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Epidémiologie humaine

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 30/05/17 Genetic Virulence Profile of Enteroaggregative Escherichia coli Strains Isolated from Danish Children with Either Acute or Persistent Diarrhea. Introduction Enteroaggregative Escherichia coli (EAEC) is an established pathotype within the group of diarrheagenic E. coli (DEC), which also includes the enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), and verocytotoxin-producing E. coli (VTEC).

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 30/05/17 Genetic Virulence Profile of Enteroaggregative Escherichia coli Strains Isolated from Danish Children with Either Acute or Persistent Diarrhea

EAEC is associated with diarrhea, failure to thrive, weight loss, and stunted growth in children living in developing countries (Steiner et al., 1998; Albert et al., 1999; Lima et al., 2000; Medina et al., 2010; Hebbelstrup Jensen et al., 2014). EAEC-positive children were seen to have increased levels of fecal lactoferrin and Il-1β, regardless of the presence of gastrointestinal symptoms in a Brazilian study (Steiner et al., 1998). This indicates a considerable inflammation potential of EAEC and severe illness, which may also be present in children in industrialized countries.

The gold standard for the identification of EAEC is by the HEp-2 cell assay. Table 1. Materials and Methods Figure 1. EUROSURVEILLANCE 25/05/17 Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. S Vygen-Bonnet 1 , B Rosner 1 , H Wilking 1 , A Fruth 2 , R Prager 2 , A Kossow 3 , C Lang 2 , S Simon 2 , J Seidel 1 4 5 , M Faber 1 , A Schielke 1 , K Michaelis 1 , A Holzer 1 , R Kamphausen 6 , D Kalhöfer 7 , S Thole 5 7 , A Mellmann 3 , A Flieger 2 , K Stark 1 + Author affiliations.

EUROSURVEILLANCE 25/05/17 Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017.

CDC 10/12/12 Multistate Outbreak of Shiga Toxin-producing Escherichia coli O157:H7 Infections Linked to Organic Spinach and Spring Mix Blend (Final Update) Introduction CDC collaborated with public health officials in several states and the U.S.

CDC 10/12/12 Multistate Outbreak of Shiga Toxin-producing Escherichia coli O157:H7 Infections Linked to Organic Spinach and Spring Mix Blend (Final Update)

Food and Drug Administration (FDA) to investigate a multistate outbreak of Shiga toxin-producing Escherichia coli O157:H7 (STEC O157:H7) infections. Results from this investigation linked this outbreak to pre-packaged leafy greens produced by State Garden of Chelsea, Massachusetts. CDC - SEPT 2006 - Multi-State Outbreak of E. coli O157:H7 Infections From Spinach.

ZOONOSES AND PUBLIC HEALTH 03/01/17 Severe Outbreak of Sorbitol-Fermenting Escherichia coli O157 via Unpasteurized Milk and Farm Visits, Finland 2012. Introduction Shiga toxin-producing Escherichia coli (STEC) O157 causes human illness with symptoms such as diarrhoea, haemorrhagic colitis and haemolytic-uraemic syndrome (HUS) (Tarr et al., 2005).

ZOONOSES AND PUBLIC HEALTH 03/01/17 Severe Outbreak of Sorbitol-Fermenting Escherichia coli O157 via Unpasteurized Milk and Farm Visits, Finland 2012

The microbiological identification of STEC O157 has traditionally relied on its inability to ferment sorbitol. However, sorbitol-fermenting E. coli O157 (SF O157) has emerged as a notable cause of outbreaks and sporadic illnesses in Europe, since first identified in Germany in 1988 (Karch and Bielaszewska, 2001; Editorial team, 2006; Alpers et al., 2009; Orth et al., 2009; King et al., 2014). Illnesses caused by SF O157 have been associated with more severe outcomes, including higher incidence of HUS and mortality (Alpers et al., 2009; Nielsen et al., 2011). Despite identified outbreaks of SF O157, the transmission routes and reservoirs of this pathogen remain largely unknown. Materials and Methods Identification of the outbreak and its source. CDC EID - DEC 2016 - Au sommaire: Secondary Shiga Toxin–Producing Escherichia coli Infection, Japan, 2010–2012.

J Infect Dis. (2002) Clinical Course and the Role of Shiga Toxin–Producing Escherichia coli Infection in the Hemolytic-Uremic Syndrome in Pediatric Patients, 1997–2000, in Germany and Austria: A Prospective Study. + Author Affiliations Reprints or correspondence: Dr.

J Infect Dis. (2002) Clinical Course and the Role of Shiga Toxin–Producing Escherichia coli Infection in the Hemolytic-Uremic Syndrome in Pediatric Patients, 1997–2000, in Germany and Austria: A Prospective Study

Lothar B. Zimmerhackl, Universitätsklinik für Kinder- und Jugendmedizin, Universität Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria (lothar-bernd.zimmerhackl@uklibk.ac.at) Abstract. EUROSURVEILLANCE 01/09/16 Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014. Methods Data collection The study period comprised two years from 1 April 2012 to 31 March 2014, during which time all NHS acute Trusts (n = 167) in England reported all cases of bacteraemia due to E. coli to Public Health England (PHE, formerly the Health Protection Agency).

