Environment International Volume 144, November 2020, Using assessment criteria for pesticides to evaluate the endocrine disrupting potential of non-pesticide chemicals: Case butylparaben. Ahn et al., 2012 H.J.
Ahn, B.S. An, E.M. Jung, H. Yang, K.C. Mol. Aker et al., 2019 A.M. Environ. Boberg et al., 2016 J. Toxicol. Boberg et al., 2010 J. Reprod. Brand et al., 2017 W. National Institute for Public Health and the Environment, Bilthoven, The Netherlands (2017) Charles and Darbre, 2013 A.K. J. Int. J. Environ. Res. Public Health 05/08/20 Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor. 1.
Résumé traduit : Dans cette étude, trois pesticides, le glyphosate, le thiaclopride et l'imidaclopride, ont été testés pour leur capacité à interférer avec la biosynthèse et / ou la signalisation des œstrogènes, afin d'évaluer leur action potentielle en tant que perturbateurs endocriniens. Parmi les composés testés, seul le glyphosate inhibe l'activité aromatase (jusqu'à 30%) via une inhibition non compétitive ou un mécanisme d'inhibition mixte selon la concentration appliquée. Ensuite, la capacité des trois pesticides à induire une activité oestrogénique a été testée dans des cellules MELN. Comparés au 17β-estradiol, le thiaclopride et l'imidaclopride ont induit une activité œstrogénique aux concentrations les plus élevées testées avec une puissance relative de 5,4 × 10−10 et 3,7 × 10−9, respectivement. La dynamique moléculaire et les simulations d'amarrage ont prédit les sites de liaison potentiels et le mode de liaison des trois pesticides sur la structure des deux cibles clés, fournissant une justification de leur mécanisme en tant que perturbateurs endocriniens. Les résultats démontrent que les trois pesticides sont des perturbateurs endocriniens potentiels car le glyphosate agit comme un inhibiteur de l'aromatase, tandis que l'imidaclopride et le thiaclopride peuvent interférer avec la signalisation induite par les œstrogènes. – guatemalt
Introduction Under the modern lifestyle, humans are exposed to various chemicals such as pesticide residuals in fruits and vegetables, antibiotics in meat and milk, preservatives in cosmetics and personal care products [1,2].
These chemicals are usually in low doses and may not have a short term significant impact on the human body, but they can cause long term damages to health . The effects of low-dose compounds on human health are mainly related to the endocrine system [4,5,6]. These compounds can in fact mimic or influence the action of endogenous hormones through various mechanisms, being therefore referred to as endocrine disrupting chemicals (EDCs) [7,8].
The modern industrial and agricultural system relies heavily on pesticides. The intensive use of glyphosate-based herbicides and neonicotinoid insecticides has caused the contamination of soil, water, air, and agricultural products [23,24,25,26,27,28]. Aromatase catalyzes the transformation of androgens to estrogens . EFSA 04/05/20 Data collection in support of the Endocrine Disruption (ED) assessment for non‐target vertebrates. To harmonise vertebrate OECD Test Guidelines for endocrine disruption testing between mammalian and non‐mammalian test species, additional Estrogen, Androgen, Thyroid and Steroidogenesis (EATS) modality endpoints in non‐mammalian models need to be assessed.
These would mean for example the addition of hormonal measurements in fish, birds and amphibians. Furthermore, a better reporting of gross pathology findings for birds would also be considered advantageous for the assessment of endocrine disrupting properties.To facilitate adoption of additional measures, guidance on how to perform, report and evaluate these new endpoints is required. In this report, a variety of methods including a systematic evidence map, an extensive literature review and a survey of ecotoxicology laboratories were adopted to collect data on the topic. PARLEMENT EUROPEEN - Réponse à question E-002747-19 Endocrine disrupting chemicals. The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 4, 1 April 2015, Neurobehavioral Deficits, Diseases, and Associated Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union.
You can change your cookie settings at any time. <a href=" Find out more</a> Skip to Main Content Sign In Register Close Advanced Search Article Navigation Volume 100 Issue 4 1 April 2015 Article Contents. PARLEMENT EUROPEEN - Réponse à question E-002846-18 Criteria for endocrine disruptors in cosmetics and food contact materials. EFSA 23/07/18 Outcome of the different consultations on the Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No. 528/2012 and (EC) No. 1107/2009.
FAS USDA 11/07/18 Commission Roadmap for Endocrine Disruptors_Brussels USEU_EU-28_7-6-2018. EUCHEMICALS VIA YOUTUBE 26/06/18 Le webinaire de @EU_ECHA sur l'application des critères d'identification des #perturbateursendocriniens pour les produits biocides est disponible en vidéo (en anglais) EFSA 07/06/18 Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009. FAS USDA 01/05/18 Criteria to Identify Endocrine Disruptors Published_Brussels USEU_EU-28_4-26-2018. FAS USDA 12/01/18 Endocrine Disruptor Criteria for Plant Protection Products Adopted_Brussels USEU_Belgium EU-28_1-9-2018. PARLEMENT EUROPEEN - Réponse à question E-006307/2017 Exemptions for endocrine disruptors.
Parliament has just rejected the Commission proposal for a regulation amending Annex II to Regulation (EC) No 1107/2009 by setting out scientific criteria for the determination of endocrine disrupting properties.
Its position was based on legal and scientific opinions from a number of organisations (the Endocrine Society, the European Society of Endocrinology, the European Society for Paediatric Endocrinology and the Centre for International Environmental Law, among others) which have stated that the Commission has gone far beyond the powers granted to it under Regulation (EC) No 1107/2009 concerning the placing of plant protection products on the market. The opinions also stated that the proposal for a regulation calls into question the Commission’s own public health objectives, which are implicit in Regulation (EC) No 1107/2009, by clearing the way for the wider use of herbicides such as glyphosate.
On what studies did the Commission base its regulation exemptions? PARLEMENT EUROPEEN - Réponse à question P-004896-17 Critères scientifiques pour la détermination de propriétés de perturbation endocrinienne. PARLEMENT EUROPEEN - Réponse à question P-004397-17 Parliament's position on the endocrine disruptor criteria derogation. EUROPE 04/07/17 Endocrine disruptors: major step towards protecting citizens and environment. Commissioner for Health and Food Safety, Vytenis Andriukaitis, said: "Today's vote represents our determination to devise a real EU policy on endocrine disruptors.
After months of discussion we are advancing in the direction of the first regulatory system in the world with legally binding criteria to define what an endocrine disruptor is. This is a great success. Once implemented, the text will ensure that any active substance used in pesticides which is identified as an endocrine disruptor for people or animals can be assessed and withdrawn from the market. We now count on the support of the European Parliament and the Council, involved in the decision making process, for a smooth adoption and entry into force of the criteria.
" EUROPE 04/07/17 Endocrine disruptors - Frequently Asked Questions. What has been voted on today?
The Member States voted in favour of the draft criteria to define endocrine disruptors in the area of plant protection products (PPPs) proposed by the European Commission after several discussions between the Commission and the Member States in a Standing Committee. Are the scientific criteria protective enough for human health and the environment? The scientific criteria identify known and presumed endocrine disruptors and evidence from animal, in-vitro or in-silico studies can be used to identify a substance as endocrine disruptor. They are based on the World Health Organisation's (WHO) definition of an endocrine disruptor that has gathered a wide consensus among scientists, Member States and stakeholders. The criteria will apply after a short transitional period of 6 months.
The Commission went beyond presenting criteria to identify endocrine disruptors for human health and also presented criteria protecting the environment. How will the criteria be applied? PARLEMENT EUROPEEN - Réponse à question E-002936-17 Regulations on the identification of substances that impair the functioning of the endocrine system. PARLEMENT EUROPEEN - Réponse à question E-000697-17 The Commission's legal proposal on endocrine disruptors. PARLEMENT EUROPEEN - Réponse à question P-000861-17 Scientific criteria for endocrine-disrupting properties — modification of derogation in the basic act — reference to EFSA. In June 2016, the Commission adopted a draft proposal on scientific criteria for the determination of endocrine-disrupting properties.
