VIRUSES 22/02/21 Aerosolized Exposure to H5N1 Influenza Virus Causes Less Severe Disease than Infection via Combined Intrabronchial, Oral, and Nasal Inoculation in Cynomolgus Macaques. Received: 8 January 2021 / Revised: 10 February 2021 / Accepted: 18 February 2021 / Published: 22 February 2021 Round 1 Reviewer 1 Report Mooij et al. demonstrated that aerosolized exposure to H5N1 influenza virus causes less severe disease than infection via combined intrabronchial, oral and nasal inoculation in monkey model.
They also suggested that not virus levels or immune activation, but route of infection determines fatal outcome for highly pathogenic avian H5N1 influenza infection. Although it still remains unknown why the phenomenon was shown, the fact that they demonstrated is very important to proceed the future pathogenic research for animal model of H5N1 influenza virus infection. Major concerns: Maybe combined inoculation with avian H5N1 influenza virus infects alveolar epithelial cells directly more frequent than aerosolized exposure. Minor concerns: Superscript and subscript numbers are not listed. Line 219; what is means “vaccine group”?
Author Response. PLOS 20/03/20 Knowledge and remaining gaps on the role of animal and human movements in the poultry production and trade networks in the global spread of avian influenza viruses – A scoping review. Abstract Poultry production has significantly increased worldwide, along with the number of avian influenza (AI) outbreaks and the potential threat for human pandemic emergence.
The role of wild bird movements in this global spread has been extensively studied while the role of animal, human and fomite movement within commercial poultry production and trade networks remains poorly understood. The aim of this work is to better understand these roles in relation to the different routes of AI spread. Sci Rep. 15/01/21 Estimating epidemiological parameters using diagnostic testing data from low pathogenicity avian influenza infected turkey houses. Outbreak data Birds on eight premises, all meat-type turkey premises, tested positive by real-time reverse transcription polymerase chain reaction (rRT-PCR) during the 2018 LPAI H5N2 outbreak in Minnesota.
Diagnostic test results were available for each of the 33 barns that tested positive across the eight premises from the time of detection until the birds were sent to processing as part of controlled marketing9. The current article focuses on the estimated time of virus introduction and adequate contact rate results for a single premises, the 2nd premises detected in Kandiyohi county in Minnesota (Kandiyohi 2).
Results from the other premises have been reported10. All five barns on Kandiyohi 2 tested positive for virus. Stochastic within-house LPAI transmission model The number of initially infected birds in a house was dependent on whether the house was the first infected on the premises, as deduced from diagnostic testing data. Multiple house estimation approach. FEMS MICROBIOLOGY REVIEWS 05/08/19 Global patterns of avian influenza A (H7): virus evolution and zoonotic threats. Skip to Main Content Advertisement Search Close Advanced Search Search Menu Skip Nav Destination Article Navigation Volume 43.
SCIENTIFIC REPORTS 25/11/20 Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens. Virus isolation and identification A total of 22 H6 AIVs were isolated from ducks and geese without any obvious clinical signs in LPMs during 2010–2017.
All of viruses were propagated in SPF chicken embryonated eggs and their virus titers ranged from 106.3 to 109.5 EID50/100 μl. Full genomes of 7 H6N2 and 15 H6N6 viruses were sequenced and deposited to the NCBI database, the accession number and abbreviations of viruses used in this study have been listed in Table 1. Molecular characterization According to sequence analysis, all of the H6 isolates shared the same amino acids (PQIETR/GLF) with single basic amino acid at the cleavage site between HA1 and HA2, which displayed a low pathogenic feature32.
Those 22 viruses contained 119E, 274H and 294 N on the NA proteins (N2 numbering36), which suggested that all viruses are sensitive to oseltamivir37. SCIENTIFIC REPORTS 04/11/20 A decision support framework for prediction of avian influenza. NATURE 02/11/20 Parallel evolution in the emergence of highly pathogenic avian influenza A viruses. 1.Webster, R.
