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CDC EID – JUNE 2017 – Au sommaire : Domestic Pig Unlikely Reservoir for MERS-CoV. Emmie de Wit, Friederike Feldmann, Eva Horne, Cynthia Martellaro, Elaine Haddock, Trenton Bushmaker, Kyle Rosenke, Atsushi Okumura, Rebecca Rosenke, Greg Saturday, Dana Scott, and Heinz Feldmann ( Author affiliations: National Institutes of Health, Hamilton, Montana, USA (E. de Wit, F.

CDC EID – JUNE 2017 – Au sommaire : Domestic Pig Unlikely Reservoir for MERS-CoV

Feldmann, E. ASSOCIATION OF PUBLIC HEALTH LABORATORIES - MAI 2014 - Public Health Laboratory Response to MERS CoV, ​US public health laboratories have responded quickly to detect the first US cases of MERS-CoV in Indiana and Florida.

ASSOCIATION OF PUBLIC HEALTH LABORATORIES - MAI 2014 - Public Health Laboratory Response to MERS CoV,

Public health labs across the country are prepared and ready to test for the virus. Situational Update The Illinois businessman who met with the Indiana MERS patient was not infected with MERS-CoV, according to an announcement by the CDC on May 28. The man, who had tested positive for MERS-CoV on an earlier serology test, tested negative on a more sensitive blood test. Researchers continue to investigate whether asymptomatic or mildly ill patients can transmit MERS-CoV. CDC EID - MARS 2017 - Au sommaire notamment: Serologic Evidence for MERS-CoV Infection in Dromedary Camels, Punjab, Pakistan, 2012–2015.

Author affiliations: Department of Clinical Medicine and Surgery, University of Agriculture, Faisalabad, Pakistan (M.

CDC EID - MARS 2017 - Au sommaire notamment: Serologic Evidence for MERS-CoV Infection in Dromedary Camels, Punjab, Pakistan, 2012–2015

Saqib, M.H. Hussain); University of Bonn Medical Centre, Bonn, Germany (A. Sieberg, M.A. CDC EID - FEV 2017 - Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus. Júlia Vergara-Alert1, Judith M.A. van den Brand1, W.

CDC EID - FEV 2017 - Livestock Susceptibility to Infection with Middle East Respiratory Syndrome Coronavirus

Curr Opin Virol. 2016 Feb;16:55-62. Cross host transmission in the emergence of MERS coronavirus. JAMA 13/12/16 Health Workers’ Risks for Respiratory Virus (MERS-CoV) BMC 25/08/16 Risk of MERS importation and onward transmission: a systematic review and analysis of cases reported to WHO. The large number of cases reported in the South Korean outbreak following a MERS case importation generated substantial concern on the risks that countries face towards importation and possible onward transmission.

BMC 25/08/16 Risk of MERS importation and onward transmission: a systematic review and analysis of cases reported to WHO

Our quantitative analysis provide important information that can help preparedness and response to such events: MERS international dissemination is strongly associated to air travel flows combined with cases incidence in the source area; transmission is more likely to occur in hospitals; large outbreaks are possible though rare; and high attention to MERS epidemic in the public and among professionals lead to efficient case management. The role of air travel as driver for pathogen international dissemination has been considered in several prospective studies [28, 29, 30, 31, 32, 33, 34, 35, 36, 37], with few retrospective validations [33, 38, 39, 40, 41, 42]. The third assumption may be responsible for some of the limitations of the model. PNAS 14/06/16 Unraveling the drivers of MERS-CoV transmission. Author Affiliations Edited by Burton H.

PNAS 14/06/16 Unraveling the drivers of MERS-CoV transmission

Singer, University of Florida, Gainesville, FL, and approved June 14, 2016 (received for review September 29, 2015) Significance Since it was discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 persons, one-third of whom died, essentially in the Middle East. Persons can get infected by direct or indirect contact with dromedary camels, and although human-to-human transmission is not self-sustaining in the Middle East, it can nonetheless generate large outbreaks, particular in hospital settings.

