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Dengue au Brésil

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INFECTIOUS DISEASES AND POVERTY 03/11/20 Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study. Study area This study was carried out in the Northeast region of Brazil, which is located between the latitudes of 1° and 18° 30′ S, and longitudes of 34° 20′ e 48° 30′ W.

INFECTIOUS DISEASES AND POVERTY 03/11/20 Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

The Northeast region includes nine states: Maranhão (MA), Piauí (PI), Ceará (CE), Rio Grande do Norte (RN), Paraíba (PB), Pernambuco (PE), Alagoas (AL), Sergipe (SE) and Bahia (BA). It occupies a territorial area of 1 554 291 km2 (18% of Brazilian territory) and had an estimated population of 57.2 million inhabitants in 2017 (second largest population among Brazilian regions) (Fig. 1). Approximately 60% of the Northeast area has a semiarid climate and an average annual rainfall of 500 mm year−1. Additionally, the region has experienced an increase in air temperature and dryness in the last decades [20]. Rev Inst Med Trop Sao Paulo. 2020 Sep 30 Survival analysis in non-congenital neurological disorders related to dengue, chikungunya and Zika virus infections in Northeast Brazil.

BMC PUBLIC HEALTH 12/06/20 Retrospective cross-sectional observational study on the epidemiological profile of dengue cases in Pernambuco state, Brazil, between 2015 and 2017. The incidence and clinical manifestations of dengue are strongly influenced by viral, environmental and host factors.

BMC PUBLIC HEALTH 12/06/20 Retrospective cross-sectional observational study on the epidemiological profile of dengue cases in Pernambuco state, Brazil, between 2015 and 2017

With regard to host, in addition to the elements closely related to immunity and genetic background, socio-demographic characteristics have also been associated with the number and severity of DENV infections [11, 17, 23, 46,47,48]. In this perspective, we report the epidemiological profile of dengue cases in Pernambuco state, Brazil, in the 2015–2017 triennium. Among the various social factors, age is one of the characteristics most related to DENV infections [9, 11, 14, 49,50,51].

In Pernambuco, during the 3 years studied, we observed that the majority of dengue cases was reported in individuals aged between 20 and 29 and 30–39 years old. Aedes aegypti et dengue au Brésil. BMC INFECT DIS 26/03/20 Google Health Trends performance reflecting dengue incidence for the Brazilian states. Digital surveillance systems have been shown to be useful for predicting country-wide dengue incidence in several countries [38, 53, 64].

BMC INFECT DIS 26/03/20 Google Health Trends performance reflecting dengue incidence for the Brazilian states

Here, we evaluate the usefulness of GHT in tracking dengue incidence both at the country and the state level in Brazil, by evaluating GHT correlation with weekly dengue incidence data over 6 years. We have shown that the performance of GHT varies across states (Fig. 3, Table 2, and additional file 3); however, it is highly correlated with dengue incidence (adjusted R squared > 0.8) in 12 Brazilian states that are geographically dispersed. Moreover, we showed that proxies of Internet penetration such as the number of Internet users in the last 3 months only partially explain the usefulness of GHT (Fig. 4). In fact, the logarithm of the total population, from among 474 potential demographic predictors, allowed us to build a model that quantified GHT usefulness with similar accuracy to that of Internet penetration data (Fig. 5).

Int. J. Environ. Res. Public Health 20/03/20 Dengue Surveillance System in Brazil: A Qualitative Study in the Federal District. 2.

Int. J. Environ. Res. Public Health 20/03/20 Dengue Surveillance System in Brazil: A Qualitative Study in the Federal District

Materials and Methods Qualitative data deriving from interviews with 17 experts (see Table 1) have been collected. These were supplemented by locally published guidelines and bulletins. To identify the role of the interviewees, ID codes are used and listed in Table 1. PLOS 12/03/20 First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil. Abstract In Brazil, Dengue (DENV) and Zika (ZIKV) viruses are reported as being transmitted exclusively by Aedes aegypti in urban settings.

