Infection. 2020 May 16. Hospitalization for Chagas disease, dengue, filariasis, leishmaniasis, schistosomiasis, strongyloidiasis, and Taenia solium taeniasis/cysticercosis, Italy, 2011-2016. 1.World Health Organization. Neglected tropical diseases. Last access 11/08/2019.2.World Health Organization. Global health estimates 2016: disease burden by cause, age, sex, by country and by region, 2000–2016. Geneva; 2018.3.Ministero dell'Interno. I numeri dell'asilo. Last access: 11/08/2019.4.International Organization of Migration. PARASITES & VECTORS 23/01/20 Testing a method of sampling for entomological determination of transmission of Wuchereria bancrofti to inform lymphatic filariasis treatment strategy in urban settings.
Data collection The study was conducted in six communities in Minna and Kaduna City in Nigeria. Kaduna city is the capital of Kaduna State and lies between latitudes 10°25′15″N and 10°36′08″N and longitudes 7°23′31″E and 7°29′33″E. Based on the 2006 national census , the Kaduna metropolis, comprising of Kaduna North, Kaduna South, parts of Chikun and Igabi Local Government Areas (LGAs), has a population of about 1,139,578 and covers an area of around 131 km2.
The indigenes of the state include the Hausa, Fulani, Gwari, Jaba, Agorok, Atyap and Bajju. The data collection team in each community included two entomologists from the University of Jos, one laboratory technician from the Federal Ministry of Health and two community researchers. Communities were selected based on TAS results indicating prevalence of W. bancrofti > 1%, belonging to an urban slum and safe for the research team (Table 1). Twenty-one pyrethrum spray catches (PSC) household sites were selected. Data management. PLOS 13/04/20 Low transmission of Wuchereria bancrofti in cross-border districts of Côte d’Ivoire: A great step towards lymphatic filariasis elimination in West Africa. Abstract Background Lymphatic filariasis (LF) is widely endemic in Côte d’Ivoire, and elimination as public health problem (EPHP) is based on annual mass drug administration (MDA) using ivermectin and albendazole.
To guide EPHP efforts, we evaluated Wuchereria bancrofti infection indices among humans, and mosquito vectors after four rounds of MDA in four cross-border health districts of Côte d’Ivoire. Methodology We monitored people and mosquitoes for W. bancrofti infections in the cross-border health districts of Aboisso, Bloléquin, Odienné and Ouangolodougou, Côte d’Ivoire.
W. bancrofti circulating filarial antigen (CFA) was identified using filariasis test strips, and antigen-positive individuals were screened for microfilaremia. Moreover, filarial mosquito vectors were sampled using window exit traps and pyrethrum sprays, and identified morphologically at species level. Principal findings Conclusions Editor: Justin V. Copyright: © 2020 Yokoly et al. Introduction Methods Ethics statement. PLOS 01/05/20 Selection and exploitation of prevalent, tandemly repeated genomic targets for improved real-time PCR-based detection of Wuchereria bancrofti and Plasmodium falciparum in mosquitoes. Abstract Background Optimization of polymerase chain reaction (PCR)-based diagnostics requires the careful selection of molecular targets that are both highly repetitive and pathogen-specific. Advances in both next-generation sequencing (NGS) technologies and bioinformatics-based analysis tools are facilitating this selection process, informing target choices and reducing labor.
Once developed, such assays provide disease control and elimination programs with an additional set of tools capable of evaluating and monitoring intervention successes. The importance of such tools is heightened as intervention efforts approach their endpoints, as accurate and complete information is an essential component of the informed decision-making process. Methodology/Principal findings Coupling Illumina-based NGS with informatics approaches, we have successfully identified the tandemly repeated elements in both the Wuchereria bancrofti and Plasmodium falciparum genomes of putatively greatest copy number. MICROORGANISMS 21/05/20 Detection of Canine Vector-Borne Filariasis and Their Wolbachia Endosymbionts in French Guiana. In French Guiana, canine heartworm disease is well known, but the diversity of filarial parasites of dogs remains largely unknown. A total of 98 canine blood samples from Cayenne and Kourou were assessed by a blood wet mount preparation, heartworm antigen test and molecular exploration of filarioid and Wolbachia DNAs, followed by a multiplex species-specific qPCR’s identification and a subsequent sequencing analysis.
