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Abl-interactor 1. ATP-binding cassette, sub-family G (WHITE), member 1. Abcg1 Official Full Name ATP-binding cassette, sub-family G (WHITE), member 1 Background.

ATP-binding cassette, sub-family G (WHITE), member 1

4-aminobutyrate aminotransferase. Official Full Name 4-aminobutyrate aminotransferase Background 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde.

4-aminobutyrate aminotransferase

The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. Apoptosis antagonizing transcription factor. Official Full Name apoptosis antagonizing transcription factor Background The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis.

apoptosis antagonizing transcription factor

This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Virology Testing Service. Virology Testing Service Creative Biogene offers a trusted and efficient virology testing service for biotechnology products and clinic products.

Virology Testing Service

Our virologist team is dedicated to developing excellent virology testing services for clients. Microbiology Services. Microbiology Services Creative Biogene, as a leader of microbiology services, offers the most comprehensive microbiology service for pharmaceuticals, biopharmaceuticals and medical devices.

Microbiology Services

We provide rapid and accurate microbiology services at various points in the manufacturing process. With years of experience in microbiology services, our team of scientists will provide reliable services for clients to meet the requirements of USP, UP and JP. According to the corresponding standards of the USP, UP and JP, microbiology testing is a critical quality control requirement for pre-clinic and clinical products. Biosafety Testing Service. Biosafety Testing Service Brief Introduction Creative Biogene is a biotechnology company specializing in providing biosafety testing service and related products to help you ensure the safety of your biological products.

Biosafety Testing Service

Creative Biogene's sophisticated equipments, advanced technologies and highly experienced staffs are available to provide you with a series of biosafety testing services, e.g. LAM PCR service, endotoxin detection & removal service, residual DNA testing, host cell protein assay, as well as the related assay kits. Creative Biogene’s goal is to provide you with the most affordable, high-quality biosafety testing services or the related products to ensure your satisfaction in a timely and professional manner. The Application of Next Generation Sequencing. The Application of Next Generation Sequencing. Green Fluorescent Protein Product - GFP Overview. Official Full Name Green Fluorescent Protein Background Green fluorescence protein (GFP) is a 27 kDa protein derived from the jellyfish Aequorea victoria, which emits green light (emission peak at a wavelenth of 509 nm) when excited by blue light (excitation peak at a wavelenth of 395 nm).

Green Fluorescent Protein Product - GFP Overview

GFP has become an invaluable tool in cell biology research, since its intrinsic fluorescence can be visualized in living cells. Biosimilar Cell Line Development. Biosimilar Cell Line Development Brief Introduction The development process of biosimilars involves: 1) selection of a reference product that is off patent (hormone/cytokine/antibody); 2) in-depth analysis of the reference product to obtain the critical quality attributes (CQAs); 3) development of a manufacturing process to match the CQAs of the reference product involving cell line establishment and optimization, protein purification, rigorous similarity evaluations between the reference product and the biosimilar etc.

Biosimilar Cell Line Development

The variation of each step could modify the final product, thus it is currently impossible to produce the same copies of large proteins from different cell clones and manufacturing processes. It is important to find a partner that has plenty of experience and experts on the biosimilar field. Leading Capabilities Creative Biogene provides integrated solutions for your biosimilar projects. Cas9 Stable Cell Lines. Cas9 Stable Cell Lines CRISPR (clustered regularly interspaced short palindromic repeats) / Cas9 (CRISPR associated protein 9) system is adapted from a naturally occurring bacterial immune system which can protect bacteria from damage caused by phage infection.

Cas9 Stable Cell Lines

As an unimagined tool for genome engineering, CRISPR/Cas9 is now commonly used. Compared with ZFNs and TALENs, CRISPR/Cas9 employs sgRNA (single guide RNA) to specify editing which makes the system more precise, time/cost-saving and quite valuable for high-throughput genome editing. So far, a large number of published papers have involved the use of CRISPR/Cas9 technology. PDEs Superfamily. PDEs Superfamily Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP.

