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Gluconeogenesis: Synthesis of New Glucose. Return to The Medical Biochemistry Page © 1996–2013 themedicalbiochemistrypage.org, LLC | info @ themedicalbiochemistrypage.org Gluconeogenesis is the biosynthesis of new glucose, (i.e. not glucose from glycogen). This process is frequently referred to as endogenous glucose production (EGP). The production of glucose from other carbon skeletons is necessary since the testes, erythrocytes and kidney medulla exclusively utilize glucose for ATP production.
The brain also utilizes large amounts of the daily glucose consumed or produced via gluconeogenesis. Synthesis of glucose from three and four carbon precursors is essentially a reversal of glycolysis. Reactions of Gluconeogenesis: Gluconeogenesis from two moles of pyruvate to two moles of 1,3-bisphosphoglycerate consumes six moles of ATP. The three reactions of glycolysis that proceed with a large negative free energy change are bypassed during gluconeogenesis by using different enzymes. Back to the top back to the top Lactate: Pyruvate: