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VIRUSES 05/07/21 Antivirals against the Chikungunya Virus. All articles published by MDPI are made immediately available worldwide under an open access license.

VIRUSES 05/07/21 Antivirals against the Chikungunya Virus

No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. Feature Papers represent the most advanced research with significant potential for high impact in the field. Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication. The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature.

MICROORGANISMS 03/08/21 Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes. Palm Creek virus (PCV) is an insect-specific flavivirus that can interfere with the replication of mosquito-borne flaviviruses in Culex mosquitoes, thereby potentially reducing disease transmission.

MICROORGANISMS 03/08/21 Interactions of the Insect-Specific Palm Creek Virus with Zika and Chikungunya Viruses in Aedes Mosquitoes

We examined whether PCV could interfere with arbovirus replication in Aedes (Ae.) aegypti and Ae. albopictus mosquitoes, major vectors for many prominent mosquito-borne viral diseases. We infected laboratory colonies of Ae. aegypti and Ae. albopictus with PCV to evaluate infection dynamics. PCV infection was found to persist to at least 21 days post-infection and could be detected in the midguts and ovaries. We then assayed for PCV–arbovirus interference by orally challenging PCV-infected mosquitoes with Zika and chikungunya viruses.

For both arboviruses, PCV infection had no effect on infection and transmission rates, indicating limited potential as a method of intervention for Aedes-transmitted arboviruses. ►▼ Show Figures Figure 1 ►▼ Show Figures Figure 1. PLOS 04/03/21 Measuring the global burden of chikungunya and Zika viruses: A systematic review. Abstract Throughout the last decade, chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have spread globally, causing a spectrum of disease that ranges from self-limited febrile illness to permanent severe disability, congenital anomalies, and early death.

PLOS 04/03/21 Measuring the global burden of chikungunya and Zika viruses: A systematic review

Nevertheless, estimates of their aggregate health impact are absent from the literature and are currently omitted from the Global Burden of Disease (GBD) reports. We systematically reviewed published literature and surveillance records to evaluate the global burden caused by CHIKV and ZIKV between 2010 and 2019, to calculate estimates of their disability-adjusted life year (DALY) impact. Extracted data on acute, chronic, and perinatal outcomes were used to create annualized DALY estimates, following techniques outlined in the GBD framework. This study is registered with PROSPERO (CRD42020192502). Author summary. Mem. Inst. Oswaldo Cruz vol.113 no.11 Rio de Janeiro 2018 Epub Oct 29, 2018 Potential role of dengue virus, chikungunya virus and Zika virus in neurological diseases.

Virus Genes. 2021 Feb 15 Prophylactic strategies to control chikungunya virus infection. Life (Basel) . 2020 Dec 30; Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus. Arboviruses, in general, are a global threat due to their morbidity and mortality, which results in an important social and economic impact.

Life (Basel) . 2020 Dec 30; Nitrogen-Based Heterocyclic Compounds: A Promising Class of Antiviral Agents against Chikungunya Virus

Chikungunya virus (CHIKV), one of the most relevant arbovirus currently known, is a re-emergent virus that causes a disease named chikungunya fever, characterized by a severe arthralgia (joint pains) that can persist for several months or years in some individuals. Until now, no vaccine or specific antiviral drug is commercially available. Nitrogen heterocyclic scaffolds are found in medications, such as aristeromycin, favipiravir, fluorouracil, 6-azauridine, thioguanine, pyrimethamine, among others. New families of natural and synthetic nitrogen analogous compounds are reported to have significant anti-CHIKV effects.

In the present work, we focus on these nitrogen-based heterocyclic compounds as an important class with CHIKV antiviral activity. ►▼ Show Figures. FRONT PUBLIC HEALTH 15/12/20 Current and Promising Antivirals Against Chikungunya Virus. VIRUSES 07/03/19 Inactivation and Removal of Chikungunya Virus and Mayaro Virus from Plasma-derived Medicinal Products. Background: Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are closely related members of the Semliki Forest complex within the genus alphavirus and are transmitted by arthropods, causing acute febrile illness in humans.

