014 to May 2015 in Guinea; the curve represents the fitted curve. (C) Number of new cases on average per day from April 2014 to May 2015 in Liberia; the curve represents the fitted curve. (D) Number of new cases on average per day from April 2014 to May 2015 in Sierra Leone; the curve represents the fitted curve.
Highlights •An epidemiological analysis of Ebola virus disease in West Africa was performed based on 26 593 cases from March 2014 to May 2015. Summary. COMP MED - JUNE 2015 - A Comparison of the Pathogenesis of Marburg Virus Disease in Humans and Nonhuman Primates and Evaluation of the Suitability of These Animal Models for Predicting Clinical Efficacy under the 'Animal Rule'. Clinical Microbiology and Infection Volume 20, Issue 6, June 2014, Biological warfare, bioterrorism, and biocrime. Biological weapons achieve their intended target effects through the infectivity of disease-causing infectious agents.
The ability to use biological agents in warfare is prohibited by the Biological and Toxin Weapon Convention. Bioterrorism is defined as the deliberate release of viruses, bacteria or other agents used to cause illness or death in people, but also in animals or plants. CELL 18/06/15 Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. Figure 1 Within and between Country Genomic Relationships of Ebola Virus Makona (A) Phylogenetic and temporal placement of recently sequenced Ebola virus (EBOV) within Sierra Leone.
New EBOV genomes (232 genomes, dark blue), sampled from June 16 through December 26, 2014, provide a high-resolution view of the accumulated genetic diversity and fill in the missing ancestry between EBOV Makona genome data sets. The maximum clade credibility (MCC) tree was inferred using Bayesian evolutionary analysis by sampling trees (BEAST), with tips anchored to sampling date. Biosensors and Bioelectronics Volume 75, 15 January 2016, Towards detection and diagnosis of Ebola virus disease at point-of-care. A Center for Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Florida International University, Miami, USAb Infectious Diseases, Department of Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, USA Received 25 June 2015, Revised 18 August 2015, Accepted 19 August 2015, Available online 20 August 2015 Choose an option to locate/access this article: Check if you have access through your login credentials or your institution Check access.
Biosensors & Bioelectronics. 05/2015; Nanozyme-strip for rapid local diagnosis of Ebola. ANNALS OF GLOBAL HEALTH - NOV/DEC 2014 - Transmission of Ebola Virus Disease: An Overview. PubMedSee all References33 See all References37 CrossRef | PubMedSee all References Although the natural reservoir host of Ebola viruses has not yet been identified, the way in which the virus first appears in a human at the start of an outbreak is unknown. However, scientists believe that the first patient becomes infected through contact with an infected animal, such as a fruit bat or primate (apes and monkeys), which is called a spillover event.
UNITED NATIONS - JANV 2015 - Socio-Economic Impacts of Ebola on Africa. The overall objective is to assess the socio-economic impacts of EVD not only on the countries with widespread and intense transmission, but West Africa more widely and the continent as a whole—both the real costs as well as growth and development prospects. The study looks at the outbreak’s impacts—qualitative and quantitative—endeavouring to grasp the interrelations among them by investigating mechanisms and channels of transmission, while trying to capture their size. Analysing these findings, the study offers recommendations to mitigate the disease’s impacts, including building more systematic coping and response mechanisms. ROBERT KOCH INSTITUT 30/12/14 Wildlife origins of West African Ebola virus disease outbreak narrowed down.
Press release of the Robert Koch Institute In April 2014, shortly after the World Health Organization announced that the Zaire Ebolavirus was responsible for a number of deaths in southeastern Guinea, an international team began the search for the animal origins of the current Ebola virus disease epidemic. The team wanted to know whether there was a larger Ebola virus outbreak happening in wildlife in the region and how the index case, a two-year-old boy in Meliandou, Guinea, might have gotten infected and sparked the epidemic that has since spread into other areas of Guinea and then Sierra Leone, Liberia, Nigeria, Senegal, USA, Spain and Mali, representing the largest ever recorded outbreak. The team first investigated whether there were signs of a recent decline in wildlife populations in the two largest protected areas in southeastern Guinea. CGIAR - JUILLET 2014 - Ebola risk assessment in the pig value chain in Uganda. Featured Articles. Transboundary and Emerging Diseases 27/08/15 Assessing the Potential Role of Pigs in the Epidemiology of Ebola Virus in Uganda.