VIRUS EVOLUTION 12/06/15 MERS-CoV recombination: implications about the reservoir and potential for adaptation. UNIVERSITY OF VETERINARY MEDICINE HANNOVER 18/12/15 MERS virus – Drying out the reservoir. The recently discovered coronavirus now referred to as MERS (for Middle East Respiratory Syndrome) causes an infectious respiratory disease in humans, which can be fatal.

UNIVERSITY OF VETERINARY MEDICINE HANNOVER 18/12/15 MERS virus – Drying out the reservoir

The virus is thought to be transmitted to humans primarily via contact with dromedary camels. Now researchers led by virologist Gerd Sutter at LMU Munich, in collaboration with teams led by Professor Bart L. Proc Natl Acad Sci U S A. 2015 Sep 15; No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses. Author Affiliations Pascal et al. (1) generated mAbs using a platform called VelocImmune and evaluated their potency against the Middle East respiratory syndrome coronavirus (MERS-CoV) in vitro side by side with mAbs previously reported and in a mouse model developed by using VelociGene technology.

Proc Natl Acad Sci U S A. 2015 Sep 15; No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses.

The authors concluded that “Traditional approaches for development of antibodies are poorly suited to combating the emergence of novel pathogens…and that this study forms the basis for a rapid response to address the public threat resulting from emerging coronaviruses or other pathogens that pose a serious threat to human health in the future.” PLOS 14/07/15 Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. Citation: Perlman S (2015) Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses.

PLOS 14/07/15 Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses

PLoS Pathog 11(7): e1005023. doi:10.1371/journal.ppat.1005023 Published: July 14, 2015 Copyright: © 2015 Stanley Perlman. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Funding: The author received no specific funding for this work. MBIO 05/09/15 Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis.

EUROPE 06/07/15 Health Security Committee/Early Warning and Response System - Statement on MERS-CoV infection advice with regard to travelling. UNIVERSITY OF VETERINARY MEDICINE HANNOVER 18/12/15 MERS virus – Drying out the reservoir. SCIENCE 17/12/15 Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. + Author Affiliations ↵†Corresponding author.

SCIENCE 17/12/15 Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia

E-mail: zhuhch@hku.hk (H.Z.); yguan@hku.hk (Y.G.) ↵* These authors contributed equally to this work. Abstract Outbreaks of Middle East respiratory syndrome (MERS) raise questions about the prevalence and evolution of the MERS coronavirus (CoV) in its animal reservoir. Our surveillance in Saudi Arabia in 2014 and 2015 showed that viruses of the MERS-CoV species and a human CoV 229E–related lineage co-circulated at high prevalence, with frequent co-infections in the upper respiratory tract of dromedary camels. Related Resources In Science Magazine In Science Translational Medicine.

Références CDC

IRTA 18/06/15 IRTA-CReSA investigates the MERS-CoV in a new European project. The new European ZAPI (Zoonosis Anticipation and Preparedness Initiative) aims to shorten the time to adequately respond to emerging infectious diseases using a “one world, one health” approach. The Centre de Recerca en Sanitat Animal (IRTA-CReSA), as a partner of the consortium, will focus the research on the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), a severe respiratory disease in human transmitted by animals. Zoonoses are those diseases and infections which are naturally transmitted between animals and human. More than 60% of pathogens known to infect human are zoonotic and have a clear relationship with the Veterinary Public Health activities. The project will yield platforms for the rapid identification and production of viral domains that can be used as veterinary vaccines and will yield platforms for the rapid development, selection and production of protective antibodies to protect the human population.

. · Press release about the project kick-off meeting: Veterinary Pathology (Impact Factor: 1.93). 11/2013; Middle East Respiratory Syndrome (MERS) Coronavirus: A New Challenge for Veterinarians? SCHOOL OF PUBLIC HEALTH AND COMMUNITY MEDICINE 25/07/14 Could MERS Coronavirus be bioterrorism? New study shows why this could be one of the explanations for the paradoxes of this virus. The MERS Coronavirus (MERS Co-V) emerged in 2012 and continues to cause illness and death more than 2 years later.

