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Epidémiologie humaine

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ECDC - AVRIL 2019 - Shiga toxin /verocytotoxin-producing Escherichia coli (STEC/VTEC) infection Annual Epidemiological Report for 2017. SANTE PUBLIQUE FRANCE 20/03/19 Système de surveillance du SHU chez l’enfant âgé de moins de 15 ans en France. Modalités de surveillance, définition de cas En France, la recherche des E. coli producteurs de shigatoxines (STEC) dans les selles n’étant pas effectuée en routine dans les laboratoires d’analyses médicales, la surveillance de ces infections est basée sur la surveillance du syndrome hémolytique et urémique (SHU).

Les objectifs de cette surveillance sont de suivre les tendances spatio-temporelles du SHU chez les enfants âgés de moins de 15 ans, de connaître les caractéristiques épidémiologiques des cas et de détecter des phénomènes épidémiques. Cette surveillance a été mise en place en 1996, par Santé publique France en collaboration avec la Société de néphrologie pédiatrique, à la suite d’une étude sur les années 1995-1996 qui avait montré que 86 % des SHU pédiatriques en France survenaient suite à une infection à STEC. Un questionnaire alimentaire pour les cas de SHU a été développé par Santé publique France. Partenaires de la surveillance. EUROSURVEILLANCE 30/08/18 Outbreak of multiple strains of non-O157 Shiga toxin-producing and enteropathogenic Escherichia coli associated with rocket salad, Finland, autumn 2016. EUROSURVEILLANCE 28/06/18 Use of an ingredient-based analysis to investigate a national outbreak of Escherichia coli O157, United Kingdom, July 2016.

EUROSURVEILLANCE 03/05/18 National outbreak of Shiga toxin-producing Escherichia coli O157:H7 linked to mixed salad leaves, United Kingdom, 2016. GLOBAL VETERINARIA - 2013 - Prevalence of Zoonotic Escherichia coli and Salmonellae in Wild Birds and Humans in Egypt with Emphasis on RAPD-PCR Fingerprinting of E. coli. Senasa comunica (AR) VIA YOUTUBE 12/01/18 Según el Ministerio de Salud, en Argentina se diagnostican más de 400 casos anuales del Síndrome Urémico Hemolítico. El Senasa brinda recomendaciones para evitar la enfermedad. INSTITUT PASTEUR 01/10/17 Rapport d'activité annuel Année d'exercice 2016 Centre National de Référence des Escherichia coli, Shigella et Salmonella - Unité de Recherche et d’Expertise des Bactéries Pathogènes Entériques. EUROSURVEILLANCE 07/09/17 Recurrent seasonal outbreak of an emerging serotype of Shiga toxin-producing Escherichia coli (STEC O55:H7 Stx2a) in the south west of England, July 2014 to September 2015.

. BMJ. ;():-. DOI: 10.1136/bmj.318.7185.684 PMID: 10073994 , , , , , . BMJ Open. ;():. DOI: 10.1136/bmjopen-2015-009933 PMID: 26826153 , , , . PLoS One. ;():. DOI: 10.1371/journal.pone.0117660 PMID: 25629697 , , , , , , et al. Euro Surveill. ;():.PMID: 18445416 , , , , , , et al. CDC EID - OCT 2017 - Mild Illness during Outbreak of Shiga Toxin−Producing Escherichia coli O157 Infections Associated with Agricultural Show, Australia. Bhakti R. Vasant ( , Russell J. Stafford, Amy V. Jennison, Sonya M. Bennett, Robert J. Author affiliations: Queensland Health, Brisbane, Queensland, Australia (B.R. Suggested citation for this article Abstract During a large outbreak of Shiga toxin−producing Escherichia coli illness associated with an agricultural show in Australia, we used whole-genome sequencing to detect an IS1203v insertion in the Shiga toxin 2c subunit A gene of Shiga toxin−producing E. coli.

