Toxicology and Applied Pharmacology Volume 322, 1 May 2017 Evaluation of the risk of perchlorate exposure in a population of late-gestation pregnant women in the United States: Application of probabilistic biologically-based dose response modeling. Highlights Probabilistic risk assessment for perchlorate in U.S. pregnant women was conducted.
No significant change in maternal fT4 predicted due to perchlorate from food alone. Drinking water concentration allowance for perchlorate estimated as 7.6–9.2 μg/L Abstract The risk of ubiquitous perchlorate exposure and the dose-response on thyroid hormone levels in pregnant women in the United States (U.S.) have yet to be characterized. Keywords Perchlorate; Biologically based dose-response modeling; Probabilistic risk assessment Choose an option to locate/access this article: EPA 30/01/17 Perchlorate in Drinking Water Frequent Questions. On this page: Where is perchlorate found?
Perchlorate occurs naturally in arid states in the Southwest United States, in nitrate fertilizer deposits in Chile, and in potash ore in the United States and Canada. It also forms naturally in the atmosphere. Perchlorate can be manufactured and used as an industrial chemical and can be found in rocket propellant, explosives, fireworks and road flares. ENVIRONMENTAL DEFENSE FUND 15/12/16 Perchlorate regulation: Critical opportunities for EPA and FDA to protect children’s brains. Tom Neltner, J.D., is Chemicals Policy Director All Americans who have been tested have perchlorate in their bodies.
Perchlorate threatens fetal and child brain development by impairing the thyroid’s ability to transport iodine in the diet into the gland to make a thyroid hormone, known as T4, that is essential to brain development. Both the Environmental Protection Agency (EPA) and the Food and Drug Administration (FDA) are scheduled to make decisions in 2017 that could significantly reduce exposure to this hazardous chemical. Based on statements in a new report by EPA, we estimate that at least 20% of pregnant women are already iodine deficient, resulting in T4 levels that put the fetuses’ developing brains at risk. ENVIRONMENTAL DEFENSE FUND 27/01/17 Too many young children get too much perchlorate from food. Tom Neltner, J.D., is Chemicals Policy Director and Maricel Maffini, Ph.D., Consultant On January 9, we described a new Food and Drug Administration (FDA) report showing that perchlorate exposure to infants and toddlers increased 34% and 23% respectively between the years around 2005 and 2010.
Young children were the most exposed age groups. FDA compared the exposure to a “safe dose” established in 2005 and saw no cause for concern. We respectfully disagree and find the levels alarming. First, we now know that the 2005 “safe dose” is no longer sufficient to protect children’s brains from the irreversible harm that can result from even transient exposures to perchlorate. Perchlorate and the brain Perchlorate interferes with the thyroid gland’s ability to use iodine from the diet, a critical element to make a thyroid hormone, known as T4. Perchlorate is not the only chemical in the diet that disrupts the function of the thyroid gland. WATER AND WASTEWATER 17/08/11 EPA Seeks Input Drinking Water Perchlorate Regulation.
Washington, DC -- The U.S.
Environmental Protection Agency (EPA) is inviting small businesses, governments, and not-for-profit organizations to participate as small entity representatives (SERs) for a small business advocacy review (SBAR) Panel. This panel will focus on the agency’s development of a rule that proposes to regulate the amount of perchlorate, a potentially harmful chemical, in drinking water.
Federal law requires agencies to establish an SBAR Panel for rules that may have a significant economic impact on a substantial number of small entities. Perchlorate is both a naturally occurring and man-made chemical that is used to produce rocket fuel, fireworks, flares and explosives. Perchlorate can also be present in bleach and in some fertilizers. EPA has determined that perchlorate meets the Safe Drinking Water Act’s three criteria for regulating a contaminant. EPA seeks self-nominations directly from the small organizations that may be subject to the rule requirements. Source: JDLE 03/02/11 L’EPA va réglementer les taux de perchlorate dans l’eau. L’Agence américaine de protection de l’environnement (EPA) a annoncé mercredi 2 février qu’elle allait mettre en place une réglementation pour le perchlorate et 16 substances chimiques toxiques dans l’eau potable.
Cette décision va à rebours de celle prise par l’administration précédente en octobre 2008 (voir le JDLE). S’appuyant sur une analyse de la littérature scientifique, l’EPA n’avait alors pas jugé nécessaire d’établir une norme de sécurité pour le perchlorate, une substance utilisée dans la production de carburants de fusées, d’explosifs militaires, de feux d’artifice mais aussi dans certains engrais et agents de blanchiment. L’EPA a pris sa décision d’élaborer, pour la première fois, une norme sanitaire pour le perchlorate, suite à une nouvelle évaluation des recherches scientifiques lancée en 2010.
Celle-ci a conclu que la substance peut altérer le fonctionnement de la thyroïde dont la production d’hormones est essentielle au développement du fœtus et des enfants.