It has been compared to SARS, which caused a pandemic more than 10 years ago, and public health response to MERS-CoV has been modeled on the response to SARS. Australian Infectious diseases epidemiologist Professor Raina MacIntyre from The School of Public Health And Community Medicine at UNSW, analysed the epidemiologic features of MERS-Cov compared to SARS and shows that it is very different to SARS in a new study, published today in Environment Systems and Decisions ( Many of the features are paradoxical and cannot be explained by known principles of epidemiology.

For example, despite outbreaks in hospitals, MERS-CoV was present in several mass gatherings such as the Hajj pilgrimage, and did not result in an epidemic. The other postulated explanation for the paradoxes of MERS-CoV is that there are many mild or asymptomatic cases which have gone undetected. PUBLIC HEALTH ENGLAND 02/05/14 (maj 09/10/14) Risk assessment of MERS-CoV to residents in the UK and guidance for travellers to the Middle East on reducing the risk of getting MERS-CoV.

PLOS 12/11/13 State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans. Background The first case of a novel coronavirus, now called Middle East respiratory syndrome coronavirus (MERS-CoV), was identified in a patient with acute pneumonia and renal failure in Jeddah, Kingdom of Saudi Arabia (KSA) in June 2012 1. Following identification of the virus a subsequent case from Qatar who was being treated in the UK was identified 2 and a hospital cluster of pneumonia among health care workers in Zarqa, Jordan in March/April of 2012 was retrospectively determined to have been caused by the same virus 3. Since then, as of 22 October 2013, 144 laboratory-confirmed and 17 probable MERS-CoV cases from nine countries (Figure 1a) have been notified to the World Health Organization (WHO) 3,4,5,6 in accordance with the provisions of the International Health Regulations (2005). WHO, in coordination and cooperation with its affected member states, and an informal network of academic and public health researchers, has compiled available information on MERS-CoV.

Treatment. PLOS 05/09/14 Emergence of the Middle East Respiratory Syndrome Coronavirus. Citation: Coleman CM, Frieman MB (2013) Emergence of the Middle East Respiratory Syndrome Coronavirus. PLoS Pathog 9(9): e1003595. doi:10.1371/journal.ppat.1003595 Editor: Vincent Racaniello, Columbia University, United States of America Published: September 5, 2013 Copyright: © 2013 Coleman, Frieman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: MBF and CC are funded by R01AI095569. Competing interests: The authors have declared that no competing interests exist. Introduction It began routinely enough.

What Is the Name of This Novel Coronavirus? The initial name of this novel coronavirus was hCoV-EMC, which stood for human coronavirus–Erasmus Medical College, where the first isolate was sequenced [3]. PLOS 04/12/14 Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives. Citation: Sharif-Yakan A, Kanj SS (2014) Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives. PLoS Pathog 10(12): e1004457. doi:10.1371/journal.ppat.1004457 Editor: Katherine R.

Spindler, University of Michigan Medical School, United States of America. Références OMS. OIE 12/05/14 Update May 2014 - Questions & Answers on Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) (Anglais). FAO 06/05/14 MERS-CoV: Towards a Better Understanding of the Disease. 06 May 2014 - The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) first emerged in 2012 and has caused 4991 human infections, including 137 deaths based on reports from affected countries as of 4 May 2014. The majority of cases have been detected in Saudi Arabia although cases were also reported in Jordan, Oman, Qatar, the United Arab Emirates and Yemen. Countries in Asia, Europe and North Africa have reported individual cases in travellers returning from the Middle East.

The last countries that reported their first imported MERS-CoV case include Egypt and the United States of America. The past few weeks have seen a sharp increase in the number of human cases, mostly in Saudi Arabia and the United Arab Emirates. Multiple new infections have been reported on a frequent basis since early April 2014 in Jeddah, Mecca and Riyadh prompting speculation that the virus may have evolved.

