The Wall Street Journal today has an article entitled, The Growing Clout of Online Patient Groups by Laura Landro, that brings to light the power and reach of grassroots patient groups: Online patient groups have become an increasingly powerful force for health-care consumers over the past decade, raising funds for research and offering patient information and support. Now, as the cumulative power of their memberships grows, these groups are becoming invaluable partners to researchers and physicians searching for cures. Patient groups are stepping up their participation in medical and public-health research and entering far-reaching collaborative efforts with researchers, scientists and drug developers. They are raising funds and taking part in studies to evaluate the impact of online patient sites.
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Dichloroacetic acid , often abbreviated DCA , is the chemical compound with formula C H Cl 2 COOH . It is an acid , an analogue of acetic acid , in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. The salts and esters of dichloroacetic acid are called dichloroacetates . Salts of DCA have been studied as potential drugs because they inhibit the enzyme pyruvate dehydrogenase kinase . [ citation needed ] Although preliminary studies have shown DCA can slow the growth of certain tumors in animal studies and in vitro studies, "Available evidence does not support the use of DCA for cancer treatment at this time." [ 2 ]
The drug dichloroacetate (DCA) has been found to be a cheap and effective method of killing human cancer cells in test cultures outside of the body. The drug works on the premise that cancer cells shut off the cell mitochondria, thus turning off the cell device in charge of apoptosis, i.e. cell destruction. With the mitochondria disabled, cells can grow unchecked and eventually metastisize to other part of the body. DCA re-activates the cell mitochondria and causes abnormal cells to die (as they are supposed to).
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OC: organ confined; EPE: extraprostatic extension; SV + : seminal vesicle involvement; LN + : lymph node involvement. The Partin Tables use clinical features of prostate cancer – Gleason score, serum PSA, and clinical stage – to predict whether the tumor will be confined to the prostate. The tables are based on the accumulated experience of urologists performing radical prostatectomy at the James Buchanan Brady Urological Institute.