G., Peiris, M., Chen, H. & Guan, Y. H5N1 outbreaks and enzootic influenza. Emerg. Infect. Dis. 12, 3–8 (2006).Article PubMed PubMed Central Google Scholar 2.Buxton Bridges, C. et al. BIORXIV 22/08/19 Parallel Evolution in the Emergence of Highly Pathogenic Avian Influenza A Viruses. INFLUENZA AND OTHER RESPIRATORY VIRUSES 23/07/19 New frontiers in applied veterinary point‐of‐capture diagnostics: Toward early detection and control of zoonotic influenza. Global population growth and shifting dietary preferences in transitioning economies are driving surging demand for animal‐source nutrition.
To meet this demand, swine and poultry production in low‐ and middle‐income countries have experienced substantial growth rates.1 Absent planned livestock sector development structures, animal production, distribution, and marketing capacities have evolved under variable conditions, presenting substantial emerging zoonotic disease vulnerabilities. Foremost among them is the threat of animal‐origin influenza of pandemic potential.
Given these limitations, response postures remain perpetually reactive, enabling continual cycles of incursion to endemicity that elevate pandemic emergence risk and present substantial economic, agricultural productivity, and food security impacts in the most vulnerable populations. Finally, early detection of novel animal‐origin influenza holds promise of interrupting the repeated cycle of incursion to endemicity. VETERINARY RESEARCH - 2015 - Susceptibility to and transmission of H5N1 and H7N1 highly pathogenic avian influenza viruses in bank voles (Myodes glareolus) TRANSBOUNDARY AND EMERGING DISEASES 09/04/19 Genetic analysis identifies potential transmission of low pathogenic avian influenza viruses between poultry farms.
Avian influenza (AI) is a highly contagious viral disease that affects birds.
Avian influenza viruses are widespread in wild waterfowl that form the natural reservoir of AI viruses (Stallknecht & Shane, 1988), and can occasionally be transmitted to commercial poultry. The viruses carry two surface glycoproteins, haemagglutinin (HA) and neuraminidase (NA), which are used for virus classification (Webster, Bean, Gorman, Chambers, & Kawaoka, 1992). In birds, 16 HA (H1‐H16) and 9 NA (N1‐N9) subtypes have been identified (Fouchier et al., 2005; Olsen et al., 2006). FRONT. VET. SCI. 22/05/19 Editorial: Epidemiology of Avian Influenza Viruses.
Avian influenza (AI) is a highly contagious viral disease, characterized by an intense circulation in many wild waterbird reservoir populations, with periodical introduction into the domestic poultry sector.
AI viruses have been the source of devastating economic losses in the poultry industry over the last three decades and have become a major veterinary and public health concern due to their zoonotic potential (1, 2). Outbreaks caused by highly pathogenic avian influenza (HPAI) viruses have caused serious animal health crises worldwide, such as the high case fatality rates in poultry, the control measures that are applied (massive pre-emptive culling or vaccination) and the consequences of virus detection on the international poultry produce trade. Undoubtedly, the rapid and continuous evolution of AI viruses make their surveillance and control particularly challenging. Timely information is required to optimize the emergency response during outbreaks. Author Contributions. FRONT. VET. SCI. 17/12/18 Detecting and Predicting Emerging Disease in Poultry With the Implementation of New Technologies and Big Data: A Focus on Avian Influenza Virus.
Jake Astill1, Rozita A.
Dara1, Evan D. Fraser1 and Shayan Sharif1* 1University of Guelph, Canada IntroductionGlobal population growth, along with rising affluence in Asia, are driving up not only our total demand for food, but also the amount of protein required to feed all of humanity (1,2). Keywords: Influenza Virus, Poultry, rapid diagnosis, big data, biosensor, Infectious Disease Received: 14 Dec 2018; Accepted: 17 Dec 2018. Copyright: © 2018 Astill, Dara, Fraser and Sharif. . * Correspondence: Dr. VIRUSES 28/08/18 The Pandemic Threat of Emerging H5 and H7 Avian Influenza Viruses. The 1918 H1N1 Spanish Influenza pandemic was the most severe pandemic in modern history.
