FRONT. VET. SCI. 29/09/21 Serological Surveillance of Rabies in Free-Range and Captive Common Vampire Bats Desmodus rotundus. Introduction Rabies is an infectious disease of viral etiology that causes acute encephalitis, with rapid and usually fatal evolution in all mammals (1).
The etiological agent is the RNA virus belonging to the family Rhabdoviridae and genus Lyssavirus, and it is a zoonosis distributed worldwide that now affects mainly low-income countries (2). Rabies virus is transmitted by contact with infected saliva through bites or scratches. Dogs are the main reservoir of rabies and are responsible for most fatal cases in humans worldwide (2). VIRUSES 04/09/21 Renewed Public Health Threat from Emerging Lyssaviruses. All articles published by MDPI are made immediately available worldwide under an open access license.
No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. Feature Papers represent the most advanced research with significant potential for high impact in the field. Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication.
The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature. VIRUSES 20/05/21 Assessing Rabies Vaccine Protection against a Novel Lyssavirus, Kotalahti Bat Lyssavirus. Rabies is a fatal encephalitis caused by an important group of viruses within the Lyssavirus genus.
The prototype virus, rabies virus, is still the most commonly reported lyssavirus and causes approximately 59,000 human fatalities annually. The human and animal burden of the other lyssavirus species is undefined. The original reports for the novel lyssavirus, Kotalahti bat lyssavirus (KBLV), were based on the detection of viral RNA alone. VIRUSES 20/03/21 Towards Development of an Anti-Vampire Bat Vaccine for Rabies Management: Inoculation of Vampire Bat Saliva Induces Immune-Mediated Resistance. The common vampire bat (Desmodus rotundus) is a hematophagous species responsible for paralytic rabies and bite damage that affects livestock, humans and wildlife from Mexico to Argentina.
Current measures to control vampires, based upon coumarin-derived poisons, are not used extensively due in part to the high cost of application, risks for bats that share roosts with vampires and residual environmental contamination. Observations that vampire bat bites may induce resistance in livestock against vampire bat salivary anticoagulants encourage research into novel vaccine-based alternatives particularly focused upon increasing livestock resistance to vampire salivary components. We evaluated the action of vampire bat saliva-Freund’s incomplete adjuvant administered to sheep with anticoagulant responses induced by repeated vampire bites in a control group and examined characteristics of vampire bat salivary secretion. ►▼ Show Figures Figure 1 ►▼ Show Figures Figure 1. NATURE 16/03/20 Knowledge gaps about rabies transmission from vampire bats to humans. BMC VETERINARY RESEARCH 10/12/20 Active surveillance for antibodies confirms circulation of lyssaviruses in Palearctic bats.
1.Malerczyk C, Freuling C, Gniel D, Giesen A, Selhorst T, et al.
Cross-neutralization of antibodies induced by vaccination with purified chick embryo cell vaccine (PCECV) against different Lyssavirus species. Hum Vaccin Immunother. 2014;10:2799–804.PubMed PubMed Central Article Google Scholar 2.Hampson K, Coudeville L, Lembo T, Sambo M, Kieffer A, Attlan M, et al. Estimating the global burden of endemic canine rabies. PLoS Negl Trop Dis. 2015;9:e0003709.PubMed PubMed Central Article CAS Google Scholar 3.Slate D, Rupprecht CC, Rooney JA, Donovan D, Lein DH, Chipman RH. Status of oral rabies vaccination in wild carnivores in the United States. ZOONOSES AND PUBLIC HEALTH 08/12/19 Faeces as a novel material to estimate lyssavirus prevalence in bat populations. Impacts People can acquire rabies by contact with rabid bats.
This makes bat rabies of concern for both public health and bat conservation. There is limited knowledge on the epidemiology of bat rabies hampering the application of preventive measures. Therefore, we should improve our strategies to investigate free‐ranging bat populations for rabies prevalence. WILDLIFE RESEARCH 01/05/17 One Health messaging about bats and rabies: how framing of risks, benefits and attributions can support public health and wildlife conservation goals. Bat Conservation International (2015).