VIRUSES 07/03/19 Inactivation and Removal of Chikungunya Virus and Mayaro Virus from Plasma-derived Medicinal Products

CHIKV has spread to almost all continents, whereas autochthonous MAYV infections have been reported in South America and in the Caribbean. Nevertheless, there was concern about potential spread of MAYV to other regions similar to CHIKV in the past. Int. J. Mol. Sci. 05/11/20 A Novel Multiplex RT-PCR Assay for Simultaneous Detection of Dengue and Chikungunya Viruses. The goal of the study was to develop a specific, sensitive, and cost-effective molecular RT-PCR diagnostic assay for the rapid and simultaneous detection of the serotypes of dengue virus (DENV) and Chikungunya virus (CHIKV) from sera of suspected febrile patients.

Int. J. Mol. Sci. 05/11/20 A Novel Multiplex RT-PCR Assay for Simultaneous Detection of Dengue and Chikungunya Viruses

A single-tube, single-step multiplex RT-PCR (mRT-PCR) assay was designed for the detection of viral genomes from clinical and field samples. Specificity and sensitivity of the mRT-PCR assay were evaluated against six different combinations using two reverse transcriptases (AMV-RT and RT-Ace) and three DNA polymerases (LA-Taq, rTaq, and Tth). Among the six combinations, the AMV-RT and LA-Taq combination was more specific and sensitive than other enzyme combinations for detecting viral genomes of DENV-1, DENV-2, DENV-3, and DENV-4 (p < 0.01), and for detecting viral genomes of CHIKV (p < 0.05). ►▼ Show Figures.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 08/09/20 Small molecule inhibitors of Chikungunya virus: mechanisms of action and antiviral drug resistance. CDC EID - OCT 2020 - Basic Reproduction Number of Chikungunya Virus Transmitted by Aedes Mosquitoes. Disclaimer: Early release articles are not considered as final versions.

CDC EID - OCT 2020 - Basic Reproduction Number of Chikungunya Virus Transmitted by Aedes Mosquitoes

Any changes will be reflected in the online version in the month the article is officially released. Author affiliations: The Royal Veterinary College, University of London, London, UK (N. Haider, R.A. Kock); National Institute for Infectious Diseases Lazzaro Spallanzani, Rome, Italy (F. Commun Biol. 2020 Jun 24 Vector Competence of Aedes Albopictus Populations for Chikungunya Virus Is Shaped by Their Demographic History. 1.Kraemer, M.

Commun Biol. 2020 Jun 24 Vector Competence of Aedes Albopictus Populations for Chikungunya Virus Is Shaped by Their Demographic History

U. et al. The global distribution of the arbovirus vectors Aedes aegypti and Ae. albopictus. Elife 4, e08347 (2015).PubMed PubMed Central Article Google Scholar 2.Mogi, M., Armbruster, P., Tuno, N., Campos, R. & Eritja, R. Simple indices provide insight to climate attributes delineating the geographic range of Aedes albopictus (Diptera: Culicidae) prior to worldwide invasion. J. PLOS 11/05/20 From importation to autochthonous transmission: Drivers of chikungunya and dengue emergence in a temperate area. Abstract Background The global spread of Aedes albopictus has exposed new geographical areas to the risk of dengue and chikungunya virus transmission.

PLOS 11/05/20 From importation to autochthonous transmission: Drivers of chikungunya and dengue emergence in a temperate area.

Several autochthonous transmission events have occurred in recent decades in Southern Europe and many indicators suggest that it will become more frequent in this region in the future. Environmental, socioeconomic and climatic factors are generally considered to trigger the emergence of these viruses. Accordingly, a greater knowledge of the determinants of this emergence in a European context is necessary to develop adapted surveillance and control strategies, and public health interventions.

PLOS 12/09/19 Chikungunya-attributable deaths: A neglected outcome of a neglected disease. Citation: Lima Neto AS, Sousa GS, Nascimento OJ, Castro MC (2019) Chikungunya-attributable deaths: A neglected outcome of a neglected disease.

PLOS 12/09/19 Chikungunya-attributable deaths: A neglected outcome of a neglected disease

PLoS Negl Trop Dis 13(9): e0007575. Editor: Brett M. Forshey, DoD - AFHSB, UNITED STATES. PATHOGENS 12/09/19 Chikungunya Virus Transmission at Low Temperature by Aedes albopictus Mosquitoes. Aedes albopictus is an important vector of chikungunya virus (CHIKV). In Australia, Ae. albopictus is currently only known to be present on the islands of the Torres Strait but, should it invade the mainland, it is projected to spread to temperate regions. The ability of Australian Ae. albopictus to transmit CHIKV at the lower temperatures typical of temperate areas has not been assessed. Ae. albopictus mosquitoes were orally challenged with a CHIKV strain from either Asian or East/Central/South African (ECSA) genotypes (107 pfu/mL), and maintained at a constant temperature of either 18 °C or 28 °C.

