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ANTIBIORESISTANCE - superbactéries NDM-1

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NATURE MICROBIOLOGY 06/02/17 Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production.

Acinetobacter baumannii

CONFEDERATION SUISSE - Rapport d’activité de la Commission fédérale d’experts pour la sécurité biologique - Législature 2008–201. EUROSURVEILLANCE 17/10/13 Au sommaire:Latent introduction to the Netherlands of multiple antibiotic resistance including NDM-1 a. CMAJ. 2011 August 9; 183(11): 1231. NDM-1 in Canada. AFP 11/08/10 Emergence d'un nouveau mécanisme de résistance aux antibiotiques. WORMS AND GERMS BLOG 11/08/10 NDM-1, a new threat? "NDM-1 superbugs" have received a lot of press the last day or two.

WORMS AND GERMS BLOG 11/08/10 NDM-1, a new threat?

That's lead to questions about whether there may be any risks for pets. It's good to see that people are thinking about how this might affect other animal species. That's a thought process that would have been rare a few years ago, and which was probably fostered by the emergence of MRSA in animals. LE FIGARO 11/08/10 L'inquiétante émergence de «superbactéries» Nous n'en sommes pas au scénario-catastrophe d'une pandémie bactérienne incontrôlable, mais l'inquiétude grandit.

LE FIGARO 11/08/10 L'inquiétante émergence de «superbactéries»

Une nouvelle génération de bactéries, touchant les poumons et l'appareil urinaire, très résistantes aux antibiotiques usuels est en train de se propager dans le monde entier. Dans une étude parue mercredi dans le journal The Lancet Infectious Diseases, des chercheurs anglais, indiens, australien et suédois tirent pour la première fois la sonnette d'alarme. HEALTH FINDER 11/08/10 Travel for Surgery May Help Spread New Superbug. CARDIFF UNIVERSITY 11/08/10 Antibiotic resistant gene discovered. JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA - MARS 2010 - An obituary- On the Death of antibiotics!

Abdul Ghafur K Consultant in Infectious Diseases and Clinical Mycology, Apollo Hospital, Chennai.

JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA - MARS 2010 - An obituary- On the Death of antibiotics!

Homosapiens is an alien species on earth. This planet belongs to bacteria. There are more bacteria on earth than all other living organisms. The human body contains more number of bacteria than human cells themselves. Indian Health care professionals involved in the treatment of patients with severe infections especially healthcare associated infections will agree that it is commonplace to come across pan-resistant Gram negative bacterial infections where we do not have a single effective antibiotic option. The easiest way of tackling the superbug problem is to use the notorious ostrich strategy which denies the existence of the problem: stop looking for these bugs, stop looking for the hidden resistance mechanisms and closing your eyes even if you find them.

We have now data from one of our own hospitals. There is no restriction on the usage of higher end antibiotics in India. References. JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA 19/01/10 New Delhi Metallo-b lactamase (NDM-1) in Enterobacteriaceae: Treatmen. Payal Deshpande*, Camilla Rodrigues**, Anjali Shetty**, Farhad Kapadia***, Ashit Hedge***, Rajeev Soman*** *Dept of Research, **Dept of Lab Medicine, ***Dept of Medicine, P.D.Hinduja National Hospital & Medical Research Centre, Mumbai, India.

JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA 19/01/10 New Delhi Metallo-b lactamase (NDM-1) in Enterobacteriaceae: Treatmen

Received: 14.12.2009; Revised: 18.01.2010; Accepted: 19.01.2010 Abstract Background : Carbapenems are among the few useful antibiotics against multidrug resistant gram negative bacteria particularly those with extended spectrum beta lactamase. + Author Affiliations A Swedish patient of Indian origin traveled to New Delhi, India, and acquired a urinary tract infection caused by a carbapenem-resistant Klebsiella pneumoniae strain that typed to the sequence type 14 complex.

