Botox receptors: identification and inhibition, Oct. 3, 2003. The vesicle proteins synaptotagmin I and II function as botulinum toxin B receptors Clostridial neurotoxins (CNTs)—tetanus and botulinum neurotoxins (BoNTs)—block neurotransmission, causing paralysis and death.
Cellular entry of CNTs requires both gangliosides and proteins, and although several binding proteins have been identified, the specific protein associated with CNT internalization has remained unclear. In the September 29 , Min Dong and colleagues at the University of Wisconsin–Madison demonstrate that the secretory vesicle proteins synaptotagmins (syts) I and II bind and internalize BoNT/B (, 162:1293-1303 September 29, 2003). Dong et al. showed that BoNT/Bs, but not related toxins, were able to bind recombinant syt ectodomains in vitro. Dermatomes. Cutaneous Innervation. ANATOMY OF THE SPINAL CORD AND REFLEXES.
LUMEN Learn 'Em Nerves. Brain and Behaviour 1B: PBL scenarios. Brain and Behaviour: Clinical Skills, Sensory Testing. Brain and Behaviour: Clinical Skills, Testing Reflexes.