THE LANCET - AVRIL 2020 - Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation. VIROLOGY JOURNAL 30/01/20 No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses. NEJM 04/10/18 Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. ECDC 26/03/18 Acute encephalitis associated with infection with Borna disease virus 1, Germany. J VIROL 26/04/17 Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
BMC Psychiatry (2016) 16:369 Primary psychosis and Borna disease virus infection in Lithuania: a case control study. A recent analysis of data from the Global Burden of Disease study (GBD 2010) revealed that mental and substance disorders are the fifth leading cause of DALYs (Disability-adjusted life years) and the leading cause of YLDs (years lived with disability), accounting for 7.4 % of global DALYs and 5.6 % of global YLDs .
The intriguing hypothesis of an infectious cause of or contribution to mental disorders has been considered for different viruses, e.g. herpes viruses and schizophrenia . However, a link, whatsoever, to Borna disease virus (BDV) appeared as a particularly promising line of research since more than two decades [3, 4], Pros and Cons of which are still under debate .
Recently, a meta-analysis on infectious agents and depression further supported BDV as the most relevant candidate agent and found statistical significance that depressed individuals are 3.25 times more likely to be infected by BDV than healthy . EFSA 31/07/17 Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): Borna disease. ANIMAL MEDICAL CENTER OF CORONA - FEV 2016 - CURRENT RESEARCH AND ADVANCES IN AVIAN BORNAVIRUS AND PROVENTRICULAR DILATATION DISEASE (AVIAN BORNAVIRAL GANGLIONEURITIS) FOR VETERINARY PROFESSIONALS 2016. The American Society for Biochemistry and Molecular Biology - 2016 - Borna disease virus assembles porous cage-like viral factories in the nucleus. Advances in Microbiology 2016,6,489-494 First Serological Evidence of Borna Disease Virus in Healthy Horses from Yucatan, Mexico.
AUSTRALIAN WILDLIFE HEALTH NETWORK 28/11/13 Avian Bornavirus and Proventricular Dilation Disease. Volume 16, Issue 2, May 2013, Pages 339–355 New and Emerging Diseases Edited By Sue Chen and Nicole R.
Wyre Keywords Avian bornavirus; Proventricular dilatation disease; Parrot; Diagnosis; Pathogenesis; Epidemiology First page preview. UNIVERSITE DE TOULOUSE III - 2015 - Thèse en ligne : Bornavirus, neurones et épigénétique : un "ménage à trois" mutuellement salutaire ? Bonnaud, Emilie (2015).
Bornavirus, neurones et épigénétique : un "ménage à trois" mutuellement salutaire ? Analyser les modalités de l'interaction des virus neurotropes avec leurs cellules cibles représente un défi majeur, cela pourrait favoriser notre compréhension de la physiopathologie de certains troubles neurologiques dont l'origine virale est parfois suspectée. Le Bornavirus (BDV), un virus neurotrope, représente un modèle idéal pour analyser les mécanismes moléculaires de la persistance virale dans les neurones et en étudier les conséquences sur l'homéostasie neuronale.
Au cours de ma thèse, nous avons découvert une nouvelle forme d'interaction virus/cellule dans laquelle une protéine du BDV perturbe la signalisation épigénétique associée à l'acétylation des histones. JUSTUS LIEBIG UNIVERSITY GIESSEN 22/12/15 Thèse en ligne : Avian Borna Virus in Psittacine Birds Viral distribution, tropism and immune response. Avian Pathology Volume 44, Issue 4, 2015 Identification of avian bornavirus in a Himalayan monal (Lophophorus impejanus) with neurological disease.
IDW ONLINE 09/07/15 Neues Bornavirus auf den Menschen übertragbar. Neues Bornavirus auf den Menschen übertragbar Wissenschaftlern des BNITM und des Friedrich-Loeffler-Instituts (FLI) gelang die Identifizierung eines neuen zoonotischen Bornavirus.
Drei Züchter von Bunthörnchen aus Sachsen-Anhalt erlagen zwischen 2011 und 2013 einer durch die Infektion mit dem neuen Virus hervorgerufenen Gehirnentzündung. Das Virus wurde höchstwahrscheinlich von Bunthörnchen auf die Züchter übertragen, dies zeigten die Wissenschaftler jetzt anhand einer Metagenomanalyse von Gewebeproben der Tiere und der verstorbenen Patienten. ECDC 25/02/15 New bornavirus discovered in variegated squirrels: Potential link to human infections. SCIENCE NORDIC 02/12/15 Deadly virus discovered in Scandinavian geese. Scientists, in collaboration with Danish hunters, analysed 333 goose heads and found that seven of them were infected with the deadly 'aquatic bird bornavirus 1’.
