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PEERJ - 2019 - Middle East Respiratory Syndrome Coronavirus and the One Health concept. VIRUSES 19/07/19 MERS Coronavirus: An Emerging Zoonotic Virus. SCIENTIFIC DATA 13/12/19 A database of geopositioned Middle East Respiratory Syndrome Coronavirus occurrences. VIRUSES 19/03/19 Host Determinants of MERS-CoV Transmission and Pathogenesis. 1.

VIRUSES 19/03/19 Host Determinants of MERS-CoV Transmission and Pathogenesis

Introduction Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel pathogen that was isolated in late 2012 [1]. Since then, the virus has caused multiple outbreaks and infected more than 2000 individuals, [2] who then develop a respiratory infection ranging in severity from asymptomatic to fatal [3,4]. UNIVERSITY ROTTERDAM 26/11/19 Thèse en ligne: MERS Coronavirus at the Human-Animal Interface. RESPIROLOGY 07/02/19 Severe acute respiratory syndrome and other emerging severe respiratory viral infections. In the World Health Organization (WHO) updated list of blue‐print priority diseases, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) are included together with disease X, which represents the concept that a pathogen currently unknown to cause human disease may lead to a serious international epidemic.1 SARS‐coronavirus (SARS‐CoV) first emerged in November 2002 in Foshan, China, where many healthcare workers (HCW) became infected.

RESPIROLOGY 07/02/19 Severe acute respiratory syndrome and other emerging severe respiratory viral infections

On 21 February 2003, a 64‐year‐old male nephrologist from Guangdong Province took the infection to Hong Kong (HK) where the infection spread to 29 countries/regions within a few weeks by 16 hotel guests and visitors who were infected by the physician. SARS‐CoV spreads predominantly via respiratory droplets and contact with fomite2 but opportunistic airborne transmission is possible. The incubation period of MERS‐CoV infection is over 5 days, but may be as long as 2 weeks (median: 5.2 days (95% CI: 1.9–14.7)). One Health Volume 8, December 2019, Some One Health based control strategies for the Middle East respiratory syndrome coronavirus. A.M.

One Health Volume 8, December 2019, Some One Health based control strategies for the Middle East respiratory syndrome coronavirus

Zaki, S. van Boheemen, T.M. Bestebroer, A.D. Osterhaus, R.A. FouchierIsolation of a novel coronavirus from a man with pneumonia in Saudi Arabia N. EUROSURVEILLANCE 28/11/19 Middle East respiratory syndrome coronavirus (MERS-CoV) neutralising antibodies in a high-risk human population, Morocco, November 2017 to January 2018. VIRUSES 19/07/19 MERS Coronavirus: An Emerging Zoonotic Virus. NATURE 10/12/18 Origin and evolution of pathogenic coronaviruses. CDC EID - MAI 2019 - Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014–2017. Ahmed Khudhair1, Marie E.

CDC EID - MAI 2019 - Risk Factors for MERS-CoV Seropositivity among Animal Market and Slaughterhouse Workers, Abu Dhabi, United Arab Emirates, 2014–2017

Killerby1 , Mariam Al Mulla, Kheir Abou Elkheir, Wassim Ternanni, Zyad Bandar, Stefan Weber, Mary Khoury, George Donnelly, Salama Al Muhairi, Abdelmalik I. Khalafalla, Suvang Trivedi, Azaibi Tamin, Natalie J. Thornburg, John T. Watson, Susan I. Author affiliations: Author affiliations: Abu Dhabi Department of Health, Abu Dhabi, United Arab Emirates (A. Suggested citation for this article. Computational and Structural Biotechnology Journal Volume 17, 2019, Epidemic Models of Contact Tracing: Systematic Review of Transmission Studies of Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome.

WHOSummary of probable SARS cases with onset of illness from 1 November 2002 to 31 July (2018), p. 2003 WHOMERS situation update July 2018 G.

