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Actualités perchlorate aux Etats-Unis

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Environment International Volume 164, June 2022, Associations of urinary perchlorate, nitrate and thiocyanate with central sensitivity to thyroid hormones: A US population-based cross-sectional study. 2.5. Statistical analysis Participants were categorized according to the quartiles of log-transformed urinary perchlorate, nitrate and thiocyanate. Continuous variables were expressed with weighted means and standard errors (SEs), and categorical variables were expressed with numbers and weighted proportions. Geometric means of urinary perchlorate, nitrate, thiocyanate, and iodine according to population characteristics were also calculated. Moreover, we estimated total daily perchlorate dose with method by Blount et al. (Blount et al., 2007), to compare the perchlorate exposure level in this study with those from previous clinical and worker studies (Lamm et al., 1999, Lawrence et al., 2000, Lawrence et al., 2001, Greer et al., 2002, Braverman et al., 2005, Braverman et al., 2006).

Pair-wise Spearman correlation coefficients were calculated to reveal the correlations among urinary perchlorate, nitrate, and thiocyanate. FOOD PACKAGING FORUM 01/11/19 FDA sued over perchlorate petition rejection. In an article published on October 30, 2019, by Chemical Watch, reporter Lisa Martine Jenkins informed that on October 29, 2019, “a group of six NGOs has filed a lawsuit against the U.S. Food and Drug Administration (FDA) over the agency’s denial of their petition to ban the use of perchlorate [in antistatic agents used] in food packaging.” The suit seeks “for the court to invalidate the petition denial and compel the FDA to reassess the issue.” Lisette van Vliet from Breast Cancer Prevention Partners said that it is “now time that the FDA answer in court for not protecting our health” (FPF reported). Perchlorate is suspected to harm brain development (FPF reported), thus being of particular concern with regards to child exposure (FPF reported). Read more. EDF_ORG 23/04/19 FDA refuses request to ban brain-damaging chemical from food packaging - Agency dodges accountability, missing chance to protect kids from the harm of perchlorate.

(Washington, D.C. – April 23, 2019) Today, the Food and Drug Administration (FDA) doubled-down on its flawed 2005 and 2017 decisions to allow the hazardous chemical, perchlorate, to be added to dry food packaging. FDA denied a request by Environmental Defense Fund, Natural Resources Defense Council, Breast Cancer Prevention Partners, Center for Environmental Health, Center for Science in the Public Interest, Center for Food Safety, Clean Water Action, Environmental Working Group, and Improving Kids’ Environment for a public hearing to challenge the agency’s conclusions. The group’s request had demonstrated both that the agency grossly underestimated the amount of perchlorate that gets into food from packaging and ignored its own studies showing young children’s exposure to the neurotoxin increased after its 2005 decision to allow the chemical’s use in food packaging.

“It is outrageous that FDA took almost two years to simply reaffirm its flawed interpretation of the law. Erik D. Journal of Exposure Science and Environmental Epidemiology volume 28, pages 21–30 (2018) Update on dietary intake of perchlorate and iodine from U.S. food and drug administration’s total diet study: 2008–2012. BLOG EDF 02/11/17 Little follow-up when FDA finds high levels of perchlorate in food. Tom Neltner, J.D., is Chemicals Policy Director and Maricel Maffini, Ph.D., Consultant FDA’s apparent lack of follow-up when faced with jaw-dropping levels of a toxic chemical in food is disturbing. For more than 40 years, the Food and Drug Administration (FDA) has conducted the Total Diet Study (TDS) to monitor levels of approximately 800 pesticides, metals, and other contaminants, as well as nutrients in food.

The TDS’s purposes are to “track trends in the average American diet and inform the development of interventions to reduce or minimize risks, when needed.” By combining levels of chemicals in food with food consumption surveys, the TDS data serve a critical role in estimating consumers’ exposure to chemicals. From 2004 to 2012 (except for 2007), FDA collects and tests about 280 food types for perchlorate, a chemical known to disrupt thyroid hormone production. FDA’s Q&A webpage masks the most disturbing part of the story FDA’s response to the FOIA raises concerns. Conclusion. Toxicology and Applied Pharmacology Volume 322, 1 May 2017 Evaluation of the risk of perchlorate exposure in a population of late-gestation pregnant women in the United States: Application of probabilistic biologically-based dose response modeling. Highlights Probabilistic risk assessment for perchlorate in U.S. pregnant women was conducted. No significant change in maternal fT4 predicted due to perchlorate from food alone.

Drinking water concentration allowance for perchlorate estimated as 7.6–9.2 μg/L Abstract The risk of ubiquitous perchlorate exposure and the dose-response on thyroid hormone levels in pregnant women in the United States (U.S.) have yet to be characterized. In the current work, we integrated a previously developed perchlorate submodel into a recently developed population-based pregnancy model to predict reductions in maternal serum free thyroxine (fT4) levels for late-gestation pregnant women in the U.S.

