FRONTIERS IN MICROBIOLOGY 11/07/22 Use of Whole-Genome Sequencing to Unravel the Genetic Diversity of a Prevalent Mycobacterium bovis Spoligotype in a Multi-Host Scenario in Spain. ANIMALS 04/06/22 Mycobacterium bovis Tuberculosis in Two Goat Farms in Multi-Host Ecosystems in Sicily (Italy): Epidemiological, Diagnostic, and Regulatory Considerations.
Mycobacterium bovis (M. bovis) is the causative agent of animal tuberculosis (bTB), infecting and causing disease in several animal species. In areas where there are complex interactions between reservoir hosts and susceptible species, the control of this pathogen is a challenge. The authors report two outbreaks of goat tuberculosis caused by M. bovis in multi-host ecosystems within two protected natural areas of Sicily, where TB is historically endemic. The first outbreak (Farm A) was identified after the incidental detection at the slaughterhouse of TB-like lesions in goat viscera ready to be disposed. Single intradermal cervical tuberculin test (SICT) was performed in Farm A on 205 goats, resulting positive in 10 (4.9%). After slaughtering, six out of ten animals showed TB-like lesions, from which M. bovis spoligotype SB0841 was isolated. ►▼ Show Figures Figure 1.
BMC VETERINARY RESEARCH 23/04/22 Mycobacterium bovis and M. caprae in Bulgaria: insight into transmission and phylogeography gained through whole-genome sequencing. The Program for Monitoring and Control of Bovine Tuberculosis in Bulgaria includes annual, one-time intradermal tuberculin testing with bovine PPD tuberculin of all cattle over 42 days of age. Doubtfully PPD tuberculin-reacted animals undergo differential tuberculin testing with bovine and avian PPD tuberculin on day 42 after the first tuberculin test. Animals positively reacted to regular and differential tuberculinization are sent for sanitary slaughter to isolation slaughterhouses. In herds with detected tuberculosis, all cattle over 42 days of age are tuberculinized every 2 months until negative results are obtained in the intradermal and laboratory tests.
The animals are tested again after 6 months and in case of repeated negative results, the herd is considered free of tuberculosis. In 2015-2020, 66 TB-affected farms with 851 TB-positive animals were identified in 11 provinces across the country. Position of Bulgarian M. bovis/M. caprae within global WGS-based phylogeny. PATHOGENS 26/02/22 Investigating Farm Fragmentation as a Risk Factor for Bovine Tuberculosis in Cattle Herds: A Matched Case-Control Study from Northern Ireland. All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. Feature Papers represent the most advanced research with significant potential for high impact in the field.
Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication. The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature.
AESAN_GOB_ES - 2021 - Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the effectiveness of maturation for more than 60 days for goat’s cheese and cheese from other species produced from raw milk from herds. ANIMALS 11/08/21 GIS as an Epidemiological Tool to Monitor the Spatial–Temporal Distribution of Tuberculosis in Large Game in a High-Risk Area in Portugal. All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. Feature Papers represent the most advanced research with significant potential for high impact in the field. Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication.
The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature. ANIMALS 10/08/21 Interaction Patterns between Wildlife and Cattle Reveal Opportunities for Mycobacteria Transmission in Farms from North-Eastern Atlantic Iberian Peninsula. Open AccessArticle Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Parque Científico y Tecnológico de Bizkaia, P812, E-48160 Derio, Spain Unité Sanitaire de la Faune, OFB/DGDPCE/DRAS, 45100 Orléans, France UMR 5558 LBBE, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, F-69280 Marcy-l’Etoile, France Author to whom correspondence should be addressed.
Academic Editors: Laila Darwich Soliva and Julie Arsenault. MICROORGANISMS 30/07/21 Whole-Genome SNP Analysis Identifies Putative Mycobacterium bovis Transmission Clusters in Livestock and Wildlife in Catalonia, Spain. The high-resolution WGS analyses of MTBC strains have provided useful insight for determining sources of infection for animal tuberculosis. In Spain, tuberculosis in livestock is caused by Mycobacterium bovis and Mycobacterium caprae, where wildlife reservoirs play an important role. We analyzed a set of 125 M. bovis isolates obtained from livestock and wildlife from Catalonia to investigate strain diversity and identify possible sources and/or causes of infection.