Computational and Structural Biotechnology Journal Volume 17, 2019, Epidemic Models of Contact Tracing: Systematic Review of Transmission Studies of Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome

Chowell, F. Abdirizak, S. NIH_GOV 14/08/18 NIH study shows how MERS coronavirus evolves to infect different species. THE OHIO STATE UNIVERSITY 14/05/18 New pig virus found to be a potential threat to humans - Study first to show possible cross-species transmission of recently discovered coronavirus. By: Misti Crane Published on May 14, 2018 COLUMBUS, Ohio – A recently identified pig virus can readily find its way into laboratory-cultured cells of people and other species, a discovery that raises concerns about the potential for outbreaks that threaten human and animal health.

THE OHIO STATE UNIVERSITY 14/05/18 New pig virus found to be a potential threat to humans - Study first to show possible cross-species transmission of recently discovered coronavirus

Researchers at The Ohio State University and Utrecht University in the Netherlands collaborated to better understand the new virus and its potential reach. Their study, the first to point to possible transmission of this virus between species, appears online in the journal PNAS. Porcine deltacoronavirus was first identified in 2012 in pigs in China, but it was not associated with disease. “Before it was found in pigs – including in the Ohio outbreak – it had only been found in various birds,” said study senior author Linda Saif, an investigator in Ohio State’s Food Animal Health Research Program at the Ohio Agricultural Research and Development Center (OARDC), in Wooster. Department of Defense Armed Forces Health Surveillance Branch 20/09/17 Global MERS-CoV Surveillance Summary. BMC PUBLIC HEALTH 02/05/18 MERS transmission and risk factors: a systematic review. The transmissibility and severity of MERS were different by outbreak countries, especially between the Middle East area and South Korea.

BMC PUBLIC HEALTH 02/05/18 MERS transmission and risk factors: a systematic review

The virus, host, and environmental factors may be the causes of the MERS outbreak-related differences between the two regions. Viruses. 2017 Sep; 9(9): 255. Identification of a Novel Inhibitor against Middle East Respiratory Syndrome Coronavirus. EUROSURVEILLANCE 08/03/18 Screening for infectious diseases among newly arrived asylum seekers, Bavaria, Germany, 2015. Samples A total of 131 alimentary samples from bats that were tested RNA-positive for four alphacoronaviruses (Rhinolophus bat CoV HKU2, Myotis bat CoV HKU6, Miniopterus bat CoV HKU8 and Hipposideros batCoV HKU10) and four lineage B (SARS-related Rhinolophus bat CoV HKU3), C (Ty-BatCoV-HKU4 and Pi-BatCoV-HKU5) and D (Rousettus bat CoV HKU9) betacoronaviruses collected in Hong Kong and the Guizhou Province, China, over a 9-year period (2006 to 2015) were included in the study (Table 1)8,11,12,13,14,15,16.

EUROSURVEILLANCE 08/03/18 Screening for infectious diseases among newly arrived asylum seekers, Bavaria, Germany, 2015

In addition, serial dilutions (2.4, 1.2, 0.6, and 0.3 μg) of the purified recombinant nucleocapsid protein of a Ty-BatCoV-HKU4 strain (SM2A) of which the sample showed positive rapid test result, three Ty-BatCoV-HKU4 RNA-negative alimentary samples of Tylonycteris pachypus and three Pi-BatCoV-HKU5 RNA-negative alimentary samples of Pipistrellus abramus were also included as controls. VIRUSES 24/02/18 MERS-CoV: Understanding the Latest Human Coronavirus Threat. NIH_ORG_PK - 2017 - Advisory on the Prevention and Control of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) during upcoming Hajj. ASSOCIATION OF PUBLIC HEALTH LABORATORIES - MAI 2014 - Public Health Laboratory Response to MERS CoV, ​US public health laboratories have responded quickly to detect the first US cases of MERS-CoV in Indiana and Florida.