As part of this, the Commission also proposed to change a derogation laid down in the basic act on pesticides. The Legal Service of the European Parliament clearly considers that the Commission would exceed its mandate with this proposal. There is another major problem with the Commission’s proposal. One key reason used by the Commission to justify the modification of the derogation from ‘negligible exposure’ to ‘negligible risk’ is an opinion by the European Food Safety Authority (EFSA) of February 2013, according to which endocrine disruptors may be assessed like most other substances of concern via a risk assessment. PARLEMENT EUROPEEN - Réponse à question E-000039-17 Endocrine-disrupting chemicals containing components that are used in pest control under CETA. Unlike the European Union, Canada applies a risk-based approach, instead of a precautionary approach.
The Canadian approach appears to be less cautious with regard to human health and the environment and is not consistent with the high level of protection demanded by the approach of precautionary and preventive actions, as described in Article 191 of TFEU. Canada has repeatedly criticised the approach relating to the EU’s plans to protect people and the environment against endocrine-disrupting chemicals by stating that this approach ‘would unduly impede trade’.
CETA encourages regulatory cooperation and the recognition of equivalent measures in the field of pest control management. Article 5.6.1 of CETA provides that the EU shall approve SPS measures which are equivalent to its own, provided that they ensure an ‘appropriate level’ of protection. ANNALS OF THE NATIONAL INSTITUTE OF HYGIENE - 2014 - Endocrine disruptors in food contact materials; is there a health threat? Ciênc. saúde coletiva vol.21 no.3 Rio de Janeiro Mar. 2016 Impact on human health of endocrine disruptors present in environmental water bodies: is there an association with obesity? Nature Reviews Endocrinology. 07/2010 Environmental causes of cancer: endocrine disruptors as carcinogens. You are using an outdated version of Firefox which is not supported by ResearchGate anymore.
Sweden initiated proceedings against the Commission in July 2014 for failure to adopt a delegated act with scientific criteria for identifying endocrine disrupting substances within the deadline set out in the Biocides Regulation. According to the Regulation the Commission should adopt the delegated act no later than 13 December 2013. The Commission has the necessary supporting data to adopt the delegated act. The judgement of this case concerns the obligation on the Commission to adopt a delegated act in accordance with the Biocides Regulation. NORDEN - 2014 - The Cost of Inaction - A socioeconomic analysis of costs linked to effects of endocrine disrupting substances on male reproductive health. EUROPE 23/07/15 Report on Public consultation on defining criteria for identifying endocrine disruptors in the context of the implementation of the Plant Protection Product Regulation and Biocidal Products Regulation.
Chemosphere Volume 139, November 2015, Dietary exposure to endocrine disrupting chemicals in metropolitan population from China: A risk assessment based on probabilistic approach. PARLEMENT EUROPEEN 09/03/15 MEPs to grill Commission over delays in tackling hormone-disrupting chemicals. Growing worries that endocrine disruptors can damage your health will be raised in MEPs’ questions to health Commissioner Vytenis Andriukaitis on Monday at 19.00. Scientists link these chemicals, present in many everyday products, to a rise in foetal and genital abnormalities, cancer and infertility. MEPs will ask the Commission to explain delays in delivering criteria for identifying and categorizing these chemicals, which they say it had a legal duty to do by December 2013. In a resolution voted in March 2013, MEPs urged the EU to act to reduce exposure to these chemicals, which scientists link to a recent rise in cases of impaired sperm quality, early onset of puberty, certain cancers and other disorders.