Shiga toxin−producing Escherichia coli (STEC) is a major cause of serious human gastrointestinal illness and have the potential to cause life-threatening complications, such as hemolytic uremic syndrome (HUS) (1). Healthy ruminants, particularly cattle, are the reservoir for STEC (5). Case-patients reported diarrhea (96%), abdominal pain (93%), bloody diarrhea (41%), and fever (32%) (Table 1( Dr. Acknowledgment. CDC EID - Volume 23, Number 7—July 2017. Au sommaire notamment: Contaminated Stream Water as Source for Escherichia coli O157 Illness in Children. Author affiliations: Napa-Solano-Yolo-Marin County Public Health Laboratory, Fairfield, California, USA Suggested citation for this article Abstract In May 2016, an outbreak of Shiga toxin–producing Escherichia coli O157 infections occurred among children who had played in a stream flowing through a park.

Analysis of E. coli isolates from the patients, stream water, and deer and coyote scat showed that feces from deer were the most likely source of contamination. In the United States, recreational water is a relatively uncommon source of Shiga toxin–producing Escherichia coli (STEC) O157 outbreaks (1). In May 2016, four cases of Shiga toxin (Stx) 1– and 2–producing E. coli O157 infection were reported to a local health department in northern California; investigation revealed a common source of exposure. The stream is a second-order waterway located in a northern California community of ≈7,500 residents. Dr. Acknowledgment References Heiman KE, Mody RK, Johnson SD, Griffin PM, Gould LH.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 30/05/17 Genetic Virulence Profile of Enteroaggregative Escherichia coli Strains Isolated from Danish Children with Either Acute or Persistent Diarrhea. Introduction Enteroaggregative Escherichia coli (EAEC) is an established pathotype within the group of diarrheagenic E. coli (DEC), which also includes the enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), and verocytotoxin-producing E. coli (VTEC). EAEC is associated with diarrhea, failure to thrive, weight loss, and stunted growth in children living in developing countries (Steiner et al., 1998; Albert et al., 1999; Lima et al., 2000; Medina et al., 2010; Hebbelstrup Jensen et al., 2014).

EAEC-positive children were seen to have increased levels of fecal lactoferrin and Il-1β, regardless of the presence of gastrointestinal symptoms in a Brazilian study (Steiner et al., 1998). This indicates a considerable inflammation potential of EAEC and severe illness, which may also be present in children in industrialized countries. The gold standard for the identification of EAEC is by the HEp-2 cell assay.

Table 1. Materials and Methods Figure 1. EUROSURVEILLANCE 25/05/17 Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. S Vygen-Bonnet 1 , B Rosner 1 , H Wilking 1 , A Fruth 2 , R Prager 2 , A Kossow 3 , C Lang 2 , S Simon 2 , J Seidel 1 4 5 , M Faber 1 , A Schielke 1 , K Michaelis 1 , A Holzer 1 , R Kamphausen 6 , D Kalhöfer 7 , S Thole 5 7 , A Mellmann 3 , A Flieger 2 , K Stark 1 + Author affiliations Citation style for this article: Vygen-Bonnet S, Rosner B, Wilking H, Fruth A, Prager R, Kossow A, Lang C, Simon S, Seidel J, Faber M, Schielke A, Michaelis K, Holzer A, Kamphausen R, Kalhöfer D, Thole S, Mellmann A, Flieger A, Stark K.

Ongoing haemolytic uraemic syndrome (HUS) outbreak caused by sorbitol-fermenting (SF) Shiga toxin-producing Escherichia coli (STEC) O157, Germany, December 2016 to May 2017. Euro Surveill. 2017;22(21):pii=30541. Received:11 May 2017; Accepted:24 May 2017 Epidemiological investigation SF E. coli O157:H-, stx1-gene negative, stx2-gene positive, eae-gene positive was identified as the outbreak strain.

Box Confirmed cases were defined as: Probable cases were defined as: Figure 1. CDC 10/12/12 Multistate Outbreak of Shiga Toxin-producing Escherichia coli O157:H7 Infections Linked to Organic Spinach and Spring Mix Blend (Final Update) Introduction CDC collaborated with public health officials in several states and the U.S. Food and Drug Administration (FDA) to investigate a multistate outbreak of Shiga toxin-producing Escherichia coli O157:H7 (STEC O157:H7) infections.