Whole-genome SNP profiles were used for phylogenetic reconstruction and pairwise SNP distance analysis. Additionally, SNPs were investigated to identify virulence and antimicrobial resistance factors to investigate clade-specific associations. Putative transmission clusters (≤12 SNPs) were identified, and associated epidemiological metadata were used to determine possible explanatory factors for transmission. ►▼ Show Figures Figure 1. MICROORGANISMS 06/05/21 Future Risk of Bovine Tuberculosis (Mycobacterium bovis) Breakdown in Cattle Herds 2013–2018: A Dominance Analysis Approach (Irlande)
Bovine tuberculosis (bTB) remains a significant endemic pathogen of cattle herds, despite multi-decadal control programmes being in place in several countries. Understanding the risks of future bTB breakdown (BD) and the associated characteristics of herds and index breakdowns could help inform risk categorisation. Such risk categories could then contribute to tailored management and policies. Here, we estimated the future risk of herd BD for the cohort of herds that were derestricted during 2013 in Ireland using multivariable logit regression models, with a dominance analysis approach.
One third of herds that were derestricted in 2013 experienced a breakdown during the follow-up five year period (1469/4459; 33%). BD length was a significant predictor of future risk, primarily driven by long BDs > 230 days relative to short BDs < 130 days (OR 95%CI: 1.157–1.851), as was having had a previous BD (OR 95%CI: 1.012–1.366). UNIVERSITAT AUTONOMA DE BARCELONA - 2018 - Thèse en ligne : Epidemiology of Bovine Tuberculosis: evaluation of surveillance and sociological factors in Spain. FRONT. VET. SCI. 25/03/21 Bovine Tuberculosis: The Emergence of a New Wildlife Maintenance Host in Ireland.
Introduction Tuberculosis (TB), an infectious disease caused by members of the Mycobacterium tuberculosis (M. tuberculosis) complex (MTBC) (1), is one of the leading causes of infectious disease mortality worldwide. As a zoonotic disease TB affects humans and multiple animal species and has been recognised as a major health risk to humans and animals for more than a century (2). In 2019, 1.4 million people died of tuberculosis (1). Bovine tuberculosis (bTB) is a chronic disease of cattle caused by members of the MTBC, primarily by M. bovis, but also M. caprae and, to a lesser extent, M. tuberculosis (3). Host density is a key driver of tuberculosis transmission rates and the aggregation of hosts (e.g., in large social groups) can create, or increase, opportunities for intra- or interspecific disease transmission (5).
The social structure of European Badgers (Meles meles) and their longevity, when infected, make them an ideal maintenance host for M. bovis (9). Materials and Methods 1. 2. GDS19 - 2019 - Tuberculose - Situation en 2018-2019. PARLEMENT EUROPEEN - Réponse à question P-003006-19 The issue of bovine TB in the United Kingdom and newly developed skin tests. FRONT. VET. SCI. 26/02/19 Negotiated management strategies for bovine tuberculosis: enhancing risk mitigation in Michigan and the UK. Transbound Emerg Dis. 2018 Oct;65(5): Management of hunting waste as control measure for tuberculosis in wild ungulates in south-central Spain. FRONT. VET. SCI. 31/12/18 Mycobacterium caprae infection of red deer in Western Austria – optimized use of pathology data to infer infection dynamics. 1Quantitative Veterinary Epidemiology (QVE), Wageningen University & Research, Netherlands 2Institute for Veterinary Disease Control, Department of Animal Health (AGES), Austria 3Department for Veterinary Affairs, Office of the State Government of Vorarlberg, Austria Austria is officially bovine tuberculosis (TB) free, but during the last decade the west of the country experienced sporadic TB cases in cattle.
Free-ranging red deer are known to be the maintenance host of Mycobacterium (M.) caprae in certain areas in Austria, where cattle can become infected on alpine pastures shared with deer. The epidemiology of TB in deer in alpine regions is still poorly understood. To inform decisions on efficient interventions against TB in deer, a method is needed to better capture the infection dynamics on population level.
Keywords: Tuberculosis, Mycobacterium caprae, Red deer (Cervus elaphus hippelaphus), Austria, Lesion score, infection dynamics Received: 29 Jul 2018; Accepted: 31 Dec 2018. FRONT. VET. SCI. 10/12/18 Wild animal tuberculosis: stakeholder value systems and management of disease. 1University College Dublin, Ireland 2School of Veterinary Medicine, College of Health and Agricultural Sciences, University College Dublin, Ireland When human health is put at risk from the transmission of animal diseases, the options for intervention often require input from stakeholders whose differing values systems contribute to decisions on disease management.
Animal Tuberculosis (TB), caused principally by Mycobacterium bovis is an archetypical zoonotic pathogen in that it can be transmitted from animals to humans and vice versa. Although elimination of zoonotic transmission of TB to humans is frequently promoted as the raison d’être for TB management in livestock, in many countries the control strategies are more likely based on minimising the impact of sustained infection on the agricultural industry. Where wild animals are implicated in the epidemiology of the disease, the options for control and eradication can require involvement of additional stakeholder groups. Edited by: CDC EID - DEC 2018 - Spatial Analysis of Wildlife Tuberculosis Based on a Serologic Survey Using Dried Blood Spots, Portugal. Nuno Santos1 , Telmo Nunes, Carlos Fonseca, Madalena Vieira-Pinto, Virgílio Almeida, Christian Gortázar, Margarida Correia-Neves, and Margarida-Correia-Neves Author affiliations: University of Minho School of Medicine, Braga, Portugal (N.
