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BMC EVOLUTIONARY BIOLOGY 13/01/17 Quantifying predictors for the spatial diffusion of avian influenza virus in China. Phylogeographic evolution of AIV in China In this study the data set consisted of 320 AIV genomes which were obtained from 27 out of the 32 provinces in China.

BMC EVOLUTIONARY BIOLOGY 13/01/17 Quantifying predictors for the spatial diffusion of avian influenza virus in China

Of these, Guangdong, Fujian, Hunan, Jiangsu and Jiangxi provinces had the highest number of sequences (Additional file 2: Figure S1). The majority of AIV in the dataset was sampled from domestic birds, with 47.2% from domestic anseriformes (ducks and geese), 32.8% from domestic galliformes (chickens), and 19.4% from wild birds (Additional file 2: Figure S1). Subtypes H5, H6, H7 and H9 are prevalent in China and are circulating in domestic birds, and our dataset includes 31.9% H5N1 and 19.1% H9N2.

Bayesian phylogenetic trees of the 6 internal segments of the 320 Chinese AIV were generated (Additional file 2: Figures S4–S7 and Additional file 3: Figure S9 A–F). The strength of phylogeny-trait association was further tested on different regions types upon the Bayesian phylogenetic trees of the PB2 segment. Zoonoses Public Health. 2017 Feb 20. Serological evidence for exposure to avian influenza viruses within poultry workers in southern China. Sci Rep. 2017 Mar 6;7:43566. Continual Antigenic Diversification in China Leads to Global Antigenic Complexity of Avian Influenza H5N1 Viruses.

PLOS 04/04/17 Influenza A H5N1 and H7N9 in China: A spatial risk analysis. Abstract Background Zoonotic avian influenza poses a major risk to China, and other parts of the world.

PLOS 04/04/17 Influenza A H5N1 and H7N9 in China: A spatial risk analysis

H5N1 has remained endemic in China and globally for nearly two decades, and in 2013, a novel zoonotic influenza A subtype H7N9 emerged in China. This study aimed to improve upon our current understanding of the spreading mechanisms of H7N9 and H5N1 by generating spatial risk profiles for each of the two virus subtypes across mainland China. Methods and findings Conclusions We provide projections of our risk models to public health policy makers so that specific high risk areas can be targeted for control measures. Int. J. Environ. Res. Public Health 2017, 14(2), 217 Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011–June 2015. 1.

Int. J. Environ. Res. Public Health 2017, 14(2), 217 Comparison of Influenza Epidemiological and Virological Characteristics between Outpatients and Inpatients in Zhejiang Province, China, March 2011–June 2015

Introduction Influenza virus is estimated to cause 3 to 5 million cases of severe illness and 250,000 to 500,000 deaths each year, while 5%–10% of adults and 20%–30% of children are infected with the influenza virus worldwide [1]. In lower and middle-income countries, influenza could result in large economic burden encompassing direct costs to the health service and households, and indirect costs of productivity losses [2,3]. Vaccination is a cost-effective way to reduce the public health and economic impacts caused by influenza.

Because of the antigenic shift and drift of the virus, the influenza vaccine composition needs regular updates. Severe acute respiratory illness (SARI) surveillance is another type of surveillance for severe influenza-associated disease. Zhejiang Province located in the Southeastern China, featuring by its blooming economy and high density of population. 2. NATURE 24/08/16 SCIENTIFIC REPORTS - Characterization of H7N2 Avian Influenza Virus in Wild Birds and Pikas in Qinghai-Tibet Plateau Area. Sample collection In an effort to evaluate wild animals in the Qinghai Province ecosystem, we captured wild birds and black-lipped pikas (Ochotona curzoniae) from August 2006 to October 2009 in Qinghai Province some captured site where are on the distributions of generalized migration routes of migratory birds18).

