UB Community for Global Health Equity via YOUTUBE 28/09/16 Nipah Virus: Countering a Global Pandemic, Dr. Stephen Luby. MICROBE POST 23/08/16 On the Horizon: Nipah Virus. RIRDC_GOV_AU 31/05/16 Milestone for Hendra virus research. Milestone for Hendra virus research 31 May 2016 Over three years of coordinated and ground breaking Hendra virus research will be shared at conference in Brisbane tomorrow.
More than 140 delegates from across Australia will share their findings at the concluding symposium for the National Hendra Virus Research Program. The Rural Industries Research and Development Corporation’s (RIRDC) Managing Director, John Harvey said the Corporation had played a key role in coordinating and managing the eight horse-related research projects carried out as part of the Program. “RIRDC has been a lead player in successfully coordinating this multi-jurisdiction research program and the outcomes have increased our knowledge on how Hendra virus is spread and the impacts the disease has on both horses and humans,” Mr Harvey said.
Trans R Soc Trop Med Hyg (2015) 109 (9): 563-571. Mapping the risk of Nipah virus spillover into human populations in South and Southeast Asia. Background Nipah virus (NiV) is a significant emerging zoonotic pathogen given its wide geographic distribution, and the severe morbidity and high mortality that accompanies infection.
Moreover, the layered landscape epidemiology surrounding spillover from reservoir host species to humans is ill-defined. Identifying landscape features that contribute to NiV spillover would likely prove helpful in preventing emergence in human populations. Methods Using an inhomogeneous Poisson model, this study investigated the role of vegetation cover, the human footprint (HFP) and reservoir Pteropus bat distribution to identify the spatial dependence of spillover and map risk across South and Southeast Asia. Results The spatial model identified HFP (RR=1.08; 95% CI 1.05–1.11) and bat distribution (RR=19.44; 95% CI 1.92–196.7) as significant predictors of NiV risk, while vegetation cover was not significant after accounting for HFP and the presence of Pteropus bats.
Advances in Biology Volume 2015 (2015) Serological Evidence of Henipavirus among Horses and Pigs in Zaria and Environs in Kaduna State, Nigeria. Zoonoses Public Health. 2016 Aug;63(5):374-85. Intangible and Economic Impacts of Hendra Virus Prevention Strategies. Hendra virus (HeV), a potentially fatal zoonotic disease spread by flying foxes, to date has always infected humans via a spillover event from equine HeV infection.
In a theoretical case study, we compared the impacts of two different HeV prevention strategies – vaccination and flying fox roost removal – using a recently developed framework that considers different stakeholder group perspectives. The perspectives of the four selected stakeholder groups regarding intangibles were inferred from public discussions and coverage in the media. For all stakeholder groups, the option to vaccinate horses was found to add value to the economic results when the intangible impacts were included in the analysis, while the option for roost removal unanimously detracted from economic analysis value when the intangible impacts were included. Curr Opin Virol. 2016 Feb;16:120-5. Hendra virus ecology and transmission. Hume E Field EcoHealth Alliance, New York, NY, USA Available online 12 March 2016 Choose an option to locate/access this article: Check if you have access through your login credentials or your institution.
J Med Virol. 2016 Mar;88(3):380-8. Origin and evolution of Nipah virus. Vaccine Volume 34, Issue 26, 3 June 2016, Status of vaccine research and development of vaccines for Nipah virus. Open Access Highlights No therapeutics or vaccines are currently approved for use in humans against NiV.
Approximately two billion people live in areas inhabited by the Pteropus bat reservoir. Soluble glycoprotein vaccines and virus vector platforms are protective in experimental animals. Exact correlates of protection against NiV have not been completely defined. The sporadic nature of NiV outbreaks makes large scale Phase III clinical trials difficult to plan. ABC 03/06/16 Black and spectacled flying foxes are main Hendra virus carriers, research shows.
Posted The message from the latest Hendra virus research is simple — vaccinate your horses against the virus if you live in a high risk bat prone area.
The statistics are frightening — more than 80 per cent of horses that contract the Hendra virus die, and four out of seven people who have contracted the disease from horses have died. This week the nation's leading Hendra scientists, vets and health officers met in Brisbane to bring together all the research into the bat-borne disease. The Hendra virus was first identified in Brisbane in the mid-1990s, when several horses under the care of horse trainer Vic Rail died.
