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Broadcast Yourself. Nature Publishing Group : science journals, jobs, and information. Home. New metabolic interdependencies revealed by plasma metabolite profiling after two dietary challenges. Oral glucose tolerance tests (OGTT) are valuable tools for diagnosis of impaired glucose tolerance and insulin resistance.
Protein intake modulates insulin secretion and sensitivity and thereby can alter the metabolic response. To assess these effects in the plasma metabolome, 15 healthy human volunteers underwent in random order an OGTT with and without 30 g of a protein-hydrolysate (OGTT + PL) followed by metabolite profiling via LC–MS/MS. Compared to the OGTT alone, plasma glucose response was reduced and insulin clearance retarded after OGTT + PL while suppression of catabolic markers such as free fatty acids, glycerol, lactate or acylcarnitines showed no difference between the two challenges. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity.
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