VIRUSES 24/08/19 Chikungunya Virus and (Re-) Emerging Alphaviruses. PLOS 18/06/19 Systems analysis of subjects acutely infected with the Chikungunya virus. VIRUSES 13/06/19 Chikungunya Virus Infections in Military Deployments in Tropical Settings—A Narrative Minireview. Chikungunya fever is a vector-borne viral disease in subtropical and tropical areas of endemicity. Apart from the burden on local populations, chikungunya virus infection also poses a risk for travelers and, in particular, soldiers during prolonged deployment-associated outdoor activities. The absence of rapid diagnostic tests makes surveillance challenging during military deployments in war and crisis zones with restricted medical infrastructure.

Consequently, both historical and up-to-date surveillance data from battlefields are scarce. From several studies and postdeployment assessments, some information on the epidemiology of chikungunya virus infections in deployed military personnel is nevertheless available. The few published data homogeneously suggest a low infection risk in the endemic setting. INTECH 13/06/19 Diagnosis and Molecular Characterization of Chikungunya Virus Infections. Chikungunya virus is transmitted to people, as mentioned above, primarily via mosquito bites (primarily during the day but also at night). Mosquitoes become infected when they feed on a person already infected with the virus and then spread the virus to other people via biting, after the virus reaches the mosquito salivary glands. Other less-frequent routes of transmission are through blood products, organ transplantation, and maternal-fetal. Pregnant women infected with CHIKV are not at increased risk of atypical or severe disease, but maternal CHIKV infection has been associated with miscarriage in the first trimester [16, 37, 38].

VIRUSES 18/10/18 Ultrastructural Analysis of Chikungunya Virus Dissemination from the Midgut of the Yellow Fever Mosquito, Aedes aegypti. PLOS 16/07/18 Current challenges and implications for dengue, chikungunya and Zika seroprevalence studies worldwide: A scoping review. Survey methods used to measure seroprevalence Ethical approval. Each article was reviewed to determine whether ethical approval was reported. Most studies obtained national ethics approval (58%), and 27% obtained international ethics approval from more than one country. Five studies reported not requiring institutional review board approval because they represented public health studies. Eleven studies did not provide indicative information about ethics approval but mentioned in their method section that mandatory written informed consent from each individual was obtained. Target population. The population type distribution is presented in Table 1. The target age groups selected for the serosurveys were variable.

Design and sample size. We were able to categorize the studies according to sample recruitment for all studies except one (Table 1). The sample size for each study varied from 46 to 5669. Only 17% of the studies provided response rates, which ranged from 40 to 100% (mean of 80%). BMC PUBLIC HEALTH 08/06/18 Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review. Methods Mol Biol. 2016;1426:243-53. Antiviral Strategies Against Chikungunya Virus. The global re-emergence of CHIKV and the high morbidity rate associated with its infection emphasizes the need to develop potent antiviral agents against CHIKV. So far, a number of classes of compounds that inhibit viral replication by targeting either a viral or a host factor have been reported. Most of the compounds have relatively modest activity and for most of them, activity in infection models (in mice) was not assessed. Some of these classes may serve as a starting point for the design of more specific and selective inhibitors of CHIKV replication.

Also, to the best of our knowledge, no information is available yet on the effect of antivirals on the chronic stage of CHIKV infection. PLOS 10/05/18 Seasonal temperature variation influences climate suitability for dengue, chikungunya, and Zika transmission. Abstract. PLOS 09/10/14 Aedes hensilli as a Potential Vector of Chikungunya and Zika Viruses. Rev Panam Salud Publica. 2017 Aug 21;41:e62. Evaluation of three commercially-available chikungunya virus immunoglobulin G immunoassays. Brief communication. Rev Panam Salud Publica. 2017 Aug 21;41:e65. Minimum infectious dose for chikungunya virus in Aedes aegypti and Ae. albopictus mosquitoes. Nat Med. 2017 Feb;23(2):192-199. A chikungunya fever vaccine utilizing an insect-specific virus platform. Int. J. Mol. Sci. 04/08/17 Co-Infection of Mosquitoes with Chikungunya and Dengue Viruses Reveals Modulation of the Replication of Both Viruses in Midguts and Salivary Glands of Aedes aegypti Mosquitoes.