THE SCRIPPS RESEARCH INSTITUTE 26/06/15 TSRI and Biotech Partners Find New Antibody Weapons against Marburg Virus. CAP TODAY 09/03/15 Biocartis to develop rapid Ebola virus triage test. Home » Top news. MICROSOFT RESEARCH - 2015 - Ebola data from the Internet: An opportunity for syndromic surveillance or a news event? Actualités CDC concernant EBOLA.
Actualités PLOS. Actualités NEJM. Actualités LANCET. World Journal of Medical Sciences 11 (3): 324-333, 2014 Ebola Hemorrhagic Fever as Emerging Zoonotic Disease. Epidemics Volume 9, December 2014, Potential for large outbreaks of Ebola virus disease. CSIRO BLOG 04/04/14 From animals to humans: understanding Ebola virus. AMERICAN SOCIETY OF PARASITOLOGISTS 28/10/14 American Society of Parasitologists Urges Support for Ebola Health Workers, End to Unfounded Travel Bans. American Journal of Clinical and Experimental Medicine - 2015 - Laboratory diagnostic tools for checking Ebola viral infections in Africa. THE ROYAL SOCIETY 01/04/15 Avoidable errors in the modelling of outbreaks of emerging pathogens, with special reference to Ebola. Abstract As an emergent infectious disease outbreak unfolds, public health response is reliant on information on key epidemiological quantities, such as transmission potential and serial interval.
Increasingly, transmission models fit to incidence data are used to estimate these parameters and guide policy. Some widely used modelling practices lead to potentially large errors in parameter estimates and, consequently, errors in model-based forecasts. American Journal of Clinical and Experimental Medicine - 2015 - Laboratory diagnostic tools for checking Ebola viral infections in Africa. Vesicular Stomatitis Virus–Based Vaccines against Lassa and Ebola Viruses - Volume 21, Number 2—February 2015. SCIENCE TRANSLATIONAL MEDICINE 20/08/14 Marburg virus infection in nonhuman primates: Therapeutic treatment by lipid-encapsulated siRNA. ANNALS OF INTERNAL MEDICINE 28/10/14 Effect of Ebola Progression on Transmission and Control in Liberia. World Journal of Medical Sciences 11 (3): 324-333, 2014 Ebola Hemorrhagic Fever as Emerging Zoonotic Disease. OJVR - 2012 - Ebola virus outbreaks in Africa: Past and present. ESCIENCE NEWS 15/08/13 Scripps Research Institute scientists reveal how deadly Ebola virus assembles.
Related images(click to enlarge) Photo courtesy of The Scripps Research Institute. Scientists at The Scripps Research Institute (TSRI) have discovered the molecular mechanism by which the deadly Ebola virus assembles, providing potential new drug targets. Surprisingly, the study showed that the same molecule that assembles and releases new viruses also rearranges itself into different shapes, with each shape controlling a different step of the virus's life cycle. "Like a 'Transformer', this protein of the Ebola virus adopts different shapes for different functions," said Erica Ollmann Saphire, Ph.D., professor in the Department of Immunology and Microbial Science at TSRI.
"It revises a central dogma of molecular biology -- that a protein molecule has one shape that predestines one biological function. " The research was published today in the peer-reviewed journal Cell. Ebola hemorrhagic fever is one of the most virulent diseases known to humankind. To conduct the study, Dr. Virus Research 153 (2010) 121–133 Genetic factors of Ebola virus virulence in guinea pigs. Dev Biol (Basel). 2013;135:211-8. Review of Ebola virus infections in domestic animals. OXFORD JOURNAL - 2011 - Ebola Virus as a Foodborne Pathogen? Cause for Consideration, but Not Panic.
EMERGING HEALTH THREATS JOURNAL - 2012 - Dead or alive: animal sampling during Ebola hemorrhagic fever outbreaks in humans. JOURNAL OF VETERINARY RESEARCH - 2012 - Ebola virus outbreaks in Africa: Past and present. NATURE 15/10/14 Ebola by the numbers: The size, spread and cost of an outbreak. PUBLIC HEALTH ENGLAND 24/10/14 Ebola: risk assessment in prison.