Bats and rabies: a public health guide. Available at [verified 7 April 2017]. Bexell, S. M., and Feng, R. X. (2013). THE LANCET 31/10/17 Comparative pathogenesis of rabies in bats and carnivores, and implications for spillover to humans. PLOS 05/03/18 Pathogenesis of bat rabies in a natural reservoir: Comparative susceptibility of the straw-colored fruit bat (Eidolon helvum) to three strains of Lagos bat virus. Abstract Rabies is a fatal neurologic disease caused by lyssavirus infection.
People are infected through contact with infected animals. The relative increase of human rabies acquired from bats calls for a better understanding of lyssavirus infections in their natural hosts. So far, there is no experimental model that mimics natural lyssavirus infection in the reservoir bat species. Lagos bat virus is a lyssavirus that is endemic in straw-colored fruit bats (Eidolon helvum) in Africa. PLOS 04/10/17 Protection of bats (Eptesicus fuscus) against rabies following topical or oronasal exposure to a recombinant raccoon poxvirus vaccine. Abstract Rabies is an ancient neglected tropical disease that causes tens of thousands of human deaths and millions of cattle deaths annually.
In order to develop a new vaccine for potential use in bats, a reservoir of rabies infection for humans and animals alike, an in silico antigen designer tool was used to create a mosaic glycoprotein (MoG) gene using available sequences from the rabies Phylogroup I glycoprotein. This sequence, which represents strains more likely to occur in bats, was cloned into raccoonpox virus (RCN) and the efficacy of this novel RCN-MoG vaccine was compared to RCN-G that expresses the glycoprotein gene from CVS-11 rabies or luciferase (RCN-luc, negative control) in mice and big brown bats (Eptesicus fuscus).
Mice vaccinated and boosted intradermally with 1 x 107 plaque forming units (PFU) of each RCN-rabies vaccine construct developed neutralizing antibodies and survived at significantly higher rates than controls. Author summary Editor: Charles E. Introduction. EMERGING HEALTH THREATS JOURNAL Vol 4 (2011) Bats, emerging infectious diseases, and the rabies paradigm revisited. Infect Ecol Epidemiol. 2017 Jun 19;7(1) Natural exposure of bats in Grenada to rabies virus.
F1000RESEARCH 23/02/17 Lyssaviruses and rabies: current conundrums, concerns, contradictions and controversies. Introduction Rabies is not a simple long-ago vestige, nightmarish myth, or literary allegory but rather a significant viral encephalitis with the highest case fatality of any conventional infectious disease.
Who else, besides those afflicted and affected, should care about rabies today? Legions—including the true animal lover, anthropologist, administrator, caver, educator, environmentalist, farmer, medical professional, traveler, health economist, hiker, historian, humanist, industrialist, legislator, modeler, philanthropist, sociologist, student, conservation biologist, and life scientist, to name a few by vocation or avocation—curious for elevated self and situational awareness, caring for the common good, intrigued by this view of life from an applied microbiological and ecological perspective or challenged by the allure for professional intervention in nature, represented by the less-than-apparent “non-low-hanging fruit”.
Table 1. An evolving viral taxonomy: what is in a name? PLOS 25/05/16 A One Health Message about Bats Increases Intentions to Follow Public Health Guidance on Bat Rabies. Abstract Since 1960, bat rabies variants have become the greatest source of human rabies deaths in the United States. Improving rabies awareness and preventing human exposure to rabid bats remains a national public health priority today. Concurrently, conservation of bats and the ecosystem benefits they provide is of increasing importance due to declining populations of many bat species. This study used a visitor-intercept experiment (N = 521) in two U.S. national parks where human and bat interactions occur on an occasional basis to examine the relative persuasiveness of four messages differing in the provision of benefit and uncertainty information on intentions to adopt a rabies exposure prevention behavior.
We found that acknowledging benefits of bats in a risk message led to greater intentions to adopt the recommended rabies exposure prevention behavior without unnecessarily stigmatizing bats. Editor: David O. PLOS NEGLECTED TROPICAL DISEASES 30/12/16 The Global Phylogeography of Lyssaviruses - Challenging the 'Out of Africa' Hypothesis. Abstract Rabies virus kills tens of thousands of people globally each year, especially in resource-limited countries. Yet, there are genetically- and antigenically-related lyssaviruses, all capable of causing the disease rabies, circulating globally among bats without causing conspicuous disease outbreaks. The species richness and greater genetic diversity of African lyssaviruses, along with the lack of antibody cross-reactivity among them, has led to the hypothesis that Africa is the origin of lyssaviruses.