Unlike more recent pandemics, most of the 1918 H1N1 virus’ genome was derived directly from an avian influenza virus. Recent avian-origin H5 A/goose/Guangdong/1/1996 (GsGd) and Asian H7N9 viruses have caused several hundred human infections with high mortality rates. While these viruses have not spread beyond infected individuals, if they evolve the ability to transmit efficiently from person-to-person, specifically via the airborne route, they will initiate a pandemic.
Therefore, this review examines H5 GsGd and Asian H7N9 viruses that have caused recent zoonotic infections with a focus on viral properties that support airborne transmission. Several GsGd H5 and Asian H7N9 viruses display molecular changes that potentiate transmission and/or exhibit ability for limited transmission between ferrets.
NATURE 01/08/18 Evolution of high pathogenicity of H5 avian influenza virus: haemagglutinin cleavage site selection of reverse-genetics mutants during passage in chickens. International Journal of Hygiene and Environmental Health Available online 9 June 2018 Mitigation strategies to reduce the generation and transmission of airborne highly pathogenic avian influenza virus particles during processing of infected poultry. Open Access Highlights Changes in the processing of H5N1-infected chickens reduce airborne transmission. Containing the first step can reduce generation of airborne virus and their transmission.
Disposable plastic bag, cooking pot, or bucket are practical containing vessels. Mechanical defeathering increases airborne virus compared to manual defeathering. Processing vaccinated chickens prevents airborne virus generation and transmission. CGIAR - 2009 - Introduction to participatory epidemiology and its application to highly pathogenic avian influenza participatory disease surveillance: A manual for participatory disease surveillance practitioners. FRONTIERS IN VETERINARY SCIENCE 03/04/18 Geographical and historical patterns in the emergences of novel highly pathogenic avian influenza (HPAI) H5 and H7 viruses in poultry. Madhur S. Dhingra1, 2, Jean Artois1, Simon Dellicour3, Philippe Lemey3, Gwenaelle Dauphin2, University of Pittsburgh - AVRIL 2017 - thèse en ligne : IMPACT OF H5N1 INFLUENZA VIRUS INFECTION ON NATURAL KILLER CELLS AND INNATE LYMPHOID CELL POPULATIONS IN MACAQUES.
Journal of Applied Ecology 07/11/16 Challenging the conceptual framework of maintenance hosts for influenza A viruses in wild birds. THE LANCET 19/05/17 Stopping emerging influenza viruses at their origin. During the past 100 years, two of four influenza virus pandemics originated in Asia. Additionally, many of the emerging influenza viruses that are deemed to have pandemic potential, including H5N1, H5N6, H6N1, H7N9, and H10N8, have crossed the species barrier from animals to human beings in Asia.1, 2, 3, 4, 5, 6 One reason for this might be the extensive interface between human beings, domestic poultry, and wild waterfowl, which is generated by the high human population density, the high density of domestic poultry, and ample opportunities for domestic birds to be exposed to wild waterfowl in some regions of Asia. This environment provides avian influenza viruses with the opportunity to evolve, reassort, and, ultimately, infect human beings.
Although zoonotic infections might have high case-fatality rates, it is unlikely that a fully avian virus will cause the next pandemic. VIRUS EVOLUTION 18/03/17 Adaptation of avian influenza virus to a swine host. Skip to Main Content Sign In Register Advanced Search Online ISSN 2057-1577 Print ISSN Copyright © 2017 Oxford University Press Connect. PLOS 09/03/17 Discordant detection of avian influenza virus subtypes in time and space between poultry and wild birds; Towards improvement of surveillance programs. Abstract. Int. J. Environ. Res. Public Health 2017, 14(3), 263; Comparative Epidemiology of Human Fatal Infections with Novel, High (H5N6 and H5N1) and Low (H7N9 and H9N2) Pathogenicity Avian Influenza A Viruses.