EUROSURVEILLANCE 01/09/16 Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014.

Cases were reported via a web-based system originally developed for the mandatory surveillance of Clostridium difficile infection and bacteraemia caused by Staphylococcus aureus. Only the first blood culture positive for E. coli was reported, with further positive blood cultures taken from the same patient within 14 days of the first sample regarded as the same episode of bacteraemia and not reported. Data items collected included the specimen date, patient demographics and care details at the time the blood culture was taken.

Data analyses. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 13/07/16 Enteroaggregative Escherichia coli in Daycare—A 1-Year Dynamic Cohort Study (Danemark) Introduction Enteroaggregative Escherichia coli (EAEC) is an established pathotype within the group of diarrheagenic E. coli (DEC), which also include enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), and Shiga toxin-producing E. coli (STEC; Croxen et al., 2013).

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 13/07/16 Enteroaggregative Escherichia coli in Daycare—A 1-Year Dynamic Cohort Study (Danemark)

EFSA 06/04/16 Joint ECDC/EFSA rapid outbreak assessment: multi-country outbreak of Shiga toxin-producing Escherichia coli infection associated with haemolytic uraemic syndrome in Romania and Italy. EUROSURVEILLANCE 17/03/16 Early findings in outbreak of haemolytic uraemic syndrome among young children caused by Shiga toxin-producing Escherichia coli, Romania, January to February 2016. E Peron 1 2 3 , A Zaharia 3 4 , LC Zota 3 4 , E Severi 5 , O Mårdh 5 , C Usein 6 , M Bălgrădean 7 8 , L Espinosa 5 , J Jansa 5 , G Scavia 9 , A Rafila 7 10 , A Serban 11 , A Pistol 4.

EUROSURVEILLANCE 17/03/16 Early findings in outbreak of haemolytic uraemic syndrome among young children caused by Shiga toxin-producing Escherichia coli, Romania, January to February 2016.

EUROSURVEILLANCE 10/04/14 Au sommaire: Results of surveillance for infections with Shiga toxin-producing Escherichia coli (STEC) of serotype O104:H4 after the large outbreak in Germany, July to December 2011. After the massive outbreak of infections with Shiga toxin-producing Escherichia coli (STEC) of serotype O104:H4 in Germany in the summer of 2011, post-outbreak surveillance for further infections with this type of STEC was maintained until the end of 2011.

EUROSURVEILLANCE 10/04/14 Au sommaire: Results of surveillance for infections with Shiga toxin-producing Escherichia coli (STEC) of serotype O104:H4 after the large outbreak in Germany, July to December 2011

This surveillance was based on national mandatory reporting of STEC infections and the associated complication of haemolytic uraemic syndrome (HUS), as well as on data obtained from a questionnaire. Between the outbreak’s end (5 July) and 31 December 2011, a total of 33 post-outbreak cases were recorded. Post-outbreak cases occurred with diminishing frequency towards the year’s end and resembled the outbreak cases in many respects, however the proportion of HUS among all post-outbreak cases was smaller than during the outbreak. Two thirds of the post-outbreak cases were likely infected by contact with known outbreak cases. Both laboratory and nosocomial spread was noted in this period. Introduction. EUROSURVEILLANCE 01/05/14 Au sommaire: Emergence of Escherichia coli encoding Shiga toxin 2f in human Shiga toxin-producing E. coli (STEC) infections in the Netherlands, January 2008 to December 2011. The Shiga toxins of Shiga toxin-producing Escherichia coli (STEC) can be divided into Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2) with several sub-variants.

EUROSURVEILLANCE 01/05/14 Au sommaire: Emergence of Escherichia coli encoding Shiga toxin 2f in human Shiga toxin-producing E. coli (STEC) infections in the Netherlands, January 2008 to December 2011

Variant Stx2f is one of the latest described, but has been rarely associated with symptomatic human infections. In the enhanced STEC surveillance in the Netherlands, 198 STEC O157 cases and 351 STEC non-O157 cases, including 87 stx2f STEC isolates, were reported between 2008 and 2011. Most stx2f strains belonged to the serogroups O63:H6 (n=47, 54%), O113:H6 (n=12, 14%) and O125:H6 (n=12, 14%). Of the 87 stx2f isolates, 84 (97%) harboured the E. coli attaching and effacing (eae) gene, but not the enterohaemorrhagic E. coli haemolysin (hly) gene. Stx2f STEC infections show milder symptoms and a less severe clinical course than STEC O157 infections. EUROSURVEILLANCE 31/10/13 Outbreak of Shiga toxin-producing E. coli O157 associated with consumption of watercress, United Kingdom, August to September 2013.

