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Antibioresistance aux Etats-Unis

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OPEN EDITION - 2020 - La publicisation des liens entre l’antibiorésistance et l’alimentation dans la presse nationale étatsunienne. 1 Le phénomène par lequel les bactéries deviennent insensibles aux antibiotiques à la suite d’un usag (...) 1Ces dernières années, l’antibiorésistance1 (la résistance des bactéries aux antibiotiques) est devenue l’un des problèmes de santé les plus « inquiétants » à l’échelle mondiale.

OPEN EDITION - 2020 - La publicisation des liens entre l’antibiorésistance et l’alimentation dans la presse nationale étatsunienne

La nécessité de mesures d’encadrement et de solutions a été soulignée par le plan international lancé en 2015, auquel participent trois agences sanitaires internationales : l’Organisation mondiale de la santé, l’Organisation mondiale de la santé animale et l’Organisation des Nations Unies pour l’alimentation et l’agriculture (OMS, 2015). 2 Il s’agit de la reconnaissance du fait que la santé humaine, la santé animale et l’environnement so (...) 2Depuis 2016, cet appel des acteurs sanitaires a été suivi par une mise à l’ordre du jour du sujet dans les rencontres des leaders politiques internationaux (G7, G20, Assemblée générale de l’ONU).

Tableau 1. FRONT. VET. SCI. 29/11/19 Strategic Priorities for Research on Antibiotic Alternatives in Animal Agriculture—Results From an Expert Workshop (Etats-Unis) Introduction Traditional antimicrobial drugs, or antibiotics, are critical tools to promote human and animal health, yet their efficacy is increasingly threatened by antibiotic resistance.

FRONT. VET. SCI. 29/11/19 Strategic Priorities for Research on Antibiotic Alternatives in Animal Agriculture—Results From an Expert Workshop (Etats-Unis)

Any exposure to antibiotics can select for resistant bacteria; therefore, their use in all settings must be carefully managed (1). In response to this global public health challenge and growing consumer concerns about food production practices, increasing numbers of food companies are voluntarily limiting the use of antibiotics in their supply chains (2). For the purpose of this study, and consistent with other established definitions [see for instance (3, 4)], alternatives to antibiotics were broadly defined as any substance that can prevent the need for or be substituted for antimicrobial drugs. CDC EID - JULY 2019 - Racial/Ethnic Disparities in Antimicrobial Drug Use, United States, 2014–2015. Disclaimer: Ahead of print articles are not considered as final versions.

CDC EID - JULY 2019 - Racial/Ethnic Disparities in Antimicrobial Drug Use, United States, 2014–2015

Any changes will be reflected in the online version in the month the article is officially released. To the Editor: We read with interest the article by Olesen and Grad (1), which reported that, in the United States during 2014–2015, the rate of antimicrobial drug use by white persons was twice that of persons of other races. The authors did not relate this finding to previous reports of ≈2 times lower incidence of sepsis (2) and ≈1.5 times lower incidence of death from infectious diseases (3) in white persons in the United States. MBIO 17/04/18 New York City House Mice (Mus musculus) as Potential Reservoirs for Pathogenic Bacteria and Antimicrobial Resistance Determinants.

House mice (Mus musculus) thrive in large urban centers worldwide.

MBIO 17/04/18 New York City House Mice (Mus musculus) as Potential Reservoirs for Pathogenic Bacteria and Antimicrobial Resistance Determinants

Nonetheless, little is known about the role that they may play in contributing to environmental contamination with potentially pathogenic bacteria. Here, we describe the fecal microbiome of house mice with emphasis on detection of pathogenic bacteria and antimicrobial resistance genes by molecular methods. Four hundred sixteen mice were collected from predominantly residential buildings in seven sites across New York City over a period of 13 months. 16S rRNA sequencing identified Bacteroidetes as dominant and revealed high levels of Proteobacteria. A targeted PCR screen of 11 bacteria, as indicated by 16S rRNA analyses, found that mice are carriers of several gastrointestinal disease-causing agents, including Shigella, Salmonella, Clostridium difficile, and diarrheagenic Escherichia coli.