NATURE 24/08/16 SCIENTIFIC REPORTS - Characterization of H7N2 Avian Influenza Virus in Wild Birds and Pikas in Qinghai-Tibet Plateau Area

Specific sites included most areas around the Qinghai lake: Qumalai, Zhiduo, Jiuzhi, Maduo, Golmud, Delingha, Wulan, Gangsha, Gonghe, Tongren, Qilian, Mengyuan and Yushu (Fig. 1). All captured animals were clinically healthy. Aquatic and passerine birds were swabbed and released. AGENCY FOR SCIENCE SINGAPORE 29/05/12 Made-In-Singapore H5N1 Bird Flu Diagnostic Kit – Detects All Known Strains of H5N1 Virus With A Single Test. Ann Glob Health. 2016 Jan-Feb;82(1):180-8. From SARS to Avian Influenza: The Role of International Factors in China's Approach to Infectious Disease Control.

Infectious Diseases of Poverty 20165:59 08/06/16 Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China. H11N9 has been reported in wild waterfowl in Brazil, Belgium, the Republic of Kazakhstan, and Japan [15–19].

Infectious Diseases of Poverty 20165:59 08/06/16 Detection of reassortant avian influenza A (H11N9) virus in environmental samples from live poultry markets in China

This subtype virus has also been isolated from ducks in southern China and Hong Kong SAR [20]. From 2009 to 2013, two H11N9 avian influenza viruses were isolated during routine surveillance. The samples were collected from chicken cages in LPMs. Phylogenetic analyses indicated that all the gene segments belonged to the Eurasian lineage. The HA, NA and NP genes originated from H11N9 viruses, whereas the internal gene segments clustered with H7N7, H7N6 and H4N6. Among influenza A viruses, H5 and H7 are considered to be notable avian influenza viruses, but not all H5 and H7 viruses display high pathogenic. Reassortment among different influenza viruses is considered to be the main mechanism for the generation of new viruses, which may bear enhanced mammalian transmission and pandemic potential.

Veterinary Microbiology Volume 187, 1 May 2016, Highly pathogenic avian influenza viruses H5N2, H5N3, and H5N8 in Taiwan in 2015. Animal Health Research Institute, 376 Chung-Cheng Road, Tamsui District, New Taipei City 25158, Taiwan Received 26 October 2015, Revised 16 March 2016, Accepted 17 March 2016, Available online 19 March 2016 Choose an option to locate/access this article: Check if you have access through your login credentials or your institution Check access.

Veterinary Microbiology Volume 187, 1 May 2016, Highly pathogenic avian influenza viruses H5N2, H5N3, and H5N8 in Taiwan in 2015

Sci Rep. 2016 May 6;6:25549. Co-circulation of H5N6, H3N2, H3N8, and Emergence of Novel Reassortant H3N6 in a Local Community in Hunan Province in China. VIROLOGY JOURNAL - 2014 - Seroprevalence Survey of Avian influenza A (H5) in wild migratory birds in Yunnan Province, Southwestern China. Scientific Reports 09/2014 Serological evidence of H7, H5 and H9 avian influenza virus co-infection among herons in a city park in Jiangxi, China. SCIENTIFIC RESEARCH - MARCH 2014 - Avian Influenza H5N1 Surveillance in Geese of Qinghai Province, China (2012) Avian Influenza H5N1 Surveillance in Geese of Qinghai Province, China (2012) Affiliation(s) The aim of study was to detect H5N1 virus in wild geese in Qinghai Province in 2012.

SCIENTIFIC RESEARCH - MARCH 2014 - Avian Influenza H5N1 Surveillance in Geese of Qinghai Province, China (2012)

The work was provided according to WHO and OIE guidelines. In 2012, we collected 532 samples from wild geese of two species: Bar-headed Goose (Anser indicus) and Graylag Goose (Anser anser). We analyzed samples by chicken embryo inoculation and PCR. Cite this paper. PREVENTIVE VETERINARY MEDICINE - 2011 - Risk-based surveillance for avian influenza control along poultry market chains in South China: The value of social network analysis.

Références PLOS

Middle East Journal of Agriculture Research, 3(2): 208-220, 2014 Toxicological effects of short-term feeding with chlorpyrifos and chlorpyrifos-methyl insecticides on adult albino rats. J Thorac Dis. Dec 2013; 5(6): 790–796. Evidence for H5 avian influenza infection in Zhejiang province, China, 2010-2012: a cross-sectional study. J. Clin. Microbiol - 2012 - Seroepidemiological evidence of Avian influenza A virus tarnsmission to pigs in Southern China. Int. J. Environ. Res. Public Health 2015, Highly Pathogenic Avian Influenza H5N1 in Mainland China. 1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China 2 Department of Public Health, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam 999025, The Netherlands * Authors to whom correspondence should be addressed.

