Human Connectome Project
DTI: Human Connectome Project. The 40 million dollar human connectome project exemplifies the relevance of studying structural and functional brain connectivity.
The NIH awarded this money to a consortium of institutions to provide an unparalleled compilation of neural data, an interface to graphically navigate this data and the opportunity to achieve never before realized conclusions about the living human brain. The human connectome project will in the near future become an amazing source of publicly available data, so keep an eye on that! Comments. Mapping The Structural Connectome in Autism. 3inShare Autism and agenesis of the corpus callosum (AgCC) are distinct conditions – the first is behavioral while the second anatomical.
Yet about 40% of people born with AgCC show clear indications of autism. Synaptic tail-chasing: Will we ever have a human connectome? The field of artificial intelligence has been set abuzz by a recent plan to create a connectome for a human brain.
To borrow a term from circuit board design, a connectome can be described as a netlist for the brain. Basically, a netlist is a file that contains a description of all the wired connections between components on the board. The actual structure of a netlist is similar to that found in object-oriented programming in that it defines electronic component in terms of “objects” instantiated from classes. Components can then be individually described by overriding values in the class definitions. For a brain, the components are the different kinds of neurons, and the wire connections are the synapses between neurons. Connectome. Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology | Biological:Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline) File:White Matter Connections Obtained with MRI Tractography.png.
Connectome. Neuroscientists plan to use a virus that carries DNA from neuron to neuron, combined with DNA sequencing technology, to understand how the brain of the mouse is wired, cell by cell.
The project proposed by Anthony Zador and others at Cold Spring Harbor Laboratory in New York, however, offers a cheaper and faster way to map neuron-to-neuron conversations happening in the brain and could shed light on disorders including autism or schizophrenia. The effort would be an exciting addition to the burgeoning field of “connectome” projects—research efforts to map the neural connections in the brain—says Amy Bernard, director of Structured Science at the Allen Institute for Brain Science in Seattle.
“Fundamental to understanding any foundation of disease or function is first understanding your parts list: what all the cells are, and how they fit together,” says Bernard. Software — INCF Neuroinformatics Portal. This page lists Open Source software packages for neuroinformatics that are or were developed in Switzerland.
We would like to build up this list of software packages, so if your group in Switzerland has developed (or part-developed) some Open Source software useful for neuroinformaticians, especially in the field of neural reconstruction, please let us know: email@example.com Cx3D Cx3D is a Java package for the simulation of the development of neural tissues. A Tutorial in Connectome Analysis: Topological and Spatial Features of Brain Networks.
A Tutorial in Connectome Analysis: Topological and Spatial Features of Brain Networks High-throughput methods for yielding the set of connections in a neural system, the connectome, are now being developed.
This tutorial describes ways to analyze the topological and spatial organization of the connectome at the macroscopic level of connectivity between brain regions as well as the microscopic level of connectivity between neurons. The New Neuron Connectome. You know what’s nuts?
That we still don’t know the basics. Forget patch clamping thousands of neurons in vivo during awake behaviour. Simultaneously. In humans. In outer space. Visualizing the Connectome - Neuroskeptic. Last year, I blogged about a new and very pretty way of displaying the data about the human ‘connectome’ – the wiring between different parts of the brain.
But there are many beautiful ways of visualizing the brain’s connections, as neuroscientists Daniel Margulies and colleagues of Leipzig discuss in a colourful paper showcasing these techniques. Here, for example, are two ways of showing the brain’s white matter tracts, as studied with diffusion tensor imaging (DTI): Another striking image is this one, a representation of the brain’s functional connectivity – the degree to which activation in each part of the brain is correlated with activity in every other part. The functional connectome is inherently difficult to visualize in 2D (or even 3D), but in this ingenious display, the brain’s surface is shown covered with hundreds of little brains, each one a colour-coded map of the connectivity from that particular point: The Margulies paper is about more than just pretty pictures, though.
Behind the Connectome Commotion | Biomedical Computation Review. Connectomics is having a moment.
