UNIVERSITY OF ZURICH - 2013 - Guidance on the environmental risk assessment of genetically modified animals. BMC VETERINARY RESEARCH 08/08/20 The 3D8 single chain variable fragment protein suppresses Newcastle disease virus transmission in transgenic chickens. 1.Iram N, Shah MS, Ismat F, Habib M, Iqbal M, Hasnain SS, Rahman M.
Heterologous expression, characterization and evaluation of the matrix protein from Newcastle disease virus as a target for antiviral therapies. Appl Microbiol Biotechnol. 2014;98:1691–701.CAS Article Google Scholar 2.Afonso CL, Miller PJ. Newcastle disease: progress and gaps in the development of vaccines and diagnostic tools.
Dev Biol (Basel). 2013;135:95–106.CAS Google Scholar 3.Senne DA, King DJ, Kapczynski DR. NATURE 09/03/20 Labs rush to study coronavirus in transgenic animals — some are in short supply. As coronavirus marches around the globe, a sleepy town on the rugged Maine coast has become an unlikely nucleus in researchers’ efforts to combat the disease, known as COVID-19.
The Jackson Laboratory, a mouse-breeding facility in Bar Harbor, is rushing to produce stocks of a transgenic mouse that scientists hope will help them to understand the virus. “We’ve been overwhelmed with requests,” says Cathleen Lutz, a neuroscientist who heads the institute’s mouse repository. The facility has already received orders from around 50 labs for more than 3,000 mice that produce a human version of the protein ACE2, which the virus causing the outbreak, SARS-CoV-2, uses to enter cells.
Normal mice seem to be resistant to infection. With more than 110,000 confirmed human cases worldwide and no sign that the coronavirus is going away, researchers are looking to animals to understand COVID-19. PEW RESEARCH CENTER 16/08/18 Most Americans Accept Genetic Engineering of Animals That Benefits Human Health, but Many Oppose Other Uses. As Americans consider the possible uses of genetic engineering in animals, their reactions are neither uniformly accepting nor resistant; instead, public reactions vary depending on the mechanism and intended purpose of the technology, particularly the extent to which it would bring health benefits to humans.
Presented with five different scenarios of animal genetic engineering that are currently available, in development or considered possible in the future, Americans provide majority support only for the two that have clear potential to pre-empt or ameliorate human illness. JOURNAL OF HUMAN GENETICS 04/12/17 Genetic engineering in nonhuman primates for human disease modeling. Laboratory animals have long played a useful role in bridging in vitro research and clinical medicine.
Mice are widely recognized as the most popular experimental animal and various disease models have been generated over the years that have greatly contributed to the elucidation of human diseases. Mouse models are genetically well controlled and their fecundity is useful for easily and clearly understanding the relationships between gene abnormalities and diseases. However, the physiological differences between rodents and humans are obvious and, in some research areas, such as the development of new drugs, it is difficult to extrapolate the results from mouse models to humans. TRANSGENIC RES. 06/01/16 Ten transgenic animal research conferences and counting. The most recent Transgenic Animal Research Conference (TARC), the 10th such conference, was held at the Granlibakken Resort and Conference Center in Tahoe City California in August 2015.
The stated objective of the TARC conferences is “to bring together representatives from the leading laboratories worldwide doing cutting edge work on transgenic research in non-murine animals, including livestock, fish and poultry species”. The first conference, held in 1997, was inspired by the earlier Nethybridge, Scotland Conference organized by Ian Wilmut, John Clark, and Rick Lathe in 1986 around the newly evolving field of genetic engineering (GE) mammals. The first conference was principally focused on the application of GE for use in agriculture and was appropriately called Transgenic Animals in Agriculture.
Like the 10th conference, presentations were a mixture of review and research papers. Our original intentions were to organize a single conference, like Nethybridge. BLOOMBERG 03/12/19 China's Mutant Pigs Could Help Save Nation From Pork Apocalypse. NATURE 26/07/19 Japan approves first human-animal embryo experiments. A Japanese stem-cell scientist is the first to receive government support to create animal embryos that contain human cells and transplant them into surrogate animals since a ban on the practice was overturned earlier this year.
