SCIENTIFIC REPORTS 03/09/18 Comments on two recent publications on GM maize and Roundup. Two studies recently published in Scientific Reports1,2 contain a number of questionable issues related to the experimental design and the interpretation of the obtained data.
We here point these out and discuss why caution about the far-reaching conclusions presented in the two studies is necessary. The first study (here called the “GM maize report”) claims that genetic transformation process caused metabolic disturbances in genetically modified (GM) NK603 Roundup-tolerant maize, questioning the compositional similarity of this cultivar to a non-GM control cultivar1. The second study (here called the “Roundup report”) reports that exposure of rats to an ultra-low dose of the glyphosate-based herbicide Roundup were found to cause significant metabolome and proteome changes allegedly indicative of liver dysfunction2.
This article has been retracted: please see Elsevier Policy on Article Withdrawal ( The journal Food and Chemical Toxicology retracts the article “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize,” which was published in this journal in November 2012.
This retraction comes after a thorough and time-consuming analysis of the published article and the data it reports, along with an investigation into the peer-review behind the article. The Editor in-Chief deferred making any public statements regarding this article until this investigation was complete, and the authors were notified of the findings. Very shortly after the publication of this article, the journal received Letters to the Editor expressing concerns about the validity of the findings it described, the proper use of animals, and even allegations of fraud. Many of these letters called upon the editors of the journal to retract the paper.
Environmental Sciences Europe 2014, 26:14 Republished study: long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. This report describes the first long-term (2-year) rodent (rat) feeding studyinvestigating possible toxic effects arising from consumption of an R-tolerant GM maize(NK603) and a complete commercial formulation of R herbicide.
The aims of thisinvestigation were essentially twofold. First, to evaluate whether the signs oftoxicity, especially with respect to liver and kidney functions, seen after 90 days'consumption of a diet containing NK603 R-tolerant GM maize [3, 7] escalated into serious ill health or dissipated over an extended period oftime. Second, to determine if low doses of full commercial R formulation at permittedlevels were still toxic, as indicated by our previous in vitro studies [8, 9]. The previous toxicity study with NK603 maize employed only this GM crop thathad been sprayed with R during cultivation .
What is also evident from our data is that ill effects were not proportional to the doseof either the NK603 GM maize ± R or R alone. Agricultural Systems Volume 127, May 2014, Modelling ex-ante the economic and environmental impacts of Genetically Modified Herbicide Tolerant maize cultivation in Europe.
Références FDA. Références SANTE CANADA. Références ANSES. Références EFSA. Weed Technology 23(2):243-246. 2009 Herbicide Options for Controlling Glyphosate-Tolerant Corn in a Corn Replant Situation. *Associate Professor, Associate Professor, and Professor, Department of Plant Sciences, University of Tennessee, Jackson, TN 38301.
Corresponding author's E-mail: firstname.lastname@example.org Abstract In the spring of 2007, a widespread freeze occurred that led to the replanting of about 81,000 hectares of corn in Tennessee. Limited research was available on effective herbicide options to control failed stands of glyphosate-tolerant corn where replanting to corn was desired. Therefore, in 2007 on three failed freeze-damaged corn stands (27,000 plants/ha) and in 2008 on two non–freeze-damaged corn stands (81,000 plants/ha), studies were initiated to determine how to control the failed stand while not harming subsequent replant corn. Nomenclature: Glyphosate; corn, Zea mays L.
Received: October 16, 2008; Accepted: March 10, 2009 Sources of Materials 1Glufosinate, Ignite, Bayer CropScience LP, Box 12014, 2 TW Alexander Drive Research Triangle Park, NC 27709. Literature Cited Andrade, F.