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As devices for reading e-books proliferate, it increasingly makes sense to make publications available in an e-book. There are a number of cases in which you might do this: If you have a blog and want to make the best posts into an e-book.
If you need to convert files from one markup format into another, pandoc is your swiss-army knife.
For the past few months we ProfHackers have been running an occasional series about using the command line.
Booktype is open-source software that allows people to write, publish and print e-books within minutes.
If you want to venture into self-publishing, then you should check out Booktango. While it touts itself as an online e-book publisher, Booktango also offers a well-optimized e-book editor for the iPad and other tablet devices.