ASSOCIATION OF PUBLIC HEALTH LABORATORIES - MAI 2014 - Public Health Laboratory Response to MERS CoV,

Public health labs across the country are prepared and ready to test for the virus. Situational Update The Illinois businessman who met with the Indiana MERS patient was not infected with MERS-CoV, according to an announcement by the CDC on May 28. The man, who had tested positive for MERS-CoV on an earlier serology test, tested negative on a more sensitive blood test. Researchers continue to investigate whether asymptomatic or mildly ill patients can transmit MERS-CoV. The Investigation CDC and state health departments continue large-scale multistate investigations to control the spread of the virus. Curr Opin Virol. 2016 Feb;16:55-62. Cross host transmission in the emergence of MERS coronavirus. JAMA 13/12/16 Health Workers’ Risks for Respiratory Virus (MERS-CoV) BMC 25/08/16 Risk of MERS importation and onward transmission: a systematic review and analysis of cases reported to WHO. The large number of cases reported in the South Korean outbreak following a MERS case importation generated substantial concern on the risks that countries face towards importation and possible onward transmission.

BMC 25/08/16 Risk of MERS importation and onward transmission: a systematic review and analysis of cases reported to WHO

Our quantitative analysis provide important information that can help preparedness and response to such events: MERS international dissemination is strongly associated to air travel flows combined with cases incidence in the source area; transmission is more likely to occur in hospitals; large outbreaks are possible though rare; and high attention to MERS epidemic in the public and among professionals lead to efficient case management. The role of air travel as driver for pathogen international dissemination has been considered in several prospective studies [28, 29, 30, 31, 32, 33, 34, 35, 36, 37], with few retrospective validations [33, 38, 39, 40, 41, 42].

The third assumption may be responsible for some of the limitations of the model. PNAS 14/06/16 Unraveling the drivers of MERS-CoV transmission. Author Affiliations Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved June 14, 2016 (received for review September 29, 2015) Significance Since it was discovered in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has infected more than 1,700 persons, one-third of whom died, essentially in the Middle East. Persons can get infected by direct or indirect contact with dromedary camels, and although human-to-human transmission is not self-sustaining in the Middle East, it can nonetheless generate large outbreaks, particular in hospital settings. VIRUS EVOLUTION 12/06/15 MERS-CoV recombination: implications about the reservoir and potential for adaptation. UNIVERSITY OF VETERINARY MEDICINE HANNOVER 18/12/15 MERS virus – Drying out the reservoir. The recently discovered coronavirus now referred to as MERS (for Middle East Respiratory Syndrome) causes an infectious respiratory disease in humans, which can be fatal.

The virus is thought to be transmitted to humans primarily via contact with dromedary camels. Now researchers led by virologist Gerd Sutter at LMU Munich, in collaboration with teams led by Professor Bart L. Haagmans of the Erasmus Medical Center (MC) in Rotterdam and Professor Albert Osterhaus of University of Veterinary Medicine Hannover, Foundation (TiHo), have successfully tested a candidate vaccine against MERS, in camels.

Proc Natl Acad Sci U S A. 2015 Sep 15; No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses. Author Affiliations Pascal et al. (1) generated mAbs using a platform called VelocImmune and evaluated their potency against the Middle East respiratory syndrome coronavirus (MERS-CoV) in vitro side by side with mAbs previously reported and in a mouse model developed by using VelociGene technology. The authors concluded that “Traditional approaches for development of antibodies are poorly suited to combating the emergence of novel pathogens…and that this study forms the basis for a rapid response to address the public threat resulting from emerging coronaviruses or other pathogens that pose a serious threat to human health in the future.”

To support the superiority of their approach, as implied by this statement, the authors cited human mAbs previously published by three groups (2⇓–4) and compared some of them with their own REGN3051 and REGN3048, which they found to be “more effective neutralizers than previously isolated MERS-CoV monoclonal antibodies.” Footnotes. PLOS 14/07/15 Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. Citation: Perlman S (2015) Research Driven by Curiosity: The Journey from Basic Molecular Biology and Virology to Studies of Human Pathogenic Coronaviruses. PLoS Pathog 11(7): e1005023. doi:10.1371/journal.ppat.1005023 Published: July 14, 2015 Copyright: © 2015 Stanley Perlman. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Funding: The author received no specific funding for this work.

Competing interests: The author declares that no competing interests exist. When I began my career in biomedical research in the early 1970s, there was nothing more exciting than the findings in basic cellular macromolecular metabolism that had been recently described. In initial studies, we showed that if suckling mice were infected with a virulent form of MHV, they succumbed to acute encephalitis. MBIO 05/09/15 Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis. EUROPE 06/07/15 Health Security Committee/Early Warning and Response System - Statement on MERS-CoV infection advice with regard to travelling.