An increase in the number of cases of Shiga toxin-producing Escherichia coli O157 PT 2 stx2 infection was reported in the United Kingdom on 9 September 2013. Of the 19 cases, 13 were interviewed, of which 10 reported consuming watercress purchased from one retailer. The retailer recalled pre-packed bagged salads containing watercress on 12 September. The descriptive epidemiology was supported by a case–case study performed after control measures were implemented. On 9 September 2013, the Public Health England (PHE) automated outbreak detection system [1] highlighted an increase in the number of cases of Shiga toxin-producing Escherichia coli (STEC) serotype O157, phage type (PT) 2, Shiga toxin type 2 (stx2), which had been reported through the PHE Gastrointestinal Bacteria Reference Unit, London. During the week commencing 2 September, 12 cases were reported, compared with around one to two cases per week in the preceding months.

Background and descriptive epidemiology Figure 1. Table. CDC EID - AOUT 2015 - Escherichia coli O157 Outbreaks in the United States, 2003–2012. Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit. This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint providership of Medscape, LLC and Emerging Infectious Diseases.

Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians. Medscape, LLC designates this Journal-based CME activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity. All other clinicians completing this activity will be issued a certificate of participation. Implications of screening and childcare exclusion policies for children with Shiga-toxin producing Escherichia coli infections: lessons learned from an outbreak in a daycare centre, Norway, 2012. INVS 06/09/13 Surveillance sanitaire en région Bourgogne et Franche-Comté. A la Une - Surveillance du Syndrome hémolytique et ur. EUROSURVEILLANCE 10/01/13 Au sommaire: A verocytotoxin-producing E. coli outbreak with a surprisingly high risk of haemolytic ur. Denmark faced an outbreak of verocytotoxin-producing E. coli (VTEC) O157:H7 infections in autumn 2012.

Thirteen cases were diagnosed of which eight had haemolytic uraemic syndrome (HUS). Epidemiological investigations suggested ground beef as the vehicle of the outbreak. The outbreak strain had a rare toxin gene subtype profile: eae, vtx1a and vtx2a, and a high proportion of HUS (62%) among cases, a finding previously linked with the outbreak subtype profile. Toxin subtyping can be useful to identify high risk VTEC strains. Encadré – Surveillance du syndrome hémolytique et urémique chez les enfants de moins de 15 ans en France. Eurosurveillance, Volume 17, Issue 34, 23 August 2012. Using an outbreak to study the sensitivity of the surveillance of enteroh. Following an outbreak of enterohaemorrhagic Escherichia coli (EHEC) in Germany 2011, we observed increases in EHEC and non-EHEC E. coli cases in Bavaria.

We compared the demographic, clinical and laboratory features of the cases reported during the outbreak period, but not related to the outbreak, to the cases reported before and after. The number of EHEC and non-EHEC E. coli cases notified per week during the outbreak was fivefold and twofold higher respectively, compared to previous years. EHEC cases notified during the outbreak were more often reported with bloody diarrhoea, and less often with unspecified diarrhoea, compared to the other periods.

They were more often hospitalised during the outbreak and the following period compared to the period before. Family Outbreak of Shiga Toxin–producing E. coli O123:H–, France, 2009. Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home CDC 24/7: Saving Lives. Protecting People.™ <div class="noscript"> Note: Javascript is disabled or is not supported by your browser. E. coli. Annales de Biologie Clinique.

Annales de Biologie Clinique. De nombreuses souches de l'espèce Escherichia coli (E. coli) sont des hôtes normaux du tractus gastro-intestinal de l'homme et des animaux, mais elles peuvent également être à l'origine de désordres gastro-intestinaux. Il est possible de trouver ces bactéries dans d'autres localisations, par exemple l'appareil génito-urinaire ou des plaies chirurgicales. Les souches produisant les toxines dangereuses mises en évidence sur des cultures cellulaires, cellules Vero (cellules rénales du singe vert d'Afrique), sont appelées Escherichia coli producteurs de vérocytotoxines ou VTEC. Ces souches sont à l'origine de colites hémorragiques chez l'homme et peuvent entraîner, dans certains cas, la mort.

En 1947, une classification utilisant le sérotypage a été développée ; elle était basée sur l'identification des antigènes de surface des bactéries E. coli (antigènes O somatiques). Cette classification a permis de diviser le groupe E. coli en 170 sérogroupes différents. Symptômes et évolution. Foodborne Disease Significance of Escherichia coli O157:H7 and Other Enterohemorrhagic E. coli. This Scientific Status Summary addresses the virulence and disease characteristics of EHEC, their reservoirs and sources, survival and growth, and disease prevention strategies.

_CSR_APH_98.8.pdf (Objet application/pdf) CDC E. Coli. CDC Home <div class="noscript"> Note: Javascript is disabled or is not supported by your browser. For this reason, some items on this page will be unavailable. For more information about this message, please visit this page: <a href="/Other/about_cdcgov.html" title="Browser requirements for CDC.gov">About CDC.gov</a>.

Escherichia coli entérohémorragique (EHEC ou VTEC) Agent infectieux et transmission. Institut de veille sanitaire. Institut de veille sanitaire. ASPC 09/10/14 Éclosion d'infection à E. coli O157:H7 associée à de la laitue servie dans des chaînes de restauration rapide dans les Maritimes et en Ontario, Canada, décembre 2012. Pour partager cette page, veuillez cliquez sur le réseau sociale de votre choix.