An Atlas of Combinatorial Transcriptional Regulation in Mouse and Man. To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Figure 1 TF Expression versus Connectivity (A) Distribution of tissue specificity for all TFs. The green curves fit the bi-modal distribution as a mixture of two Gaussians. (B) Scatterplot of tissue specificity (y axis) versus number of neighbors (x axis). (C) TFs are binned into four groups of approximately equal size based on their number of interactions (x axis). Figure 2 A Homeobox Network Associated with Tissue Differentiation (A) Performance of tissue separation with (green solid curve) or without (black solid curve) information about TF protein-protein interactions ( Table S2 ).
(B) Tissue dimensionality reduction by ncKPCA into the first two Principle Components (PCs), considering features derived from the six most informative TF-TF interactions. (D) CVI for the separation of stem cells ( Table S6 ) using Sammon Mapping. Figure 3 Figure 4 Figure S1. The Human Protein Atlas. Early restriction of peripheral and proximal cell lineages during formation of the lung. Author Affiliations Edited by Michael J. Welsh, University of Iowa, College of Medicine, Iowa City, IA, and approved June 6, 2002 (received for review April 19, 2002) Abstract To establish the timing of lineage restriction among endodermal derivatives, we developed a method to label permanently subsets of lung precursor cells at defined times during development by using Cre recombinase to activate floxed alkaline phosphatase or green fluorescent protein genes under control of doxycycline-dependent surfactant protein C promoter.
Epithelial cells forming thyroid, parathyroid, esophagus, and thymus are derived from adjacent foregut tissues at approximately embryonic day (E) 9–9.5 in the mouse (1, 2). The lung buds appear on the lateral aspects of the foregut before formation of the trachea. The present study was undertaken to identify the timing of cell fate restriction and lineage relationships among cells that serve as progenitors of the respiratory epithelium during lung morphogenesis. Tbx1 regulates progenitor cell proliferation in the... [Dev Biol. 2010.
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