WIPO - 2007 - immunisation par champignons transgeniques. NATURE 14/04/16 Gene-edited CRISPR mushroom escapes US regulation - A fungus engineered with the CRISPR–Cas9 technique can be cultivated and sold without further oversight. Jose A.
Bernat Bacete/Getty Images The common white button mushroom (Agaricus bisporus) has been modified to resist browning. The US Department of Agriculture (USDA) will not regulate a mushroom genetically modified with the gene-editing tool CRISPR–Cas9. GENE EDITING 18/10/16 Questions asked on CRISPR-edited mushrooms bypassing GM regulation. In an April 2016 commentary in Nature, a genetically modified mushroom, created by Yinong Yang, a scientist at Pennsylvania State University, was reported in which had bypassed regulation from the US Department of Agriculture.
The modification deletes part of a gene in the polyphenol oxidase (PPO) family, which is responsible for the mushrooms going brown. The edited mushrooms can then be left on the supermarket shelf longer without going off. This loophole was due to the type of gene editing being performed, which used the CRISPR/Cas9 approach to knock out the gene. Because no foreign DNA was detected at the editing site, it was considered not applicable for regulation.
Now, a new correspondence in Nature Biotechnology from Jungeun Kim & Jin-Soo Kim from the Seoul National University, has questioned this decision. FOOD SAFETY MAGAZINE 21/04/16 Genetically Modified Mushrooms One Step Closer to Store Shelves. News | April 21, 2016 By Staff The U.S.
Department of Agriculture (USDA) has decided that it will not regulate the cultivation or sale of a genetically modified mushroom. With the help of the CRISPR gene-editing tool and a plant pathologist at Pennsylvania State University, this mushroom will be the first of its kind utilizing that tool to escape federal oversight. The specific mushroom fungus undergoing modification is Agaricus bisporus, a variety of popular white button mushrooms. IOBLOG 19/04/16 CRISPR GM mushrooms do not require USDA approval. A mushroom created using CRISPR genetic modification The US Department of Agriculture (USDA) said that it is not necessary to regulate the cultivation and sale of genetically modified mushrooms because they do not contain any foreign DNA.
That decision is unprecedented for genetically modified organisms using CRISPR, a relatively new genetic modification technique that is best known for its applications in the human embryos than in vegetables. Unlike older methods used to create GMOs, CRISPR does not insert the DNA of viruses and bacteria in target organisms to make the proper changes, and for that reason, the GM mushrooms do not fall within the rules of USDA. The USDA SAYS THAT THE LACK OF FOREIGN DNA PRESENTS NO THREAT TO OTHER PLANTS. AGROMEDIA 30/06/14 Un édulcorant produit à partir de champignons OGM. ENGADGET 16/04/16 Genetically modified mushrooms cleared by the USDA. INFOGM 26/10/16 États-Unis - Le champignon OGM (Crispr) doit-il être évalué ?