Mr Rail himself succumbed to what became known as the Hendra virus, named after the suburb of Hendra where his training facility was located. HORSETALK 01/08/16 New field test for Hendra virus in horses could deliver result in minutes. The development of a rapid and mobile diagnostic test for Australia’s deadly Hendra virus in horses holds the promise of a result in just 10 minutes.
Hendra is a bat-borne virus that is capable of infecting horses, with deadly consequences. The virus has also proved capable of infecting humans through contact with infected bodily fluids from ill horses. Four of the seven confirmed cases in humans have proved fatal. The current testing regime requires laboratory testing and can take 36 hours or more before results are known. QUEENSLAND GOVERNMENT - 2013 - Guidelines for veterinarians handling potential Hendra virus infection in horses. CSIRO 16/07/13 Boosting the frontline fight against the Hendra virus. Equivac® HeV–the first vaccine to protect Australian horse owners and the equine industry against the deadly Hendra virus.
Animal to human transmission One of the biggest threats to Australia's society today is major pandemics transferred, not from human to human, but from animals to humans. The Hendra virus is transmitted from animals to humans and is a Bio-Safety Level-4 disease agent, which is the most dangerous level in the world. The Hendra virus that was first identified in horses in 1994 is a Bio-Safety Level-4 disease agent, which is the most dangerous level in the world. It is an infection that is transmitted from animals to people and reflects the alarming trend in 70 per cent of all emerging infectious diseases found in people over the past two decades.
The transmission of the virus between humans and horses is still unknown but once transmitted can be fatal, with four of the seven people infected with the virus dying as a result. Isolate and identify An effective vaccine. ABC 03/06/16 Black and spectacled flying foxes are main Hendra virus carriers, research shows. VIROLOGY JOURNAL 27/11/14 Detailed morphological characterisation of Hendra virus infection of different cell types using super-resolution and conventional imaging. Trop Med Surg - 2013 - Nipah virus. STEPS CENTRE - 2014 - Towards one health? Evolution of international collaboration networks on Nipah virus research from 1999 to 2011. NIAID_NIH_GOV 14/03/14 NIAID Scientists Track Foodborne Transmission of Nipah Virus in Hamsters. A new NIAID study shows that Nipah virus infection can occur after consuming sap contaminated with the virus.
The result provides additional evidence that infected fruit bats likely are contaminating sap harvested from date palm trees, thus spreading the virus to people in parts of Southeast Asia. Background Nipah virus first was identified in 1998 when an outbreak in Malaysia and Singapore sickened 276 people. To date, there have been more than 500 cases with nearly 300 deaths throughout parts of Southeast Asia. The virus targets the lungs and causes brain swelling. There is no treatment for Nipah, though scientists are continuing studies of an experimental vaccine and treatment. Fruit bats are thought to be the natural reservoir, or carrier, of Nipah virus. CSIRO 07/04/15 New weapon against deadly Hendra virus.
Electron micrograph of Hendra virus.
Last week Queensland’s Department of Heath announced they will soon begin testing a human antibody treatment against the deadly Hendra virus with the help of humans. ‘Hendra’ is a potentially fatal virus that can cause disease and death in horses and, occasionally, people. The virus is found in flying foxes, which are interestingly naturally immune to it. The announcement of human trials is particularly exciting for us because of our intimate history with this virus and our involvement in the development of the monoclonal antibody in question – m102.4. Hendra virus first came into the spotlight in 1994, when Queensland horse trainer Vic Rail, his stable hand and many of his horses, became ill to a mystery disease. The Australian Veterinary Association recommends that all horses in Australia are vaccinated against the Hendra virus.
The recent development of the ‘seek and destroy’ human monoclonal antibody known as m102.4 was truly a global effort. CDC EID - Volume 20, Number 6—June 2014 Au sommaire: Novel Henipa-like Virus, Mojiang Paramyxovirus, in Rats, China, 2012. Suggested citation for this article To the Editor: The genus Henipavirus (family Paramyxoviridae) contains 3 established species (Hendra virus, Nipah virus, and Cedar virus) and 19 newly identified species, including 1full-length sequenced virus, Bat Paramyxovirus Eidhel/GH-M74a/GHA/2009 (1,2).