Int. J. Environ. Res. Public Health 2015, Highly Pathogenic Avian Influenza H5N1 in Mainland China

Received: 4 March 2015 / Revised: 20 April 2015 / Accepted: 28 April 2015 / Published: 8 May 2015. EUROSURVEILLANCE 26/06/14 Au sommaire: Genesis of the novel human-infecting influenza A(H10N8) virus and potential genetic diversity of the virus in poultry, China. Human infection with a novel influenza A(H10N8) virus was first described in China in December 2013.

EUROSURVEILLANCE 26/06/14 Au sommaire: Genesis of the novel human-infecting influenza A(H10N8) virus and potential genetic diversity of the virus in poultry, China

However, the origin and genetic diversity of this virus is still poorly understood. We performed a phylogenetic analysis and coalescent analysis of two viruses from the first case of influenza A(H10N8) (A/Jiangxi-Donghu/346-1/2013 and A/Jiangxi-Donghu/346-2/2013 and a novel A(H10N8) virus (A/chicken/Jiangxi/102/2013) isolated from a live poultry market that the patient had visited. The haemagglutinin (HA), neuraminidase (NA), PA subunit of the virus polymerase complex, nucleoprotein (NP), M and nonstructural protein (NS) genes of the three virus strains shared the same genetic origins. The origins of their HA and NA genes were similar: originally from wild birds to ducks, and then to chickens. BMC 27/10/14 Antibodies against H10N8 Avian Influenza Virus among Animal Workers in Guangdong Province before November 30, 2013, the First Recognized Human H10N8 Case.

Research article Wenbao Qi1, Shuo Su1, Chencheng Xiao1, Pei Zhou1, Huanan Li1, Changwen Ke3, Gregory C Gray2, Guihong Zhang1* and Ming Liao1* * Corresponding authors: Guihong Zhang guihongzh@scau.edu.cn - Ming Liao mliao@scau.edu.cn Author Affiliations.

BMC 27/10/14 Antibodies against H10N8 Avian Influenza Virus among Animal Workers in Guangdong Province before November 30, 2013, the First Recognized Human H10N8 Case

Int. J. Environ. Res. Public Health 2015, Highly Pathogenic Avian Influenza H5N1 in Mainland China. Scientific Reports 09/2014 Serological evidence of H7, H5 and H9 avian influenza virus co-infection among herons in a city park in Jiangxi, China. BMC 13/02/15 Spatial, temporal and genetic dynamics of highly pathogenic avian influenza A (H5N1) virus in China. SCIENTIFIC RESEARCH - MARCH 2014 - Avian Influenza H5N1 Surveillance in Geese of Qinghai Province, China (2012)

Références CDC

J. Clin. Microbiol - 2012 - Seroepidemiological evidence of Avian influenza A virus transmission to pigs in Southern China. ECDC 08/05/13 Human infection with a novel avian influenza virus, A(H7N9) - China. GENOMEA - JUIL/AOUT 2013 - Complete Genome Sequence of Avian Influenza Virus A/chicken/Jiangsu/1001/2013(H5N2), Demonstrating Co. LEGISLATIVE COUNCIL (HK) 12/03/13 Avian influenza vaccination programme in local chicken farms. PROTEIN CELL - 2013 - Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan. Journal of Infection Available online 6 January 2014 Emergence in China of human disease due to avian influenza A(H10N8) – Cause. Accepted 31 December 2013. published online 08 January 2014.

Journal of Infection Available online 6 January 2014 Emergence in China of human disease due to avian influenza A(H10N8) – Cause for concern? – guatemalt

In December 2013, China reported the first human case of avian influenza A(H10N8). A 73-year-old female with chronic diseases who had visited a live poultry market succumbed with community-acquired pneumonia. While human infections with avian influenza viruses are usually associated with subtypes prevalent in poultries, A(H10N8) isolates were mostly found in migratory birds and only recently in poultries.