Results from this investigation linked this outbreak to pre-packaged leafy greens produced by State Garden of Chelsea, Massachusetts. Public health investigators used DNA “fingerprints” of E. coli bacteria obtained through diagnostic testing with pulsed-field gel electrophoresis, or PFGE, to identify cases of illness that were part of this outbreak.

They used data from PulseNet, the national subtyping network made up of state and local public health laboratories and federal food regulatory laboratories that performs molecular surveillance of foodborne infections. The type of bacteria responsible for this outbreak was among those referred to as Shiga toxin-producing E. coli or STEC. This particular outbreak appears to be over. CDC - SEPT 2006 - Multi-State Outbreak of E. coli O157:H7 Infections From Spinach. ZOONOSES AND PUBLIC HEALTH 03/01/17 Severe Outbreak of Sorbitol-Fermenting Escherichia coli O157 via Unpasteurized Milk and Farm Visits, Finland 2012. Introduction Shiga toxin-producing Escherichia coli (STEC) O157 causes human illness with symptoms such as diarrhoea, haemorrhagic colitis and haemolytic-uraemic syndrome (HUS) (Tarr et al., 2005).

The microbiological identification of STEC O157 has traditionally relied on its inability to ferment sorbitol. However, sorbitol-fermenting E. coli O157 (SF O157) has emerged as a notable cause of outbreaks and sporadic illnesses in Europe, since first identified in Germany in 1988 (Karch and Bielaszewska, 2001; Editorial team, 2006; Alpers et al., 2009; Orth et al., 2009; King et al., 2014). Illnesses caused by SF O157 have been associated with more severe outcomes, including higher incidence of HUS and mortality (Alpers et al., 2009; Nielsen et al., 2011). Despite identified outbreaks of SF O157, the transmission routes and reservoirs of this pathogen remain largely unknown. Materials and Methods Identification of the outbreak and its source Microbiology of human samples Questionnaire study. CDC EID - DEC 2016 - Au sommaire: Secondary Shiga Toxin–Producing Escherichia coli Infection, Japan, 2010–2012.

J Infect Dis. (2002) Clinical Course and the Role of Shiga Toxin–Producing Escherichia coli Infection in the Hemolytic-Uremic Syndrome in Pediatric Patients, 1997–2000, in Germany and Austria: A Prospective Study. + Author Affiliations Reprints or correspondence: Dr. Lothar B. Zimmerhackl, Universitätsklinik für Kinder- und Jugendmedizin, Universität Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria ( Abstract Hemolytic-uremic syndrome (HUS) is mainly associated with foodborne infections by Shiga toxin–producing Escherichia coli (STEC).

From January 1997 through December 2000, 394 children with HUS were evaluated in a prospective multicenter surveillance study in Germany and Austria (incidences, 0.7/100,000 and 0.4/100,000 children <15 years old, respectively). Hemolytic-uremic syndrome (HUS) is the most common cause of acute renal failure in children.

Sources for Shiga toxin–producing E. coli (STEC) infections include contaminated food, milk, raw milk derivatives, meat, and other substances, including water [8]. Methods To find non-O157 STEC, the enrichment cultures were cultured on SMAC agar and on enterohemolysin agar (Heipha). Results Figure 1 Figure 2 Table 1. EUROSURVEILLANCE 01/09/16 Descriptive epidemiology of Escherichia coli bacteraemia in England, April 2012 to March 2014. Methods Data collection The study period comprised two years from 1 April 2012 to 31 March 2014, during which time all NHS acute Trusts (n = 167) in England reported all cases of bacteraemia due to E. coli to Public Health England (PHE, formerly the Health Protection Agency).

