bioinformatics
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Aubrey de Grey - Wikipedia, the free encyclopedia
Aubrey David Nicholas Jasper de Grey (born 20 April 1963) is an English author and theoretician in the field of gerontology , and the Chief Science Officer of the SENS Foundation . He is editor-in-chief of the academic journal Rejuvenation Research , author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is perhaps best known for his view that human beings could, in theory, live to lifespans far in excess of that which any authenticated cases have lived to today.We describe a sensitive mRNA profiling technology, PMAGE (for “polony multiplex analysis of gene expression”), which detects messenger RNAs (mRNAs) as rare as one transcript per three cells. PMAGE incorporates an improved ligation-based method to sequence 14-nucleotide tags derived from individual mRNA molecules. One sequence tag from each mRNA molecule is amplified onto a separate 1-micrometer bead, denoted as a polymerase colony or polony, and about 5 million polonies are arrayed in a flow cell for parallel sequencing.
Polony Multiplex Analysis of Gene Expression (PMAGE) in Mouse Hy
Version 2.2 includes many improvements and new features: a CAD-style Model Shape Editor, an updated mEPN-3D Scheme with a new pallette of 3D shapes, Compartment Containers & Polylines for graphml/mEPN diagrams, Anaglyph Stereoscopic Viewing, official support for OpenCL 1.1 & support for OpenGL Advanced GLSL Shaders for MacOSX 10.7 (Lion). Network-based approaches are becoming increasingly popular for the analysis of complex systems of interaction and high dimensional data. Networks can be produced from a wide variety of relationships between entities. In biology this includes the interactions between individuals, disease transmission, sequence similarity, metabolic pathways, protein interactions, pathways, regulatory cascades, gene expression, etc. BioLayout Express 3D has been specifically designed for visualization, clustering, exploration and analysis of very large network graphs in two- and three-dimensional space derived primarily, but not exclusively, from biological data.
http://www.biolayout.org
The Wall Street firm, which was publicly criticized a few weeks ago by one of its own for running roughshod over the interests of clients – dubbed “muppets” in internal speak – in the pursuit of profit, has now pulled off what looks like the trade of the year. But this one comes at the expense of its own shareholders. Commentary
today.reuters.com/news/articlenews.aspx
Giant Insects Might Reign If Only There Wa
The study, “No giants today: tracheal oxygen supply to the legs limits beetle size,’’ was presented at Comparative Physiology 2006: Integrating Diversity. The Paleozoic period, about 300 million years ago, was a time of huge and abundant plant life and rather large insects -- dragonflies had two-and-a-half-foot wing spans, for example. The air’s oxygen content was 35% during this period, compared to the 21% we breathe now, Kaiser said. Researchers have speculated that the higher oxygen concentration allowed insects to grow much bigger. Tubes carry oxygen First, a bit of background: Insects don’t breathe like we do and don’t use blood to transport oxygen.
The human genome complete sequencing project in 2003 revealed the enormous instruction manual necessary to define a human being. However, there are still many unanswered questions. There are few indications on where the functional elements are found in this manual. To explain how we develop, scientists will have to decode the entire network of biological complexes that regulate development.
Biology News Net : Microarray Archive
Gene Expression
Finding your soulmate, for a neuron, is a daunting task. With so many opportunities for casual hook-ups, how do you know when you find “the one”? In the early 1960’s Roger Sperry proposed his famous “chemoaffinity theory” to explain how neural connectivity arises. This was based on observations of remarkable specificity in the projections of nerves regenerating from the eye of frogs to their targets in the brain. His first version of this theory proposed that each neuron found its target by expression of matching labels on their respective surfaces. He quickly realised, however, that with ~200,000 neurons in the retina, the genome was not large enough to encode separate connectivity molecules for each one.
Ensembl Genome Browser
Browse a Genome The Ensembl project produces genome databases for vertebrates and other eukaryotic species, and makes this information freely available online. Ensembl is a joint project between EMBL - EBI and the Wellcome Trust Sanger Institute to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. Ensembl receives major funding from the Wellcome Trust. Our acknowledgements page includes a list of additional current and previous funding bodies.
Luis Rochas Current Research Project
Complex Adaptive Systems and Computational Intelligence Almost all interesting processes in nature are highly cross linked. In many systems, however, we can distinguish a set of fundamental building blocks, which interact nonlinearly to form compound structures or functions with an identity that requires more explanatory devices than those used to explain the building blocks.
For those who are not aware of digital evolution, I am writing a quick short summary. Digital evolution means evolution of computer programs who compete for limited resources such as CPU and memory. In short, it goes something like this: - You define an extremely limited instruction set for Virtual Machine (Physics).
BioHacking
The Inner Life Of A Cell - Hemmy.net, A so
This stunning animation by BioVisions peers into the inner life of a cell. The background music really adds up to the atmosphere. One of the best abstract animation that I have ever seen. 1 videoclip after the jump.As creative as we become, and as industrious and as good as we are at designing and manufacturing living things, which we've been doing since the stone age — no matter how good we get at that, it's like calling a candle a supernova. A candle is not a super nova; it's not even in the same league. And we, as intelligent designers, are not in the same league as the "Intelligent Designer" that designed the whole shebang. We're not designing sub-atomic particles from scratch; we're not designing the Big Bang.
CONSTRUCTIVE BIOLOGY
In the not-too-distant future, the majority of electronic devices will be connected via the Internet or wireless protocols, bringing convenience and simplicity to daily living, but adding layers of technology and complexity to devices we use everyday. Jerry Fiddler offers a glimpse to his vision of the future: "The Connected World." He discusses how this "world system" will evolve through the convergence of multiple technologies resulting in one, giant interoperable system. You will learn how the road to the connected world is wide open, and that today marks the beginning of a new era in the embedded industry.