PLOS 12/03/20 First report of Aedes albopictus infected by Dengue and Zika virus in a rural outbreak in Brazil

This study established the vectors and viruses involved in an arbovirus outbreak that occurred in 2019 in a rural area of Espírito Santo state, Brazil. Mosquitoes collected were morphologically identified, sorted in samples, and submitted to molecular analysis for arboviruses detection. Phylogenetic reconstruction was performed for the viral sequence obtained. All 393 mosquitoes were identified as Aedes albopictus. PLOS 03/02/20 Interdependence between confirmed and discarded cases of dengue, chikungunya and Zika viruses in Brazil: A multivariate time-series analysis. Abstract The co-circulation of different arboviruses in the same time and space poses a significant threat to public health given their rapid geographic dispersion and serious health, social, and economic impact.

PLOS 03/02/20 Interdependence between confirmed and discarded cases of dengue, chikungunya and Zika viruses in Brazil: A multivariate time-series analysis

Therefore, it is crucial to have high quality of case registration to estimate the real impact of each arboviruses in the population. In this work, a Vector Autoregressive (VAR) model was developed to investigate the interrelationships between discarded and confirmed cases of dengue, chikungunya, and Zika in Brazil. We used data from the Brazilian National Notifiable Diseases Information System (SINAN) from 2010 to 2017. SCIENTIFIC REPORTS 04/02/20 Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil. This is the first article, to the best of our knowledge, in which an association, at the ecological level, between previous dengue fever epidemics and the Zika-related microcephaly epidemic was described.

SCIENTIFIC REPORTS 04/02/20 Association of past dengue fever epidemics with the risk of Zika microcephaly at the population level in Brazil

It should be noted that the notification system for Zika was only implemented in February 2016, when the Zika epidemic was decreasing in the NE region. Therefore, we could not control for Zika incidence in the models. It is possible that the differences in microcephaly rates were a consequence of different ZIKV attack rates across the regions, as suggested in a recent paper37. In this study, after testing for other concurrent factors, ZIKV was assumed to be the only cause of the microcephaly epidemic, with no unmeasured confounders or effect modifiers. Hypothesized interaction between dengue and Zika infections on the development of microcephaly.

In a cohort of ZIKV-infected pregnant women, previous DENV infection was not associated with disease severity and abnormal birth outcomes48. BMC Infectious Diseases 20/05/19 Seroprevalence for dengue virus in a hyperendemic area and associated socioeconomic and demographic factors using a cross-sectional design and a geostatistical approach, state of São Paulo, Brazil. The high seroprevalence that we founded in our study reveals a large burden of disease of DENV in São José do Rio Preto.

BMC Infectious Diseases 20/05/19 Seroprevalence for dengue virus in a hyperendemic area and associated socioeconomic and demographic factors using a cross-sectional design and a geostatistical approach, state of São Paulo, Brazil

The seroprevalence found in people aged 10–19 years, slightly lower than the seroprevalences for the other age groups, also reveals high rates of transmission in the recent past. These results can be seen as a consequence of events of the last five and four decades, respectively, in Brazil and the state of São Paulo. The process of reinfestation of the country by Ae. aegypti, after its eradication, began in the 1970s [47] and currently the vector is present in all its States. Dengue et changement climatique au Brésil. PLOS 22/04/19 Spatio-temporal dynamics of dengue in Brazil: Seasonal travelling waves and determinants of regional synchrony.

Abstract Dengue continues to be the most important vector-borne viral disease globally and in Brazil, where more than 1.4 million cases and over 500 deaths were reported in 2016.