The zoonotic pathogens Hendra virus and Nipah virus have been associated with lethal neurologic and respiratory diseases in humans, horses, and pigs (3–5). The known natural reservoirs of henipaviruses are fruit bats (1,3); these viruses have not been reported in other wild animals. We report on a novel henipa-like virus, Mojiang paramyxovirus (MojV), in rats (Rattus flavipectus) in China. In June 2012, in Mojiang Hani Autonomous County, Yunnan Province, China, severe pneumonia without a known cause was diagnosed in 3 persons who had been working in an abandoned mine; all 3 patients died. MojV shares similar features with known henipaviruses. CDC EID - FEV 2015 - Outbreak of Henipavirus Infection, Philippines, 2014. Paola Katrina G. Ching, Vikki Carr de los Reyes, Maria Nemia Sucaldito, Enrique Tayag, Alah Baby Columna-Vingno, Fedelino F.
Malbas, Gilbert C. Bolo, James J. CDC EID - MARS 2014 – Au sommaire: Hendra Virus Vaccine, a One Health Approach to Protecting Horse, Human, and Environmental Health. Deborah Middleton1 ( , Jackie Pallister1, Reuben Klein, Yan-Ru Feng, Jessica Haining, Rachel Arkinstall, Leah Frazer, Jin-An Huang, Nigel Edwards, Mark Wareing, Martin Elhay, Zia Hashmi, John Bingham, Manabu Yamada, Dayna Johnson, John White, Adam Foord, Hans G. Heine, Glenn A. Marsh, Christopher C.
NSW GOVERNMENT - PRIMARY INDUSTRIES AGRICULTURE - JUILLET 2011 - Hendra virus - Frequently Asked Questions. Last updated: 24 June 2012. QUEENSLAND GOVERNMENT 12/09/12 Frequently asked questions about dogs and Hendra virus. In July 2011, test results confirmed the presence of antibodies to Hendra virus in a dog sampled on a Hendra virus infected property. This was the first reported case of Hendra virus antibody detection in a dog outside of an experimental setting. This means at some point the dog had been infected with Hendra virus. The dog reportedly showed no signs of illness. DEPARTMENT OF JUSTICE (Queensland - Australie) - 2015 - Hendra virus – information for veterinarians. NSW GOVERNMENT 05/12/13 The objective of this policy is to minimise the human health risk, animal welfare, economic and trade impacts associated with Hendra virus. CIRAD 03/04/14 Ecology of Flying foxes and the risk of Nipah virus emergence in Cambodia. CSIRO 07/04/15 New weapon against deadly Hendra virus.
QUEENSLAND GOVERNMENT 01/04/15 Everyday Queenslanders commit to fight against Hendra. ANIMAL HEALTH AUSTRALIA 01/04/15 Improved hendra virus vaccine information. Ahead of Print -Outbreak of Henipavirus Infection, Philippines, 2014 - Volume 21, Number 2—February 2015. Detailed morphological characterisation of Hendra virus infection of different cell types using super-resolution and conventional imaging.
STEPS CENTRE - 2014 - Towards one health? Evolution of international collaboration networks on Nipah virus research from 1999 to 2011. CDC EID - FEV 2015 - Outbreak of Henipavirus Infection, Philippines, 2014. GOVERNMENT OF SOUTH AUSTRALIA - BIOSECURITY SA - JUILLET 2011 - Understanding Hendra virus For equine veterinarians. JOURNAL OF INFECTION IN DEVELOPING COUNTRIES – AVRIL 2013 - Pathogenesis of Hendra and Nipah virus infection in humans.
Review Articles. DAFF_QLD_GOV_AU - MAI 2013 - Hendra virus Information for horse owners, handlers, competitors and event organisers. Pathogens 2013, 2(2), 264-287; Henipavirus Infections: Lessons from Animal Models. Open AccessThis article isfreely availablere-usable. COLLEGE DE FRANCE 10/06/13 Présentation : Understanding all Steps of Nipah Virus Transmission. BIOSECURITY QUEENSLAND - Perspective on Hendra virus. AUSTRALIAN WILDLIFE HEALTH NETWORK 23/05/10 - Exotic - Nipah Virus fact sheet. NIH_GOV 13/03/14 NIAID Scientists Track Foodborne Transmission of Nipah Virus in Hamsters. FREE PATENTS ONLINE 13/06/13 Human Monoclonal Antibodies Against Hendra and Nipah Viruses. This application claims the benefit of U.S. Provisional Patent Application No. 60/661,766, filed Mar. 14, 2005, U.S. Provisional Patent Application No. 60/678,547, filed May 5, 2005, and U.S.
