Contemporary Clinical Trials - Cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment resistant depression in primary care: The CoBalT randomised controlled trial protocol. Abstract Background Antidepressants are often the first-line treatment for depression but only one third of patients respond fully to pharmacotherapy.
This paper describes the protocol for a randomised controlled trial (RCT) designed to evaluate the clinical and cost effectiveness of cognitive behavioural therapy (CBT) as an adjunct to pharmacotherapy for patients with treatment resistant depression in primary care. Methods/design.
Internal Time — Till Roenneberg. Early birds and night owls are born, not made.
Sleep patterns may be the most obvious manifestation of the highly individualized biological clocks we inherit, but these clocks also regulate bodily functions from digestion to hormone levels to cognition. Living at odds with our internal timepieces, Till Roenneberg shows, can make us chronically sleep deprived and more likely to smoke, gain weight, feel depressed, fall ill, and fail geometry. By understanding and respecting our internal time, we can live better. Internal Time combines storytelling with accessible science tutorials to explain how our internal clocks work—for example, why morning classes are so unpopular and why “lazy” adolescents are wise to avoid them.
We learn why the constant twilight of our largely indoor lives makes us dependent on alarm clocks and tired, and why social demands and work schedules lead to a social jet lag that compromises our daily functioning.