PLOS 22/04/19 Spatio-temporal dynamics of dengue in Brazil: Seasonal travelling waves and determinants of regional synchrony

Mosquito control programmes and other interventions have not stopped the alarming trend of increasingly large epidemics in the past few years. Here, we analyzed monthly dengue cases reported in Brazil between 2001 and 2016 to better characterise the key drivers of dengue epidemics. Spatio-temporal analysis revealed recurring travelling waves of disease occurrence. Using wavelet methods, we characterised the average seasonal pattern of dengue in Brazil, which starts in the western states of Acre and Rondônia, then travels eastward to the coast before reaching the northeast of the country. Author summary. MEM INST OSWALDO CRUZ, RIO DE JANEIRO, 104(6) September 2009 Container productivity, daily survival rates and dispersal of Aedes aegypti mosquitoes in a high income dengue epidemic neighbourhood of Rio de Janeiro: presumed influence of differential urban. Container productivity, daily survival rates and dispersal of Aedes aegypti mosquitoes in a high income dengue epidemic neighbourhood of Rio de Janeiro: presumed influence of differential urban structure on mosquito biology Mariana Rocha David; Ricardo Lourenço-de-Oliveira; Rafael Maciel de Freitas+ Laboratório de Transmissores de Hematozoários, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil Different urban structures might affect the life history parameters of Aedes aegypti and, consequently, dengue transmission.

MEM INST OSWALDO CRUZ, RIO DE JANEIRO, 104(6) September 2009 Container productivity, daily survival rates and dispersal of Aedes aegypti mosquitoes in a high income dengue epidemic neighbourhood of Rio de Janeiro: presumed influence of differential urban

Container productivity, probability of daily survival (PDS) and dispersal rates were estimated for mosquito populations in a high income neighbourhood of Rio de Janeiro. Results were contrasted with those previously found in a suburban district, as well as those recorded in a slum. BMC PUBLIC HEALTH 21/03/19 30 years of fatal dengue cases in Brazil: a review. BMC 27/07/18 30 years of dengue fatal cases in Brazil: a laboratorial-based investigation of 1047 cases. NATURE 19/07/18 Quantifying the spatial spread of dengue in a non-endemic Brazilian metropolis via transmission chain reconstruction. PLOS 13/03/18 Dengue virus in Aedes aegypti and Aedes albopictus in urban areas in the state of Rio Grande do Norte, Brazil: Importance of virological and entomological surveillance.

Abstract Background Vector control remains the sole effective method to prevent dengue virus (DENV) transmission, although a vaccine for dengue has recently become available and testing of its efficacy and coverage is being performed in multiple places. Entomological surveillance is a key factor in alerting authorities to possible outbreaks, but until now natural DENV infection of mosquito populations has been scarcely used as an early warning system to monitor fluctuating prevalence of infected mosquitoes. The purpose of this study was to determine the burden of adult and larval/pupae of Aedes aegypti and Aedes albopictus with DENV in urban areas in the state of Rio Grande do Norte, Brazil.

Methodology/Principal findings Immature insect forms (larvae and pupae) were collected from April 2011 to March 2012, whereas the collection of adults was conducted along 3 years: May 2011 to April 2014. Conclusions/Significance. Epidemiol. Serv. Saude, Brasília, 26(3), Jul-Sep 2017 Identification of surveillance and control priority areas for dengue and other arboviruses transmitted by Aedes aegypti in Natal-RN, Brazil: experience report. PLOS 17/11/17 The introduction of dengue follows transportation infrastructure changes in the state of Acre, Brazil: A network-based analysis. Abstract Human mobility, presence and passive transportation of Aedes aegypti mosquito, and environmental characteristics are a group of factors which contribute to the success of dengue spread and establishment.

To understand this process, we assess data from dengue national and municipal basins regarding population and demographics, transportation network, human mobility, and Ae. aegypti monitoring for the Brazilian state of Acre since the first recorded dengue case in the year 2000 to the year 2015. During this period, several changes in Acre’s transport infrastructure and urbanization have been started. Mem. Inst. Oswaldo Cruz vol.112 no.8 Rio de Janeiro Aug. 2017 Surveillance of deaths caused by arboviruses in Brazil: from dengue to chikungunya. Epidemiol. Serv. Saúde vol.25 no.4 Brasília Oct./Dec. 2016 Dengue incidence trend in Brazil, 2002-2012. Introdução A dengue é uma doença infecciosa febril aguda, que pode ser benigna ou grave, classificada pela Organização Mundial da Saúde (OMS) como dengue sem e com sinais de alarme e dengue grave.1 É considerada um problema de Saúde Pública em todo o mundo, especialmente nos países tropicais, cujas condições socioambientais favorecem o desenvolvimento e a proliferação de seu principal vetor, o mosquito Aedes aegypti.2.