Keywords Perchlorate; Biologically based dose-response modeling; Probabilistic risk assessment Choose an option to locate/access this article: EPA 30/01/17 Perchlorate in Drinking Water Frequent Questions. On this page: Where is perchlorate found? Perchlorate occurs naturally in arid states in the Southwest United States, in nitrate fertilizer deposits in Chile, and in potash ore in the United States and Canada. It also forms naturally in the atmosphere. Perchlorate can be manufactured and used as an industrial chemical and can be found in rocket propellant, explosives, fireworks and road flares.

It has also been found in some public drinking water systems and in food. Why is perchlorate in drinking water a health concern? Perchlorate can disrupt the normal function of the thyroid gland in both children and adults. How does perchlorate get into my drinking water? Perchlorate dissolves easily, is relatively stable and is mobile in water. Besides drinking water, how else can people be exposed to perchlorate? People are exposed to perchlorate primarily through eating contaminated food or drinking water. How do I know if perchlorate is in my water? Can perchlorate be boiled out of my water? ENVIRONMENTAL DEFENSE FUND 15/12/16 Perchlorate regulation: Critical opportunities for EPA and FDA to protect children’s brains.

Tom Neltner, J.D., is Chemicals Policy Director All Americans who have been tested have perchlorate in their bodies. Perchlorate threatens fetal and child brain development by impairing the thyroid’s ability to transport iodine in the diet into the gland to make a thyroid hormone, known as T4, that is essential to brain development. Both the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) are scheduled to make decisions in 2017 that could significantly reduce exposure to this hazardous chemical. Based on statements in a new report by EPA, we estimate that at least 20% of pregnant women are already iodine deficient, resulting in T4 levels that put the fetuses’ developing brains at risk. For this population of pregnant women, any perchlorate exposure results in an even greater risk of impaired brain development in their children and potentially a lifetime of behavioral and learning difficulties. ENVIRONMENTAL DEFENSE FUND 27/01/17 Too many young children get too much perchlorate from food.

Tom Neltner, J.D., is Chemicals Policy Director and Maricel Maffini, Ph.D., Consultant On January 9, we described a new Food and Drug Administration (FDA) report showing that perchlorate exposure to infants and toddlers increased 34% and 23% respectively between the years around 2005 and 2010. Young children were the most exposed age groups. FDA compared the exposure to a “safe dose” established in 2005 and saw no cause for concern. We respectfully disagree and find the levels alarming. First, we now know that the 2005 “safe dose” is no longer sufficient to protect children’s brains from the irreversible harm that can result from even transient exposures to perchlorate.

Perchlorate and the brain Perchlorate interferes with the thyroid gland’s ability to use iodine from the diet, a critical element to make a thyroid hormone, known as T4. Perchlorate is not the only chemical in the diet that disrupts the function of the thyroid gland. WATER AND WASTEWATER 17/08/11 EPA Seeks Input Drinking Water Perchlorate Regulation. Washington, DC -- The U.S. Environmental Protection Agency (EPA) is inviting small businesses, governments, and not-for-profit organizations to participate as small entity representatives (SERs) for a small business advocacy review (SBAR) Panel.

This panel will focus on the agency’s development of a rule that proposes to regulate the amount of perchlorate, a potentially harmful chemical, in drinking water. Federal law requires agencies to establish an SBAR Panel for rules that may have a significant economic impact on a substantial number of small entities. Perchlorate is both a naturally occurring and man-made chemical that is used to produce rocket fuel, fireworks, flares and explosives. Perchlorate can also be present in bleach and in some fertilizers. EPA has determined that perchlorate meets the Safe Drinking Water Act’s three criteria for regulating a contaminant.

EPA seeks self-nominations directly from the small organizations that may be subject to the rule requirements. JDLE 03/02/11 L’EPA va réglementer les taux de perchlorate dans l’eau. L’Agence américaine de protection de l’environnement (EPA) a annoncé mercredi 2 février qu’elle allait mettre en place une réglementation pour le perchlorate et 16 substances chimiques toxiques dans l’eau potable. Cette décision va à rebours de celle prise par l’administration précédente en octobre 2008 (voir le JDLE). S’appuyant sur une analyse de la littérature scientifique, l’EPA n’avait alors pas jugé nécessaire d’établir une norme de sécurité pour le perchlorate, une substance utilisée dans la production de carburants de fusées, d’explosifs militaires, de feux d’artifice mais aussi dans certains engrais et agents de blanchiment. L’EPA a pris sa décision d’élaborer, pour la première fois, une norme sanitaire pour le perchlorate, suite à une nouvelle évaluation des recherches scientifiques lancée en 2010.

Celle-ci a conclu que la substance peut altérer le fonctionnement de la thyroïde dont la production d’hormones est essentielle au développement du fœtus et des enfants.