IMPORTANCE Mice are commensal pests often found in close proximity to humans, especially in urban centers. PCR detection of AMR genes. SCIENCE DAILY 17/04/18 Of mice and disease: Antibiotic-resistant bacteria discovered in NYC house mice A study of mice collected from apartment buildings reveals they carry several disease-causing pathogens, some of which may be resistant to treatments. A study by scientists at the Center for Infection and Immunity (CII) at Columbia University's Mailman School of Public Health finds New York City house mice carry bacteria responsible for mild to life-threatening gastroenteritis in people, and some of these bacteria may be resistant to antibiotics.

SCIENCE DAILY 17/04/18 Of mice and disease: Antibiotic-resistant bacteria discovered in NYC house mice A study of mice collected from apartment buildings reveals they carry several disease-causing pathogens, some of which may be resistant to treatments

Findings appear in the journal mBio. The researchers collected 416 mice from residential buildings at seven sites across New York City over a period of one year. A genetic analysis of their droppings revealed that the mice carry several gastrointestinal disease-causing bacteria, including C. difficile, E. coli, Shigella, as well as Salmonella, a leading cause of bacterial food poisoning in the U.S. with 1.4 million reported cases annually along with 15,000 hospitalizations and 400 deaths.

They also found evidence of genes mediating antimicrobial resistance to several common antibiotics. MMWR Morb Mortal Wkly Rep. 2018 Apr 6;67(13): Vital Signs: Containment of Novel Multidrug-Resistant Organisms and Resistance Mechanisms - United States, 2006-2017. Although the proportion of Klebsiella spp. and E. coli that had either an ESBL or CRE phenotype both declined during 2006–2015, larger decreases and a lower overall percent resistant were observed for the CRE phenotype.

MMWR Morb Mortal Wkly Rep. 2018 Apr 6;67(13): Vital Signs: Containment of Novel Multidrug-Resistant Organisms and Resistance Mechanisms - United States, 2006-2017.

This difference might be attributable, at least in part, to the more directed response employed to slow the spread of CRE once it was identified. Although CDC’s containment approach had not yet been fully initiated when the decline in CRE began, these data suggest that an early aggressive response, as outlined in CRE-specific infection prevention recommendations released beginning in 2009 (6), can slow emergence and even decrease the occurrence of infections from resistant pathogens. As laboratory capacity improved, ARLN testing volume and public health responses increased over the first three quarters of 2017, demonstrating that recent investments in detection and response capacity are facilitating prompt identification of and response to emerging resistant organisms.

CDC_GOV - 2017 - Antibiotic use in the United States - Progress and opportunities. FDA 07/12/17 2016 SUMMARY REPORT On Antimicrobials Sold or Distributed for Use in Food-Producing Animals. CFA - CONSUMER FEDERATION OF AMERICA - OCT 2017 - Going Local: Initiatives to Reduce Antibiotics in the Food Supply. Infect Dis Clin North Am. 2016 Jun;30(2):377-390. Multidrug-Resistant Bacteria in the Community: Trends and Lessons Learned. CDC 03/08/17 Antibiotic Resistance Lab Network. About the AR Lab Network Established in 2016, CDC’s Antibiotic Resistance Laboratory Network (AR Lab Network) supports nationwide lab capacity to rapidly detect antibiotic resistance in healthcare, food, and the community, and inform local responses to prevent spread and protect people.

CDC 03/08/17 Antibiotic Resistance Lab Network

The AR Lab Network includes seven regional labs, the National Tuberculosis Molecular Surveillance Center (National TB Center), and labs in 50 states, six cities, and Puerto Rico. As a whole, the network tracks changes in resistance and helps identify and respond to outbreaks faster. AR Lab Network Regional Labs and the National TB Molecular Surveillance Center detect existing and emerging types of antibiotic resistance, track emerging resistance more effectively, and generate stronger data to protect people and combat future resistance threats. This ambitious approach transforms the nation’s laboratory landscape by establishing the much-needed infrastructure across the nation.