Références EUROSURVEILLANCE

MBIO January/February 2014 Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus. MAHIDOL UNIVERSITY - OCT 2013 - Regional Workshop on Emerging Infectious Diseases: Novel Corona Viruses. THE LANCET 24/05/14 MERS-CoV enigma deepens as reported cases surge. THE LANCET 12/01/15 Middle East respiratory syndrome in the shadow of Ebola. Journal of Infectious Diseases Advance 11/11/13 An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus. Infectious Diseases of Poverty 2013, 2:31 Chinese social media reaction to the MERS-CoV and avian influenza A(H7N9) outbreaks. EUROPEAN RESPIRATORY JOURNAL 01/05/14 Middle East respiratory syndrome coronavirus: epidemic potential or a storm in a teacup? Environment Systems and Decisions 25/07/14 The discrepant epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV)

Environment Systems and DecisionsFormerly The Environmentalist201434:9506. ECDC 21/01/15 Risk posed to EU by MERS-CoV remains low. ​The risk posed to the EU by MERS-CoV remains low, the latest update to the ECDC rapid risk assessment on severe respiratory disease associated with MERS-CoV concludes. No cases have been reported in Europe since late September 2014, when Austria and Turkey both reported imported cases of the disease. It remains possible that other cases of MERS-CoV could be imported to the EU following exposure in the Middle East, but the risk of sustained human-to-human transmission is low. The source of infection and mode of transmission of the disease have not yet been confirmed. As of 11 January 2015, 972 cases, including 394 deaths, had been reported by local health authorities worldwide.

In order to minimise the risk to Europe, and to support effective detection and implementation of relevant infection control procedures, it is important that health care professionals remain fully aware that the disease continues to circulate in the Middle East. The Open Virology Journal - 2010 - Understanding Human Coronavirus HcoV-NL63. NATURE 09/06/15 South Korean MERS outbreak spotlights lack of research How Middle East respiratory syndrome jumps from animals to humans remains a puzzle. CIDRAP 18/05/15 UAE confirms MERS infection; Saudi cases pass 1,000. PIG PROGRESS - Cartographie : PEDv outbreaks worldwide. Virology Journal 2015, 12:42 Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar. Microbes and Infection Volume 16, Issue 7, July 2014, Calling for rapid development of a safe and effective MERS vaccine. Ahead of Print -Lack of Middle East Respiratory Syndrome Coronavirus Transmission from Infected Camels - Volume 21, Number 4—April 2015.

Author affiliations: Kafrelsheikh University, Egypt (M.G. Ian M Mackay, PhD sur Twitter : "The annual march of #MERS... Estimation of MERS-Coronavirus Reproductive Number and Case Fatality Rate for the Spring 2014 Saudi Arabia Outbreak: Insights from Publicly Available Data. Emergence of the Middle East Respiratory Syndrome Coronavirus.

Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia, 2014. PUBLIC HEALTH ENGLAND 02/05/14 (maj 09/10/14) Risk assessment of MERS-CoV to residents in the UK and guidance for travellers to. Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa. INSERM 06/11/13 Assessment of the MERS-CoV epidemic situation in the Middle East region. EPIDEMIC_BIO_ED_AC_UK 28/04/14 Camel origins of the April Jeddah MERS-CoV outbreak. EPIDEMIC_BIO_ED_AC_UK 13/09/13 Rough Analysis of MERS-CoV case data to date. EPIDEMIC_BIO_ED_AC_UK 28/07/13 MERS-CoV potential animal reservoirs and related bat coronaviruses.

EPIDEMIC_BIO_ED_AC_UK - Autres articles sur les Coronavirus. RKI 26/03/13 Update on Robert Koch Institute (RKI) risk assessment on disease from the novel coronavirus (HCoV-EMC) CIDRAP 06/05/13 Saudis cite health facility as coronavirus cluster grows. CIDRAP 09/05/13 Saudi coronavirus case cluster grows to 15. Virology Journal 2013, 10:66 A novel coronavirus capable of lethal human infections: an emerging picture. MBIO - NOV/DEC 2012 - Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capab.

Viruses 2012, 4(11), 3044-3068 Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development. The Journal of Infectious Diseases Advance 11/04/13 A New Virulent Human Coronavirus: How Much Does Tissue Culture Tropism Tell. PARLEMENT EUROPEEN - Réponse à question : E-003186-13 Rare infection claims its ninth victim. PARLEMENT EUROPEEN - Réponse à question : E-001956-13 New coronavirus. ECDC 19/02/13 Severe respiratory disease associated with a novel coronavirus.