This hypothesis was tested using a probabilistic phylogeographical approach. The nucleoprotein gene sequences from 153 representatives of 16 lyssavirus species, collected between 1956 and 2015, were used to develop a phylogenetic tree which incorporated relevant geographic and temporal data relating to the viruses. Author Summary. PLOS 08/08/16 Serological Evidence of Lyssaviruses among Bats on Southwestern Indian Ocean Islands. Abstract We provide serological evidence of lyssavirus circulation among bats on southwestern Indian Ocean (SWIO) islands. A total of 572 bats belonging to 22 species were collected on Anjouan, Mayotte, La Réunion, Mauritius, Mahé and Madagascar and screened by the Rapid Fluorescent Focus Inhibition Test for the presence of neutralising antibodies against the two main rabies related lyssaviruses circulating on the African continent: Duvenhage lyssavirus (DUVV) and Lagos bat lyssavirus (LBV), representing phylogroups I and II, respectively.
A total of 97 and 42 sera were able to neutralise DUVV and LBV, respectively. COLORADO STATE UNIVERSITY via YOUTUBE 06/09/16 Communicating About Bats and Disease in National Parks. CDC EID - Volume 22, Number 4—April 2016. Au sommaire notamment: Cross-Neutralization between Human and African Bat Mumps Viruses. Author affiliations: National Institute of Infectious Diseases, Tokyo, Japan (H. Katoh, T. Kubota, M. INFECTION ECOLOGY & EPIDEMIOLOGY - 2016 - Lyssavirus-reactive antibodies in Swedish bats.
Anna-Lena Hammarin, Msc1, Louise Treiberg Berndtsson, DVM2, Kerstin Falk, PhD, Associate Professor1, Marie Nedinge, Ms3, Gert Olsson, PhD4 and Åke Lundkvist, PhD, Professor5* 1Department of Microbiology, Public Health Agency of Sweden, Stockholm, Sweden; 2National Veterinary Institute, Uppsala, Sweden; 3Swedish Environmental Protection Agency, Stockholm, Sweden; 4Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences, Umeå, Sweden; 5Department of Medical Biochemistry and Microbiology, Zoonosis Science Center and Department of Medical Sciences, Uppsala University, and Laboratory of Clinical Microbiology, Uppsala University Hospital, Uppsala, Sweden Introduction: To study the presence of European bat lyssavirus (EBLV) infections in bat reservoirs in Sweden, active surveillance was performed during the summers from 2008 to 2013.
Keywords: bat; Lyssavirus; rabies; EBLV; Myotis daubentonii; Daubenton’s bat; Northern bat Fig. 1. Fig. 2. CDC EID - AOUT 2016 – Au sommaire notamment : Lyssavirus in Indian Flying Foxes, Sri Lanka. Panduka S. Gunawardena1, Denise A. PLOS 26/07/16 A Systematic Review of Human Bat Rabies Virus Variant Cases: Evaluating Unprotected Physical Contact with Claws and Teeth in Support of Accurate Risk Assessments. Abstract. ROYAL SOCIETY - 2014 - Ecological dynamics of emerging bat virus spillover. PLOS 19/06/14 Vampire Bats and Rabies: Toward an Ecological Solution to a Public Health Problem.
Citation: Stoner-Duncan B, Streicker DG, Tedeschi CM (2014) Vampire Bats and Rabies: Toward an Ecological Solution to a Public Health Problem. PLoS Negl Trop Dis 8(6): e2867. doi:10.1371/journal.pntd.0002867 Editor: Neal D. Rev. Inst. Med. Trop. Sao Paulo 57(1):63-72, January-February, 2015 BAT-BORNE RABIES IN LATIN AMERICA.