UNIVERSITY OF VETERINARY MEDICINE HANNOVER 18/12/15 MERS virus – Drying out the reservoir. SCIENCE 17/12/15 Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia. + Author Affiliations ↵†Corresponding author. E-mail: zhuhch@hku.hk (H.Z.); yguan@hku.hk (Y.G.) ↵* These authors contributed equally to this work. Abstract.

Références CDC concernant MERS-CoV

IRTA 18/06/15 IRTA-CReSA investigates the MERS-CoV in a new European project. The new European ZAPI (Zoonosis Anticipation and Preparedness Initiative) aims to shorten the time to adequately respond to emerging infectious diseases using a “one world, one health” approach. Veterinary Pathology (Impact Factor: 1.93). 11/2013; Middle East Respiratory Syndrome (MERS) Coronavirus: A New Challenge for Veterinarians?

SCHOOL OF PUBLIC HEALTH AND COMMUNITY MEDICINE 25/07/14 Could MERS Coronavirus be bioterrorism? New study shows why this could be one of the explanations for the paradoxes of this virus. The MERS Coronavirus (MERS Co-V) emerged in 2012 and continues to cause illness and death more than 2 years later. It has been compared to SARS, which caused a pandemic more than 10 years ago, and public health response to MERS-CoV has been modeled on the response to SARS. PUBLIC HEALTH ENGLAND 02/05/14 (maj 09/10/14) Risk assessment of MERS-CoV to residents in the UK and guidance for travellers to the Middle East on reducing the risk of getting MERS-CoV.

PLOS 12/11/13 State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans. Background The first case of a novel coronavirus, now called Middle East respiratory syndrome coronavirus (MERS-CoV), was identified in a patient with acute pneumonia and renal failure in Jeddah, Kingdom of Saudi Arabia (KSA) in June 2012 1. Following identification of the virus a subsequent case from Qatar who was being treated in the UK was identified 2 and a hospital cluster of pneumonia among health care workers in Zarqa, Jordan in March/April of 2012 was retrospectively determined to have been caused by the same virus 3. Since then, as of 22 October 2013, 144 laboratory-confirmed and 17 probable MERS-CoV cases from nine countries (Figure 1a) have been notified to the World Health Organization (WHO) 3,4,5,6 in accordance with the provisions of the International Health Regulations (2005).

WHO, in coordination and cooperation with its affected member states, and an informal network of academic and public health researchers, has compiled available information on MERS-CoV. PLOS 05/09/14 Emergence of the Middle East Respiratory Syndrome Coronavirus. PLOS 04/12/14 Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives. Citation: Sharif-Yakan A, Kanj SS (2014) Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives.

Références OMS. OIE 12/05/14 Update May 2014 - Questions & Answers on Middle East Respiratory Syndrome Coronavirus (MERS‐CoV) (Anglais). FAO 06/05/14 MERS-CoV: Towards a Better Understanding of the Disease. 06 May 2014 - The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) first emerged in 2012 and has caused 4991 human infections, including 137 deaths based on reports from affected countries as of 4 May 2014. The majority of cases have been detected in Saudi Arabia although cases were also reported in Jordan, Oman, Qatar, the United Arab Emirates and Yemen.

Countries in Asia, Europe and North Africa have reported individual cases in travellers returning from the Middle East. The last countries that reported their first imported MERS-CoV case include Egypt and the United States of America. The past few weeks have seen a sharp increase in the number of human cases, mostly in Saudi Arabia and the United Arab Emirates. Multiple new infections have been reported on a frequent basis since early April 2014 in Jeddah, Mecca and Riyadh prompting speculation that the virus may have evolved.