CDC EID - FEV 2017 - Au sommaire notamment: Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity. Hongbo Guo1, Erik de Vries1, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, and Cornelis A.M. de Haan. CDC EID - MARS 2005 - Rumor Surveillance and Avian Influenza H5N1. CDC EID - FEV 2017 - H5Nx Panzootic Bird Flu—Influenza’s Newest Worldwide Evolutionary Tour. Author affiliations: National Institutes of Health, Bethesda, Maryland, USA (J.K. Taubenberger, D.M. Morens); Associate Editor, Emerging Infectious Diseases, Atlanta, Georgia, USA (D.M. Morens) PLOS 23/11/16 Avian Influenza Risk Surveillance in North America with Online Media. Abstract. Infectious Diseases of Poverty (2015) 4:50 Prediction of the next highly pathogenic avian influenza pandemic that can cause illness in humans.
During the past decade, an endless stream of avian influenza viruses (AIVs), including H1N1, H5N1, and H7N9, has emerged, leading to humans developing malignant respiratory diseases. INFECTION ECOLOGY & EPIDEMIOLOGY 08/09/15 Mallard or chicken? Comparing the isolation of avian influenza A viruses in embryonated Mallard and chicken eggs. Infection Ecology and Epidemiology 11/10/16 Risk of resistant avian influenza A virus in wild waterfowl as a result of environmental release of oseltamivir.
Anna Gillman, MD, PhD1,2* 1Section for Infectious Diseases, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; 2Zoonosis Science Centre, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden. PLOS 13/10/16 Persistence of Low Pathogenic Influenza A Virus in Water: A Systematic Review and Quantitative Meta-Analysis. Tierarztl Prax Ausg G Grosstiere Nutztiere. 2016;44(1):26-33. [Role of the poultry red mite (Dermanyssus gallinae) in the transmission of avian influenza A virus].
JOURNAL OF MEDICAL VIROLOGY - 2013 - Susceptibility of Human and Avian Influenza Viruses to Human and Chicken Saliva. AGENCY FOR SCIENCE SINGAPORE 29/05/12 Made-In-Singapore H5N1 Bird Flu Diagnostic Kit – Detects All Known Strains of H5N1 Virus With A Single Test. Applied Biosafety Vol. 16, No. 1, 2011 Effect of Drying and Exposure to Vaporous Hydrogen Peroxide on the Inactivation of Highly Pathogenic Avian Influenza (H5N1) on Non-porous Surfaces. This study demonstrated the combined effect of drying and vaporous hydrogen peroxide exposure on inactivating highly pathogenic avian influenza (H5N1) on the non-porous materials glass, Hypalon® rubber glove, and stainless steel. Veterinary Science - 2012 - Study of Maternal Antibody’s Neutralization Ability for Anti AI H5 in Chicken’s Egg Yolk Induce From Several Commercial Vaccines Against Field of AI H5N1 Virus.
Critical Reviews in Microbiology Volume 41, Issue 4, 2015 Laridae: A neglected reservoir that could play a major role in avian influenza virus epidemiological dynamics. WebImagesPlus… EU-SPRI CONFERENCE - 2014 - Avian influenza narratives and research landscapes: towards new science policy approaches in biomedicine. FRONTIERS IN MICROBIOLOGY 24/06/16 Pathogenesis and phylogenetic analyses of two avian influenza H7N1 viruses isolated from wild birds. Hongmei Jin1, Deli Wang3, Jing Sun1, 4, Yanfang Cui3, Guang Chen1, 5, Xiaolin Zhang1, Jiajie Zhang1, Xiang Li1, Hongliang Chai1*, Yuwei Gao2*, Yanbing Li3* and. FRONTIERS IN VETERINARY SCIENCE 23/05/16 Commentary: Differences in the Epidemiology of Human Cases of Avian Influenza A (H7N9) and A (H5N1) Viruses Infection.
Clinical Infectious Diseases 04/05/15 Differences in the epidemiology of human cases of avian influenza A(H7N9) and A(H5N1) viruses infection. International Congress Series 1263 (2004) 114–117 Molecular determinants of the pathogenicity of H5N1 influenza viruses in chickens. Int. J. Livest. Res.. 2013; 3(4): 5-13 Avian Influenza - The Eminent Pandemic Threat.