Santos, M. Correia-Neves); Portugal Government Associate Laboratory, Braga/Guimarães, Portugal (N. Santos, M. Correia-Neves); University of Lisbon, Lisbon, Portugal (T. Suggested citation for this article Abstract We investigated the spatial epidemiology of bovine tuberculosis (TB) in wildlife in a multihost system. Figure 1 Figure 1. Bovine tuberculosis (TB) is a zoonotic disease caused by Mycobacterium bovis and other members of the M. tuberculosis complex, whose natural hosts are wild and domestic mammals (1). In Portugal, control of bovine TB has resulted in a low prevalence in livestock (4.5 cases/10,000 cattle and 2.9 cases /1,000 herds) in 2017 (3). Bovine TB in wildlife shows spatial structuring in the Iberian Peninsula. Collection of Samples Dr. FRONTIERS IN VETERINARY SCIENCE 27/09/18 Evaluation of the Performance of the IDvet IFN-Gamma Test for Diagnosis of Bovine Tuberculosis in Spain. Introduction Bovine tuberculosis (bTB), caused by members of the Mycobacterium tuberculosis complex (mainly M. bovis, and to a lesser extent, M. caprae) is an important zoonotic disease with a global distribution that has major implications for both animal and human health (1).
Implementation of control and eradication programs has led to a significant decrease of the bTB prevalence and to disease eradication in many industrialized countries (1–3). However, eradication efforts have not been uniformly successful, in part because currently available diagnostic tests cannot correctly determine the M. bovis infection status of all tested cattle (4).
M. bovis infection in cattle is usually chronic, can remain subclinical for a long period, and infected cattle can become infectious long before they exhibit clinical signs of bTB (4). When present, the clinical signs of bTB are not pathognomonic. Materials and Methods Study Population Study 1. Study 2. Diagnostic Tests IFN-γ Assay Bovigam® IFN-γ . RETINTA_ES - SEPT 2018 - Présentation : Brucelosis, Tuberculosis y EETs. ENVA - 2017 - Thèse en ligne : La tuberculose des animaux de boucherie du grand-duché de Luxembourg. FRONTIERS IN VETERINARY SCIENCE 13/04/18 Comparison of alternative meat inspection regimes for pigs from non-controlled housing – considering the cost of error Original Research Denmark has not had cases of bovine tuberculosis (bovTB) for more than 30 ye. 1Food Safety & Veterinary Issues, Danish Agriculture and Food Council, Denmark 2Department of Economics, School of Arts and Social Sciences, City of London College, United Kingdom 3Department of Hygiene and Preventive Medicine, Kafrelsheikh University, Egypt 4Veterinary Epidemiology, Economics and Public Health Group, Royal Veterinary College, United Kingdom 5Department of Epidemiological Sciences, Animal and Plant Health Agency (United Kingdom), United Kingdom Denmark has not had cases of bovine tuberculosis (bovTB) for more than 30 years but is obliged by trade agreements to undertake traditional meat inspection (TMI) of finisher pigs from non-controlled housing to detect bovTB.
TMI is associated with higher probability of detecting bovTB but is also more costly than visual-only inspection (VOI). Keywords: surveillance, Outdoor production, early warning, Mycobacterium bovis, Meat inspection, cost of error, pigs Received: 21 Dec 2017; Accepted: 13 Apr 2018. FRONTIERS IN VETERINARY SCIENCE 03/04/18 The herd sensitivity of abattoir surveillance for bovine tuberculosis: simulating the effects of current and potentially modified meat inspection procedures in Irish cattle. 1National Veterinary Institute, Technical University of Denmark, Denmark 2Section of Herd Health and Animal Husbandry, School of Veterinary Medicine, University College Dublin, Ireland 3Centre for Veterinary Epidemiology and Risk Analysis, School of Veterinary Medicine, University College Dublin, Ireland The European Food Safety Authority (EFSA) has published a series of opinions to assess the impact of changing from the current meat inspection procedures (CMI) to visual-only inspection (VOI) procedures.
