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Aubrey David Nicholas Jasper de Grey ( / d ə ˈ ɡ r eɪ / ; born 20 April 1963 [ citation needed ] ) is an English author and theoretician in the field of gerontology , and the Chief Science Officer of the SENS Research Foundation . He is editor-in-chief of the academic journal Rejuvenation Research , author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that human beings alive today could live to lifespans far in excess of any authenticated cases.
We describe a sensitive mRNA profiling technology, PMAGE (for “polony multiplex analysis of gene expression”), which detects messenger RNAs (mRNAs) as rare as one transcript per three cells. PMAGE incorporates an improved ligation-based method to sequence 14-nucleotide tags derived from individual mRNA molecules. One sequence tag from each mRNA molecule is amplified onto a separate 1-micrometer bead, denoted as a polymerase colony or polony, and about 5 million polonies are arrayed in a flow cell for parallel sequencing.
The delicate lady bug in your garden could be frighteningly large if only there was a greater concentration of oxygen in the air, a new study concludes. The study adds support to the theory that some insects were much larger during the late Paleozoic period because they had a much richer oxygen supply, said the study’s lead author Alexander Kaiser. The study, “No giants today: tracheal oxygen supply to the legs limits beetle size,’’ was presented at Comparative Physiology 2006: Integrating Diversity. The Paleozoic period, about 300 million years ago, was a time of huge and abundant plant life and rather large insects -- dragonflies had two-and-a-half-foot wing spans, for example. The air’s oxygen content was 35% during this period, compared to the 21% we breathe now, Kaiser said. Researchers have speculated that the higher oxygen concentration allowed insects to grow much bigger.
The human genome complete sequencing project in 2003 revealed the enormous instruction manual necessary to define a human being. However, there are still many unanswered questions. There are few indications on where the functional elements are found in this manual. To explain how we develop, scientists will have to decode the entire network of biological complexes that regulate development.
Manolis Kellis , Ph.D. Associate Professor with tenure MIT Computer Science and Electrical Engineering Department MIT Computational Biology Group , head Computer Science and Artificial Intelligence Laboratory Broad Institute of MIT and Harvard Stata Center - 32D.524 - 617.253.2419 ( contact ) AIT Niki Award for Science and Engineering , 2011 Presidential Early Career Award (PECASE) , 2010 Ruth and Joel Spira Teaching Award , 2009 Alfred P. Sloan Foundation Award , 2008 National Science Foundation Career Award , 2007 Karl Van Tassel Career Development Chair, 2007 Technology Review Top Young Innovators , 2006 Distinguished Alumnus (1964) Career Development Chair, 2005 MIT Sprowls Award for Best PhD Thesis in Computer Science, 2004
Complex Adaptive Systems and Computational Intelligence Almost all interesting processes in nature are highly cross linked. In many systems, however, we can distinguish a set of fundamental building blocks, which interact nonlinearly to form compound structures or functions with an identity that requires more explanatory devices than those used to explain the building blocks.
For those who are not aware of digital evolution, I am writing a quick short summary. Digital evolution means evolution of computer programs who compete for limited resources such as CPU and memory. In short, it goes something like this: - You define a universe, which is virtual memory (space) and CPU (time) - You create energy (CPU cycles) - You define an extremely limited instruction set for Virtual Machine (Physics).
As creative as we become, and as industrious and as good as we are at designing and manufacturing living things, which we've been doing since the stone age — no matter how good we get at that, it's like calling a candle a supernova. A candle is not a super nova; it's not even in the same league. And we, as intelligent designers, are not in the same league as the "Intelligent Designer" that designed the whole shebang. We're not designing sub-atomic particles from scratch; we're not designing the Big Bang.
In the not-too-distant future, the majority of electronic devices will be connected via the Internet or wireless protocols, bringing convenience and simplicity to daily living, but adding layers of technology and complexity to devices we use everyday. Jerry Fiddler offers a glimpse to his vision of the future: "The Connected World." He discusses how this "world system" will evolve through the convergence of multiple technologies resulting in one, giant interoperable system. You will learn how the road to the connected world is wide open, and that today marks the beginning of a new era in the embedded industry.
This article first appeared in the January 25, 2005 issue of NetFuture . In January, 1956, Herbert Simon, who would later win the Nobel prize in economics, walked into his classroom at Carnegie Institute of Technology and announced, "Over Christmas Allen Newell and I invented a thinking machine". His invention was the "Logic Theorist", a computer program designed to work through and prove logical theorems. Simon's casual announcement -- which, had it been true, would surely have rivaled in importance the Promethean discovery of fire -- galvanized researchers in the discipline that would soon become known as artificial intelligence (AI). The following year Simon spoke of the discipline's promise this way:
My thesis work was about creating synthetic texture using reaction-diffusion. Reaction-diffusion is a process in which two or more chemicals diffuse over a surface and react with one another to produce stable patterns. Reaction-diffusion can produce a variety of spot and stripe patterns, much like those found on many animals. Developmental biologists think that some of the patterns found in nature may be the result of reaction-diffusion processes. Often in computer graphics we want to add "texture" to an object, that is, some pattern of colors or bumps. We can texture a computer model by simulating a reaction-diffusion process on the surface of the model.
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Welcome to the Wong Lab. A) OVERVIEW Our group develops methods and software for the analysis of the data from high throughput genomics projects. Particular interests include the analysis of gene expression profiles and cis-regulatory sequences. We are working closely with collaborating laboratories in investigations of cancer and developmental biology. We develop and enhance tools in exploratory data analysis, multivariate analysis, information theory, machine learning, Monte Carlo, graph theory, linear and nonlinear differential equations, and applied them to problems in computational and systems biology.