The Council of Ministers decided last month to back Sweden in taking the European Commission to the Court of Justice for failure to act over the chemicals, found in products ranging from pesticides to toys, medical devices and cosmetics. NATIONAL FOOD INSTITUTE (DK) 18/03/15 Paper and board food packaging contains endocrine active chemicals. For paper and board food packaging only little regulation and legislation exists, and the composition of the packaging is in many cases unknown for the consumer and the authorities. A PhD project at the National Food Institute, Technical University of Denmark, shows that paper and board food packaging contain well-known and new endocrine active chemicals. Food packaging constitutes a potential source of chemical contamination of food products, and in this way humans may be exposed to these chemicals. Bisphenol A is used in such plastic packaging as cans and plastic bottles but is also present in some paper and board packaging made from recycled paper.
Indian J Med Res 140 (Supplement), November 2014, pp 29-35 Environmental & lifestyle factors in deterioration of male reproductive health. FRONTIERS IN ENVIRONMENTAL SCIENCE 17/02/15 Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system. Keywords: endocrine disrupting chemicals (EDCs), bisphenol A (BPA), nonylphenol (NP), phthalates, Testicular Dysgenesis Syndrome (TDS) Citation: De Falco M, Forte M and Laforgia V (2015) Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system. Front. Environ. Sci. 3:3. doi: 10.3389/fenvs.2015.00003 Received: 29 November 2014; Accepted: 14 January 2015; Published online: 17 February 2015. Copyright © 2015 De Falco, Forte and Laforgia. *Correspondence: Maria De Falco, Section of Evolutionary and Comparative Biology, Department of Biology, Via Mezzocannone, 8 80134 Naples, Italy e-mail: email@example.com.
Asian Journal of Andrology (2010) 12: 152–156 Male reproductive organs are at risk from environmental hazards. CORPORATE EUROPE - MAI 2015 - A toxic affair - how the chemical lobby blocked action on hormone disrupting chemicals. EUROPE 22/05/15 Second round table on the impact assessment on criteria to identify endocrine disruptors (Brussels, 24 April 2015) EUROPE 22/05/15 Second round table on the impact assessment on criteria to identify endocrine disruptors (Brussels, 24 April 2015) Indian J Med Res 140 (Supplement), November 2014, pp 29-35 Environmental & lifestyle factors in deterioration of male reproductive health. Asian Journal of Andrology (2010) 12: 152–156 Male reproductive organs are at risk from environmental hazards. NATIONAL FOOD INSTITUTE (DK) 18/03/15 Paper and board food packaging contains endocrine active chemicals.
For paper and board food packaging only little regulation and legislation exists, and the composition of the packaging is in many cases unknown for the consumer and the authorities. A PhD project at the National Food Institute, Technical University of Denmark, shows that paper and board food packaging contain well-known and new endocrine active chemicals. Food packaging constitutes a potential source of chemical contamination of food products, and in this way humans may be exposed to these chemicals.
Bisphenol A is used in such plastic packaging as cans and plastic bottles but is also present in some paper and board packaging made from recycled paper. Fluorinated substances are used for surface treatment of paper and board packaging. "Now we know that bisphenol A analogues and fluorinated substances have the potential to cause adverse health effects in humans. " FRONTIERS IN ENVIRONMENTAL SCIENCE 17/02/15 Estrogenic and anti-androgenic endocrine disrupting chemicals and their impact on the male reproductive system. EUROPE 02/02/15 Endocrine Disruptors: Commission publishes replies to the public consultation.
Financial costs of inaction on EDCs. Int. J. Mol. Sci. 2013, 14(8), 16732-16801 The Effects of Nanomaterials as Endocrine Disruptors. Institute of Public Health, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, Roma 00168, Italy * Author to whom correspondence should be addressed. European Commission Joint Research Centre - 2013 - Key scientific issues relevant to the identification and characterisation of. BFR 21/03/13 Appeal for harmonized scientific criteria for identification and assessment of endocrine disruptors. EHP - JUIN 2012 - Low-Dose Effects of Endocrine Disruptors, with Laura Vandenberg. Interdisciplinary Studies on Environmental Chemistry â€” Biological Responses to Contaminants, - 2010 - Endocrine Disruption, Re. Environmental Sciences Europe 2011, 23:15 Endocrine disruptor screening: regulatory perspectives and needs.