First hint that body’s ‘biological age’ can be reversed. A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age.
For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation. The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm. “I’d expected to see slowing down of the clock, but not a reversal,” says geneticist Steve Horvath at the University of California, Los Angeles, who conducted the epigenetic analysis. “That felt kind of futuristic.” “It may be that there is an effect,” says cell biologist Wolfgang Wagner at the University of Aachen in Germany.
NIAGEN 300_30-Day Supply. Elysium Health. 7 Nutrients To Protect Your Brain From Aging: Flavanols, Fish, Nuts, And Blueberries May Prevent Alzheimer’s. While genetics and exercise play a large role in your brain health and risk of developing dementia, diet is quite influential, too.
There is no magical elixir that can cure or completely prevent dementia or Alzheimer’s disease, but scientists have been able to pinpoint certain nutrients that are associated with improved cognitive function or memory. Keeping your diet full of the foods that contain them, then, can help you protect your brain. Cocoa Flavanols Cocoa flavanols are found naturally in cocoa and can be beneficial to your brain health; they make dark chocolate healthier than regular chocolate, which has been washed out with milk and sugar. A 2014 study examined the impact of eating a high cocoa flavanol diet over the course of three months. Omega-3 Fatty Acids Fish that are rich in omega-3 fatty acids, like salmon, mackerel, and tuna, are going to not only help your heart health, but they’ll also give you a boost in brainpower.
Nuts Magnesium Blueberries Cruciferous Vegetables. Cause of aging: Naturally produced compound rewinds aspects of age-related demise in mice. Researchers have discovered a cause of aging in mammals that may be reversible.
The essence of this finding is a series of molecular events that enable communication inside cells between the nucleus and mitochondria. As communication breaks down, aging accelerates. By administering a molecule naturally produced by the human body, scientists restored the communication network in older mice. Subsequent tissue samples showed key biological hallmarks that were comparable to those of much younger animals.
"The aging process we discovered is like a married couple -- when they are young, they communicate well, but over time, living in close quarters for many years, communication breaks down," said Harvard Medical School Professor of Genetics David Sinclair, senior author on the study. This study was a joint project between Harvard Medical School, the National Institute on Aging, and the University of New South Wales, Sydney, Australia, where Sinclair also holds a position. Cancer connection. NADH is a scientific breakthrough which increases ATP life's energy – The NADH Store.
Beyond Resveratrol: The Anti-Aging NAD Fad. Aging cells.
Old human fibroblasts showing their mitochondria in large branched networks (red), their nuclear DNA (blue) and sites of DNA damage (green). (Image: Glyn Nelson/Flickr) Whenever I see my 10-year-old daughter brimming over with so much energy that she jumps up in the middle of supper to run around the table, I think to myself, "those young mitochondria. " Mitochondria are our cells' energy dynamos. Descended from bacteria that colonized other cells about 2 billion years, they get flaky as we age. Recent research suggests it may be possible to reverse mitochondrial decay with dietary supplements that increase cellular levels of a molecule called NAD (nicotinamide adenine dinucleotide).
Structure of nicotinamide adenine dinucleotide, oxidized (NAD+). NAD is a linchpin of energy metabolism, among other roles, and its diminishing level with age has been implicated in mitochondrial deterioration. NMN isn't available as a consumer product. Why pterostilbene instead of resveratrol?