(Photo: Fick Thomsen) Swollen stomach, constipation, and death, are the symptoms of 'aquatic bird bornavirus 1', which affects almost half of all wild geese in North America. Scientists have discovered cases among wild geese in Scandinavia, which, until now, had been unaffected by the deadly virus. . "It’s the first time that the virus has been found among geese in Europe and we’re worried that it's going to spread like it did in North America," says co-author Mads Bertelsen, veterinarian at Copenhagen Zoo, Denmark.
The study is published in the scientific journal Emerging Infectious Diseases, where Bertelsen and his colleagues report cases of the virus among Scandinavian grey geese, barnacle geese, and pink-footed geese. Hunters help scientists find infected geese. CDC EID - DEC 2015 - Aquatic Bird Bornavirus 1 in Wild Geese, Denmark. Author affiliations: University of Copenhagen, Copenhagen (A.F.
Thomsen, J.B. Nielsen); Copenhagen Zoo, Copenhagen, Denmark (A.F. Thomsen, J.B. Nielsen, M.F. Bertelsen); Technical University of Denmark, Copenhagen (C.K. NEJM 09/07/15 A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis. Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms.
With the use of a metagenomic approach that incorporated next-generation sequencing and real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contact squirrel and in brain samples from the three patients. Phylogenetic analyses showed that this virus, tentatively named variegated squirrel 1 bornavirus (VSBV-1), forms a lineage separate from that of the known bornavirus species. (Funded by the Federal Ministry of Food and Agriculture [Germany] and others.) Supported in part by intramural funding from the Federal Ministry of Food and Agriculture (Germany), by a contract research project for the Bundeswehr Medical Service (FV E/U2AD/CF512/DF557 META-InfRisk, to Drs.
Drs. We thank J.A. Source Information. VIROLOGY JOURNAL 12/03/15 Health care professionals at risk of infection with Borna disease virus – evidence from a large hospital in China (Chongqing) Ethics statement All subjects gave their written informed consent after a detailed introduction to the study.
Either of the parents of the minors gave their written informed consent on behalf of their participating child. Among the MDD patients 17 adolescents aged 15–17 years were included. The study was approved by the Ethics Committee of Chongqing Medical University (#2011002) and was performed according to the Helsinki Declaration. Study population. PNAS 09/09/14 Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. INSERM 17/11/14 Un virus contre les maladies neuro-dégénératives. 17 novembre 2014 © Caroline Charlier, Equipe Daniel Dunia Qui aurait cru qu’un virus puisse aider à lutter contre les maladies neurodégénératives ?
C’est pourtant ce que suggèrent les résultats des derniers travaux d’une équipe Inserm*. Les chercheurs viennent en effet de montrer qu’une protéine virale issue du Bornavirus protège les neurones de la dégénérescence. L’équipe l’admet bien volontiers : cette découverte est fortuite ! Lutter contre le stress mitochondrial En collaboration avec Jean Michel Peyrin** et avec l'équipe de Stéphane Hunot***, les chercheurs ont réalisé différentes expériences visant à comprendre le fonctionnement de cette protéine et à tester son potentiel thérapeutique. « Les résultats ont montré que la protéine X exprimée seule, en dehors du contexte d'une infection, bloque les dommages mitochondriaux induits par un stress et responsables de la mort des neurones.
Par voie intranasale chez la souris Notes Source M. APMIS Suppl. 124: Vol. 116: 00–00, 2008 Borna disease virus: evidence of naturally-occurring infection in cats in Australia. Virology Journal 2014, 11:161 Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. MICROBEWIKI - Borna Disease Virus (Human). Korean Journal of Veterinary Service 03/2014 First detection of avian bornavirus by RT-PCR in proventricular dilatation disease-suspected Hahns Macaw (Ara nobilis nobilis) in Korea.
Acta Veterinaria Scandinavica 2013, 55:77 Serological markers of Bornavirus infection found in horses in Iceland. Veterinary Microbiology Volume 172, Issues 1–2, 6 August 2014, No contact transmission of avian bornavirus in experimentally infected cockatiels (Nymphicus hollandicus) and domestic canaries (Serinus canaria forma domestica) A Institute for Virology, University Medical Center Freiburg, Hermann-Herder-Str. 11, D-79104 Freiburg, Germanyb Clinic for Birds, Reptiles, Amphibians and Ornamental Fish, Centre for Clinical Veterinary Medicine, University Ludwig Maximilian Munich, Sonnenstr. 18, D-85764 Oberschleißheim, Germanyc Department of Veterinary Sciences, University Ludwig Maximilian Munich, Veterinärstr. 13, D-80539 Munich, Germany Received 24 March 2014, Revised 29 April 2014, Accepted 3 May 2014, Available online 13 May 2014 Choose an option to locate/access this article: Check if you have access through your login credentials or your institution Check access doi:10.1016/j.vetmic.2014.05.011 Get rights and content Highlights We infected cockatiels and canary birds with avian bornaviruses (ABV).
