University - Department of Molecular Biology - Zemer Gitai. Brynildsen - Chemical and Biological Engineering. With the ever-increasing incidence of antibiotic-resistant infections and a weak pipeline of new antibiotics, our antibiotic arsenal is in danger of becoming obsolete. Since conventional antibiotic discovery is failing to keep pace with the rise of resistance, fresh perspectives and novel methodologies are needed to address this critical public health issue.
The main focus of our group is to use both computational and experimental techniques in systems biology, synthetic biology, and metabolic engineering to understand and combat infectious disease. We focus on three key areas: host-pathogen interactions, bacterial persistence, and biofilms. Host-pathogen interactions: The increase in the frequency of antibiotic-resistant strains has researchers searching for new antimicrobials or novel ways to potentiate current therapeutics. One exciting approach with great potential is antivirulence therapy, which focuses on disrupting the ability of a pathogen to infect a host. Link Lab. July 17 Our latest paper on enzymes that can "untie" lasso peptides has been accepted at JACS. Check it out here. June 9 After completing his third rotation in the Link Lab, molecular biology grad student Joseph Koos has joined the group.
Welcome Joe! June 4 Edwin, Eugenia, Hannah, Jen, and Santiago graduated and are off to bigger and better things. May 17 Mikhail has been awarded a Dodds Fellowship, one of Princeton's honorific fellowships. Apr 8 Jamie has been promoted to Associate Professor effective July 1. Feb 14 Jamie is named a 2013 Sloan Research Fellow in Chemistry! Read More Jan 8 New grad students Jack Lu and Frank Piscotta from Chemical and Biological Engineering and Chuhan Zong from Chemistry have joined the Link Lab. Aug 8 Our paper on lasso peptide discovery has been accepted at PNAS! Read More Aug 7 Students from last year's Project SEED cohort are featured in a video on the ACS website. Read More Jul 9 Our review article on lasso peptides has been accepted at Natural Product Reports.
University - Department of Molecular Biology - Saeed Tavazoie. University - Department of Molecular Biology - Laura Landweber. University - Department of Molecular Biology - Edward Cox. University - Department of Molecular Biology - Bonnie Bassler.