Although not possible to predict whether this single intrusion by A(H10N8) is an accident or the start of another epidemic like the preceding A(H7N9) and A(H5N1), several features suggest that A(H10N8) is a potential threat to humans. Recombinant H10 could attach to human respiratory epithelium, and A(H10N4) virus could cause severe infections in minks and chickens. Avian Influenza A (H5N1) Virus Antibodies in Pigs and Residents of Swine Farms, Southern China Original Research Article Journ. Received 10 July 2013; received in revised form 11 September 2013; accepted 13 September 2013. published online 14 November 2013.

Background Since 1997, the H5 avian influenza viruses (AIVs) circulating in China have become an international concern. Clade 2.3.2 of H5N1 AIVs is genetically distinct from the viruses isolated before 2007 and antigenically different from the vaccine strains widely used in China. Swine farms in rural China are thought to play an important role in AIVs ecology. Objectives A seroepidemiological study was undertaken among swine farm residents and pigs to understand the prevalence of antibodies against H5N1 AIVs in southern China. GENOMEA - NOV/DEC 2013 - Genome Sequences of an H5N1 Highly Pathogenic Avian Influenza - Virus Isolated from Vaccinated Layers i. GEOCOMPUTATION - 2013 - Modelling the Avian Influenza H5N1 Virus Infection in Human and Analyzing its Evolution in China.

JANV 2014 - Update on the continuous spread and expansion of H5N1 highly pathogenic avian influenza Clade 2.3.2.1 in Asia. EUROSURVEILLANCE - AVRIL 203 - Genetic analysis of novel avian A(H7N9) influenza viruses isolated from patients in China, Februa. ECDC 27/01/14 Human infection with a novel avian influenza A(H7N9) virus, China. THE LANCET 01/05/13 Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structur. J. VIROL - 2009 - Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus derived from Wild Pikas in China. J. VIROL - 2009 - Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus derived from Wild Pikas in China. Virology Journal 2012, 9:148 The antigenic property of the H5N1 avian influenza viruses isolated in central China.

OMS - 2012 - Cumulative number of confirmed human cases for avian influenza A(H5N1) reported to WHO, 2003-2012. BMC Infectious Diseases 2012, 12:93 Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, Research article Xiang Huo1†, Rongqiang Zu1†, Xian Qi1, Yuanfang Qin1, Liang Li1, Fenyang Tang1, Zhibin Hu2 and Fengcai Zhu1* * Corresponding author: Fengcai Zhu jszfc@vip.sina.com † Equal contributors Author Affiliations 1 Jiangsu Provincial Center for Disease Control and Prevention, Jiangsu Rd. 172#, Nanjing 210009, China 2 College of Public Health, Nanjing Medical University, Hanzhong Rd. 140#, Nanjing, China For all author emails, please log on. BMC Infectious Diseases 2012, 12:93 doi:10.1186/1471-2334-12-93 Published: 18 April 2012 Abstract Background Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal.

Methods A seroepidemiological survey was conducted in poultry workers, a group expected to have the highest level of exposure to H5N1-infected birds, from 3 counties with habitat lakes of wildfowl in Jiangsu province, China. Results The overall seropositive rate was 2.61% for H5N1 antibodies. Conclusions. VACCINE NEWS 20/04/12 China culls nearly 100,000 chickens in response to bird flu. Avian influenza China’s Ministry of Agriculture recently reported an outbreak of highly epidemic H5N1 avian influenza among poultry stocks. The outbreak began in the township of Touying in the northwestern Ningxia autonomous region.

More than 23,000 chickens at several farms have shown signs and symptoms of avian flu, according to the AFP. The MOA said that preventative measures have been put in place to stop the outbreak from spreading. Government officials have culled nearly 100,000 chickens in response, and a quarantine team has arrived in the city of Guyuan to teach poultry farmers how to protect their animals, according to WorldPoultry.net. “The epidemic is under control now,” the MOA said in a statement, ChinaDaily.com.cn reports. Experts consider China to be at high risk for a bird flu epidemic because it has the world’s largest poultry population and in many rural areas chickens are kept close to humans. This story filed in Asia and tagged H5N1.