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Biologie de synthèse dans le secteur agroalimentaire

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BOVINE VETERINARIAN 08/10/14 New vaccine technology combats Bluetongue virus (issu de biologie synthétique) Scientists have developed a faster method of producing an effective vaccine for the devastating animal disease caused by Bluetongue virus (BTV); a virus that has infected and killed thousands of livestock throughout the world.

BOVINE VETERINARIAN 08/10/14 New vaccine technology combats Bluetongue virus (issu de biologie synthétique)

BTV is spread to cattle, sheep and some other wild ruminants by a type of midge, which is a biting insect. Infected animals experience a range of symptoms, which are fatal in some cases. There are also indirect impacts including weight loss and reduced milk production. Previous prevention measures have included the culling of animals along with the use of inactivated vaccines. Inactivated vaccines contain viruses that have been killed by chemical methods. However, despite being effective, they only offer protection against a specific strain of the virus. “Synthetic” viral particles are created rapidly in the laboratory using sequence information from the genetic material of the virus. NATURE 13/05/19 Synthetic biology strategies for microbial biosynthesis of plant natural products. 1.Nielsen, J.

NATURE 13/05/19 Synthetic biology strategies for microbial biosynthesis of plant natural products

& Keasling, J. D. Engineering cellular metabolism. Cell 164, 1185–1197 (2016).Article CAS PubMed PubMed Central Google Scholar 2.Kosuri, S. & Church, G. M. Large-scale de novo DNA synthesis: technologies and applications. THE PLANT JOURNAL - JULY 2016 - Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms. The large genetic redundancy and complexity of the signalling networks in higher plants represents an experimental limitation for the comprehension of the function of the individual components and the system as a whole (Cannon et al., 2004).

THE PLANT JOURNAL - JULY 2016 - Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms

Such intricate pathways are best studied by simplification: in lower organisms, in isolated signalling blocks/modules or in completely heterologous systems, disposing of the environment complexity and factors likely to interfere with the study of the isolated actors. We describe here the application of synthetic biology strategies and a set of heterologous platforms that can be implemented to facilitate the analysis and signalling pathway dissection.

These systems span a range of evolutionary distance and orthogonality, from other higher and lower plants, up to yeast, animal and in vitro systems. Plant Science Center ETH-Z VIA YOUTUBE 12/12/16 Natural Products-from plant based production to synthetic biology. DAILY MONITOR (UG) 21/07/17 Advancing from genetic modification to synthetic biology in plant breeding. The arguments and controversies arising from use of genetic modification mechanism in plant breeding will continue to surface but agricultural scientists globally are moving on with application of emerging new technologies for improved plant breeding to the benefit of farmers and consumers.

DAILY MONITOR (UG) 21/07/17 Advancing from genetic modification to synthetic biology in plant breeding

Crop domestication has evolved over the years and it has been a prime example of how humans have modified the many species surrounding them to meet their needs. Humans have progressed from selecting plants for the most useful flora to actively growing designated crops in the form of agriculture for calculated breeding that is performed today. As these improvements evolved into modern agriculture, man’s ability to modify the traits of plants for societal needs has become more targeted. Although many of these traits have revolved around agricultural yield for the purpose of food production, modern society also requires the use of crops as a clean energy source in the form of biofuels.

CROPLIFE 16/06/17 Global Industry Coalition Submission of Information on Synthetic Biology. Crit Rev Food Sci Nutr. 2016 Aug 17;56(11):1777-89. Synthetic Biology: Applications in the Food Sector. Synthetic biology also termed as “genomic alchemy” represents a powerful area of science that is based on the convergence of biological sciences with systems engineering.

Crit Rev Food Sci Nutr. 2016 Aug 17;56(11):1777-89. Synthetic Biology: Applications in the Food Sector.

It has been fittingly described as “moving from reading the genetic code to writing it” as it focuses on building, modeling, designing and fabricating novel biological systems using customized gene components that result in artificially created genetic circuitry. The scientifically compelling idea of the technological manipulation of life has been advocated since long time.

FOE 18/08/14 Synthetic biology vanilla: “natural” and “sustainable?” THE PLANT JOURNAL 20/06/16 Biotechnology and synthetic biology approaches for metabolic engineering of bioenergy crops. MACQUARIE UNIVERSITY 15/09/15 Application of Synthetic Biology to increased Agricultural Productivity in Australia. ISPSW Strategy Series - MARS 2015 - The DNA-®evolution of Agriculture. FARMING FUTURES 02/09/15 Synthetic biology can help us to secure a sustainable food supply. Synthetic biology can help us to secure a sustainable food supply.