Thereafter, a phylogeny based on maximum likelihood was carried out to facilitate specific identification. Five dogs were microfilaremic. Heartworm antigens were detected in 15 (15.3%) dogs. ►▼ Show Figures Graphical abstract This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. BIOENGINEER 03/12/19 Researchers use genomics to discover potential new treatment for parasite disease. Experimental drug found to disrupt genes activated by worm parasite that causes lymphatic filariasis (elephantiasis) Using innovative RNA sequencing techniques, researchers at the University of Maryland School of Medicine (UMSOM) Institute for Genome Sciences identified a promising novel treatment for lymphatic filariasis, a disabling parasitic disease that is difficult to treat.
The potential new therapy is an experimental cancer drug called JQ1 and targets proteins found prominently in the worm’s genome; it appears to effectively kill the adult worms in a laboratory setting, according to the study which was published today in the journal mSystems. Lymphatic filariasis affects over 120 million people worldwide, mostly in the tropics of Asia, Western Pacific and Africa and parts of the Caribbean and South America.
Those in the U.S. who have the disease, which is spread by mosquitoes that carry the baby worms, were infected while traveling abroad. About the Institute for Genome Sciences. USDAID 15/10/18 Vietnam Eliminates Lymphatic Filariasis as a Public Health Problem. The World Health Organization (WHO) announced the Republic of Vietnam has eliminated lymphatic filariasis (LF) as a public health problem. The U.S. Agency for International Development (USAID) congratulates the Government of Vietnam and partners on this extraordinary, decades-long achievement. Globally, only a handful of countries endemic for LF have received formal validation of the elimination of LF by WHO. Lymphatic filariasis, also known as elephantiasis, is a parasitic disease transmitted to humans via mosquitoes.
The USAID NTD Program began supporting Vietnam in its efforts to eliminate LF in 2011, through projects implemented by FHI 360 and RTI International. USAID is a global leader in elimination and control of seven of the most prevalent NTDs, including lymphatic filariasis, and strategically supports countries to plan, finance, and implement solutions to their own development challenges. Read the WHO press release. Trop. Med. Infect. Dis. 2019, 4(1) Investigation of Mixture Modelling Algorithms as a Tool for Determining the Statistical Likelihood of Serological Exposure to Filariasis Utilizing Historical Data from the Lymphatic Filariasis Surveillance Program in Van.
As the prevalence of lymphatic filariasis declines, it becomes crucial to adequately eliminate residual areas of endemicity and implement surveillance. To this end, serological assays have been developed, including the Bm14 Filariasis CELISA which recommends a specific optical density cut-off level. We used mixture modelling to assess positive cut-offs of Bm14 serology in children in Vanuatu using historical OD (Optical Density) ELISA values collected from a transmission assessment survey (2005) and a targeted child survey (2008).
Mixture modelling is a statistical technique using probability distributions to identify subpopulations of positive and negative results (absolute cut-off value) and an 80% indeterminate range around the absolute cut-off (80% cut-off). Depending on programmatic choices, utilizing the lower 80% cut-off ensures the inclusion of all likely positives, however with the trade-off of lower specificity. Study IQ education Via YOUTUBE 15/06/18 What is Lymphatic Filariasis ? New treatment strategy to eliminate Lymphatic Filariasis. Shankar IAS Academy VIA YOUTUBE 17/11/18 Insurgency In India | Ramsar Convention | Rupay | Lymphatic Filariasis - UPSC Prelims 2019. PLOS 26/07/18 Molecular xenomonitoring for Wuchereria bancrofti in Culex quinquefasciatus in two districts in Bangladesh supports transmission assessment survey findings. Abstract Background Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped.