Hiromitsu Nakauchi, who leads teams at the University of Tokyo and Stanford University in California, plans to grow human cells in mouse and rat embryos and then transplant those embryos into surrogate animals. Nakauchi's ultimate goal is to produce animals with organs made of human cells that can, eventually, be transplanted into people. Until March, Japan explicitly forbade the growth of animal embryos containing human cells beyond 14 days or the transplant of such embryos into a surrogate uterus. Sci Rep. 2017 Aug 30;7(1):10065. RNAi combining Sleeping Beauty transposon system inhibits ex vivo expression of foot-and-mouth disease virus VP1 in transgenic sheep cells. CHINA DAILY 02/04/19 Transgenic monkeys carrying human gene show human-like brain development. BEIJING -- Researchers from China and the United States have created transgenic monkeys carrying a human gene that is important for brain development, and the monkeys showed human-like brain development.
Scientists have identified several genes that are linked to primate brain size. MCPH1 is a gene that is expressed during fetal brain development. Mutations in MCPH1 can lead to microcephaly, a developmental disorder characterized by a small brain. Iran J Pharm Res. 2013 Autumn; 12(4): 579. Transgenic Animals in Pharmaceutical and Biological Research in Iran. SCIENCE MEDIA CENTRE 06/12/18 expert reaction to study looking at long-term function of genetically modified pig hearts transplanted into baboons. December 6, 2018 Research published in Nature demonstrates that baboons implanted with genetically modified pig hearts have been able to survive for up to 195 days.
Prof Jeremy Pearson, Associate Medical Director at the British Heart Foundation, said: “The potential to solve the shortage of available human hearts for transplantation by using pig hearts has been an aspiration for scientists for more than 40 years, but has proved to be a difficult journey. The biggest hurdle is rapid rejection of the pig heart by the human immune system. This has been largely overcome by the development of genetically modified pigs, that have successively reduced this complication. “This new research takes us a step closer to the use of pig hearts in humans. Prof Barry Fuller, Professor in Surgical Science & Low Temperature Medicine, UCL & Royal Free London NHS Foundation Trust Transplantation Services, said: Declared interests.
JOURNAL OF HUMAN GENETICS 04/12/17 Genetic engineering in nonhuman primates for human disease modeling. Laboratory animals have long played a useful role in bridging in vitro research and clinical medicine.
Mice are widely recognized as the most popular experimental animal and various disease models have been generated over the years that have greatly contributed to the elucidation of human diseases. Mouse models are genetically well controlled and their fecundity is useful for easily and clearly understanding the relationships between gene abnormalities and diseases. However, the physiological differences between rodents and humans are obvious and, in some research areas, such as the development of new drugs, it is difficult to extrapolate the results from mouse models to humans. INTERNATIONAL JOURNAL OF SCIENCE, ENVIRONMENT AND TECHNOLOGY - 2017 - ADVANCES IN TRANSGENIC ANIMAL PRODUCTION AND APPLICATIONS.
Transgenic Res. 2017 Aug 5. Advances in transgenic animal models and techniques. THE SUN 13/07/17 Millions of genetically modified animals are being bred, caged and killed ‘without any scientific gain’, charity warns. MILLIONS of genetically modified animals are being bred simply to wait for their death in bleak laboratories, it has emerged.
In 2016 the UK completed 3.94 million procedures on living animals, of which nearly half (49 per cent) are associated with the production of genetically altered animals, Home Office stats revealed. Getty Images Scientists often use genetically modified animals to test how drugs work on certain diseases and deliberately breed "ill" animals with mutant genes. To make sure that there will always be animals with the correct mutation available to test on, scientists tend to constantly breed animals - even when they aren't needed. If researchers know that they might need seven animals later in the year, they will constantly breed them up until that point to ensure that there is supply.
Those that aren't used in the tests will be culled. Mice are the most popular animal for testing, but there has been an increase in the use of dogs in Britain, latest figures show. J Pineal Res. 2017 Aug;63(1). An AANAT/ASMT transgenic animal model constructed with CRISPR/Cas9 system serving as the mammary gland bioreactor to produce melatonin-enriched milk in sheep. Melatonin as a potent antioxidant exhibits important nutritional and medicinal values. To produce melatonin-enriched milk will benefit the consumers. In this study, a sheep bioreactor which generates melatonin-enriched milk has been successfully developed by the technology that combined CRISPR/Cas9 system and microinjection. FAS USDA 08/05/17 Government Responds to Genetically Modified Animals Report_Ottawa_Canada_5-3-2017.