Cases were reported via a web-based system originally developed for the mandatory surveillance of Clostridium difficile infection and bacteraemia caused by Staphylococcus aureus. Only the first blood culture positive for E. coli was reported, with further positive blood cultures taken from the same patient within 14 days of the first sample regarded as the same episode of bacteraemia and not reported. Data items collected included the specimen date, patient demographics and care details at the time the blood culture was taken. Data analyses Data processing and analyses were performed using Stata12 (Stata Corporation, College Station, TX, US). Antibiotic susceptibility Results Figure 1 Figure 2 Figure 3 Table 1 Figure 4. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 13/07/16 Enteroaggregative Escherichia coli in Daycare—A 1-Year Dynamic Cohort Study (Danemark)

Introduction Enteroaggregative Escherichia coli (EAEC) is an established pathotype within the group of diarrheagenic E. coli (DEC), which also include enteropathogenic E. coli (EPEC), enterotoxigenic E. coli (ETEC), enteroinvasive E. coli (EIEC), and Shiga toxin-producing E. coli (STEC; Croxen et al., 2013). EAEC has been associated with cases of persistent diarrhea in children living in developing countries (Steiner et al., 1998), traveler's diarrhea (Adachi et al., 2001), and, most recently, cases of domestically acquired diarrhea in industrialized countries (Jenkins et al., 2006). Large outbreaks of EAEC-associated diarrhea have been reported in England (Dallman et al., 2014), Germany (Bielaszewska et al., 2011), Japan (Itoh et al., 1997), and South Korea (Shin et al., 2015).

The pathogenic properties of EAEC are under scrutiny, since EAEC can be isolated from asymptomatic carriers as well as from severe cases of diarrhea (Nüesch-Inderbinen et al., 2013; Tobias et al., 2015). Ethics. EFSA 06/04/16 Joint ECDC/EFSA rapid outbreak assessment: multi-country outbreak of Shiga toxin-producing Escherichia coli infection associated with haemolytic uraemic syndrome in Romania and Italy. EUROSURVEILLANCE 17/03/16 Early findings in outbreak of haemolytic uraemic syndrome among young children caused by Shiga toxin-producing Escherichia coli, Romania, January to February 2016. E Peron 1 2 3 , A Zaharia 3 4 , LC Zota 3 4 , E Severi 5 , O Mårdh 5 , C Usein 6 , M Bălgrădean 7 8 , L Espinosa 5 , J Jansa 5 , G Scavia 9 , A Rafila 7 10 , A Serban 11 , A Pistol 4 + Author affiliations Citation style for this article: Peron E, Zaharia A, Zota L, Severi E, Mårdh O, Usein C, Bălgrădean M, Espinosa L, Jansa J, Scavia G, Rafila A, Serban A, Pistol A.

Early findings in outbreak of haemolytic uraemic syndrome among young children caused by Shiga toxin-producing Escherichia coli, Romania, January to February 2016. Euro Surveill. 2016;21(11):pii=30170. Received:04 March 2016; Accepted:17 March 2016 On 9 and 10 February 2016, the National Institute of Public Health of Romania (NIPH) was alerted about 12 paediatric cases of haemolytic uraemic syndrome (HUS). Outbreak investigation In Romania, four regional hospitals (in Bucharest, Cluj, Iasi and Timisoara) are referral centres for management of HUS cases.

Findings Figure 1 HUS: haemolytic uraemic syndrome. Figure 2 Figure 3 Discussion. EUROSURVEILLANCE 10/04/14 Au sommaire: Results of surveillance for infections with Shiga toxin-producing Escherichia coli (STEC) of serotype O104:H4 after the large outbreak in Germany, July to December 2011. After the massive outbreak of infections with Shiga toxin-producing Escherichia coli (STEC) of serotype O104:H4 in Germany in the summer of 2011, post-outbreak surveillance for further infections with this type of STEC was maintained until the end of 2011.

This surveillance was based on national mandatory reporting of STEC infections and the associated complication of haemolytic uraemic syndrome (HUS), as well as on data obtained from a questionnaire. Between the outbreak’s end (5 July) and 31 December 2011, a total of 33 post-outbreak cases were recorded. Post-outbreak cases occurred with diminishing frequency towards the year’s end and resembled the outbreak cases in many respects, however the proportion of HUS among all post-outbreak cases was smaller than during the outbreak. Two thirds of the post-outbreak cases were likely infected by contact with known outbreak cases. Both laboratory and nosocomial spread was noted in this period. Introduction Methods Results Table 1.

