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LA CLINICA TERAPEUTICA 14/02/19 Clostridium difficile. A review on an emerging infection. CONTAGIONLIVE 23/12/20 C. Difficile: Are We Making Progress? Clostridioides difficile is an anaerobic, spore-forming, toxin-producing gram-positive rod that has been identified as a cause of antibiotic-associated colitis.

CONTAGIONLIVE 23/12/20 C. Difficile: Are We Making Progress?

Over the last decade, the frequency and severity of C. difficile infection (CDI) has been increasing worldwide, and it is now one of the most common hospital-acquired infections. We have more reliable surveillance CDI data from the Centers for Disease Control and Prevention (CDC) in part because C. difficile became a reportable infection for all healthcare facilities participating in Medicare and Medicaid since 2013. The North American pulsed-field gel electrophoresis type 1 (NAP1) strain of C. difficile, also known as ribotype 027, is one of several described hypervirulent strains. The NAP1 strain has been implicated in outbreaks for almost 20 years.6 Most pathogenic strains of C. difficile produce two toxins, an enterotoxin tcdA and a cytotoxin tcdB. Charles R. References CDC. MICROORGANISMS 10/10/19 Characterization of the Immune Response during Infection Caused by Clostridioides difficile. The high risk of complications and death following Clostridioides difficile infection (CDI) requires identifying patients with severe disease and treating them accordingly.

MICROORGANISMS 10/10/19 Characterization of the Immune Response during Infection Caused by Clostridioides difficile

We characterized the immune response of CDI patients in relation to infection severity. Concentrations of 28 cytokines and chemokines were measured in serum samples, obtained from 54 CDI patients within a median timeframe of 24–48 h after laboratory confirmation of C. difficile infection. Demographic and clinical data were retrospectively collected from medical records. Disease severity score was determined by “Score indices for Clostridioides difficile infection severity”. Of 54 patients (mean age, 76.6 years, 61.1% female), 38 (70.4%) had mild disease and 16 (29.6%) had moderate disease. NATURE 18/01/18 Dietary trehalose enhances virulence of epidemic Clostridium difficile. Cochrane Database Syst Rev. 2017 Dec 19; Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.

Plain language summary The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use What is Clostridium difficile-associated diarrhea?

Cochrane Database Syst Rev. 2017 Dec 19; Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.

Antibiotics are among the most prescribed medications worldwide. Antibiotic treatment may disturb the balance of organisms that normally populate the gut. This can result in a range of symptoms, most notably, diarrhea. What are probiotics? Probiotics are live organisms (bacteria or yeast). thought to improve the balance of organisms that populate the gut, counteracting potential disturbances to the gut microbial balance that are associated with antibiotic use, and reducing the risk of colonization by pathogenic bacteria.

What did the researchers investigate? The researchers investigated whether probiotics prevent CDAD in adults and children receiving antibiotic therapy and whether probiotics causes any harms (side effects). What did the researchers find? Résumé simplifié. GEORGIA STATE UNIVERSITY - 2015 - Thèse en ligne : Effect of probiotics in the mitigation of Clostridium difficile associated disease. Toxins 2016, 8(5), 153; The Regulatory Networks That Control Clostridium difficile Toxin Synthesis. One of the most important groups of environmental cues that control toxin production is likely to be nutritional signals, such as carbon sources or certain amino acids.

Toxins 2016, 8(5), 153; The Regulatory Networks That Control Clostridium difficile Toxin Synthesis

Different combinations of carbon sources that can be used by C. difficile to produce energy are available in culture media, which makes difficult the study of the detailed role of a particular substrate on toxin formation. It is likely that complex analysis to follow the temporal use and degradation pathways of the different carbon sources would help to further our knowledge of the regulatory network controlling toxin production [74].

However, despite this limit, addition of single substrates in culture media led to the emergence of an understanding of the associated regulatory mechanisms. The presence of glucose or other rapidly metabolizable carbon sources in a complex growth medium represses toxin production independently of the pH changes due to the glucose metabolism [19,22]. BMC SYSTEMS BIOLOGY 16/02/17 Making life difficult for Clostridium difficile: augmenting the pathogen’s metabolic model with transcriptomic and codon usage data for better therapeutic target characterization. Clostridium difficile is a gram-positive, spore-forming, anaerobic bacterium, which infects or colonizes various animal species.