How the AR Lab Network Works. AASV 27/12/16 FDA Annual Summary Report on Antimicrobials Sold or Distributed in 2015 for Use in Food-Producing Animals. December 27, 2016 — The U.S.

AASV 27/12/16 FDA Annual Summary Report on Antimicrobials Sold or Distributed in 2015 for Use in Food-Producing Animals

Food and Drug Administration today published its annual report summarizing sales and distribution data for all antimicrobial drugs approved for use in food-producing animals. The report shows that sales and distribution of all antimicrobials increased 1 percent from 2014 through 2015, tying for the lowest annual increase since 2009. The percentage of those antimicrobials that are considered medically important in human medicine increased by 2 percent from 2014 through 2015. FDA 01/10/15 Présentation : Medically important antimicrobials in animal agriculture.

CDC EID - Volume 20, Number 12—December 2014. Au sommaire: Effects of Knowledge, Attitudes, and Practices of Primary Care Providers on Antibiotic Selection, United States. Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA Suggested citation for this article Abstract Appropriate selection of antibiotic drugs is critical to optimize treatment of infections and limit the spread of antibiotic resistance.

CDC EID - Volume 20, Number 12—December 2014. Au sommaire: Effects of Knowledge, Attitudes, and Practices of Primary Care Providers on Antibiotic Selection, United States

To better inform public health efforts to improve prescribing of antibiotic drugs, we conducted in-depth interviews with 36 primary care providers in the United States (physicians, nurse practitioners, and physician assistants) to explore knowledge, attitudes, and self-reported practices regarding antibiotic drug resistance and antibiotic drug selection for common infections. NIH 07/04/14 NIH Funding Opportunity Focuses on Diagnostics for Hospital-Based Antibacterial-Resistant Infections - Awards to Total up to $12 Million in 2015.

​The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, recently announced a research funding opportunity to develop and/or produce diagnostics to quickly detect the key bacteria responsible for antibacterial-resistant infections in hospital settings.

NIH 07/04/14 NIH Funding Opportunity Focuses on Diagnostics for Hospital-Based Antibacterial-Resistant Infections - Awards to Total up to $12 Million in 2015

NIAID expects to fund 10-15 awards for a total of up to $12 million in 2015. The maximum length of each award is 5 years. Drug-resistant bacterial infections are a growing worldwide problem, causing significant illness, death and healthcare cost. Many of these infections are acquired in hospitals and other healthcare settings, where rapid and sensitive testing for specific types of bacteria are needed to enable physicians to determine the most effective treatments to improve individual patient outcomes and help curb bacterial resistance.

Investigators from academic organizations are eligible to submit proposals, but must establish a partnership with an industrial organization. CDC - Antimicrobial Resistance Threat Report 2013. Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content Get Email Updates To receive email updates about this page, enter your email address: CDC EID – MAI 2014 – Au sommaire: Factors Associated with Antimicrobial Drug Use in Medicaid Programs. Author affiliations: University of Pennsylvania, Philadelphia, Pennsylvania, USA. SAVEANTIBIOTICS via TWITTER 18/06/14 INFOGRAPHIE sur l'usage des antibiotiques aux Etats-Unis. CDC EID - Volume 21, Number 9—September 2015. Au sommaire: Emerging Infections Program as Surveillance for Antimicrobial Drug Resistance ; Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S.K.

Fridkin, A.A. Cleveland, I. See); Minnesota Department of Public Health, St. Paul, Minnesota, USA (R. Lynfield) Suggested citation for this article Abstract Across the United States, antimicrobial drug–resistant infections affect a diverse population, and effective interventions require concerted efforts across various public health and clinical programs. The 1992 Institute of Medicine report Emerging Infections: Microbial Threats to Health in the United States describes the ability of microbes to adapt, the development of antimicrobial drug resistance, and the importance of recognizing and monitoring emerging microbial threats to human health (1).

