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How to Grow a Mind: Statistics, Structure, and Abstraction
Thomas L. Griffiths 3 , and Noah D.
In many ways biology is defined by the idea (and reality) of containers and well-defined barriers. These enable the distinction of self from the rest of the universe, separation of cells from each other, and the definition of organelles within a cell. Although many biological barriers and compartmental boundaries are lipid-based membranes, there is a growing awareness, brought about by some spectacular structural biology, of protein-based compartments that act as isolated environments within the cell. On page 81 of this issue, Tanaka et al. ( 1 ) add to the growing number of examples of protein-based microcompartments, reporting the structure of a microcompartment that sequesters ethanolamine metabolism in the bacterium Escherichia coli .
Some Enzymes Just Need a Space of Their Own -- Kang and Douglas
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