BMC SYSTEMS BIOLOGY 16/02/17 Making life difficult for Clostridium difficile: augmenting the pathogen’s metabolic model with transcriptomic and codon usage data for better therapeutic target characterization

Clinical manifestations in humans range from asymptomatic colonization to mild diarrhea, pseudomembranous colitis, and death [1]. Infection by this bacterium is associated not only with significant patient morbidity and mortality, but also with a large economic burden for healthcare systems [2]. Clinical Microbiology and Infection Available online 7 February 2018 New insights into transmission of Clostridium difficile infection—narrative review. JavaScript is disabled on your browser.

Clinical Microbiology and Infection Available online 7 February 2018 New insights into transmission of Clostridium difficile infection—narrative review

Please enable JavaScript to use all the features on this page. Abstract Background Traditionally, Clostridium difficile has been considered a typical healthcare-associated pathogen—that is, one transmitted within healthcare facilities and thus prevented by implementation of standard infection control measures. Recently this concept has been challenged by studies suggesting a relevant role for community acquisition of C. difficile. Aims To discusses the current literature, compiled during the last decade, reporting on sources of acquisition of C. difficile and subsequent transmission. Sources The databases PubMed, Medline, Embase and the Cochrane Database were searched for articles published from 1 January 2007 to 30 June 2017 reporting on possible transmission pathways of C. difficile and/or suggesting a source of acquisition of C. difficile.

Content Implications Keywords. PLOS 16/05/17 Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses. Abstract Background.

PLOS 16/05/17 Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses

Alimentary Pharmacology & Therapeutics 30/03/11 Increased health burden associated with Clostridium difficile diarrhoea in patients with inflammatory bowel disease. NATURE - JUILLET 2009 - Clostridium difficile infection: new developments in epidemiology and pathogenesis. Journal of Medical Microbiology (2012), 61, 169–179 Clostridium difficile: a problem of concern in developed countries and still a mystery in Latin America. 4th international Clostridium difficile symposium - 20th to 22nd September 2012 - Bled - Slovenija - Résumés en ligne.

Ther Adv Infect Dis. 2016 Feb; 3(1): 23–42. Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection. PLOS 16/05/17 Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses. Journal of the Formosan Medical Association Volume 114, Issue 7, July 2015 Occurrence of Clostridium difficile in two types of wastewater treatment plants. Wastewater is a potential environmental source of Clostridium difficile, although a direct link with community-acquired C. difficile infection (CA-CDI) in humans has not yet been established.

Journal of the Formosan Medical Association Volume 114, Issue 7, July 2015 Occurrence of Clostridium difficile in two types of wastewater treatment plants

The present study was performed to determine the occurrence of C. difficile in two types of wastewater treatment plants (WWTPs) in Isfahan, Iran. A total of 95 samples were taken from a conventional activated sludge treatment plant and a waste stabilization ponds system, and analyzed for the presence of C. difficile. EUROSURVEILLANCE 21/07/16 Survey of Clostridium difficile infection surveillance systems in Europe, 2011.

A Kola 1 , C Wiuff 2 , T Akerlund 3 , BH van Benthem 4 , B Coignard 5 , O Lyytikäinen 6 , D Weitzel-Kage 1 , C Suetens 7 , MH Wilcox 8 9 , EJ Kuijper 10 , P Gastmeier 1 , on behalf of members of ECDIS-Net 11 + Author affiliations Citation style for this article: Kola A, Wiuff C, Akerlund T, van Benthem BH, Coignard B, Lyytikäinen O, Weitzel-Kage D, Suetens C, Wilcox MH, Kuijper EJ, Gastmeier P, on behalf of members of ECDIS-Net.

EUROSURVEILLANCE 21/07/16 Survey of Clostridium difficile infection surveillance systems in Europe, 2011.

BIOMED - 2012 - Outcome of ICU patients with Clostridium difficile infection. NEJM - 2015 - Burden of Clostridium difficile Infection in the United States. Background The magnitude and scope of Clostridium difficile infection in the United States continue to evolve.

NEJM - 2015 - Burden of Clostridium difficile Infection in the United States

Methods In 2011, we performed active population- and laboratory-based surveillance across 10 geographic areas in the United States to identify cases of C. difficile infection (stool specimens positive for C. difficile on either toxin or molecular assay in residents ≥1 year of age). Cases were classified as community-associated or health care–associated.