During the post-MDA period, transmission assessment surveys (TAS) are recommended by the World Health Organization to monitor the presence of the parasite in humans. Molecular xenomonitoring (MX), a method by which parasite infection in the mosquito population is monitored, has also been proposed as a sensitive method to determine whether the parasite is still present in the human population. The aim of this study was to conduct an MX evaluation in two areas of Bangladesh, one previously endemic district that had stopped MDA (Panchagarh), and part of a non-endemic district (Gaibandha) that borders the district where transmission was most recently recorded. Methodology/Principal findings Conclusions/Significance Author summary Introduction Methods. PLOS 17/09/18 Towards elimination of lymphatic filariasis in southeastern Madagascar: Successes and challenges for interrupting transmission.
Abstract Introduction A global strategy of mass drug administration (MDA) has greatly reduced the burden of lymphatic filariasis (LF) in endemic countries. In Madagascar, the National Programme to eliminate LF has scaled-up annual MDA of albendazole and diethylcarbamazine across the country in the last decade, but its impact on LF transmission has never been reported. The objective of this study was to evaluate progress towards LF elimination in southeastern Madagascar. Methods Three different surveys were carried out in parallel in four health districts of the Vatovavy Fitovinany region in 2016: i) a school-based transmission assessment survey (TAS) in the districts of Manakara Atsimo, Mananjary, and Vohipeno (following a successful pre-TAS in 2013); ii) a district-representative community prevalence survey in Ifanadiana district; and iii) a community prevalence survey in sentinel and spot-check sites of these four districts.
Principal findings Conclusions Author summary Editor: Peter U. Parasites & Vectors 20/07/18 Lymphatic filariasis control in Tanzania: infection, disease perceptions and drug uptake patterns in an endemic community after multiple rounds of mass drug administration. PARASITES & VECTORS 11/04/19 Risk factors for lymphatic filariasis in two villages of the Democratic Republic of the Congo. Nt- end VIA YOUTUBE 28/10/18 LIFE CYCLE OF Wuchereria Bancrofti. IRANIAN JOURNAL OF PUBLIC HEALTH 06/10/18 The Prevalence of Lymphatic Filariasis in Elementary School Children Living in Endemic Areas: A Baseline Survey Prior to Mass Drug Administration in Pekalongan District-Indonesia.
Keywords: Mass treatment, Wuchereria bancrofti, Elimination, Filariasis, Children Abstract Abstract Background: WHO initiated lymphatic filariasis (LF) elimination globally. Pekalongan District, as LF endemic area, started a program of mass drug administration (MDA) to combat LF in 2015. This study aimed to determine prevalence of Wuchereria bancrofti infection prior to the MDA. References 1. CONTINENTAL J. BIOLOGICAL SCIENCES - 2017 - Lymphatic filariasis in Some Wards in Bodinga Local Government Area of Sokoto State, Nigeria.
April 21, 2017 Journal article Open Access Attah O. A; Adamu T; Yahaya M. M; Farouq, A. A; Bala, A.Y; Kanya, D. The National Lymphatic Filariasis Elimination Programme (NLFEP) is committed to eradicate the lymphatic filariasis (LF) from Nigeria. Trop. Med. Infect. Dis. 2019, 4(1) Investigation of Mixture Modelling Algorithms as a Tool for Determining the Statistical Likelihood of Serological Exposure to Filariasis Utilizing Historical Data from the Lymphatic Filariasis Surveillance Program in Va. JOURNAL OF VECTOR BORNE DISEASES - MARS 2011 - Au sommaire notamment: How endemic countries can accelerate lymphatic filariasis elimination? An analytical review identify strategic and programmatic interventions. PLOS 12/11/18 The prevalence of lymphatic filariasis infection and disease following six rounds of mass drug administration in Mandalay Region, Myanmar.
Abstract Lymphatic filariasis is widely endemic in Myanmar. Despite the establishment of an elimination program in 2000, knowledge of the remaining burden of disease relies predominantly on programmatic information. To assist the program, we conducted an independent cross-sectional household cluster survey to determine the prevalence of filariasis infection, morbidity and mass-drug administration coverage in four townships of the Mandalay Region: Amarapura, Patheingyi, Tada-U and Wundwin. The survey included 1014 individuals from 430 randomly selected households in 24 villages.
