Small molecule enoxacin is a cancer... [Proc Natl Acad Sci U S A. 2011. MicroRNAs Differentially Regulated by Akt Isoforms Control EMT and Stem Cell Renewal in Cancer Cells. 20080102_Capriotti_Marti-Renom_CBIO08. NCIR: a database of non-canonical interactions in known RNA structures — Nucleic Acids Res. + Author Affiliations Abstract The secondary and tertiary structure of an RNA molecule typically includes a number of non-canonical base–base interactions.
The known occurrences of these interactions are tabulated in the NCIR database, which can be accessed from The number of examples is now over 1400, which is an increase of >700% since the database was first published. This dramatic increase reflects the addition of data from the recently published crystal structures of the 50S (2.4 Å) and 30S (3.0 Å) ribosomal subunits.
In addition, non-canonical interactions observed in published crystal and NMR structures of tRNAs, group I introns, ribozymes, RNA aptamers and synthetic oligonucleotides are included. Received September 17, 2001; Accepted September 18, 2001. More than half the nucleotides in typical RNAs participate in normal Watson–Crick base pairing, which constitutes the regular A-form helices. This work was supported in part by grants from the Robert A. Footnotes. MicroRNA-133 regulates the expression of GLUT4 by ... [Biochem Biophys Res Commun. 2009] - PubMed result. MicroRNA Silencing in Primates: Towards Development of Novel Therapeutics — Cancer Res. + Author Affiliations Requests for reprints: Sakari Kauppinen, Santaris Pharma, Kogle Allé 6, DK-2970 Hørsholm, Denmark.
Phone: 45-45179838; Fax: 45-45179898; E-mail: sk@santaris.com . Abstract MicroRNAs (miRNA) comprise an abundant class of small noncoding RNAs that act as important posttranscriptional regulators of gene expression. Accumulating evidence showing that aberrantly expressed miRNAs play important roles in human cancers underscores them as potential targets for therapeutic intervention. Background MicroRNAs (miRNAs) are a class of small noncoding RNAs that bind to partially complementary sites in the 3′ untranslated regions (UTR) of target mRNAs and modulate gene expression by facilitating translational repression or mRNA degradation ( 1 ).
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer. Targeting Receptor Stability. MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells. To view the full text, please login as a subscribed user or purchase a subscription.
Click here to view the full text on ScienceDirect. Figure 1 miR-451 Is Downregulated in Glioma Cell Migration (A) Representative images of RFP-labeled glioma cells in the spheroid assay at day 0 and day 3 are shown. RNA was extracted from multiple spheroid assays for subsequent profiling. (B) Scatter plot showing miR profiling data for U87 cells at day 0 and day 3 of the spheroid migration assay. (C) Downregulation of miR-451 was validated by qRT-PCR in three independent glioma cell lines at day 0 and day 3 of migration in the spheroid assay.
Figure 2 miR-451 Controls Migration and Proliferation in Glioma Cell Lines (A) Effect of miR-451 expression on glioma spheroid migration. (B) Effects of miR-451 in additional motility assays. MiRWalk - The Database on Predicted and Published MicroRNAs. How to cite miRWalk database?
Dweep, H., Sticht, C., Pandey, P., Gretz, N., miRWalk - database: prediction of possible miRNA binding sites by "walking" the genes of 3 genomes, Journal of Biomedical Informatics, 44: 839-7, 2011. (JBIPubMed) miRWalk Citations : Google Scholar Scopus PubMed March/29/2011 - Last Update The Predicted Target module is updated with the lastest versions of 3rd party programs and the Validated Target module is last upated on 15th March 2013.
The miRWalk database consists of two modules. The Predicted Targets module hosts miRNA-target interactions information on the complete sequence of all known genes of Human, Mouse and Rat including all the transcripts and mitochondrial genes. The Validated Targets module hosts experimentally verified miRNA interaction information associated with genes, pathways, organs, diseases, cell lines, OMIM disorders and literature on miRNAs. It covers the following features:- 1.