Following on the heels of genomics, proteomics, transcriptomics, metabolomics, and microbiomics, the latest “omic” to seize the spotlight is generating the kind of buzz that makes other disciplines fluorescent green with envy. As the name suggests, connectomics maps connections—specifically, the ones between the neurons in an animal’s brain or nervous system. Connectome project releases brain data. The Human Connectome Project, a five-year endeavor to link brain connectivity to human behavior, has released a set of high-quality imaging and behavioral data to the scientific community. The project has two major goals: to collect vast amounts of data using advanced brain imaging methods on a large population of healthy adults, and to make the data freely available so that scientists worldwide can make further discoveries about brain circuitry.
The initial data release includes brain imaging scans plus behavioral information -- individual differences in personality, cognitive capabilities, emotional characteristics and perceptual function -- obtained from 68 healthy adult volunteers. Over the next several years, the number of subjects studied will increase steadily to a final target of 1,200. The initial release is an important milestone because the new data have much higher resolution in space and time than data obtained by conventional brain scans.
Life Science Technologies: This Is Your Brain: Mapping the Connectome. It's been 20 years since Francis Crick and Edward Jones, in the midst of the so-called Decade of the Brain, lamented science's lack of even a basic understanding of human neuroanatomy. "Clearly what is needed for a modern human brain anatomy is the introduction of some radically new techniques," the pair wrote in 1993. Clearly, researchers were listening. Connectome News, Videos, Reviews and Gossip - io9. 2013 | The brain: with all its cells and their connections. Scientists succeed in the complete reconstruction of a piece of retina August 07, 2013 Decoding the essence of being – understanding the brain and all its connections, that is Connectomics.
Scientists from the Max Planck Institutes for Medical Research in Heidelberg, of Neurobiology in Martinsried near Munich, and the Massachusetts Institute of Technology (MIT) now made an important step in this direction: After analyzing data for four years, aided by about 200 undergraduate students, the scientists created a precise diagram of all nerve cells and their connections in a piece of mouse retina. Sequencing the Connectome. Connectivity determines the function of neural circuits. Historically, circuit mapping has usually been viewed as a problem of microscopy, but no current method can achieve high-throughput mapping of entire circuits with single neuron precision. Here we describe a novel approach to determining connectivity. We propose BOINC (“barcoding of individual neuronal connections”), a method for converting the problem of connectivity into a form that can be read out by high-throughput DNA sequencing. The appeal of using sequencing is that its scale—sequencing billions of nucleotides per day is now routine—is a natural match to the complexity of neural circuits.
An inexpensive high-throughput technique for establishing circuit connectivity at single neuron resolution could transform neuroscience research. Viking Connectome Annotation System | Marc Lab, University of Utah. Connectome. The human connectome is a detailed description of the functional and structural connectivities between all cortical areas and subcortical structures in the human brain. The INM-1 aims for a multi-modal and multi-scale brain model, which respresents the basis for any kind of network analysis and simulation. The team „Connectome“ develops a novel neuroimaging technique () to map nerve fibers and their pathways in white and gray matter of the human postmortem brain with a resolution at the sub-millimeter scale. The basic idea is to apply fundamental principles of polarizing imaging in different optical setups, thus providing complementary scales of resolution to bridge the gap between structural descriptions of the human connectome at single fiber dimensions and at macroscopic fiber pathway levels.
Human Gene Connectome (HGC)
Multi-Modal Multi-Level Network and Neuroimaging Visualization and Analysis. Sex differences in the structural connectome of the human brain. Untitled. Home - Developing Human Connectome Project. Mouse Connectome Project. Connectome | MISSION. Connectome. The Human Connectome Project. Human Connectome Project. Human Connectome Project. Connectome. Diffusions-Tensor-Bildgebung. Konnektom. Neuronal Connections and the Mind - The Connectome | Jon Lieff, M.D. Neuronal Connections and the Mind - The Connectome | Jon Lieff, M.D. The Connectome – The Frontal Cortex. Human Connectome Project | Mapping the human brain connectivity. Human Connectome Project | Mapping the human brain connectivity.