Household members one year and older were assessed for antigenaemia using immunochromatographic test cards and if positive, microfilaraemia by night-time thick blood smear. Author summary Lymphatic filariasis (LF) is a mosquito-transmitted worm infection that causes chronic and progressive swelling of the limbs (lymphoedema) and testis (hydrocoele). Editor: Peter U. Copyright: © 2018 Dickson et al. Introduction. PLOS 26/07/18 Molecular xenomonitoring for Wuchereria bancrofti in Culex quinquefasciatus in two districts in Bangladesh supports transmission assessment survey findings.
Abstract Background Careful monitoring for recrudescence of Wuchereria bancrofti infection is necessary in communities where mass drug administration (MDA) for the elimination of lymphatic filariasis (LF) as a public health problem has been stopped. During the post-MDA period, transmission assessment surveys (TAS) are recommended by the World Health Organization to monitor the presence of the parasite in humans. Molecular xenomonitoring (MX), a method by which parasite infection in the mosquito population is monitored, has also been proposed as a sensitive method to determine whether the parasite is still present in the human population.
The aim of this study was to conduct an MX evaluation in two areas of Bangladesh, one previously endemic district that had stopped MDA (Panchagarh), and part of a non-endemic district (Gaibandha) that borders the district where transmission was most recently recorded. Methodology/Principal findings Conclusions/Significance Author summary Introduction Methods. Trop. Med. Infect. Dis. 2017, 2(3), 32; Lymphatic Filariasis in Mainland Southeast Asia: A Systematic Review and Meta-Analysis of Prevalence and Disease Burden. THE LANCET - JUNE 2018 - Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary? THE HINDU 19/06/18 Experts for treating lymphatic filariasis through research. A lot has happened in the approach to lymphatic filariasis. From being a neglected disease in the 1970s, clinical advances have revolutionised the approach to lymphoedema, according to Eric Ottesen, director, Neglected Tropical Diseases-Support Centre, Task Force for Global Health, U.S.
Delivering the second Dr. V. Kumaraswami Endowment Lecture at the National Institute for Research in Tuberculosis (NIRT) on Monday, he spoke on “solving the lymphatic filariasis problem through research”. Talking about the Global Programme to Eliminate Lymphatic Filariasis, he said, “The goal is to eliminate lymphatic filariasis as a public health problem and stop the spread of infection by interrupting transmission and reduce suffering caused by the disease through morbidity control efforts,” he said. He pointed out that the cumulative treatment administered during the Mass Drug Administration (MDA) in 67 countries was 6.7 billion.
He recalled the contribution of V. PLOS 26/09/17 How much will it cost to eradicate lymphatic filariasis? An analysis of the financial and economic costs of intensified efforts against lymphatic filariasis. Rev. Inst. Med. trop. S. Paulo vol.59 São Paulo 2017 Epub Apr 20, 2017 Knowledge, attitudes and perceptions regarding lymphatic filariasis: study on systematic noncompliance with mass drug administration. PLOS 10/05/18 Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects. Epidemics Volume 18, March 2017, Predicting lymphatic filariasis transmission and elimination dynamics using a multi-model ensemble framework. PLOS 29/06/17 First evidence of lymphatic filariasis transmission interruption in Cameroon: Progress towards elimination. PLOS 03/10/16 Climate Change Influences on the Global Potential Distribution of the Mosquito Culex quinquefasciatus, Vector of West Nile Virus and Lymphatic Filariasis.
PLOS 19/05/17 Detecting infection hotspots: Modeling the surveillance challenge for elimination of lymphatic filariasis. Cec Ugc via YOUTUBE 03/08/15 Vector Borne Diseases : Leishmaniasis & Lymphatic Filariasis. Parasitol Res. 2017 Mar;116(3):963-970. Molecular identification and phylogenetic analysis of Wuchereria bancrofti from human blood samples in Egypt. PLOS 16/02/17 Partnering for impact: Integrated transmission assessment surveys for lymphatic filariasis, soil transmitted helminths and malaria in Haiti. ASSAM JOURNAL OF INTERNATL MEDICINE - JANV 2017 - USG Scrotum as an Important Investigating Tool for Lymphatic Filariasis. Indian Journal of Public Health Research & Development, April-June 2016, Vol. 7, No. 2 Prevalence of Lymphatic Filariasis and Economic Impact of Chronic Forms of the Disease in a Group of Weavers in the Godavari Districts of Andhra Pradesh.
