Cancer Immunology. Get to know the department With a long-standing reputation for quality academics and research, our department focuses on readying students and postdoctoral trainees to work in a wide range of environments, including academia, medical research, biotech and the food industry. Discover more reasons to study with us. Effects of a High-Selenium Yeast Supplement on Celecoxib Plasma Levels: A Randomized Phase II Trial -- Frank et al. 13 (2): 299 -- Cancer Epidemiology Biomarkers & Prevention. A Randomized Phase II Trial + Author Affiliations Abstract A combination of celecoxib and selenium was used in a randomized double-blind Phase II trial as a preliminary study to a multicenter Phase III colorectal cancer chemoprevention trial using these two agents together.
The purpose of this trial was to determine whether high-selenium baker’s yeast [(Saccharomyces cerevisiae) 200 μg once daily] in combination with celecoxib (400 mg once daily) altered the steady-state plasma concentration of celecoxib or produced clinically significant toxicities. Seventy-three healthy subjects (ages 40–75 years) were recruited to the 6-week study from the general local population and were randomized to either the celecoxib plus selenized baker’s yeast group or the celecoxib plus placebo group after a 2-week run in period of celecoxib only. Introduction Colorectal cancer remains the second leading cause of cancer mortality in the United States (1) .
Materials and Methods Participants. Study Design. Results. Debunking the Zone Diet. Debunking the "Zone Diet" Enter the "Zone": A Giant Leap Backwards byCharles R. Attwood, M.D., F.A.A.P. nne, an old friend of mine, walked up to Barry Sears at the Tom Landry Sports Medicine and Research Center in Dallas. She complained that the program outlined in his book, Enter The Zone -- more lean meat, egg whites, poultry and fish, while limiting many grains, vegetables, and fruits -- just didn't work for her.
She didn't feel good, and her performance level (swimming) had declined. Anne was now back on her vegetables, fruits, and whole grains. "Stay with what works best," he said, "but you know, Anne, it's not the fat and protein that's so important. Though this was contrary to everything I had told her about nutrition, the book's message was loud and clear: "All those trendy high-carbohydrate diets," he had written, "may be increasing your risk of developing heart disease. " "To complete a 'Zone-favorable' meal," he advises, "always add fat, the building blocks for eicosanoids. " IDD : Institute For Diabetes Discovery. ADVANCED GLYCATION END PRODUCTS.
A recent study presented at the annual meeting of the Diabetes Association in San Francisco shows that eating browned foods may cause heart attacks, strokes and nerve damage. Scientists have known for many years that cooking proteins with sugars in the absence of water/ forms advanced glycation products that can damage tissues in the body.
Diabetics suffer a very high incidence of nerve, artery and kidney damage because high blood sugar levels in their bodies markedly accelerate the chemical reactions that form advanced glycation products. The frightening new news is that eating foods with these advanced glycation products raises blood and tissue levels and increases nerve damage. Cooking with water prevents sugars from binding to proteins to form these poisonous chemicals. Glycation and Crosslinking Proteins - Legendary Pharmaceuticals. Pathological consequences Glycation changes the shape and properties of proteins. Crosslinking reduces the flexibility, elasticity, and functionality of the proteins.
Furthermore, the chemical modifications of glycation and crosslinking can initiate harmful inflammatory and autoimmune responses. "AGE and nonenzymatic crosslinks are demonstrated to signal inflammatory cytokines, extracellular matrix expansion, angiogenesis, and growth factors. " [deGroof] Glycation has been found in connective tissue collagen, arterial collagen, kidney glomerular basement membrane, eye lens crystallins, nerve myelin proteins and in the circulating low-density lipoprotein (LDL) of the blood. [Bucala] Arterial stiffening causes an increase in the pulse pressure wave which travels through the blood vessels after each heartbeat.
Diabetic Complications Inhibitors of Glycation Crosslinking Crosslink Breakers Nevertheless, aminoguanidine and aspirin do not seem to break A.G.E. crosslinks which have already formed. Sugars linked to human aging process. There has been quite a bit of new data coming in with regard to the way sugar actually contributes to the aging process. The thought was that sugar that is taken into the body actually creates a scenario where human cells throughout the body age faster when raw sugar is consumed.
The results of several related studies presented at the June, 2002 meeting of the American Diabetes Association confirm the findings that high-glycemic carbohydrates--sugars and starchy foods such as pasta, potatoes, and bread--cause an inflammatory response that accelerates aging and contributes to a variety of diseases (heart disease, some types of cancer, arthritis, Alzheimer’s, etc.). In addition, one of the studies showed that the antioxidant vitamins E and C block this inflammatory response.
Junk Food Causes Inflammation Blood samples were taken before eating and at one, two and three hours after eating, to detect any increase in free radicals or blood mediators of inflammation. Antioxidants to the Rescue. Townsend Letter for Doctors and Patients: Chronic fatigue, aging, mitochondrial function and nutritional supplements. In Search of..... - TV.com www.tv.com/shows/in-search-of Narrarated by Leonard Nimoy, In search of was a 30 minute syndicated show that covered a wide range of paranormal topics.
It pioneered a lot of the methodology that ... Search Engine - Download.com download.cnet.com/s/search-engine search engine free download - GSA Search Engine Ranker, Nomao - The personalized search engine, Zoom Search Engine, and many more programs Google Search - Download.com download.cnet.com/s/google-search google search free download - Google Search, Google Toolbar for Internet Explorer, Google Search, and many more programs Star Search - Episode Guide - TV.com www.tv.com/shows/star-search-2003/episodes Star Search episode guides on TV.com.
Alternative Medicine Review: Beneficial effects of alphalipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress - Abstracts: recently published abstracts -