VETERINARY RESEARCH - 2014 - The NS segment of H5N1 avian influenza viruses (AIV) enhances the virulence of an H7N1 AIV in chickens. Global Veterinaria 11 (5): 609-613, 2013 The Potential Role of Animals in the Epidemiology of Avian Influenza Virus H5N1 and Its Public Health Implications. State Key Laboratory of Pathogen and Biosecurity (Beijing) - 2013 - Construction of a chimeric secretory IgA and its neutralization activity against Avian Influenza Virus H5N1. Kasetsart J. (Nat. Sci.) 47 : 720 - 732 (2013) Minimal Susceptibility to Highly Pathogenic Avian Infl uenza H5N1 Viral Infection of Pigeons (Columba livia) and Potential Transmission of the Virus to Comingled Domestic Chickens.
Hong Kong Med J 2013;19(Suppl 4):S24-8 Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium. THE LANCET - DEC 2013 - Human infection with avian influenza A H6N1 virus: an epidemiological analysis. Viruses 2013, 5(8), 1964-1977 Avian Influenza: Mixed Infections and Missing Viruses. International Journal of Scientific & Engineering Research, Volume 4, Issue 6, June-2013 617 Epitope designing on avian influenza disease. Babes-Bolyai University 11/02/14 Avian Influenza Surveillance in the Danube Delta using Sentinel Geese and Ducks.
Theor Popul Biol. Dec 2013; 90(100): 135–144. Economic epidemiology of avian influenza on smallholder poultry farms. AVIA PATHOLOGY - 2013 - Differences in highly pathogenic avian influenza viral pathogenesis and associated early inflammatory response in chickens and ducks. JOURNAL OF INFECTIOUS DISEASE 29/10/14 How Low Is the Risk of Influenza A(H5N1) Infection? GENOME 25/09/14 Complete Genome Sequence of a Novel Reassortant Avian Influenza H9N9 Virus Isolated from Chicken in Eastern China. AVIAN PATHOLOGY - JUNE 2003 - Seroprevalence of avian influenza virus and its relationship with increased mortality and decreased egg production. PNAS 28/05/13 Interventions for avian influenza A (H5N1) risk management in live bird market networks.
Instituto de Investigación en Recursos Cinegéticos - Poster : Serological Testing for Avian Influenza Viruses in Wild Birds: Comparison of Two Commercial Competition ELISAs. Air Water Borne Diseases 2015, 4:1 Potential Role of Fresh Water Apple Snails on H5N1 Influenza Virus Persistence and Concentration in Nature. FRONTIERS IN MICROBIOLOGY 06/11/15 Biosurveillance of avian influenza and Newcastle disease viruses in the Barda region of Azerbaijan using real time RT-PCR and hemagglutination inhibition.
Indian J Med Res 139, May 2014, pp 782-785 Pathogenicity of avian influenza H11N1 virus isolated from wild aquatic bird Eurasian Spoonbill (Platalea leucorodia) Pakistan journal of zoology. 10/2011; 43(5). Study on Pathogenesis of Low Pathogenic Avian Influenza Virus H9 in Broiler Chickens. Rev. Bras. Cienc. Avic. vol.16 no.2 Campinas Apr./June 2014 Evaluation of a commercial ELISA kit (IDEXX) to differentiate AI virus-infected poultry from AI-vaccinated poultry (DIVA) JOURNAL OF VIROLOGY 29/04/15 Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses.
Ecohealth. 2009 Sep;6(3):449-57. ONCFS - The Potential Distance of Highly Pathogenic Avian Influenza Virus Dispersal by Mallard, Common Teal and Eurasian Pochard. Virol Sin. 2015 Jul 31. Identification of a novel strain of influenza A (H9N2) virus in chicken. WATTAG 07/05/15 Analysis: Solutions for trade during avian influenza outbreak. Journal of virological methods 10/2013; Rapid molecular haemagglutinin subtyping of Avian Influenza isolates by specific real-time RT-PCR tests.