MDPI and ACS Style Le Coupanec, A.; Tchankouo-Nguetcheu, S.; Roux, P.; Khun, H.; Huerre, M.; Morales-Vargas, R.; Enguehard, M.; Lavillette, D.; Missé, D.; Choumet, V. Vaccine Volume 35, Issue 29, 22 June 2017 Deinococcus Mn2+-peptide complex: A novel approach to alphavirus vaccine development. Open Access Highlights. BMC Microbiology 03/05/17 Simultaneous detection of chikungunya virus, dengue virus and human pathogenic Leptospira genomes using a multiplex TaqMan® assay. NATURE SCIENTIFIC REPORT 20/03/17 A smartphone-based diagnostic platform for rapid detection of Zika, chikungunya, and dengue viruses.

Assay speed and sensitivity We aimed to develop a rapid and reliable QUASR RT-LAMP assay for ZIKV, while relying on previously reported RT-LAMP assays for CHIKV and DENV17,19,22. Am J Trop Med Hyg. 2016 Dec 5. pii: 16-0516. Detection of Wolbachia in Aedes albopictus and Their Effects on Chikungunya Virus. Asian Pacific Journal of Tropical Medicine Volume 9, Issue 10, October 2016 Chikungunya infection: A potential re-emerging global threat. Abstract Infectious diseases are indeed a lifelong threat to everyone irrespective of age, sex, lifestyle and socio-economic status. The infectious diseases have persisted among the prominent causes of death globally. PLoS Negl Trop Dis. 2016 Apr 28;10(4):e0004677. The wMel Strain of Wolbachia Reduces Transmission of Chikungunya Virus in Aedes aegypti.

Annals of Clinical Microbiology and Antimicrobials 22/07/16 ChikDenMaZika Syndrome: the challenge of diagnosing arboviral infections in the midst of concurrent epidemics. Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses - Volume 22, Number 7—July 2016. EUROSURVEILLANCE 19/05/16 Global distribution and environmental suitability for chikungunya virus, 1952 to 2015. BMC 03/03/16 Co-distribution and co-infection of chikungunya and dengue viruses. SCIENTIFIC DATA 07/07/15 The global compendium of Aedes aegypti and Ae. albopictus occurrence. PLOS 26/06/14 Arrival of Chikungunya Virus in the New World: Prospects for Spread and Impact on Public Health. CDC EID - AOUT 2014 - Preparedness for Threat of Chikungunya in the Pacific.

CDC EID - Volume 20, Number 8—August 2014   PDF Version[PDF - 7.58 MB - 1 67 pages]. Au sommaire notamment: Transcontinental Movement of Asian Genotype Chikungunya Virus. CDC EID - Volume 20, Number 8—August 2014   PDF Version[PDF - 7.58 MB - 167 pages]. Au sommaire notamment: Movement of Chikungunya Virus into the Western Hemisphere. CDC EID - Volume 20, Number 12—December 2014. Au sommaire: Evaluation of Commercially Available Serologic Diagnostic Tests for Chikungunya Virus. Viruses 2014, 6(11), 4628-4663 Chikungunya Virus–Vector Interactions. SCIENCE NEWS 02/06/15 Chikungunya is on the move - The virus has found a new hemisphere and might get a new latitude. Chikungunya Virus–Vector Interactions. NEW MICROBIOLOGICA, 36, 211-227, 2013 Chikungunya virus infection: an overview.

Molecular Ecology (2012) 21, 2297–2309 Chikungunya virus impacts the diversity of symbiotic bacteria in mosquito vector. Journal of Ophthalmic Inflammation and Infection 2013, 3:35 Chikungunya and the eye: a review. INTECH - MARS 2012 - Au sommaire: The Re-Emergence of an Old Disease: Chikungunya Fever. World J Virol 2012 February 12; 1(1): 11-22 Emerging and re-emerging viruses: A global challenge illustrated by Chikungunya viru. PLOS 24/01/12 Climate Teleconnections and Recent Patterns of Human and Animal Disease Outbreaks. Journal of Vector Ecology Volume 36, Issue 1, pages 108–116, June 2011 Surveillance of the chikungunya vector Aedes albopictus ( AuthorMapper. Chikungunya: A Potentially Emerging Epidemic?

Indian Journal of Medical Microbiology: Table of Contents.