Metabolic Acidosis : Article by Karen L Stavile, MD. There are 3 approaches to understanding acid/base balance: A qualitative approach using the Henderson/Hasselbalch equation, a semiqualitative approach with base excess, and the Strong Ion Theory.
The 3 theories are reviewed below. Henderson-Hasselbalch approach to acid/base physiology The Henderson-Hasselbalch equation describes the relationship between blood pH and the components of the H2 CO3 buffering system. Acid-Base Balance. High-sucrose diet and metabolic acidosis have some similar effects on bone and they both reduce the formation of dentine.
This series of experiments was conducted in order to get information about the effects of acidosis and alkalosis on dentine during primary dentinogenesis and also to ascertain if high-sucrose diet affects dentine formation via acidosis. Chronic metabolic acidosis (0.25 mol/L of NH4Cl in drinking water), chronic metabolic alkalosis (0.25 mol/L of NaHCO3 in drinking water) and chronic respiratory alkalosis (atmospheric pressure equivalent to an altitude of 3000 m) were induced in the rats immediately after weaning for 6 and 7 weeks. One subgroup from each of the main groups was fed a high-sucrose (43%) diet and one a standard maintenance diet, each ad libitum. The control groups had the same diets, but normal drinking water and atmospheric pressure.