Références EUROSURVEILLANCE

MBIO January/February 2014 Spread, Circulation, and Evolution of the Middle East Respiratory Syndrome Coronavirus. MAHIDOL UNIVERSITY - OCT 2013 - Regional Workshop on Emerging Infectious Diseases: Novel Corona Viruses. THE LANCET 24/05/14 MERS-CoV enigma deepens as reported cases surge. Experts are puzzled by an explosion of new cases of MERS-CoV, as a WHO committee raises concerns over the handling of the outbreak. David Holmes reports. THE LANCET 12/01/15 Middle East respiratory syndrome in the shadow of Ebola. Journal of Infectious Diseases Advance 11/11/13 An animal model of MERS produced by infection of Rhesus Macaques with MERS coronavirus. Infectious Diseases of Poverty 2013, 2:31 Chinese social media reaction to the MERS-CoV and avian influenza A(H7N9) outbreaks. The Chinese online community reacted rapidly to news about infectious disease outbreaks both within and beyond China, as shown in our study. This paper is the first to document this online response using Weibo and to compare the reaction to the MERS-CoV outbreak in 2012 with the reaction to the human infections of avian influenza A(H7N9) in 2013.

We found that the reaction to the H7N9 outbreak in 2013 was about two orders of magnitude stronger than the one to the MERS-CoV outbreak in 2012. EUROPEAN RESPIRATORY JOURNAL 01/05/14 Middle East respiratory syndrome coronavirus: epidemic potential or a storm in a teacup? Environment Systems and Decisions 25/07/14 The discrepant epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) ECDC 21/01/15 Risk posed to EU by MERS-CoV remains low. The Open Virology Journal - 2010 - Understanding Human Coronavirus HcoV-NL63.

NATURE 09/06/15 South Korean MERS outbreak spotlights lack of research How Middle East respiratory syndrome jumps from animals to humans remains a puzzle. CIDRAP 18/05/15 UAE confirms MERS infection; Saudi cases pass 1,000. PIG PROGRESS - Cartographie : PEDv outbreaks worldwide. Virology Journal 2015, 12:42 Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar. Microbes and Infection Volume 16, Issue 7, July 2014, Calling for rapid development of a safe and effective MERS vaccine. Ahead of Print -Lack of Middle East Respiratory Syndrome Coronavirus Transmission from Infected Camels - Volume 21, Number 4—April 2015. Ian M Mackay, PhD sur Twitter : "The annual march of #MERS... Estimation of MERS-Coronavirus Reproductive Number and Case Fatality Rate for the Spring 2014 Saudi Arabia Outbreak: Insights from Publicly Available Data.

Emergence of the Middle East Respiratory Syndrome Coronavirus. Emergence of MERS-CoV in the Middle East: Origins, Transmission, Treatment, and Perspectives. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia, 2014. PUBLIC HEALTH ENGLAND 02/05/14 (maj 09/10/14) Risk assessment of MERS-CoV to residents in the UK and guidance for travellers to. Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa. INSERM 06/11/13 Assessment of the MERS-CoV epidemic situation in the Middle East region. EPIDEMIC_BIO_ED_AC_UK 13/09/13 Rough Analysis of MERS-CoV case data to date. EPIDEMIC_BIO_ED_AC_UK - Autres articles sur les Coronavirus. RKI 26/03/13 Update on Robert Koch Institute (RKI) risk assessment on disease from the novel coronavirus (HCoV-EMC)

CIDRAP 06/05/13 Saudis cite health facility as coronavirus cluster grows. CIDRAP 09/05/13 Saudi coronavirus case cluster grows to 15. Virology Journal 2013, 10:66 A novel coronavirus capable of lethal human infections: an emerging picture. MBIO - NOV/DEC 2012 - Human Coronavirus EMC Does Not Require the SARS-Coronavirus Receptor and Maintains Broad Replicative Capab. Viruses 2012, 4(11), 3044-3068 Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development.

Viruses 2012, 4(11), 3044-3068 Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies – guatemalt

The Journal of Infectious Diseases Advance 11/04/13 A New Virulent Human Coronavirus: How Much Does Tissue Culture Tropism Tell. PARLEMENT EUROPEEN - Réponse à question : E-003186-13 Rare infection claims its ninth victim. PARLEMENT EUROPEEN - Réponse à question : E-001956-13 New coronavirus. ECDC 19/02/13 Severe respiratory disease associated with a novel coronavirus.