Concern has been raised that changes from CMI to VOI would adversely affect the effectiveness of surveillance for bovine tuberculosis (bTB) in EU member states, both for countries with and without official status of bTB freedom (OTF and non-OTF countries, respectively). This study was conducted to estimate the impact of a change from CMI to VOI in abattoirs on herd-level detection sensitivity in Ireland, a non-OTF country. Received: 01 Feb 2018; Accepted: 03 Apr 2018. Edited by: FRONTIERS IN VETERINARY SCIENCE 04/04/18 Trends and Predictors Of Large Tuberculosis Episodes In Cattle Herds In Ireland. 1Centre for Veterinary Epidemiology and Risk Analysis, University College Dublin, Ireland 2Department of Agriculture Food and the Marine, Ireland 3Tipperary District Veterinary Office, Ireland Persistence of bovine tuberculosis (bTB) in cattle is an important feature of Mycobacterium bovis infection, presenting either as herd recurrence or local persistence. One risk factor associated with the risk of recurrent episodes is the severity of a previous bTB episode (severity reflecting the number of bTB reactors identified during the episode).
In this study, we have sought to identify predictors that can distinguish between small (less severe) and large (more severe) bTB episodes, and to describe nationally the severity of bTB episodes over time. The study included descriptive statistics of the proportion of episodes by severity from 2004 to 2015 and a case-control study. Keywords: bovine tuberculosis, Mycobacterium bovis, large outbreaks, Ireland, Cattle Edited by: * Correspondence: Dr. BMC Veterinary Research 07/03/18 Prevalence of bovine tuberculosis in cattle, goats, and camels of traditional livestock raising communities in Eritrea. REV.SCI. OFF. INT. EPIZ - 2017 - Parasite prevalence in Mycobacterium spp. infected dairy goats in the Region of Murcia (south-east Spain) FRONTIERS IN VETERINARY SCIENCE 27/11/17 Farmer and Veterinarian Attitudes towards the Bovine Tuberculosis Eradication Programme in Spain: What Is Going on in the Field?
FRONTIERS IN VETERINARY SCIENCE 10/11/17 Farmer and vet attitudes towards the bovine tuberculosis eradication programme in Spain: what is going on in the field? EFSA 04/08/17 Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): bovine tuberculosis. NUFFIELD INTERNATIONAL - SEPT 2016 - Bovine TB eradication programmes in Europe. CDC EID - DEC 2016 - Au sommaire: Tuberculosis-Associated Death among Adult Wild Boars, Spain, 2009–2014. AGRICULTURE_GOV_IE - Statutory Instruments 2016. Au sommaire: SI 309 - Animal Health and Welfare(Bovine Tuberculosis)(Amendment)Regulations 2016 (pdf 104Kb) UNIVERSITY OF COPENHAGEN - 2012 - Estimation of surveillance system sensitivity for bovine tuberculosis in Denmark. Preventive Veterinary Medicine Volume 121, Issues 1–2, 1 September 2015, Risk-based testing of imported animals: A case study for bovine tuberculosis in The Netherlands.
AFSCA 04/11/15 Bulletin de l'AFSCA Bulletin N°63 (Novembre 2015) Au sommaire notamment: Dossier Tuberculose bovine. DG SANCO 27/05/15 IE Ireland - Animal health - bovine tuberculosis eradication. Preventive Veterinary Medicine Volume 116, Issue 3, 1 October 2014 Farm-level risk factors for the occurrence, new infection or persistence of tuberculosis in cattle herds from South-Central Spain. Spatial and Spatio-temporal Epidemiology - 2014 - Spatio-temporal variability of bovine tuberculosis eradication in Spain (2006-2011)
VEILLE SANITAIRE AU ROYAUME UNI ET EN BELGIQUE CONCERNANT LA TUBERCULOSE DES RUMINANTS. PLOS 23/12/14 Spatial Dynamics of Bovine Tuberculosis in the Autonomous Community of Madrid, Spain (2010–2012) THIRD INTERNATIONAL EPIZOOTIOLOGY DAYS & XV SERBIAN EPIZOOTIOLOGY DAYS PROCEEDINGS - MAI 2013 - Au sommaire:THE SPREAD OF TUBERC. Sélection de rapports OAV traitant spécifiquement de tuberculose. DG SANCO 12/05/05 Trends and sources of zoonotic agents in animals, feedingstuffs, food and man in the European Union and Norway. EFSA 20/10/09 Scientific review on Tuberculosis in wildlife in the EU. DG SANCO 07/10/10 food safety - Task Force for monitoring disease eradication in the member states. BMC Veterinary Research 2012, 8:100 Eradication of bovine tuberculosis at a herd-level in Madrid, Spain: study of within-herd tr.
EFSA 14/06/12 Scientific Opinion on Review of the European Union Summary Report on trends and sources of zoonoses, zoonotic agen. INTECH - AVRIL 2012 - Zoonosis. Au sommaire: Bovine Tuberculosis in European Bison as Possible Zoonotic Impact in Poland. CRESA - OCT 2011 - Elimination of bovine tuberculosis has been heterogeneous in Spain. Veterinary Medicine International Volume 2011 (2011) Multihost Tuberculosis: Insights from the Portuguese Control Program.