Cockatiels developed typical disease, whereas canary birds did not. Universitats Klinikum FREIBURG - 2014 - Epidemiology and pathogenesis of avian bornavirus infections. Since the first discovery of avian bornaviruses in 2008, the knowledge on these viruses has markedly increased. However, many questions regarding their epidemiology and pathology remain unsolved. CDC EID - Volume 20, Number 12—December 2014. Au sommaire: Avian Bornavirus in Free-Ranging Psittacine Birds, Brazil. Author affiliations: Freie Universitaet Berlin, Berlin, Germany (N.M. Encinas-Nagel, H.M. Viruses, Vol. 5, 2013 Nucleocytoplasmic Shuttling of Viral Proteins in Borna Disease Virus Infection. AVIAN PATHOLOGY 14/04/11 Occurrence of avian bornavirus infection in captive psittacines in various European countries and its association to proventricular dilatation disease. Journal of Virology - 2011 - A novel Borna disease virus vector system that stably expresses foreign proteins from an intercistr.
+ Author Affiliations Borna disease virus (BDV), a nonsegmented, negative-strand RNA virus, infects a wide variety of mammalian species and readily establishes a long-lasting, persistent infection in brain cells. Therefore, this virus could be a promising candidate as a novel RNA virus vector enabling stable gene expression in the central nervous system (CNS). Previous studies demonstrated that the 5′ untranslated region of the genome is the only site for insertion and expression of a foreign gene. In this study, we established a novel BDV vector in which an additional transcription cassette has been inserted into an intercistronic noncoding region between the viral phosphoprotein (P) and matrix (M) genes. The recombinant BDV (rBDV) carrying green fluorescent protein (GFP) between the P and M genes, rBDV P/M-GFP, expressed GFP efficiently in cultured cells and rodent brains for a long period of time without attenuation.
Fig. 1. VETERINARY MEDICINE 13/06/12 Avian bornavirus in the urine of infected birds. INTECH - OCT 2011 - Borna Disease Virus and Psychiatric Disorders: Can Viruses Influence Psychiatric Disorders? J. Virol. March 2012 vol. 86 no. 5 2512-2522 Borna Disease Virus Infects Human Neural Progenitor Cells and Impairs Neurogenesis. + Author Affiliations Understanding the complex mechanisms by which infectious agents can disrupt behavior represents a major challenge.
The Borna disease virus (BDV), a potential human pathogen, provides a unique model to study such mechanisms. Because BDV induces neurodegeneration in brain areas that are still undergoing maturation at the time of infection, we tested the hypothesis that BDV interferes with neurogenesis. We showed that human neural stem/progenitor cells are highly permissive to BDV, although infection does not alter their survival or undifferentiated phenotype. MEDICAL NEWS 02/02/12 New Study May End 2 Decades Of Suspicion: Does Borna Disease Virus Cause Mental Illness? SCIENCE DAILY 31/01/12 Does Borna Disease Virus Cause Mental Illness? Over the past 30 years, numerous studies have linked Borna disease virus (BDV) with mental illnesses such as bipolar disorder, schizophrenia, anxiety disorder, and dementia. Genetic fragments and antibodies to this RNA virus, which causes behavior disorders in a range of mammals and birds, have been found to be prevalent in psychiatric patients, but study results have been inconsistent.
Now, the first blinded, case-control study to examine this issue finds no association between the virus and psychiatric illness. The study, conducted by researchers at the Center for Infection and Immunity at Columbia University's Mailman School of Public Health and collaborators at seven other institutions in the U.S., Germany and Australia, can be found online at Molecular Psychiatry. "Our study provides compelling evidence that bornaviruses do not play a role in schizophrenia or mood disorders," says Mady Hornig, MD, director of translational research at the Center for Infection and Immunity.
INTECH - MARS 2012 - Implicating the Need for Serological Testing of Borna Disease Virus and Dengue Virus During Blood Transfusi. UPPSALA UNIVERSITY - 2011 - Dissertation en ligne : Borna disease virus and its hosts.