Theriogenology. 2016 Jul 1;86(1):160-9. New insights and current tools for genetically engineered (GE) sheep and goats. Genetically engineered sheep and goats represent useful models applied to proof of concepts, large-scale production of novel products or processes, and improvement of animal traits, which is of interest in biomedicine, biopharma, and livestock. This disruptive biotechnology arose in the 80s by injecting DNA fragments into the pronucleus of zygote-staged embryos. Pronuclear microinjection set the transgenic concept into people's mind but was characterized by inefficient and often frustrating results mostly because of uncontrolled and/or random integration and unpredictable transgene expression. Somatic cell nuclear transfer launched the second wave in the late 90s, solving several weaknesses of the previous technique by making feasible the transfer of a genetically modified and fully characterized cell into an enucleated oocyte, capable of cell reprogramming to generate genetically engineered animals.
PLOS 03/11/16 A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork. Abstract Our laboratory recently produced genetically engineered (GE) Meishan pigs containing a ZFN-edited myostatin loss-of-function mutant. These GE pigs develop and grow as normal as wild type pigs but produce pork with greater lean yield and lower fat mass. UNIVERSITY OF EDINBURGH via YOUTUBE 04/11/11 Food for the Future: the Potential of GM Animals.
UNIVERSITY OF NEBRASKA via YOUTUBE 14/01/15 Genetically Modified Animals: the Facts, the Fear Mongering, and the Future. PHYSORG 11/02/16 Opposition to genetically modified animals could leave millions hungry. In a world with a ballooning population and deteriorating environment, we will need to use every trick in the book to stave off mass starvation, disease and political chaos. According the Food and Agriculture Organization of the United Nations, there are 795 million people (more than 10% of the world population) who are chronically undernourished. This includes 161 million children, of which 3.1 million die from hunger each year. We need to double food production, with less land and less water, and prevent further environmental degradation. NAS-SITES - NOV 2015 - Présentation: Regulation of GM‐Animals in Argentina. NATURE 18/11/15 China's bold push into genetically customized animals New kinds of dogs, goats, monkeys and pigs are being made quickly, though scientists voice worries about ethics.
A technician at the genomics institute BGI in Shenzhen, China, holds a genetically-modified micropig. An article by Scientific American. China’s western Shaanxi Province is known for rugged windswept terrain and its coal and wool, but not necessarily its science. Yet at the Shaanxi Provincial Engineering and Technology Research Center for Shaanbei Cashmere Goats, scientists have just created a new kind of goat, with bigger muscles and longer hair than normal.
BMC Proceedings 2014, 8(Suppl 4):O30 Transgenic animal models for the production of human immunocompounds in milk to prevent diarrhea, malnourishment and child mortality: perspectives for the Brazilian Semi-Arid region. BRITISH FOOD JOURNAL 17/10/13 Attitudes towards genetically modified animals in food production. DOVEPRESS 15/04/15 Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy. 1State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People’s Republic of China; 2Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA Abstract: Huntington’s disease (HD) is caused by a genetic mutation that results in polyglutamine expansion in the N-terminal regions of huntingtin. As a result, this polyQ expansion leads to the misfolding and aggregation of mutant huntingtin as well as age-dependent neurodegeneration.
GLOBAL BIOETHICS 12/03/14 Impacts of genetically modified animals on the ecosystem and human activities. BBC 25/02/15 Is the world ready for GM animals? UNIVERSITY OF MARYLAND - 2014 - Cow of the Future: Genetically Engineering a Microbe to Reduce Bovine Methane Emissions. Comp Med. 2012 December; 62(6): 472–479. Transgenic rabbit models for studying human cardiovascular diseases. PLOS 13/03/13 Consuming Transgenic Goats' Milk Containing the Antimicrobial Protein Lysozyme Helps Resolve Diarrhea in Young Pigs. Abstract. Biochemistry and Biotechnology Research - AVRIL 2014 - Genetic engineering in animal production: Applications and prospects. Trends in Food Science & Technology Volume 44, Issue 2, August 2015, Genetically modified animals: Options and issues for traceability and enforcement.
African Journal of Biotechnology 08/05/13 Development of transgenic chickens by spermmediated gene transfer. Full Length Research Paper Essam A. BioMed Research International Volume 2013 (2013), Expression Systems and Species Used for Transgenic Animal Bioreactors. TRENDS IN BIOTECHNOLOGY - MAY 2013 - An algorithm for the identification of genetically modified animals. New Biotechnology Volume 30, Issue 5, 25 June 2013, Genetically modified animals from life-science, socio-economic and ethical p.
New Biotechnology Volume 30, Issue 5, 25 June 2013, Genetically modified animals from life-science, socio-economic and ethical perspectives: examining issues in an EU policy context – guatemalt