The Open Zoology Journal, 2012, 5, (Suppl 1-M5) 27-37 DNA Barcoding Facilitates Bat Species Identification for Improved Surveillance of Bat-associated Rabies across Canada. The Open Zoology Journal, 2012, 5: 27-37 Susan A. Veterinary Microbiology 151, 3-4 (2011) 39 Active surveillance of bat rabies in France: a 5-year study (2004-2009) International Research Journal of Medical Sciences - JUNE 2013 - Transmission of Rabies in Human and Role of Bats: A Review. BMC Veterinary Research 2013, 9:174 Bat rabies surveillance in Finland. CTV 06/07/14 Bat infected with rabies found outside Whitby college campus (Toronto) HORSETALK 18/05/13 First case of Australian Bat Lyssavirus in a horse. Transmission electron micrograph showing a bat brain infected with lyssavirus. © CSIRO Australia has recorded its first case of Australian Bat Lyssavirus (ABLV) in a horse. Queensland’s chief biosecurity officer, Dr Jim Thompson, said the horse was euthanised on May 11 after falling ill. Biosecurity Queensland quarantined the property on the Southern Downs.
“Another horse showing similar symptoms was euthanised at the same property five days earlier,” Thompson said. “There are 20 other horses on the property. “The site will remain under quarantine while further testing is conducted on the remaining horses.” Thompson said the horse had tested negative for Hendra virus, but further testing returned a positive result for ABLV, which is carried by bats and flying foxes. Staff from the Darling Downs Hospital and Health Service Public Health Unit will visit the property to assess the situation and identify any human potentially exposed to the horse. The virus causes severe brain swelling. CDC EID - SEPT 2013 – Au sommaire notamment:Enzootic and Epizootic Rabies Associated with Vampire Bats, Peru
Skip directly to local search Skip directly to A to Z list Skip directly to navigation Skip directly to site content Skip directly to page options CDC Home CDC 24/7: Saving Lives. PLOS - JUIN 2014 - Vampire Bats and Rabies: Toward an Ecological Solution to a Public Health Problem. PLOS 20/05/13 Ecological Factors Associated with European Bat Lyssavirus Seroprevalenc in Spanish Bats. Bats have been proposed as major reservoirs for diverse emerging infectious viral diseases, with rabies being the best known in Europe.
However, studies exploring the ecological interaction between lyssaviruses and their natural hosts are scarce. This study completes our active surveillance work on Spanish bat colonies that began in 1992. Herein, we analyzed ecological factors that might affect the infection dynamics observed in those colonies. Australian Wildlife Health Network - DEC 2012 - Australian Bat Lyssavirus Report. Rev Panam Salud Publica vol.34 n.2 Washington Aug. 2013 Spatial epidemiology of bat-borne rabies in Colombia. Spatial epidemiology of bat-borne rabies in Colombia Luis E. EscobarI; A. Townsend PetersonII. CDC EID - SEPT 2013 – Au sommaire notamment: Enzootic and Epizootic Rabies Associated with Vampire Bats, Peru.
Rene Edgar Condori-Condori , Daniel G. 2011 - Rabid Bats Reported in the United States during 2010. Skip directly to search Skip directly to A to Z list Skip directly to site content. CDC MMWR 13/04/12 Rabies Risk Assessment of Exposures to a Bat on a Commercial Airliner — United States, August 2011. SOUTH AMERICAN INSTITUTE OF GOVERNMENT IN HEALTH 06/08/12 Amazon Peruvians show protection against bat rabies. 2011 - INVESTIGATING THE ROLE OF BATS IN EMERGING ZOONOSES. DEFRA - 2011 - European bat lyssavirus (EBLV) CBSNEWS 13/08/10 Vampire Bats Kill 4 Kids, Attack 500 in Peru. INSTITUT PASTEUR - 2010 - Laboratory Surveillance of rabies in humans, domestic animals and bats in Madagascar, 2005-2010. Zoonoses Public Health. 2012 Sep 11. Bat Rabies Surveillance in Europe.
Journal of Theoretical Biology Volume 314, 7 December 2012, A simple spatiotemporal rabies model for skunk and bat interaction i. Travel Medicine and Infectious Disease Volume 10, Issue 2, March 2012 The other rabies viruses: The emergence and importance of. SCIENCE NEWS 08/09/12 Rabies resistance arises in backwater thick with vampire bats. SCIENCE DAILY 01/08/12 First Indication of People Naturally Protected Against Rabies Found in Remote Amazonian Communities Regul. Virus Research Volume 165, Issue 2, May 2012, Rabies virus distribution in tissues and molecular characterization of strains fro. UNIVERSITY OF GEORGIA 18/05/12 Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats.
BBC 13/06/12 Culling bats does not halt rabies, says report.