Pathogen Portal. About the Pathogen Portal The Pathogen Portal supports and links to five Bioinformatics Resource Centers (BRCs). Each BRC specializes in a different group of pathogens, focusing on, but not limited to, pathogens causing (Re-)Emerging Infectious Diseases, and those in the NIAID Category A-C Priority Pathogen lists for biodefense research. The scope of the BRCs also includes Invertebrate Vectors of Human Disease. In addition to supporting, and serving as an entryway to, the BRCs, the Pathogen Portal's scientific focus is integrating host-response data that span the pathogens and vectors supported by the BRCs, thereby moving towards an integrative view of Host-Pathogen-Environment interactions, also known as the Disease Triangle. Originating from plant pathology, the concept of the Disease Triangle provides an ecological view of disease which is increasingly relevant to the Health Sciences.
Free Statistics.
T3DB: Home. Drug Profiling. Nuclear Receptors. ToxCast. Nano-Toxicity. Cytokines. Stem Cells. Caspases-Apoptosis. The Evolution of Bioinformatics in Toxicology: Advancing Toxicogenomics. First discussed in the public literature in 1999 (Nuwaysir et al., 1999), toxicogenomics was first described as a term to illustrate the integration of toxicological research with the emerging new technologies designed to broadly interrogate the functional genome (i.e., RNA, protein, metabolite profiling, and polymorphisms/functional DNA mutations). Since then, there has been a steady adoption of the principles and technologies relevant to toxicogenomics throughout academic and industry laboratories, and there have been many scientific advances in various toxicology-related disciplines since.
Examples of the integration of the technology within toxicological research will be highlighted in this review. Making Sense of the Data: Classification and Prediction Analysis Example of toxicogenomics flow scheme. Clustering Example of typical “clustering” figure. Statistical Comparison of Classes Workflow for analysis of microarray data. GSK Compounds | Tocris Bioscience. NATIONAL TOXICOLOGY PROGRAM HIGH CONTENT ASSAYS.