Current Infectious Disease Reports 05/12/14 Avian Influenza: Recent Epidemiology, Travel-Related Risk, and Management. AVIAN PATHOLOGY - JUNE 2003 - Seroprevalence of avian influenza virus and its relationship with increased mortality and decreased egg production. JOURNAL OF INFECTIOUS DISEASE 29/10/14 How Low Is the Risk of Influenza A(H5N1) Infection? PEERJ 30/10/14 A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin. Scientifica Volume 2014 (2014), A Review of the Antiviral Susceptibility of Human and Avian Influenza Viruses over the Last Decade. REVISTA 21 (2): 94-103, 2013 INFLUENZA H5N1 - NEXT PANDEMIC? Trakia Journal of Sciences, No 1, pp 59-64, 2014 SHEDDING OF THE AVIAN INFLUENZA A H6N2 SUBTYPE VIRUS ISOLATE IN NUMIDA MELEAGRIS. VETERINARY RESEARCH 04/06/14 High doses of highly pathogenic avian influenza virus in chicken meat are required to infect ferrets.
NEW SCIENTIST 11/06/14 Wild bird flu could mutate into deadly human pandemic. AVIANINFLUENZA_ORG - The Economic and Social Impacts of Avian Influenza. VIROLOGY JOURNAL - 2013 - Systemic distribution of different low pathogenic avian influenza (LPAI) viruses in chicken. INFLUENZA RESEARCH AND TREATMENT - 2013 - Monoclonal Antibody Targeting Neutralizing Epitope on H5N1 Influenza Virus of Clade 1. Selected Paper prepared for presentation at the Agricultural & Applied Economics Association’s 2013 AAEA & CAES Joint Annual Mee.
Selected Paper prepared for presentation at the Agricultural & Applied Economics Association’s 2013 AAEA & CAES Joint Annual Meeting, Washington, DC, August 4- 6, 2013 Impacts of BSE and Avian Influenza on U.S. Meat Demand – guatemalt
MEAT POULTRY 22/08/13 Ducks hosts for a variety of bird flu viruses. INFLUENZA RESEARCH AND TREATMENT 16/08/13 Comparative Serological Assays for the Study of H5 and H7 Avian Influenza Viruses. Sensors 2012, 12, 12506-12518; A SPR Aptasensor for Detection of Avian Influenza Virus H5N1. Clinical Infectious Diseases 05/02/13 Assessment of Serosurveys for H5N1. Influenza Research and Treatment Volume 2012 (2012) Persistence of Avian Influenza Viruses in Various Artificially Frozen Enviro.
Viruses 2013, 5, 1431-1446; Viral and Host Factors Required for Avian H5N1 Influenza A Virus Replication in Mammalian Cells. Selected Paper prepared for presentation at the Agricultural & Applied Economics - Association’s 2011 AAEA & NAREA Joint Annual. POULTRY SCIENCE - AOUT 2008 - Consumer Knowledge and Risk Perceptions of Avian Influenza. Veterinary Research Vol. 41 No. 3 (May-June 2010) Anthropogenic factors and the risk of Highly Pathogenic Avian Influenza H5N1:
Journal of Biological Research-Thessaloniki 15: 135 – 144, 2011 Tracking possible ways of transmission of the highly pathogenic. NSF 06/07/10 Borne on the Wing: Avian Influenza Risk in U.S. Wild Songbirds Mapped. EcoHealth 6, 58–70, 2009 Industrial Food Animal Production and Global Health Risks: Exploring the Ecosystems and Economics of Av. LLOYDS - PANDEMIC POTENTIAL INSURANCE IMPACTS.
International Institute for Sustainable Development (IISD) 14/04/06 SCIENTIFIC SEMINAR ON AVIAN INFLUENZA, THE ENVIRONMENT AND M. CIDRAP 20/02/08 Avian Influenza (Bird Flu): Agricultural and Wildlife Considerations.