CDC 09/06/15 The 2013 NARMS Annual Human Isolates Report. Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home CDC 24/7: Saving Lives. Protecting People. NIAA via SWINECAST 23/04/15 Where Are We With Antibiotics In Agriculture? FDA via SWINECAST 23/04/15 Antimicrobial FDA Perspective. JDLE 25/09/13 L’antibiorésistance tue chaque année 23.000 Américains. Les dangers de l'antibiorésistance précisés Les bactéries antibiorésistantes infectent chaque année au moins 2 millions d’Américains et en tuent 23.000, révèlent les centres de contrôle et de prévention des maladies (CDC) dans leur rapport 2013 sur le sujet. Outre son poids humain, l’antibiorésistance engendre un coût de santé annuel de 20 milliards de dollars (14,8 Md€), avec des pertes de productivité estimées à 35 Md$ (26 Md€). «Les antibiotiques constituent une ressource limitée, précieuse: plus nous les utilisons aujourd’hui, moins nous en aurons d’efficaces demain», rappelle Steve Solomon, directeur du bureau Antibiorésistance des CDC, dans un communiqué.

De plus en plus répandue, l’antibiorésistance est en effet liée à un usage abusif des antibiotiques. SCIENCES ET AVENIR 18/09/13 Les résistances aux antibiotiques tuent 23.000 américains par an. Aux USA, les empoisonnements par e-liquide augmentent. Mais restent six fois moindres qu'avec les cigarettes classiques. En France, une étude est lancée... Fabriquer des tissus et des organes humains, couche après couche, selon une technique dérivée de l'impression 3D, c'est la promesse de la bio-impression.

L'ex-ministre des sports et nouvelle secrétaire d'état au commerce est hospitalisée depuis vendredi. Prendre des suppléments de zinc permettrait de réduire la durée des symptômes du rhume de moitié. Une tétine-thermomètre pour suivre la température en continu de son enfant, sur son smartphone ou sa tablette. CDC 23/04/13 ANTIBIOTIC RESISTANCE THREATS in the United States, 2013. CIDRAP 16/09/13 CDC: Antibiotic-resistant bugs sicken 2 million a year. The US Centers for Disease Control and Prevention (CDC) said today that antibiotic-resistant pathogens sicken 2 million Americans a year and listed the three most urgent threats as Clostridium difficile, carbapenem-resistant Enterobacteriaceae (CRE), and Neisseria gonorrhoeae.

The agency's first all-encompassing report on antibiotic disease threats spans 114 pages and ranks the pathogens in part to spur a multipronged effort to prioritize and battle the problems. Antibiotic-resistant microorganisms play a role in 23,000 deaths each year, the CDC said. At a media briefing today, CDC Director Tom Frieden, MD, MPH, said the landmark report provides a snapshot of the antibiotic-resistant organisms that have the biggest impact on human health. He said the numbers are very conservative estimates that don't take into account infections that occur outside hospitals, such as nursing homes and dialysis centers. "The bottom line is stewardship," Frieden said. SCIENCES ET AVENIR 18/09/13 Les résistances aux antibiotiques tuent 23.000 américains par an. GAO - JUIN 2011 - ANTIBIOTIC RESISTANCE - Data Gaps Will Remain Despite HHS Taking Steps to Improve Monitoring. SOCIETY FOR HEALTHCARE EPIDEMIOLOGY OF AMERICA - Multi-Resistant Gram-Negative Bacteria. 2006 - Management of Multidrug-Resistant Organisms In Healthcare Settings, 2006 Jane D.

2009 - The Interagency Task Force on Antimicrobial Resistance and A Public Health Action Plan to Combat Antimicrobial Resi. 2011 Annual Report.