FARMING FUTURES 02/09/15 Synthetic biology can help us to secure a sustainable food supply.

Huw Jones of Rothamsted Research explains. It will not be long before crop plants are designed and built, bottom up, using the principles of synthetic biology. Plant breeding using classical, top-down or forward genetic approaches has served us well in the millennia since people settled in agricultural communities and started crossing plants, selecting individuals with traits that made farming easier and the edible parts more nutritious.

But it is slow, unpredictable and limited by the variation available in the breeders’ gene pool. If the rate of extreme weather events continues increasing, breeding based on currently available genetic variation and forward genetics approaches will struggle to provide predictably high crop yields that are resilient to future climate change in the time frames required. An alternative to top-down genetic crop improvement is the so called ‘reverse genetic’ approach. Why? EMBRAPA - MAI 2016 - Présentation : Synthetic biology and its applications in Agriculture. INNOVATEUK_ORG 26/01/16 Synthetic biology in the real world: Case studies - Detection of food spoilage organisms using bionanotechnology. New synthetic biology technologies are starting to offer exciting opportunities across a range of industries including manufacturing, pharmaceuticals, biofuels and health.

INNOVATEUK_ORG 26/01/16 Synthetic biology in the real world: Case studies - Detection of food spoilage organisms using bionanotechnology

Research Council funding in collaboration with a wide variety of national and international partners across academia and industry, is supporting the long-term growth of UK synthetic biology, development of a highly skilled workforce and an infrastructure to underpin and enable cutting edge research in industry and academia, as well as providing support for synthetic biology start-up companies. The pervasive potential of synthetic biology is brought to life through a series of case studies ranging from a biosensor toolkit with the ability to treat chronic conditions such as diabetes through to using enzymes from yeast mould to unlock cleaner routes to producing biofuel. EUROPE 18/12/15 Présentations de : WORKSHOP ON SYNTHETIC BIOLOGY TOOK PLACE ON 10 DECEMBER 2015. WASHINGTON POST 17/12/15 How synthetic biology could solve our banana problem.

ECOWATCH 27/08/14 Häagen-Dazs Says No to ‘Extreme’ Genetic Engineering Techniques. Ice cream lovers who prefer to steer clear of genetically modified organisms (GMO) will be happy to hear that Häagen-Dazs has confirmed it will not use vanilla produced via synthetic biology, a new set of “extreme” genetic engineering techniques.

ECOWATCH 27/08/14 Häagen-Dazs Says No to ‘Extreme’ Genetic Engineering Techniques

Synthetic biology, or synbio, vanilla is designed to replace natural vanillin flavoring from vanilla beans, and is made in labs using artificial DNA and reprogrammed, genetically engineered yeast, according to a Friends of the Earth statement. The companies Evolva and International Flavors and Fragrances plan to sell synbio vanilla flavoring this year, marketing it as “natural.” WAGENINGEN UNIVERSITY 18/03/10 Présentation : Synthetic Biology in Food & Health. EUROPE - 2010 - 7th FWP - Bacterial Synthetic Minimal Genomes for Biotechnology (BASYNTHEC) (INRA) Bacterial Synthetic Minimal Genomes for Biotechnology [Print to PDF] [Print to RTF] Project details Total cost: EU contribution: Coordinated in: France.

EUROPE - 2010 - 7th FWP - Bacterial Synthetic Minimal Genomes for Biotechnology (BASYNTHEC) (INRA)

INRA Domaine de Vilvert - MICA-CT1 : Biologie des systèmes, biologie synthétique et biotechnologies. Objet d'étude : protéome, séquençage Question sociétale et finalité, contexte : biologie prédictive Dispositif technique et méthode d'étude : génomique fonctionnelle, ingénierie métabolique, spectrométrie de masse, électrophorèse bidimensionnelle, chromatographie liquide, identification, empreinte de masses peptidiques, biologie synthétique, modélisation Afficher la suite.