Provisional Patent Application No. 60/718,902, filed Sep. 20, 2005, the disclosures of all of which are hereby expressly incorporated by reference in their entireties. This invention relates generally to the field of immunology and specifically to monoclonal antibodies that bind or neutralize Hendra and Nipah viruses. Nipah virus (NiV) and Hendra virus (HeV) are closely related emerging paramyxoviruses that comprise the Henipavirus genus (Anonymous 1999 MMWR Morb Mortal Wkly Rep Ward, J. The broad species tropisms and the ability to cause fatal disease in both animals and humans distinguish HeV and NiV from all other known paramyxoviruses (reviewed in Eaton, B. NiV has recently re-emerged in Bangladesh.
FIG. 2: Inhibition of HeV Env-mediated syncytia formation by m101. FIG. 3. FIG. 4. FIG. 5. QUEENSLAND OMBUDSMAN 03/11/11 Hendra virus report: FAQS. Biosecurity Queensland - 2012 - Présentation : Hendra virus responses. UNIVERSITY OF SYDNEY - 2012 - A longitudinal cohort evaluate risk (HHALTER) A Longitudinal cohort study To Evaluate Risk HHALTER is a three-year project funded by the Commonwealth of Australia, the State of New South Wales, the State of Queensland and the Rural Industries Research and Development Corporation under the National Hendra Virus Research Program. The overarching goal of the project is to help inform strategies that reduce the transmission of Hendra virus from flying foxes to horses and from horses to humans. This will be achieved by engaging with ‘horse people’ and ensuring that they are included at the centre of Hendra virus-related policy development and research At the heart of the HHALTER study is a large and inclusive cohort of horse owners and people involved with horses that we will study over a two-year period.
We would like this cohort to include people involved with horses from all sectors of the horse industryand from all States and Territories. This research program acknowledges that the situation with Hendra virus in Australia is dynamic. NSW GOVERNMENT - PRIMARY INDUSTRIES AGRICULTURE - AOUT 2011 - $6m for cross border Hendra virus research. NSW animal owners have so far made 126 submissions of 418 samples for testing for Hendra virus to the Elizabeth Macarthur Agricultural Institute (EMAI) . The vast majority of samples came from horses. Some were from dogs. Curr Top Microbiol Immunol. 2012 Apr 3. Ecological Aspects of Hendra Virus. Virus Research Volume 162, Issues 1–2, December 2011, A review of Nipah and Hendra viruses with an historical aside.
PNAS 30/08/12 Interdisciplinary approaches to understanding disease emergence: The past, present, and future drivers of Nipah vi. Current Opinion in Virology Volume 2, Issue 3, June 2012, Pages 242–247 Hendra and Nipah viruses: why are they so deadly? Volume 2, Issue 3, June 2012, Pages 242–247. Ecological Aspects of Hendra Virus. [Curr Top Microbiol Immunol. 2012. Pathology Research International Volume 2011 (2011), Pathology of Acute Henipavirus Infection in Humans and Animals.
ROYAL SOCIETY 11/05/11 Urban habituation, ecological connectivity and epidemic dampening: the emergence of Hendra virus from fly. + Author Affiliations * Authors for correspondence (firstname.lastname@example.org; email@example.com). Abstract Anthropogenic environmental change is often implicated in the emergence of new zoonoses from wildlife; however, there is little mechanistic understanding of these causal links. Here, we examine the transmission dynamics of an emerging zoonotic paramyxovirus, Hendra virus (HeV), in its endemic host, Australian Pteropus bats (fruit bats or flying foxes).
Center for Food Security and Public Health, Iowa State University, 2011 Présentation: Nipah. JITMM-1-12-2010-C7-Christopher-Morrissey. Perkins. Dog infected with hendra virus ABC Sydney - Explore by Topic - Australian Broadcasting Corporation. Hendra Virus, not just a Queensland problem. Hendra-alert-for-the-horse-industry. Biosecurity-bulletin-update-7-July-2011. Urgent Call for Research - Hendra Virus. NPR 25/02/17 A Taste For Pork Helped A Deadly Virus Jump To Humans.