CARDIF UNIVERSITY 15/03/17 Creating artemisinin. Researchers at Cardiff University have devised a new way of creating a drug commonly used as the first line of defence against malaria around the world.
Artemisinin is a drug recommended by the World Health Organisation for treatment of all cases of severe malaria and works by attacking all stages of the malaria parasite in the blood. The worldwide supply of artemisinin relies predominantly on the extraction of the product from the plant Artemisia annua, therefore researchers have been striving to find a way of efficiently producing the drug in the lab. There is an urgent need to produce the drug at low cost, because the current demand for artemisinin comes mainly from the developing world. In a new paper published in the leading chemistry journal Angewandte Chemie, the Cardiff University team have described a new method which reverses part of the production process that we see in nature.
The full paper can be downloaded from here. The Open Infectious Diseases Journal, 2010, 4, 63-73 63 Parasite Vaccines: Recent Progress in, and Problems Associated with their Development.
USAID - 2013 - Malaria Operational Plan - Year Five – Fiscal Year 2013. SWISS TPH 23/12/14 Nanotechnology Prevents Host Cell Invasion by Malaria Parasites. [Translate to Français:] After maturation several daughter parasites (yellow) are released from a single infected red blood cell.
For many infectious diseases no vaccine exists yet to prevent the disease. In addition, resistance against currently used drugs is spreading rapidly. Therefore, innovative strategies with different mechanisms of action are needed to fight these diseases. An example for such infections is malaria caused by Plasmodium falciparum parasites, which are transmitted by Anopheles mosquitoes.
Nanomimics are Polymer Vesicles with Host Cell Receptors on the Surface Researchers of the research groups led by Prof. Malaria Parasites Can Be Blocked very Efficiently After maturation in red blood cells during 48 h, malaria parasites burst open their host cell and infect other red blood cells. This project was funded by the Swiss National Science Foundation and the NCCR Molecular Systems Engineering.
ASTMH 06/10/16 Diagnosis and Treatment of Plasmodium vivax Malaria. + Author Affiliations + Author Notes Authors' addresses: J.
Kevin Baird, Eijkman-Oxford Clinical Research Unit, Oxford University, Jakarta, Indonesia, E-mail: firstname.lastname@example.org. Neena Valecha, Epidemiology and Clinical Research Division, National Institute for Malaria Research, ECR, New Delhi, India, E-mail: email@example.com. Stephan Duparc, Medical R&D, Medicines for Malaria Venture, Geneva, Switzerland, E-mail: firstname.lastname@example.org. JOURNAL OF ANIMAL ECOLOGY 26/08/16 Co-infections and environmental conditions drive the distributions of blood parasites in wild birds.
Field Sampling and Laboratory Methods New Caledonia is a subtropical Pacific archipelago consisting of four main islands (Fig. 1a).
The archipelago supports four Zosterops spp., including the regionally widespread Zosterops lateralis, the New Caledonian endemic Zosterops xanthochrous, and two single-island endemics, Zosterops minutus and Zosterops inornatus (both of which only occur on the island of Lifou; Dutson 2012). All four species are omnivorous passerines that occur in mixed-species flocks. We captured Zosterops spp. with mist nets on the four main islands from January to March 2014.
Sites were chosen to represent the three primary forested habitats in New Caledonia, namely dry lowland forest (Grand Terre, Ouvéa), lowland rain forest (Ouvéa, Lifou and Maré) and montane rain forest (Grand Terre; see Fig. Avian malaria PCR screening and sequencing followed Clark et al. (2015), with the following variations. Pennsylvania State University - 2014 - Dissertation en ligne : Predicting the consequences of diverse life history in Malaria parasites: synchrony and transmission investment. Open Access.
NATURE 23/02/16 Synthetic biology’s first malaria drug meets market resistance. William Daniels/Panos The plant Artemisia annua (pictured being harvested in Tanzania) was the only source of artemisinin before biochemists invented a synthetic route.
When Paris-based pharmaceutical giant Sanofi started to sell malaria drugs made with the help of genetically engineered yeast in 2014, the move was hailed as a triumph for synthetic biology. The yeast was fermented in a vat to produce a chemical that Sanofi converted into artemisinin, which is used to make leading malaria treatments called artemisinin-based combination therapies (ACTs). Many hoped that the process would offer a cheap and plentiful supply of drugs to tackle a disease that claims almost half a million lives worldwide every year. Travel Medicine and Infectious Disease (2015) 13, 48e60 Risk factors associated with malaria deaths in travellers: A literature review. ARXIV 25/11/13 Controlling Infections with Infections: Evaluating the Usefulness of Paratransgenesis for Malaria Control. CURRENT SCIENCE, VOL. 101, NO. 3, 10 AUGUST 2011 Global malaria burden and achieving universal coverage of interventions: a glimpse on progress and impact.
Malaria cases to be confirmed by a diagnostic test.
Drones help scientists understand emerging zoonotic malaria. Unmanned aerial vehicles, or drones, can collect detailed information in real time at relatively low cost for ecological research, according to researchers from the London School of Hygiene & Tropical Medicine.
In a new Opinion piece published in the Cell Press journal Trends in Parasitology, experts demonstrate that drones can be used to understand how environmental factors influence the spread of infectious diseases. Lead author Kimberly Fornace, Research Fellow at the School and a member of the Monkeybar project team which is using drones to study emerging zoonotic malaria in South East Asia, said: “Drones can provide highly accurate information on changes to land, such as deforestation or changing types of agriculture. This helps to understand the impact on the movement and distribution of people, animals, and insects that carry disease.” TRENDS IN PARASITOLOGY 01/02/13 How much vector control is needed to achieve malaria elimination? International Journal of Current Trends in Pharmaceutical Research 2013, Vol.1 (2): 97-104 Review on Pathology and Chemoprophyla. BMC Genomics 2012, 13:614 Anopheles salivary gland proteomes from major malaria vectors. Psyche Volume 2012 (2012), Chemical Constituents and Combined Larvicidal Effects of Selected Essential Oils against Anopheles cr.
TRIALS - 2013 - The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized co.
Actualités PLOS. Actualités CDC. Journal of Tropical Medicine Volume 2011, Low- and High-Tech Approaches to Control Plasmodium Parasite Transmission by Anopheles. JOURNAL OF VECTOR BORNE DISEASES - MARS 2011. Actualités INTECH. BIOMED 25/04/14 Malaria – the big push towards eliminating a killer. NIH 13/06/14 Researchers Develop Genetic Barcode to Identify Geographical Origin of Malaria Parasites. New Tool May Improve Disease Surveillance Researchers have developed a genetic barcode that accurately identifies the geographical origin of malaria-causing parasites.
The barcode could eventually be used to identify the source of malaria outbreaks and to track the spread of the disease. The study, which highlights the importance of conducting field studies in malaria-endemic areas, appears in the June 13, 2014, online issue of Nature Communications. Dr. Fairhurst’s Cambodian colleague approaches a villager’s home to assess a patient with malaria. Background Malaria is caused by Plasmodium parasites, and P. falciparum is the deadliest. Sci Rep. 2014; 4: 5127. A viral over-expression system for the major malaria mosquito Anopheles gambiae.