PLOS 26/08/16 Mortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil. Abstract Dengue is a major public health problem in tropical and subtropical areas worldwide. There is a lack of information on the risk factors for death due to severe dengue fever in developing countries, including Brazil where the state of Amazonas is located. This knowledge is important for decision making and the implementation of effective measures for patient care. This study aimed to identify factors associated with death among patients with severe dengue, in Amazonas from 2001 to 2013.

We conducted a retrospective cohort study based on secondary data from the epidemiological surveillance of dengue provided by the Fundação de Vigilância em Saúde do Amazonas, FVS (Health Surveillance Foundation) of the Secretaria de Saúde do Amazonas, SUSAM (Health Secretariat of the State of Amazonas). INSTITUTO OSWALDO CRUZ-FIOCRUZ - 2014 - Challenges encountered using standard vector control measures for dengue in Boa Vista, Brazil. UNIVERSITY OF NEBARSKA - 2015 - Thèse en ligne : Utility of mosquito surveillance data for spatial prioritization of vector control against dengue viruses in three Brazilian cities. AFP 16/01/16 Brésil: la dengue a fait 863 morts en 2015 (+82,4%)

Maladie virale transmise par les moustiques, la dengue a fait 863 morts en 2015 au Brésil, en hausse de 82,4% sur un an, a annoncé vendredi le gouvernement à quelques mois des jeux Olympiques d'août à Rio. En 2014, 473 personnes étaient décédées, selon le rapport du ministère de la Santé. La moitié des cas de 2015 (454) ont été enregistrés dans l'Etat de Sao Paulo (sud-est), suivi de ceux du Goias (centre, 86), du Minas Gerais (sud-est, 69) et du Ceara (nord-est, 66). A Rio de Janeiro, où se tiendront les jeux Olympiques dans sept mois, 25 personnes sont décédées, 15 de plus qu'en 2014.

Selon le ministère de la Santé, les cas graves de dengue sont passés en un an de 764 à 1.569. Plus de 1,6 million de cas probables ont été relevés dans tout le pays, soit une hausse de 179% en un an. Le Brésil est devenu fin décembre le troisième pays du monde à autoriser un vaccin contre la dengue, après le Mexique et les Philippines. Rev. Soc. Bras. Med. Trop. vol.48 no.4 Uberaba July/Aug. 2015 Trends and factors associated with dengue mortality and fatality in Brazil. Cad. Saúde Pública, Rio de Janeiro, 28(11):2189-2197, nov, 2012 Temporal analysis of the relationship between dengue and meteorological variables in the city of Rio de Janeiro, Brazil, 2001-2009. PLOS 27/02/14 Detection Of Four Dengue Serotypes Suggests Rise In Hyperendemicity In Urban Centers Of Brazil.

Citation: Villabona-Arenas CJ, de Oliveira JL, Capra CdS, Balarini K, Loureiro M, Fonseca CRTP, et al. (2014) Detection Of Four Dengue Serotypes Suggests Rise In Hyperendemicity In Urban Centers Of Brazil. PLoS Negl Trop Dis 8(2): e2620. doi:10.1371/journal.pntd.0002620 Academic Editor : Rebeca Rico-Hesse, Baylor College of Medicine, United States of America Published: February 27, 2014 Copyright: © 2014 Villabona-Arenas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: This work was supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo) grant 2010/19059-7. Competing interests: The authors have declared that no competing interests exist. PLOS 28/04/14 Sensitivity and Specificity of the World Health Organization Dengue Classification Schemes for Severe Dengue Assessment in Children in Rio de Janeiro. Abstract Background The clinical definition of severe dengue fever remains a challenge for researchers in hyperendemic areas like Brazil.