PDEs Superfamily

They are critical regulators of the intracellular concentrations of cAMP and cGMP as well as of their signaling pathways and downstream biological effects. PDEs have been exploited pharmacologically for more than half a century, and some of the most successful drugs worldwide today affect PDE function. Recently, mutations in PDE genes have been identified as causative of certain human genetic diseases; even more recently, functional variants of PDE genes have been suggested to play a potential role in predisposition to tumors and/or cancer, especially in cAMP-sensitive tissues. TNF and TNFR Superfamily. TNF and TNFR Superfamily A recognized triumph in immunotherapy has been the development of neutralizing antibodies and Fc fusion proteins which inhibit the binding of tumour necrosis factor (TNF) to one or both of its receptors-TNF receptor 1 (TNFR1) and TNFR2. As a primary function of the TNF superfamily molecules is to regulate cell survival, inhibition of these interactions prevents the activation of signaling pathways downstream of the TNFRs, thereby minimizing the pro-inflammatory programme which initiates in immune cells and decreasing the pathology of autoimmune and inflammatory diseases.

Overview of TNF and TNFR superfamily To date, a total of 19 ligands and 30 receptors have been identified as belonging to the TNF and TNFR superfamilies. In many cases, one ligand can bind several different receptors, thus leading to distinct signaling responses; conversely, different ligands often share the same receptor (Figure 1). TLR Family.

TLR Family Toll-like receptors (TLRs) play central roles in innate immune defense against infection by binding to microbial molecules. Because humans have only a small number of innate immune receptors available to counteract a virtually unlimited number of microbial molecules, these receptors cannot be too restricted in their antigen specificity. Instead, as has been proposed, they recognize common patterns in a large number of microbial molecules and are sometimes referred to as pattern recognition receptors (PRRs). Application of Luciferase Cells. Application of Luciferase Cells. Application of Luciferase Cells. Luciferase Product - Luciferase Overview. MicroRNA Agomir/ Antagomir Synthesis Service. MicroRNA Agomir/ Antagomir Synthesis Service miRNAs play important roles in various cellular processes including apoptosis, cell division, and proliferation and others.

Ion Channel Stable Cell Lines. Ion Channel Stable Cell Lines Membranes, or phospholipid bilayers, which are electrical insulators, build a hydrophobic, low dielectric barrier to hydrophilic and charged molecules. Ion channels are a sort of membrane protein complexes. Their function is to facilitate the diffusion of ions across biological membranes. Ion channels provide a high conducting, hydrophilic pathway across the hydrophobic interior of the membrane. Ion channels act as gateways which allow ions to travel through them to respond to multiple signal events. To obtain more specific biophysical and pharmacological analysis, scientists simplify ion channels by expressing it in cultured, non-neuronal cell lines.

Applications Advantages. Biosimilar Cell Line Development. Structure and Application: Green Fluorescent Protein. Green Fluorescent Protein. Structure and Application Green Fluorescent Protein. LAM PCR Service. The application of viral vectors in gene therapy is rapidly developing and the therapeutic results are highly promising. However, actively and passively integrating (viral) vectors may fail to deliver, or trigger severe side effects by undirected or unintended integration into the genome of the target cell. Thus, the analysis of vector integration sites in target cells is extremely important to address both biological and safety issues. Creative Biogene, as a leading biotechnology company in the world, has extensive expertise and experience which are available to provide you with customer LAM PCR service to analyze the viral vector insertion/integration site.

Residual DNA Testing. Host Cell Protein Assay. CD200 and CD200R in Inflammation and Tumor Tolerance. The main role of the immune system is to protect the organism against damage by ensuring an adequate response against various pathogens such as viruses, fungi, bacteria, parasites, environmental harm stimuli including allergens, haptens, and also from damage that may result from inappropriate immune system activation. Therefore, the immune system has to comprise mechanisms that maintain homeostasis, including both activatory and inhibitory mechanisms. Fosmid Library Construction Protocol. The fosmid system has been widely used in the construction of large-insert genomic libraries. Material Testing Service. Creative Biogene offers the most comprehensive material testing services for pharmaceutics, biopharmaceutics and pre-clinic/clinic products.

Transmission Electron Microscopy. Creative Biogene offers an expertise transmission electron microscopy service for clients. Next Generation Sequencing. LAM PCR Service. Residual DNA Testing. Host Cell Protein Assay.