In a sample of cases of C. difficile infection, specimens were cultured and isolates underwent molecular typing. Results A total of 15,461 cases of C. difficile infection were identified in the 10 geographic areas; 65.8% were health care–associated, but only 24.2% had onset during hospitalization. Conclusions C. difficile was responsible for almost half a million infections and was associated with approximately 29,000 deaths in 2011. Source Information The authors' affiliations are listed in the Appendix. Cienc. Rural vol.43 no.1 Santa Maria Jan. 2013 Epub Nov 22, 2012 Clostridium difficile infection: main features and occurrence i. Clostridium difficile infection: main features and occurrence in domestic species in Brazil Infecção por Clostridium difficile: principais características e ocorrência em animais domésticos no Brasil Rodrigo Otávio Silveira SilvaI; Roberto Maurício de Carvalho GuedesI; Francisco Carlos Faria LobatoI, 1 IEscola de Veterinária, Universidade Federal de Minas Gerais (UFMG), 30123-970, Belo Horizonte, MG, Brasil.

Cienc. Rural vol.43 no.1 Santa Maria Jan. 2013 Epub Nov 22, 2012 Clostridium difficile infection: main features and occurrence in domestic species in Brazil – guatemalt

E-mail: lobato.francisco@yahoo.com.br. Prevalence of Clostridium difficile colonization among healthcare workers. Veterinary World - 2013 - Detection of toxigenic Clostridium difficile in powdered infant and follow-up formulae in Egypt. J Infect Dis. (2013) Overlapping Roles for Toxins in Clostridium difficile Infection. Can J Infect Dis Med Microbiol. 2012 Spring; 23(1): 28–30. Detection of Clostridium difficile in retail ground meat products i. Antimicrobial Resistance and Infection Control 2013, 2:21 Epidemiology of Clostridium difficile infection in Asia.

FOOD TECHNOLOGY - 2012 - Clostridium difficile: An emerging food safety risk. CDC EID – OCT 2012 – Attributing Cause of Death for Patients with Clostridium difficile Infection. Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home CDC 24/7: Saving Lives. Protecting People.™ <div class="noscript"> Note: Javascript is disabled or is not supported by your browser.

The Journal of hospital infection - 2010, vol. 75, no4, pp. 287-291 - Infection due to C. difficile ribotype 078: first report o. Titre du document / Document title Auteur(s) / Author(s) Affiliation(s) du ou des auteurs / Author(s) Affiliation(s) (1) Department of Clinical Microbiology, Beaumont Hospital, Dublin, IRLANDE(2) Health Protection Surveillance Centre, Dublin, IRLANDE(3) Department of Microbiology, Leeds Teaching Hospitals & University of Leeds, Leeds General Infirmary, Leeds, ROYAUME-UNI.

Toxins 2010, 2(7), 1848-1880; The Enterotoxicity of Clostridium difficile Toxins. J Antimicrob Chemother 2012; 67: 742–748 Time interval of increased risk for Clostridium difficile infection after exposure to a. Infectious Diseases in Obstetrics and Gynecology Volume 2011 (2011), The Emergence of Clostridium difficile Infection among Peri. BELGIAN INFECTION CONTROL SOCIETY / INSTITUT SCIENTIFIQUE DE SANTE PUBLIQUE - SEPT 2011 - Surveillance des infections à Clostrid.

ANAEROBE 29/09/10 Analysis of prevalence, risk factors and molecular epidemiology of Clostridium difficile infection in Kuwait o. Abstract We conducted a prospective study to evaluate the prevalence and epidemiology of CDI in Kuwait government hospitals over a 3-year period, January 2003 to December 2005, to determine the ribotypes responsible for CDI and to estimate the prevalence of ribotype 027. We also conducted a case-control study to identify the risk factors in our patient population. A total of 697 stool samples from patients with suspected CDI were obtained and sent to Anaerobe Reference Laboratory, Faculty of Medicine, Kuwait University for Clostridium difficile toxin detection, culture and PCR ribotyping. During the period, 73 (10.5%) out of 697 patients met the case definition of CDI. Of these, 56 (76.7%) were hospital-acquired and 17 (23.3%) were from outpatient clinics. Keywords. Zoonoses and Public Health 24/09/10 The Ecology and Pathobiology of Clostridium difficile Infections: An Interdisciplinary Chall.

STATENS SERUM INSTITUT (Danemark) - MAI 2010 - Clostridium difficile increase. About diseases and vaccines No 18 - 2010 Methicilin-resistant Staphylococcus aureus (MRSA) 2009. WIKIPEDIA ANGLOPHONE - Clostridium difficile.