SOUTHEAST ASIAN J TROP MED PUBLIC HEALTH - MAI 2012 - Geographic information system (GIS) mapping of lymphatic filariasis endemic areas of Gampaha district, Sri Lanka based on epidemiological and entomological screening. SOUTHEAST ASIAN J TROP MED PUBLIC HEALTH - NOV 2014 - PREVALENCE OF LYMPHATIC FILARIASIS, MALARIA AND SOIL TRANSMITTED HELMINTHIASIS IN A COMMUNITY OF BARDIYA DISTRICT, WESTERN NEPAL. Acta Tropica Volume 135, July 2014, Lymphatic filariasis and onchocerciasis prevention, treatment, and control costs across diverse settings: A systematic review. Transactions of the Royal Society of Tropical Medicine and Hygiene Volume 106, Issue 2, February 2012, Lymphatic filariasis in western Ethiopia with special emphasis on prevalence of Wuchereria bancrofti antigenaemia in and around onchocerciasis endemic a.
THE LANCET - MARS 2016 - Reducing the population requiring interventions against lymphatic filariasis in Africa. Asian Pacific Journal of Tropical Disease Volume 6, Issue 7, July 2016, Lymphatic filariasis: Surveillance action among immigrants from endemic areas, Acre State, Brazilian Amazon. Trends in Parasitology Volume 33, Issue 2, February 2017, Can Lymphatic Filariasis Be Eliminated by 2020?
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PLOS 27/12/11 The Emerging Story of Disability Associated with Lymphatic Filariasis: A Critical Review. PLOS 05/11/15 Shrinking the Lymphatic Filariasis Map of Ethiopia: Reassessing the Population at Risk through Nationwide Mapping. PLOS 09/10/15 What Is Needed to Eradicate Lymphatic Filariasis? A Model-Based Assessment on the Impact of Scaling Up Mass Drug Administration Programs. PLOS 11/07/13 Population Genetics of the Filarial Worm Wuchereria bancrofti in a Post-treatment Region of Papua New Guinea: Insights into Diversity and Life History.
PLOS 20/02/14 Mapping the Geographical Distribution of Lymphatic Filariasis in Zambia. INTERNATIONAL JOURNAL OF MEDICINE AND MEDICAL SCIENCES - MARS 2015 - Wuchereria bancrofti antigenaemia among school children: A case study of four communities in the Kassena-Nankana east district of the upper east region of Ghana. CDC EID - Volume 20, Number 7—July 2014. Au sommaire notamment: Zoonotic Filariasis Caused by Novel Brugia sp. Nematode, United States, 2011. PLOS 29/05/14 Exploring the Potential of Flubendazole in Filariasis Control: Evaluation of the Systemic Exposure for Different Pharmaceutical Preparations. Infection, Genetics and Evolution 10 (2010) 159–177 Review on global co-transmission of human Plasmodium species and Wuchereria bancrofti by Anopheles mosquitoes. PLOS 19/12/16 The Impact of Lymphatic Filariasis Mass Drug Administration Scaling Down on Soil-Transmitted Helminth Control in School-Age Children. Present Situation and Expected Impact from 2016 to 2020.
PLOS 01/12/16 Using Community-Level Prevalence of Loa loa Infection to Predict the Proportion of Highly-Infected Individuals: Statistical Modelling to Support Lymphatic Filariasis and Onchocerciasis Elimination Programs. PLOS 09/09/15 Mapping of Bancroftian Filariasis in Cameroon: Prospects for Elimination. INTECH - MARS 2012 - Lymphatic Filariasis Transmission and Control: A Mathematical Modelling Approach. MEDICAL JOURNAL ARMED FORCES INDIA - 2014 - Monitoring of malaria, Japanese encephalitis and filariasis vectors. PLOS - FEV 2010 - Detection of Wuchereria bancrofti L3 Larvae in Mosquitoes: A Reverse Transcriptase PCR Assay Evaluating Infect. Journal of Tropical Medicine Volume 2011 (2011) Current Evidence on the Use of Antifilarial Agents in the Management of Bancroft.