INRA Domaine de Vilvert - MICA-CT1 : Biologie des systèmes, biologie synthétique et biotechnologies

University of Nottingham 21/05/13 Introduction to Opportunities in Plant Synthetic Biology. INSIGHT - OCT 2014 - Plant synthetic biology takes root. FERA / UNIVERSITY OF YORK - Présentation : Plant Synthetic Biology: a New Platform for Industrial Biotechnology? EUREKALERT 21/02/10 Biotech, nanotech and synthetic biology roles in future food supply explored. SAN DIEGO - Some say the world's population will swell to 9 billion people by 2030 and that will present significant challenges for agriculture to provide enough food to meet demand, says University of Idaho animal scientist Rod Hill. Hill and Larry Branen, a University of Idaho food scientist, organized a symposium during the American Association for the Advancement of Science annual meeting Sunday to explore ways biotechnology could provide healthy and plentiful animal-based foods to meet future demands.

Synthetic biology, nanotechnology, genetic engineering and other applications of biotechnology - and the public's role in determining their acceptable uses -- were all addressed by panelists during the session. The goal for the session, which was part of the nation's largest and most prestigious general science meeting held annually, was to encourage a dialogue among scientists and the public, said Hill, a Moscow-based molecular physiologist who studies muscle growth in cattle. EUROPE - DG RECHERCHE - Biotechnologies, Agriculture and Food - 2009 - 19th Meeting of the EC-US Task Force on Biotechnology Research.

The European Commission (EC) - United States (US) Task Force on Biotechnology Research met for the 19th time at the Lawrence Berkeley National Laboratory in San Francisco, USA, June 25-26, 2009. The meeting was co-chaired by Judith St. John, Deputy Administrator, US Department of Agriculture Agricultural Research Service (USDA ARS), US, and Timothy Hall, Acting Director for Biotechnologies, Agriculture and Food Research, Research Directorate - General, European Commission. SCIENTIFIC AMERICAN 25/04/13 Can Synthetic Biology Keep Your Food Safe? Sample6 hopes to use their new contamination test to keep food, like these packaged greens, safe from listeria. On a hot summer day, nothing spells refreshment quite like a slice of juicy, orange cantaloupe.

But in summer 2011, cantaloupes reached plates with an unwanted addition: listeria. In the deadliest foodborne illness outbreak since 1925, cantaloupes contaminated with this bacterium killed 33 people. Unfortunately, cantaloupes weren’t the end of the story. A year later, listeria tainted another well-loved American staple: cheese. A few months from now, a Boston-based start-up company will market a test kit that will do just that: detect this deadly bacterium in the processing plant, before it reaches the grocery store.

Scheduled for launch in July, the test developed by Sample6 Technologies provides results in three to four hours, compared to 16 and 48 hours for current assays for bacterial contamination. “It’s much better if you test the process as it is working.” Food Technol. Biotechnol. 51 (2013) Synthetic Biology: A Novel Approach for the Construction of Industrial Microorganisms. FOOD SCIENCE TECHNOLOGY JOURNAL 02/03/15 New Synthetic Biology Centre. Researchers at the University of Warwick have won a £12 million award to create a new Centre to develop advanced technologies in synthetic biology. Vince Cable announced the new Centre as part of a £40M investment in UK synthetic biology coming from the Biotechnology and Biological Sciences Research Council (BBSRC), Engineering and Physical Sciences Research Council (EPSRC), the Medical Research Council (MRC) and capital investment from UK Government.

The UK Government has identified synthetic biology as one of the ‘Eight Great Technologies’ in which Britain can be a world leader. The Warwick Integrative Synthetic Biology centre (WISB) brings together researchers from across the University in disciplines including Life Sciences, Engineering, Chemistry, Computer Science, Education, and Law. It will address a wide range of applications, such as pharmaceuticals, high-value and commodity chemicals, innovative treatments for disease, environmental bioremediation and food security. MINISTERE DE LA RECHERCHE - 2011 - Investissements d'avenir - Biotechnologies et bioressources - PROJET SYNTHACS Ce projet propose une alternative à l’utilisation de la pétrochimie pour produire, à partir de biomasse renouvelable, la méthionine, l’un des. INRA 10/10/14 Réflexion : la biologie de synthèse a besoin des sciences sociales.

Les progrès de la biologie, alliés à ceux de l’informatique et de la modélisation, laissent entrevoir des possibilités encore inédites il y a vingt ans. Bien qu’on soit encore loin de « programmer » la vie, on sait aujourd’hui construire un génome synthétique et le faire fonctionner dans une bactérie vivante. C’est le champ de la biologie de synthèse, un domaine émergent, qui ambitionne de concevoir des fonctions ou organismes nouveaux dans un but de connaissances et d’applications. Comment utiliser ces nouvelles connaissances ?