The ability of the traditional (1997) as well as the revised (2009) World Health Organization (WHO) dengue case classification schemes to detect severe dengue cases was evaluated in 267 children admitted to hospital with laboratory-confirmed dengue. Principal Findings Using the traditional scheme, 28.5% of patients could not be assigned to any category, while the revised scheme categorized all patients. Conclusions/Significance. PLOS 12/08/14 Laboratory Surveillance of Dengue in Rio Grande do Sul, Brazil, from 2007 to 2013. Abstract Background. CDC EID - Volume 20, Number 10—October 2014. Au sommaire notamment: Probable Importation of Dengue Virus Type 4 to Angola from Brazil.

Suggested citation for this article To the Editor: The prevalence of dengue virus (DENV) infection in Africa may have been grossly underestimated for many years (1). Development, Characterization and Application of Monoclonal Antibodies against Brazilian Dengue Virus Isolates. Cad. Saúde Pública vol.29 no.8 Rio de Janeiro Aug. 2013 Spatial distribution of dengue incidence and socio-environmental conditi. RECIFE - 2012 - Análise da competência vetorial para o vírus Dengue em populações naturais de Aedes aegypti e Aedes albopictus d.

INTECH - MARS 2012 - Au sommaire: Molecular Characterization of Dengue Virus Circulating in Manaus, the Capital City of the Stat. Edited by Alfonso J. PLOS 27/12/11 Dengue Virus Type 4 Phylogenetics in Brazil 2011: Looking beyond the Veil. PLOS ONE 04/01/11 From Re-Emergence to Hyperendemicity: The Natural History of the Dengue Epidemic in Brazil. Jornal de Pediatria - Vol. 81, No.3, 2005 191 The challenge of diagnosing dengue in children. Revista da Sociedade Brasileira de Medicina Tropical 33(1):95-96, jan-fev, 2000. First isolation of dengue 1 virus from Aedes ae. Revista Brasileira de Climatologia N. 9 – JUL/DEZ/2011 DENGUE EPIDEMICS IN MIDDLE-SOUTH OF BRAZIL: CLIMATE CONTRAINTS (?) AND SO. Mem. Inst. Oswaldo Cruz vol.93 n.2 Rio de Janeiro Mar./Apr. 1998 Retrospective Study on Dengue in Fortaleza, State of Ceará, Bra.

Mem. Inst. Oswaldo Cruz vol.96 no.7 Rio de Janeiro Oct. 2001 Dengue Virus Type 3 in Rio de Janeiro, Brazil. Mem. Inst. Oswaldo Cruz vol.98 no.7 Rio de Janeiro Oct. 2003 Uncertainties regarding dengue modeling in Rio de Janeiro, Brazil. MEMORIAS DO INSTITUTO OSWALDO CRUZ Vol. 107(2) March 2012 HLA-A*01 allele: a risk factor for dengue haemorrhagic fever in Brazil. Mem. Inst. Oswaldo Cruz v.102 n.5 Rio de Janeiro ago. 2007 Distribution of dengue vectors in neighborhoods with different urbani. Cad. Saúde Pública vol.16 n.1 Rio de Janeiro Jan./Mar. 2000 Molecular epidemiology of dengue viruses in Brazil. Braz J Infect Dis vol.10 no.6 Salvador Dec. 2006 Dengue and laboratory tests a clinician should know for a correct diagnosis. Braz J Infect Dis vol.8 no.6 Salvador Dec. 2004 Dengue: a review of the laboratory tests a clinician must know to achieve a corr.

Braz J Infect Dis vol.9 no.3 Salvador June 2005 Hemorrhagic encephalopathy in dengue shock syndrome: a case report. Braz J Infect Dis vol.9 no.4 Salvador Aug. 2005 Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, BRESIL GUIDE 02/10/06 DENGUE - Une maladie grave à ne surtout pas négliger. Aedes aegypti au Brésil.