Figure 1. EUROSURVEILLANCE 01/05/14 Au sommaire: Emergence of Escherichia coli encoding Shiga toxin 2f in human Shiga toxin-producing E. coli (STEC) infections in the Netherlands, January 2008 to December 2011. The Shiga toxins of Shiga toxin-producing Escherichia coli (STEC) can be divided into Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2) with several sub-variants.

Variant Stx2f is one of the latest described, but has been rarely associated with symptomatic human infections. In the enhanced STEC surveillance in the Netherlands, 198 STEC O157 cases and 351 STEC non-O157 cases, including 87 stx2f STEC isolates, were reported between 2008 and 2011. Most stx2f strains belonged to the serogroups O63:H6 (n=47, 54%), O113:H6 (n=12, 14%) and O125:H6 (n=12, 14%). Of the 87 stx2f isolates, 84 (97%) harboured the E. coli attaching and effacing (eae) gene, but not the enterohaemorrhagic E. coli haemolysin (hly) gene. Stx2f STEC infections show milder symptoms and a less severe clinical course than STEC O157 infections. Almost all infections with stx2f (n=83, 95%) occurred between June and December, compared to 170/198 (86%) of STEC O157 and 173/264 (66%) of other STEC non-O157. Introduction Methods. EUROSURVEILLANCE 31/10/13 Outbreak of Shiga toxin-producing E. coli O157 associated with consumption of watercress, United Kingdom, August to September 2013.

An increase in the number of cases of Shiga toxin-producing Escherichia coli O157 PT 2 stx2 infection was reported in the United Kingdom on 9 September 2013. Of the 19 cases, 13 were interviewed, of which 10 reported consuming watercress purchased from one retailer. The retailer recalled pre-packed bagged salads containing watercress on 12 September. The descriptive epidemiology was supported by a case–case study performed after control measures were implemented. On 9 September 2013, the Public Health England (PHE) automated outbreak detection system [1] highlighted an increase in the number of cases of Shiga toxin-producing Escherichia coli (STEC) serotype O157, phage type (PT) 2, Shiga toxin type 2 (stx2), which had been reported through the PHE Gastrointestinal Bacteria Reference Unit, London. During the week commencing 2 September, 12 cases were reported, compared with around one to two cases per week in the preceding months.

Background and descriptive epidemiology Figure 1. Table. CDC EID - AOUT 2015 - Escherichia coli O157 Outbreaks in the United States, 2003–2012. BMC Infectious Diseases | Abstract | Implications of screening and childcare exclusion policies for children with Shiga-toxin producing Escherichia coli infections: lessons learned from an outbreak in a daycare centre, Norway, 2012. INVS 06/09/13 Surveillance sanitaire en région Bourgogne et Franche-Comté. A la Une - Surveillance du Syndrome hémolytique et ur. EUROSURVEILLANCE 10/01/13 Au sommaire: A verocytotoxin-producing E. coli outbreak with a surprisingly high risk of haemolytic ur.

Encadré – Surveillance du syndrome hémolytique et urémique chez les enfants de moins de 15 ans en France. Eurosurveillance, Volume 17, Issue 34, 23 August 2012. Using an outbreak to study the sensitivity of the surveillance of enteroh. Family Outbreak of Shiga Toxin–producing E. coli O123:H–, France, 2009 | CDC EID. E. coli. Annales de Biologie Clinique. Annales de Biologie Clinique. Foodborne Disease Significance of Escherichia coli O157:H7 and Other Enterohemorrhagic E. coli. _CSR_APH_98.8.pdf (Objet application/pdf) Home | CDC E. Coli. Escherichia coli entérohémorragique (EHEC ou VTEC) Institut de veille sanitaire. Institut de veille sanitaire. ASPC 09/10/14 Éclosion d'infection à E. coli O157:H7 associée à de la laitue servie dans des chaînes de restauration rapide dans les Maritimes et en Ontario, Canada, décembre 2012.