The isolate, Klebsiella pneumoniae 05-506, was shown to possess a metallo-β-lactamase (MBL) but was negative for previously known MBL genes. Gene libraries and amplification of class 1 integrons revealed three resistance-conferring regions; the first contained blaCMY-4 flanked by ISEcP1 and blc. The second region of 4.8 kb contained a complex class 1 integron with the gene cassettes arr-2, a new erythromycin esterase gene; ereC; aadA1; and cmlA7. An intact ISCR1 element was shown to be downstream from the qac/sul genes. Journal of Antimicrobial Chemotherapy (2009) 64, Suppl. 1, i3–i10 The changing epidemiology of resistance. CDC MMWR 25/06/10 Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta-Lactamase. June 25, 2010 / 59(24);750 During January--June 2010, three Enterobacteriaceae isolates carrying a newly described resistance mechanism, the New Delhi metallo-beta-lactamase (NDM-1) (1), were identified from three U.S. states at the CDC antimicrobial susceptibility laboratory.

CDC MMWR 25/06/10 Detection of Enterobacteriaceae Isolates Carrying Metallo-Beta-Lactamase

This is the first report of NDM-1 in the United States, and the first report of metallo-beta-lactamase carriage among Enterobacteriaceae in the United States. These isolates, which include an Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, carry blaNDM-1, which confers resistance to all beta-lactam agents except aztreonam (a monobactam antimicrobial) (1); all three isolates were aztreonam resistant, presumably by a different mechanism. In the United Kingdom, where these organisms are increasingly common, carriage of Enterobacteriaceae containing blaNDM-1 has been closely linked to receipt of medical care in India and Pakistan (2). References Yong D, Toleman MA, Giske CG, et al. THE GUARDIAN 11/08/10 Antibiotics' efficiency wanes due to global spread of drug-resistant bacteria - Gene giving high levels of.

International travel and medical tourism have led to the rapid, global spread of drug-resistant bacteria that may presage the end of antibiotics and leave doctors struggling to treat infected patients, scientists warn today.

THE GUARDIAN 11/08/10 Antibiotics' efficiency wanes due to global spread of drug-resistant bacteria - Gene giving high levels of

A new gene conferring high levels of resistance to almost all antibiotics has been found to be widespread in forms of gut bacteria that can cause potentially life-threatening pneumonia and urinary tract infections. In just three years, says Professor Tim Walsh of Cardiff University who discovered the gene, it has grown in prevalence from being rarely observed at all to existing in between 1% and 3% in patients with Enterobacteriaceae infections in India. "It is absolutely staggering," said Walsh. "Because of international travel, globalisation and medical tourism, [the gene] now has the opportunity to go anywhere in the world very quickly. " Walsh says it is not possible to know how widespread the bacteria now is in the UK.

"In many ways, this is it," he said. THE LANCET 11/08/10 Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, MINISTERE DE LA SANTE 18/08/10 Emergence d’entérobactéries, dites "NDM-1", hautement résistantes à de nombreux antibiotiques. La revue The Lancet a publié le 11 août 2010 une étude [ 2 ] sur l’émergence et la diffusion de bactéries dites « NDM-1 » résistantes à toutes les ß-lactamines (pénicillines et céphalosporines) ainsi qu’à des antibiotiques très puissants, les carbapénèmes (à usage hospitalier).

MINISTERE DE LA SANTE 18/08/10 Emergence d’entérobactéries, dites "NDM-1", hautement résistantes à de nombreux antibiotiques

En France, quelques rares bactéries présentant une résistance similaire mais porteuses d’un gène autre que NDM-1 ont été mises en évidence de manière isolée depuis 2004 et deux épidémies nosocomiales d’une dizaine de cas chacune avec de telles bactéries sont survenues dans les six derniers mois. Dans la plupart des situations, le premier patient venait d’un hôpital étranger. Dans ce contexte, la Direction générale de la Santé a sollicité début 2009 l’avis du Haut Conseil de Santé Publique (HCSP) en vue de définir les mesures de gestion permettant de réduire les risques d’émergence et de maîtriser la diffusion de tels micro-organismes hautement résistants et la survenue d’épidémie.

NEJM 16/12/10 NDM-1 — A Cause for Worldwide Concern.