BULL WORLD HEALTH ORGAN - 1975 - Diagnosis of Lassa fever and the isolation and management of patients. PLOS - MARS 2009 - Risk Maps of Lassa Fever in West Africa. Abstract Background Lassa fever is caused by a viral haemorrhagic arenavirus that affects two to three million people in West Africa, causing a mortality of between 5,000 and 10,000 each year.
The natural reservoir of Lassa virus is the multi-mammate rat Mastomys natalensis, which lives in houses and surrounding fields. With the aim of gaining more information to control this disease, we here carry out a spatial analysis of Lassa fever data from human cases and infected rodent hosts covering the period 1965–2007. Information on contemporary environmental conditions (temperature, rainfall, vegetation) was derived from NASA Terra MODIS satellite sensor data and other sources and for elevation from the GTOPO30 surface for the region from Senegal to the Congo.
Emerging Infectious Diseases journal Vol. 12, No. 5, May 2006, is now available on the Web. Heartland virus (HRTV) is a recently described phlebovirus initially isolated in 2009 from 2 humans who had leukopenia and thrombocytopenia.
Serologic assessment of domestic and wild animal populations near the residence of 1 of these persons showed high exposure rates to raccoons, white-tailed deer, and horses. To our knowledge, no laboratory-based assessments of viremic potential of animals infected with HRTV have been performed. We experimentally inoculated several vertebrates (raccoons, goats, chickens, rabbits, hamsters, C57BL/6 mice, and interferon-α/β/γ receptor–deficient [Ag129]) mice with this virus.
All animals showed immune responses against HRTV after primary or secondary exposure. CDR Weekly Vol 16 No 30 (28 July 2006) Lassa fever in Germany: follow up of possible contacts. Last updated: 27 July 2006 Volume 16, No.30 (PDF file CDR Home | News On July 20 2006, a patient who travelled from Freetown (Sierra Leone) to Germany via Abidjan (Ivory Coast) and Brussels on 10/11 July was diagnosed with Lassa fever.
The patient had a history of a progressive neurological condition over several months in Sierra Leone but on 5 July they developed a fever with worsening neurological symptoms. On arrival in Germany the patient was taken to a local hospital and is still under specialist medical care. Education and Prevention Materials - "Lassa" Online Video Documentary. "Lassa" Video Documentary This documentary, produced by Viral Special Pathogens Branch, reviews the 16-year collaboration between the CDC and the government of Sierra Leone to control Lassa fever in West Africa.
Filmed primarily in Sierra Leone, the full-color video looks at the disease, the tragedy it causes, and tells the unfolding story of the epidemiology, natural history, and control of Lassa fever through the work of the Lassa Fever Project set up by CDC in 1976. Order a hardcopy of "Lassa" Print and Video Materials Available by Mail Transcript for "Lassa" Video Narrator Everybody loves a parade! *Natural background sound; patient's heavy breathing *Background sound; health workers talking Villager My wife was first treated for malaria, and after three days, we brought her here to the hospital at Segbwema. *Background sounds The history of Lassa fever began in 1969 with the mysterious death of two missionary nurses and a near fatal illness of a third. Am. J. Trop. Med. Hyg., 23(6), 1974, pp. 1140-1149 Lassa Fever in the Eastern Province of Sierra Leone, 1970–1972. Am. J. Trop. Med. Hyg., 19(4), 1970, pp. 670-676 Lassa Fever, a New Virus Disease of Man from West Africa.
THE NY SUN 22/01/08 John Frame, 90, Discovered Lassa Fever. John Frame, who died January 16 at 90, was a missionary doctor who identified Lassa fever, a viral disease that infects up to half a million people in West Africa each year, killing about 5,000.
It was Frame's insight that the hemorrhagic symptoms that killed several missionary nurses were manifestations of a previously unknown disease. So virulent was the pathogen that several researchers were infected and one died when it was first identified in 1969.